ライフサイエンスコーパス: exocytosis

1 omposition, and defects in granule-regulated exocytosis.

2 cells demonstrated differential patterns of exocytosis.

3 cells involves bacterial subversion of host exocytosis.

4 cells, suggesting contributions to regulated exocytosis.

5 relation unravels one of the complexities of exocytosis.

6 been proposed to act as a 'brake' on insulin exocytosis.

7 assemble cytoskeleton to facilitate cadherin exocytosis.

8 thepsin B extracellular release by lysosomal exocytosis.

9 of vesicles with the cell plasma membrane in exocytosis.

10 iments and that occurs in vivo, e.g., during exocytosis.

11 clathrin-mediated endocytosis and increasing exocytosis.

12 the secretion of cytokines via constitutive exocytosis.

13 e proteins in platelets and assessed granule exocytosis.

14 ism for Ca(2+)-independent, PIP(2)-dependent exocytosis.

15 d transmitter release during insulin granule exocytosis.

16 er spike than disk electrodes when measuring exocytosis.

17 omal degradation or ALIX-syntenin-1-mediated exocytosis.

18 the vesicle membrane as a mean of regulating exocytosis.

19 host proteins required for synaptic vesicle exocytosis.

20 the surface membrane through Arf6-dependent exocytosis.

21 nterbouton transport and regulates evoked SV exocytosis.

22 ](i) facilitated, whereas ketamine inhibited exocytosis.

23 sicles to the site of membrane fusion during exocytosis.

24 y with the same biphasic kinetics as insulin exocytosis.

25 acting domains was sufficient to support DCV exocytosis.

26 d that Stx3, and not Stx4, is crucial for MC exocytosis.

27 , supporting its proposed functional role in exocytosis.

28 rotransmission presynaptically by inhibiting exocytosis.

29 sed on how to correct the defects in insulin exocytosis.

30 ining of individual chromaffin granules upon exocytosis.

31 king of the transporters via endocytosis and exocytosis.

32 NARE complexes driving fast Ca(2+)-dependent exocytosis.

33 ng, and under some circumstances triggering, exocytosis.

34 the surface membrane through Arf6-dependent exocytosis.

35 xocyst, are dispensable for synaptic vesicle exocytosis.

36 TXBP6), were proposed to negatively regulate exocytosis.

37 ptic vesicle recycling and the properties of exocytosis.

38 ommon mechanism that disrupts SNARE-mediated exocytosis.

39 polymerization on secretory vesicles during exocytosis.

40 ree, but not a power-of-one, relationship to exocytosis.

41 ly lysed YAC-1 thymoma cells through granule exocytosis.

42 iate assembly of the secretory machinery for exocytosis.

43 icking, but that Rtn4a specifically enhances exocytosis.

44 , providing a new tool for studying nonlytic exocytosis.

45 f genes involved in lysosomal biogenesis and exocytosis.

46 ) proteins play essential roles in regulated exocytosis.

47 recise role of Munc18-2 during lytic granule exocytosis.

48 um, which is an important organelle for endo/exocytosis.

49 ight facilitate fusion pore formation during exocytosis.

50 1 and 2 (RIM1/2) are essential regulators of exocytosis.

51 domains functions as a Ca(2+) sensor for SG exocytosis.

52 by an amount that, on average, was close to exocytosis.

53 er, is sufficient to trigger RRP but not SRP exocytosis.

54 near-complete block in secretagogue-induced exocytosis.

55 when deposited in the plasmamembrane during exocytosis.

56 at ACAP2 acts as a negative regulator of WPB exocytosis.

57 etory vesicles to the plasma membrane before exocytosis.

58 pollen tube tips characterized by intensive exocytosis.

59 pled to opposing changes in lysosomal pH and exocytosis.

60 bling both invadopodia outgrowth and MT1-MMP exocytosis.

61 in the control of intracellular calcium and exocytosis.

62 had a milder clinical phenotype and reduced exocytosis.

63 ulates secretion routes, increasing lysosome exocytosis.

64 channels are essential for Ca(2+)-triggered exocytosis.

65 dily releasable pool size, Ca(2+) influx, or exocytosis.

66 unveil key aspects of negative regulation of exocytosis.

67 ted insulin and glucagon granule docking and exocytosis.

68 functions ranging from gene transcription to exocytosis.

69 in secretory vesicles through SNARE-mediated exocytosis.

70 RIMS2 regulates synaptic membrane exocytosis.

71 at the calyx of Held, which abolished evoked exocytosis.

72 and generate the forces required to complete exocytosis(5-7).

73 mated the sum of phagocytosis (4.18 min) and exocytosis (6.71 min) times.

74 to overcome the energy barrier and complete exocytosis(7).

75 They release multiple immune mediators via exocytosis, a process that requires SNARE proteins, incl

76 n the number of synaptic vesicles primed for exocytosis accounts for the potentiation of neurotransmi

77 cells lacking otoferlin, yet cannot sustain exocytosis after long repeated stimulation.

78 (Rab3a, syntaxin-1A, and VAMP2) involved in exocytosis also localize with alpha-syn, supporting its

79 ng, including, mechanisms of endocytosis and exocytosis, although the exact role of alpha-Syn in thes

80 Upon exocytosis, AMPARs diffuse in the plasma membrane to rea

81 VAMP2 is essential for vesicular exocytosis and activity-dependent neurotransmitter relea

82 erinuclear region and a decrease in lysosome exocytosis and cell surface PLP levels.

83 rve local clearance of cortical actin during exocytosis and determine that pharmacologic or genetic d

84 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range

85 that higher temperature facilitates vesicle exocytosis and electrical tuning to higher sound frequen

86 rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the

87 cycle, notably in triggering both ultrafast exocytosis and endocytosis and recruiting synaptic vesic

88 Synaptic vesicle exocytosis and endocytosis are tightly coupled, and thei

89 cells of filamentous fungi concentrate both exocytosis and endocytosis at the apex.

90 The coupling of exocytosis and endocytosis is assumed to be Ca(2+) depen

91 regulators, cytosolic protein transporters, exocytosis and endocytosis regulators, and proteins nece

92 est a role for otoferlin in synaptic vesicle exocytosis and endocytosis, it is unclear whether these

93 cluding endomembrane trafficking, signaling, exocytosis and endocytosis.

94 ctively) in synaptic vesicle trafficking and exocytosis and in overall synaptic organization.

95 Src inhibition increased exocytosis and inhibited clathrin-mediated endocytosis o

96 rticle collisions on electrodes, vesicles in exocytosis and phagocytosis, intracellular vesicle trans

97 ovel functional role for CD56 in stimulating exocytosis and promoting cytotoxicity in human NK cells.

98 ular process of neurotransmitter release via exocytosis and provide a better physical framework to un

99 g VGLUT-pHluorin to monitor synaptic vesicle exocytosis and retrieval in intact animals.

100 ht be prevented by alphaSNAP, which inhibits exocytosis and SNARE-dependent liposome fusion.

101 ex-plasma membrane interface is critical for exocytosis and the post-fertilization block to sperm bin

102 to study the mechanisms of plant and fungal exocytosis and the roles of exocytosis in fungus-plant i

103 e the final stages of the SV cycle preceding exocytosis and thereby shape the efficacy and plasticity

104 y of EXOC2 transcript, a severe reduction in exocytosis and vesicle fusion, and undetectable levels o

105 non-neuronal cells where they play a role in exocytosis and vesicle trafficking.

106 of short-interval repetitive stimuli on both exocytosis and vesicular content in a model cell line.

107 be used for quantitative comparison between exocytosis and vesicular content in intracellular vesicl

108 novel factor promoting histamine-evoked WPB exocytosis and VWF secretion.

109 of parasitized cells is dependent on granule exocytosis and, specifically, granzyme B.

110 ified pathways and changes in degranulation (exocytosis) and adhesion were analysed.

111 -localises with myosin XI at sites of active exocytosis, and at the growing tip both proteins are spa

112 on optical recordings of membrane potential, exocytosis, and Ca(2+) in cultured hippocampal neurons.

113 Rescue with Ca(V)2 restored exocytosis, and Ca(V)2 active zone targeting depended on

114 soform of unknown function, plays no role in exocytosis, and instead plays multiple roles in intracel

115 t functions, including phagocytosis, granule exocytosis, and migration.

116 on of all four RAB3 genes nearly ablated DCV exocytosis, and re-expression of RAB3A restored this def

117 ng molecular defects in vesicle endocytosis, exocytosis, and recycling.

118 Cytotoxicity, lytic granule exocytosis, and the phosphorylation of Pyk2 are rescued

119 lacking Syt1 exhibited marked reductions in exocytosis as measured by electroretinography and single

120 , the size and kinetics of Ca(2+) -dependent exocytosis, as well as the replenishment of synaptic ves

121 gement, both at the active zone-related with exocytosis-as well as at the endocytic zone-periactive z

122 n protein, is essential for synaptic vesicle exocytosis at auditory hair cell ribbon synapses.

123 To capture synaptic vesicle exocytosis at cultured mouse hippocampal synapses, we in

124 is impairs activity-driven Ca(2+) influx and exocytosis at nerve terminals.

125 To confirm DA exocytosis based on aptasensors, DA sensitivity and sele

126 re, we suggest that variation in the rate of exocytosis beyond simple Poisson dynamics may be needed

127 ficient to account for the role of amisyn in exocytosis: Both the pleckstrin homology domain and the

128 Only Rtn4a overexpression increased exocytosis, but not overall levels, of several cell surf

129 lease, and overexpression inhibits regulated exocytosis, but previous work has failed to identify a c

130 NE exocytosis by airway neutrophils occurs in all children

131 These data suggest that the inhibition of exocytosis by G(i/o)-coupled GPCRs through the Gbetagamm

132 d that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor

133 for synaptotagmin-1 (Syt1) in photoreceptor exocytosis by using novel mouse lines in which Syt1 was

134 ng strength between calcium channels and the exocytosis calcium sensor at inner hair cell synapses ch

135 dicate that enhanced release of BDNF through exocytosis caused by activation of VDCCs and subsequent

136 , in terms of, e.g., cellular adhesion, endo/exocytosis, cellular uptake, and mechanosensing.

137 a(2+)-sensitive Syt1 oligomers, acting as an exocytosis clamp, are critical for maintaining the balan

138 ompared synaptic vesicle proteins, endo- and exocytosis cofactors, cytoskeleton components, and traff

139 into the mechanism of multigranular compound exocytosis commonly observed in various secretory cells.

140 mals exhibit enhanced spontaneous and evoked exocytosis compared to WT animals.

141 esting chaotropes can extend the duration of exocytosis compared with kosmotropic anions (e.g., Cl(-)

142 sic machinery responsible for this regulated exocytosis consists of specific proteins present both at

143 Hence, our findings establish an exocytosis-coordinated mechanism underlying the cellular

144 This measure of NE exocytosis correlated with lung damage (R = 0.55; P = 0.

145 the mechanisms underlying WPB biogenesis and exocytosis could enable therapeutic modulation of endoge

146 The opening of a fusion pore during exocytosis creates the first aqueous connection between

147 y, the open syntaxin KI partially suppresses exocytosis defects of various mutants, including snt-1/s

148 Exocytosis depends on cytosolic domains of SNARE protein

149 ding-uptake depended directly on valency and exocytosis-detachment was inversely related to this para

150 esicle-bound priming factor required for DCV exocytosis, dissipates the pH gradient across DCV membra

151 ronized secretion assay, we report here that exocytosis does not occur randomly at the cell surface b

152 domain of Munc13, enhances calcium-dependent exocytosis downstream of vesicle priming, revealing a no

153 , a major Ca(2+)-sensor for synaptic vesicle exocytosis, drove the formation of an intermediate: comm

154 e for this reduced sensitivity by increasing exocytosis efficiency and the size of the readily releas

155 embrane reflects a balance of their roles in exocytosis, endocytosis, and recycling.

156 otein Particle II (TRAPPII) is essential for exocytosis, endocytosis, protein sorting and cytokinesis

157 to such movement: tight spatial focusing of exocytosis enhances the directional persistence of movem

158 Regulated exocytosis establishes a narrow fusion pore as initial a

159 cell-to-cell transfer represents a nonlytic exocytosis event, followed by phagocytosis into a macrop

160 Although BLOC-2 depletion impaired exocytosis, exocyst depletion augmented WPB exocytosis,

161 rect plasma membrane translocation, lysosome exocytosis, exosome formation, membrane vesiculation, au

162 more, several herbivores lost the pancreatic exocytosis factor SYCN, providing an explanation for con

163 Upon exocytosis, Flower translocates from SVs to periactive z

164 synthesis caused massive spontaneous vesicle exocytosis, followed by arrested endocytosis, accounting

165 an essential signal that switches on insulin exocytosis for glucose and branched-chain oxoacids as se

166 owed that HCN1 channels restrict the rate of exocytosis from a subset of cortical synaptic terminals

167 are single-cell amperometric measurements of exocytosis from pheochromocytoma (PC12) cells between tw

168 Localized lysosome exocytosis fuels generation of large, invasive cellular

169 in part by inhibiting a separation-specific exocytosis function of the NDR/LATS kinase Cbk1, a key c

170 abolism, fatty acid oxidation, ion channels, exocytosis, homeostasis, and insulin gene regulation.

171 processes ranging from protein activation to exocytosis, however, require particles to be near a memb

172 by epithelial cell extrusion and goblet cell exocytosis; however, LAP-induced cell junction opening m

173 Actin and microtubules both play a role in exocytosis; however, their interplay is not understood.

174 at facilitating opening of syntaxin enhances exocytosis in a wide range of genetic backgrounds, and m

175 Exocytosis in alpha-cells is tightly linked to the openi

176 lowed a trajectory from their generation and exocytosis in beta cells to uptake and presentation in i

177 plant and fungal exocytosis and the roles of exocytosis in fungus-plant interactions.

178 d the size and kinetics of Ca(2+) -dependent exocytosis in IHCs was unaffected, indicating the presen

179 n tag allow direct visualization of integrin exocytosis in live cells and revealed targeted delivery

180 interaction of actin and microtubules during exocytosis in lung alveolar type II (ATII) cells that se

181 or how TPC1 regulates Ca(2+) homeostasis and exocytosis in mast cells in vivo and ex vivo.

182 reticulum Ca(2+) stores, thereby regulating exocytosis in mast cells.

183 cerbate SV endocytosis but impairs sustained exocytosis in MB neurons and alters specific motor funct

184 other than Stx3 and -4 is also required for exocytosis in MCs.

185 the fast and transient release component of exocytosis in mouse hair cells lacking otoferlin, yet ca

186 tivities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering

187 Endosidin2 (ES2) is known to inhibit exocytosis in plant and mammalian cells by targeting the

188 18-1 or Munc18-3, is essential for regulated exocytosis in platelets and platelet participation in th

189 Exocytosis in platelets is mediated by SNARE proteins, a

190 ) uncaging can trigger rapid, syt1-dependent exocytosis in the absence of Ca(2+) influx, suggesting t

191 s have established roles in synaptic vesicle exocytosis in the mammalian brain.

192 NAMPT impaired synaptic vesicle endocytosis/exocytosis in the NMJs.

193 he cement glands supports the involvement of exocytosis in the secretion of the permanent adhesives.

194 o unc-13/Munc13 and unc-10/RIM, and enhanced exocytosis in tom-1/Tomosyn mutants.

195 y of cat spermatozoa and prevented acrosomal exocytosis in vitro.

196 tivity in cell division and cortical granule exocytosis, in developmentally programmed cell death whe

197 cellular processes, such as endocytosis and exocytosis, in which they are believed to act as microdo

198 es, suggesting that Rtn4a generally enhances exocytosis independently of changes in ER morphology.

199 exocytosis, exocyst depletion augmented WPB exocytosis, indicating that it acts as a clamp.

200 m at intracellular ionic strengths and, upon exocytosis into seawater, lysin and sp18 are dispersed t

201 s to kill pathogen-infected cells is granule exocytosis, involving the release of perforin and granzy

202 Exocytosis is a fundamental membrane fusion process by w

203 Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins.

204 e used this defect to show that this form of exocytosis is not only required to accelerate MC degranu

205 14, and CFTR DeltaF508, three proteins whose exocytosis is sensitive to ER stress.

206 e in an activity-dependent manner, but their exocytosis is slow and desynchronized.

207 Exocytosis is the intracellular trafficking step where a

208 ut the molecular mechanism mediating rhoptry exocytosis is unknown.

209 Confocal microscopy imaging indicated that exocytosis is up-regulated in protrusions of Listeria in

210 Platelet degranulation, a form of regulated exocytosis, is crucial for hemostasis and thrombosis.

211 le it is unlikely that XPR1 directly affects exocytosis, it may protect Ca(2+) signaling.

212 The removal of Stx3 affected only regulated exocytosis, leaving other MC effector responses intact,

213 secretory granule release by binding to the exocytosis machinery, an effect that is enhanced by prio

214 ium-sensing proteins of the synaptic vesicle exocytosis machinery, and changes in Synaptotagmin prote

215 h repeated stimuli suggesting a depletion of exocytosis machinery.

216 Exocytosis mediates the release of neurotransmitters and

217 SNARE proteins are essential for exocytosis, mediating the fusion of vesicles with their

218 riggered secretion from a compound to a full exocytosis mode, in which SGs individually fuse with the

219 nce emerges about the detailed mechanisms of exocytosis, new questions and controversies have come to

220 n be used to explain the cellular changes in exocytosis observed by single-cell amperometry for diffe

221 That exocytosis of a multispanning membrane protein regulates

222 ge-dependent anion channel-1 (VDAC-1) and by exocytosis of ATP localized within membrane vesicles.

223 Amperometry recording reveals the exocytosis of catecholamine from individual vesicles as

224 e CSC delivery to the PM by coordinating the exocytosis of CESA-containing compartments.

225 Two-photon microscopy revealed that exocytosis of GLP-1 is biphasic, with a first peak at 1-

226 ner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic vesicles during voltage acti

227 voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic

228 se (IS) formation and have severely impaired exocytosis of lytic granules.

229 by preventing anterograde translocation and exocytosis of MT1-MMP.

230 ren harbored BAL fluid neutrophils with high exocytosis of primary granules, before the detection of

231 secretory vesicle fusion and the subsequent exocytosis of proteins that contribute to metastasis.

232 is, plays an essential role in the lysosomal exocytosis of selected tau species.

233 lucose-stimulated secretion of RESP18HD upon exocytosis of SGs from insulinoma INS-1 cells is associa

234 ced first-phase GSIS, selective reduction of exocytosis of short-dock (but not no-dock) newcomer SGs

235 Regulated exocytosis of synaptic vesicles is substantially faster

236 mited to conventional synapses but occurs by exocytosis of the dense-cored vesicles from axonal varic

237 During exocytosis of the hormone amyloid the pH increases from

238 Exocytosis of the hormone glucagon-like peptide 1 (GLP-1

239 elevation of [Ca(2+) ](i) and initiation of exocytosis of the insulin-containing secretory granules.

240 Inhibition of PI3K-dependent exocytosis of TRPC6 is thought to be the underlying mech

241 Endothelial exocytosis of Weibel-Palade body (WPB) is one of the fir

242 Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation o

243 Activity-evoked kiss and run exocytosis opens synaptic DCV fusion pores away from act

244 Although not required for normal platelet exocytosis or hemostasis, VAMP-3(-/-) mice had less plat

245 er level SCPs, such as vesicle transport and exocytosis or microtubule growth characteristic of each

246 g the activities of SCPs involved in vesicle exocytosis or microtubule growth could lead to formation

247 ulated membrane proteins following defective exocytosis or recycling.

248 bited histamine-evoked, Ca(2+)-dependent WPB exocytosis, presumably by inactivating the target Rab GT

249 ing the concept that TFEB-mediated lysosomal exocytosis promotes cellular clearance, we show that red

250 we present a balanced review of the role of exocytosis proteins in T2D, with thoughts on novel strat

251 with numerous reports of deficiencies in the exocytosis proteins that regulate insulin release from b

252 WPB exocytosis provides a novel route for release of ILVs du

253 The underlying mechanisms of compound exocytosis remain largely unresolved.

254 The identity of the Stxs involved in MC exocytosis remains controversial.

255 hin the events of SNARE complex assembly for exocytosis remains unclear.

256 The fundamental process of polarised exocytosis requires the interconnected activity of molec

257 The stimulation of CD63 exocytosis requires virus replication.

258 ults support the idea that TFEB-mediated tau exocytosis serves as a clearance mechanism to reduce int

259 tional chemical synapses in synaptic vesicle exocytosis.SIGNIFICANCE STATEMENT RAB3A-interacting mole

260 cting proteins, amisyn and dynamin-1, to the exocytosis site in insulin-secreting beta-cells.

261 hs localize PSD95 with patterning similar to exocytosis site location.

262 In neuronal exocytosis, SNARE assembly into a stable four-helix bund

263 o required membrane traffic, RAB13-dependent exocytosis, specifically, but not trafficking events reg

264 ntil recently, a consensus formed that after exocytosis, SVs are recovered by either fusion pore clos

265 nt pathways, including calcium ion dependent exocytosis, synaptic transport and the Kyoto Encyclopedi

266 ceptual framework of regulation of microneme exocytosis that ensures egress, motility, and invasion.

267 ransmitters, enabling the quantal release by exocytosis that underlies synaptic transmission.

268 e secretory granule has an acidic pH but, on exocytosis, the beta-endorphin fibril would encounter ne

269 While not preventing glucose-induced insulin exocytosis, the diminished granule availability substant

270 ired the tight coupling of calcium influx to exocytosis, thereby suppressing neurotransmitter release

271 uce signaling, mediate adhesion, and promote exocytosis through interactions with focal adhesion kina

272 Thus, homeostatic modulation of presynaptic exocytosis through specific mechanisms stabilizes synapt

273 the crucial spatiotemporal cue that couples exocytosis to ADBE and subsequent SV reformation.

274 ransmission, acting directly at the level of exocytosis to dampen connection strength selectively whe

275 aptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransm

276 s, the brain relies on a specialized form of exocytosis to mediate information flow throughout its va

277 astrocyte CRAC channels stimulated vesicular exocytosis to mediate the release of gliotransmitters, i

278 ults demonstrate that Listeria exploits host exocytosis to stimulate intercellular spread of bacteria

279 HEK293T cells increased basal autophagy and exocytosis, two cellular functions that are independentl

280 n of ceramide pathways and calcium sensitive exocytosis underlies seizures and large body size associ

281 Vesicle exocytosis underpins signaling and development in plants

282 eptor triggers feedback mechanisms that bias exocytosis upgradient and endocytosis downgradient, thus

283 ortically-localized vesicles which underwent exocytosis upon activation.

284 ulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels.

285 /2) and t(fall)) that define the duration of exocytosis vary with the Hofmeister series (Cl(-) < Br(-

286 Insulin granule exocytosis was accelerated twofold, but the secreted ins

287 The process for lipid modulation of nonlytic exocytosis was associated with actin changes in macropha

288 The increase in insulin exocytosis was attributed mainly to an enhanced recruitm

289 By contrast, a third, slower component of exocytosis was blocked by the peptide, as was the functi

290 slides were optimized, and neurotransmitter exocytosis was evoked by injecting solutions with elevat

291 d closing of the membrane fusion pore during exocytosis was found to be strongly dependent on the cou

292 e were treated with NMN, vesicle endocytosis/exocytosis was improved and endplate morphology was rest

293 Moreover, when endosome translocation or exocytosis was inhibited by depletion of Protrudin or Sy

294 Nifedipine-resistant RRP exocytosis was poorly affected by 5 mm intracellular EGT

295 In RIM1/2-deficient neurons, DCV exocytosis was undetectable.

296 ore a potentially significant role of 5RK in exocytosis, we next amperometrically analyzed catecholam

297 f trophoblast cells, and inhibited lysosomal exocytosis, whereby the secretion of lysosomal-associate

298 ilize synaptic ribbons to sustain continuous exocytosis while making rapid, fine adjustments to relea

299 r inability to engage multigranular compound exocytosis, while leaving most single-vesicle fusion eve

300 lls for which localized Ca2+ influx triggers exocytosis with high probability and minimal latency.