ライフサイエンスコーパス: exonuclease

1 sembly' (TEDA) method that only uses a 5'-3' exonuclease.

2 into a viable target for the Xrn2 terminator exonuclease.

3 enhanced 2.5-fold by incorporating the Trex2 exonuclease.

4 ied ONs demonstrate high stability toward 3'-exonuclease.

5 complex, frequently in combination with Cas4 exonuclease.

6 degradation of this structure by the RNase R exonuclease.

7 urn leads to their degradation by the DIS3L2 exonuclease.

8 leading to their degradation via the DIS3L2 exonuclease.

9 ked ends and are resistant to degradation by exonucleases.

10 t of DNA assembly methods that employ single exonucleases.

11 ay naturally inhibit degradation by cellular exonucleases.

12 rmits digestion of the RNA body by conserved exonucleases.

13 activities of various 3'-end polymerases and exonucleases.

14 y protecting it from phosphatases and 5-to-3 exonucleases.

15 organs and (iii) protects siRNAs from 5-to-3 exonucleases.

16 , we identify potential inhibitors for DEDDh exonucleases.

17 ss requiring several nuclear and cytoplasmic exonucleases.

18 loom's syndrome (BLM) helicase together with exonuclease 1 (EXO1) and DNA2 nucleases catalyze kilobas

19 in loss of MutLalpha-specific regulation of exonuclease 1 (Exo1) during DNA repair.

20 log 3 (Msh3) stimulates 5' to 3' excision by exonuclease 1 (Exo1) from a single-strand break 5' to th

21 Exonuclease 1 (Exo1) is a 5'-->3' exonuclease and 5'-fla

22 Exonuclease 1 (Exo1) is an evolutionarily conserved euka

23 Next, MRN loads exonuclease 1 (Exo1) onto the free DNA ends to initiate

24 Here, we demonstrate that exonuclease 1 (EXO1) plays a key role in the resolution

25 study, we show that Metnase associates with exonuclease 1 (Exo1), a 5'-exonuclease crucial for 5'-en

26 luding the Bloom syndrome (BLM) helicase and exonuclease 1 (EXO1), play a major role in generating th

27 Human exonuclease 1 (hExo1) is a member of the RAD2/XPG struct

28 One such enzyme is the human exonuclease 1 (hExo1) metalloenzyme, which cleaves DNA s

29 Mutations in the three-prime repair exonuclease 1 (TREX1) cause a spectrum of human autoimmu

30 Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like disease Aicar

31 Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleav

32 Three-prime repair exonuclease 1 knockout (Trex1(-/-)) mice suffer from sys

33 tudies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, pre

34 k1 activation following DNA end-resection by Exonuclease 1.

35 end resection in budding yeast cells lacking exonuclease 1.

36 caused by mutations of TREX1 (3-prime repair exonuclease-1).

37 his study, we demonstrated the role of novel exonuclease 5 (EXO5) gene in androgen-induced double str

38 Among them, the L151P mutation in the exonuclease 5 (EXO5) gene was present in all affected si

39 Polymerases and exonucleases act on 3' ends of nascent RNAs to promote t

40 nding protects the prespacer boundaries from exonuclease action.

41 Unlike an exonuclease active site mutant that we previously charac

42 ransfer, followed by biased binding into the exonuclease active site.

43 e entry path of the primer strand in the PHP-exonuclease active site.

44 6 mutation that lacks Pol e's polymerase and exonuclease activities has increased dNTP concentrations

45 Both endonuclease and exonuclease activities of MRE11 were required for MMEJ,

46 nts, we show that both the DNA synthesis and exonuclease activities of the POLD1 subunit contribute t

47 in DNA and have weak endoribonuclease and 3'-exonuclease activities on r8oxoG substrate.

48 is a vertebrate nuclease with both endo- and exonuclease activities that acts on a wide range of nucl

49 RNase J1 is a homodimer with exonuclease activity aided by two metal cofactors at the

50 east Polepsilon-P286R analog retains partial exonuclease activity and is more accurate than exonuclea

51 type I alkaline nuclease, UL12, has 5'-to-3' exonuclease activity and shares homology with nucleases

52 Together, the 3'->5' exonuclease activity and the variable mismatch extension

53 However, TREX1 mutants competent for DNA exonuclease activity are also linked to AGS.

54 in remarkable protection of that oligo from exonuclease activity as it remains hybridized to the dsD

55 of the protein complex leading to a loss of exonuclease activity from Mre11.

56 patient highlighted the significance of APE1 exonuclease activity in cancer etiology.

57 omain of OsCCR4a and OsCCR4b exhibited 3'-5' exonuclease activity in vitro, and point mutation of a c

58 Notably, APE1's exonuclease activity is critical for SSB repair and SSB

59 We conclude that UL12 exonuclease activity is essential for the production of

60 rand displacement synthesis unless its 3'-5' exonuclease activity is removed.

61 Depletion of MRE11 and abrogation of its exonuclease activity negatively impact viral replication

62 e the 5' flap endonuclease but not the 5'-3' exonuclease activity of Fen1, and chemically inhibiting

63 -driven expression but is independent of the exonuclease activity of gp5.

64 d newly replicated genome is degraded by the exonuclease activity of MRE11, and the fragmented nascen

65 sion site is enlarged into a DNA gap via the exonuclease activity of MRX, which is stimulated by Sae2

66 The proofreading exonuclease activity of replicative DNA polymerase excis

67 ed nucleotides are excised through the 3'-5' exonuclease activity of the DNA polymerase holoenzyme.

68 Surprisingly, the 3'->5' exonuclease activity of the hPolepsilon holoenzyme was s

69 he three small subunits regulates the 3'->5' exonuclease activity of the hPolepsilon holoenzyme.

70 inhibitors, ATA and PV6R, indeed inhibit the exonuclease activity of the viral protein NP exonuclease

71 n together, our results demonstrate that the exonuclease activity of UL12 is essential for the produc

72 We demonstrate that the exonuclease activity of UL12 is essential for the produc

73 In this communication, we confirm that the exonuclease activity of UL12 is essential for viral repl

74 They exhibit 5' exonuclease activity on single-stranded DNA, hydrolyzing

75 eavage activity was not required for Exo1 5'-exonuclease activity on the lagging strand daughter DNA,

76 suggest that Metnase enhances Exo1-mediated exonuclease activity on the lagging strand DNA by facili

77 ase is often used either alone for its 3'-5' exonuclease activity or together with a 5'-3' exonucleas

78 vity, but confers on hEXOG a strong 5'-dsDNA exonuclease activity that precisely excises a dinucleoti

79 dation than pol; under oxidative conditions, exonuclease activity therefore declines more rapidly tha

80 2 nuclease, which is hypothesized to use its exonuclease activity to digest through the lesion to pro

81 orthogonal method, LC-MS, to investigate 3' exonuclease activity toward the antisense strand metabol

82 HDH activity although it does not have 5'-3' exonuclease activity, and the Rat1-Rai1 complex can comp

83 Purified human Poldelta-R689W has normal exonuclease activity, but the nucleotide selectivity of

84 ffinity, reduced thermostability, diminished exonuclease activity, defective catalytic activity, and

85 results demonstrate that independent of its exonuclease activity, the proofreading subunit of the re

86 gamma result in the stimulation of their 3'-exonuclease activity.

87 e other human RecQ family members to possess exonuclease activity.

88 ed the helicase activity of WRN, but not its exonuclease activity.

89 nd selectively reduces WRN helicase, but not exonuclease activity.

90 CNA, although PCNA is dispensable for APE1's exonuclease activity.

91 p-dependent endonuclease activity, but lacks exonuclease activity.

92 nuclease activity and in parallel with MRE11 exonuclease activity.

93 KBM mediates Ku-dependent stimulation of WRN exonuclease activity.

94 tive DNA polymerase with an associated 3'-5' exonuclease activity.

95 ce of which severely diminishes its 3' to 5' exonuclease activity.

96 e inhibitor from excision by the viral 3'-5' exonuclease activity.

97 the quantitative determination of acidic 5' exonuclease activity.

98 tain endonuclease activity in the absence of exonuclease activity.

99 cer initiation in vivo, independent of their exonuclease activity.

100 Exonuclease 1 (Exo1) is a 5'-->3' exonuclease and 5'-flap endonuclease that plays a critic

101 This model explains how both exonuclease and endonuclease activities of Mre11 functio

102 ombinant proteins, we show that the combined exonuclease and endonuclease activities of recombinant M

103 recognizes DNA double-strand breaks and has exonuclease and endonuclease activities that help to ini

104 ne expression in bacteria, and catalyze both exonuclease and endonuclease activity.

105 ork provides important insights into the PHP-exonuclease and reveals unique properties that make it a

106 ands, acting primarily as a processive 5'-3' exonuclease and secondarily as a 5'-flap endonuclease.

107 Its dominant, processive 5'-3' exonuclease and secondary 5'-flap endonuclease activitie

108 e demonstrate that MrfB is a metal-dependent exonuclease and that the N-terminus of MrfB is required

109 The (R) isomer provided protection from 5' exonuclease and the (S) isomer provided protection from

110 revisiae Full-length resection requires Exo1 exonuclease and the DSB-responsive kinase Tel1, but not

111 ith short homologous ends were treated by T5 exonuclease and then transformed into Escherichia coli t

112 cation and 3' uridylation and thus relies on exonucleases and nucleotidyl transferases.

113 RNA cap protects the primary transcript from exonucleases and recruits cap-binding complexes that med

114 n) in this region, within a gene encoding an exonuclease, associates with parasite recrudescence foll

115 SARS-CoV-2 has an exonuclease-based proofreader to maintain the viral geno

116 Surprisingly, EXO1 is not the major 5' -> 3' exonuclease, but the DSB-responsive kinase ATM proved a

117 yme was originally identified as a 3' --> 5' exonuclease, but we show here that NrnA is bidirectional

118 Several viral and human DEDDh exonucleases can serve as antiviral drug targets due to

119 We show that the absence of 3' exonucleases can trigger levels of over-replication in t

120 nalysis by the chromatin immunoprecipitation-exonuclease (ChIP-exo) method allowed the identification

121 e effect that Rad9 exerts over the Sgs1/Dna2 exonuclease complex.

122 ch begins with 5' end resection, mediated by exonuclease complexes, one of which contains Exo1.

123 his study we have investigated how 3' and 5' exonucleases contribute towards the successful terminati

124 e associates with exonuclease 1 (Exo1), a 5'-exonuclease crucial for 5'-end resection to mediate DNA

125 onuclease activity and is more accurate than exonuclease-dead Polepsilon.

126 Two mouse models of polymerase exonuclease deficiency shed light on mechanisms of mutat

127 Combining exonuclease deficiency with a polymerisation domain subs

128 tor effects far exceeding the effect of Pole exonuclease deficiency.

129 Thus, we used WRN exonuclease-deficiency as a model to investigate the fat

130 Notably, in WRN exonuclease-deficient cells, persistence of RAD51 correl

131 An APE1 exonuclease-deficient mutant identified in somatic tissu

132 g a well-defined replicon, we show that both exonuclease-deficient Pole (Pole-exo-) and Pole-P301R ge

133 show that Poldelta can remove errors made by exonuclease-deficient Polepsilon in vitro.

134 RNAs and the increased protection against 5'-exonuclease degradation afforded by the ANA modification

135 cooperate to recruit CtIP and promote MRE11 exonuclease-dependent fork restart while suppressing the

136 niently prepared from PCR products by lambda-exonuclease digestion and streptavidin magnetic bead iso

137 we determined that ligand binding alters the exonuclease digestion kinetics to an extent that closely

138 n of cDNA ends (RACE), 5' radiolabeling, and exonuclease digestion, which revealed the following obse

139 tin immunoprecipitation (ChIP) with 5' -> 3' exonuclease digestion.

140 chromatin immunoprecipitation with 5' to 3' exonuclease digestion.

141 ich is rarely accompanied by extensive ssDNA exonuclease digestion.

142 merase PAPD5, which if remaining recruit the exonuclease DIS3L or DIS3L2 to degrade the miRNA.

143 Depletion of PAPD5 or the cytoplasmic exonuclease DIS3L rescues the effect of PARN depletion o

144 ole of the Perlman syndrome-associated 3'-5' exonuclease Dis3l2 in rRNA processing.

145 Here, we present a 'T5 exonuclease DNA assembly' (TEDA) method that only uses a

146 ssays, we show here that the bacterial 3'-5' exonucleases DnaQ and ExoT can trim long 3' overhangs of

147 ur findings implicate the E. coli host 3'-5' exonucleases DnaQ and ExoT in spacer adaptation and reve

148 ed of an N-terminal DNA flap endonuclease/5' exonuclease domain (FEN/EXO) and a C-terminal DNA polyme

149 Crystal structures of the exonuclease domain in complex with Mn2+/Mg2+ revealed a

150 Human tumors with exonuclease domain mutations in the gene encoding DNA po

151 Much attention has been focused on POLE exonuclease domain mutations, which occur frequently in

152 Substitutions in the exonuclease domain of DNA polymerase e cause ultramutate

153 Alterations in the exonuclease domain of DNA polymerase epsilon (Polepsilon

154 y subunits (Pol31 and Pol32) lie next to the exonuclease domain of Pol3 but do not engage the DNA.

155 ) proteins and/or documented mutation in the exonuclease domain of POLE; and (2) MMRP cohort with nor

156 (MMR) proteins, and DNA sequencing for POLE exonuclease domain were done to classify tumors as p53 a

157 l changes in the protein are confined to the exonuclease domain, with R301 pointing towards the exonu

158 We also identify Exonuclease domain-containing 1 (EXD1) as a partner of t

159 EXD2 (3'-5' exonuclease domain-containing protein 2) is an essential

160 lon) mutation is a P286R substitution in the exonuclease domain.

161 ein with a conserved DEDDy superfamily 3'-5' exonuclease domain.

162 QL5 and DmWRNexo, which contains a conserved exonuclease domain.

163 ol III residues along the fingers, thumb and exonuclease domains.

164 epair (MMR) across biology depicts extensive exonuclease-driven strand-specific excision that begins

165 erminal segments absent in other DnaQ family exonucleases enclose the central chimeric active sites.

166 The isolated recombinant exonuclease-endonuclease-phosphatase domain of OsCCR4a a

167 al and zygotic factors such as the conserved exonuclease ERI-1.

168 Mre11 exonuclease, EXD2, and Exo1 execute resection, and Artem

169 erase with polymerase (pol) and proofreading exonuclease (exo) activities.

170 This mutant protein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities

171 tu at the metal core of Bacteriophage-lambda Exonuclease (Exo-lambda), during catalysis.

172 ion involves phosphorylation of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like k

173 naling pathway that controls the activity of exonuclease Exo1 to prevent aberrant fork resection duri

174 th several nucleases, including the 5' dsDNA exonuclease EXO1.

175 bly mediated by helicases, are suppressed by exonucleases ExoI and RecJ.

176 during RC DNA to CCC DNA conversion, two 3' exonucleases, exonuclease I (Exo I) and Exo III, were us

177 RICE1 exhibited a DnaQ-like exonuclease fold and formed a homohexamer with the activ

178 tro integration assays, deep sequencing, and exonuclease footprinting, we show that Cas1-2/I-E-via th

179 xonuclease activity or together with a 5'-3' exonuclease for its DNA polymerase activity.

180 PAP I competes with the 3' -> 5' exonucleases for pre-tRNA substrates adding short poly(A

181 ase that is distinct from the canonical DEDD exonucleases found in the Escherichia coli and eukaryoti

182 le possible mechanism by showing that the 3'-exonuclease function of the polymerase is not needed.

183 ike gamma DNA polymerases, ablation of 3'-5' exonuclease function resulted in a modest 5-8-fold error

184 In mutants of FRY1 and the nuclear 5'-3' exonuclease genes XRN2 and XRN3, we find that a large nu

185 The PHP-exonuclease has a trinuclear zinc center, coordinated by

186 Recently, the WRN exonuclease has been linked to protection of stalled for

187 to CCC DNA conversion, two 3' exonucleases, exonuclease I (Exo I) and Exo III, were used in combinat

188 plementary strands of aptamer (CSs) complex, exonuclease I (Exo I) and gold electrode.

189 The sensing platform is based on exonuclease I (Exo I), terminal deoxynucleotidyl transfe

190 pe structure on the surface of electrode and exonuclease I (Exo I).

191 etected the activities of two model enzymes, exonuclease I and uracil DNA glycosylase with high sensi

192 ble method that utilizes exonuclease III and exonuclease I to interrogate the binding properties of s

193 Dictyostelium cells disrupted in exonuclease I, a critical factor for HR, are sensitive t

194 a biological role for the first 5' to 3' RNA exonuclease identified in E. coli.

195 leic acid self-assembly circuitry and enzyme exonuclease III (Exo III) for the differentiation of sin

196 The enzyme Exonuclease III (Exo III) is a useful tool in this regar

197 Herein, we report a type of exonuclease III (Exo III)-powered stochastic DNA walker

198 escribe a generalizable method that utilizes exonuclease III and exonuclease I to interrogate the bin

199 Mechanistically, Rad50 restricts the Mre11 exonuclease in an ATP binding-dependent manner, preventi

200 1 may function non-redundantly as a 3'-to-5' exonuclease in conjunction with PARN.

201 ments revealed PLD3 as the principal acid 5' exonuclease in HeLa cells, where it showed a markedly hi

202 d the (S) isomer provided protection from 3' exonuclease in the context of a terminally modified olig

203 r another function of UL12, we introduced an exonuclease-inactivating mutation into the viral genome.

204 These results reveal a distinct mechanism of exonuclease inactivation by the P301R substitution and a

205 lease site, an outcome not observed with the exonuclease-inactive Pol epsilon-D290A,E292A variant lac

206 er these observations are consistent with an exonuclease-independent MMR strand excision mechanism th

207 d by a 3' to 5' single-stranded DNA-specific exonuclease, indicating Cas9 exposes the 3' flap for pot

208 Finally, we show that ssDNA exonucleases inhibit natural transformation in Acinetoba

209 he resistance of circular dsDNA molecules to exonuclease, internally calibrated with the native plasm

210 nuclease, transforming it from a destructive exonuclease into a recombination-promoting repair enzyme

211 a HLM present in yeast Xrn1, the main 5'-3' exonuclease involved in mRNA decay.

212 The mechanism of the PHP-exonuclease is not known.

213 However, the biological role of the WRN exonuclease is poorly defined.

214 Here, we show that this exonuclease is strongly upregulated in human psoriasis,

215 n different biological matrices show that 5'-exonuclease is the most prevalent nuclease activity in e

216 mediates, we investigate the requirements of exonucleases known to be involved in 5.8S maturation at

217 A recombination system that includes a 5'-3' exonuclease (lambda Exo) and a single strand annealing p

218 Redbeta interacts with lambda exonuclease (lambdaexo), the other component of the Red

219 Subsequently, a group of 3' -> 5' exonucleases mature the 3' ends of the majority of tRNAs

220 Thus, rational removal of ssDNA exonucleases may be broadly applicable for enhancing the

221 aE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiot

222 d by a mechanism involving the mitochondrial exonuclease MGME1, and the loss of this enzyme results i

223 eviously uncharacterized helicase (mrfA) and exonuclease (mrfB).

224 In ssDNA exonuclease mutants, one arm of homology can be reduced

225 y known RNA viruses to encode a proofreading exonuclease (nsp14-ExoN), as well as other replicase pro

226 exonuclease activity of the viral protein NP exonuclease of Lassa fever virus in vitro.

227 omes this inhibition to promote the 3' -> 5' exonuclease of MRX, which requires ATP hydrolysis by Rad

228 ted based on crystal structures of 5' and 3' exonuclease oligonucleotide complexes with 5'-(R)- and 5

229 processivity factor for Exo1, retaining the exonuclease on DNA for long-range resection.

230 restriction fragments can be degraded by DNA exonucleases or ligated by T3 and T4 DNA ligases.

231 hat RNase AM, a recently identified 5' to 3' exonuclease, performs the last step of 5S rRNA 5'-end ma

232 is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic core.

233 at is highly conserved with the endonuclease/exonuclease/phosphatase (EEP) domain-containing CCR4 fam

234 than that of the Gibson method utilizing T5 exonuclease, Phusion DNA polymerase, and DNA ligase.

235 The conserved herpesviral alkaline exonucleases play an important role in viral genome clea

236 The DEDDh family of exonucleases plays essential roles in DNA and RNA metabo

237 e common architectural features, such as the exonuclease/polymerase and C-terminal domains (CTDs) of

238 pair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting dam

239 mutations impact APE2 DNA binding and 3'-5' exonuclease processing, and also prevent efficient APE2-

240 ike activity is supplied by DnaQ-superfamily exonucleases, providing a beautiful example of cellular

241 nd provide nucleotide-level insight into the exonuclease requirements for mammalian rRNA processing.

242 We apply these exonuclease-resistant cssDNAs to the self-assembly of wi

243 Our work identifies a class of exonucleases responsible for miRNA 3' truncation in vivo

244 We found that trimming by these exonucleases results in an asymmetric intermediate, beca

245 ectrophoresis well and low susceptibility to exonucleases revealed that the biologically relevant ecD

246 ecome standard in the field to use the 3'-5' exonuclease RNase R.

247 at does not involve any of the six 3' --> 5' exonucleases (RNase T, RNase PH, RNase D, RNase BN, RNas

248 Furthermore, the PHP-exonuclease shows a striking similarity to E. coli endon

249 Thus, we applied an exonuclease single-strand recovery step in our SELEX to

250 a DNA polymerization site (pol) and a 3'-5' exonuclease site (exo) for proofreading.

251 frayed primer-ends that are shuttled to the exonuclease site and excised efficiently.

252 tion limits access of the 3'-terminus to the exonuclease site and promotes binding at the polymerase

253 pontaneous partitioning of primer-end to the exonuclease site as a "cost of proofreading".

254 The exonuclease site is distal from the polymerization site,

255 that R301 interferes with DNA binding to the exonuclease site, an outcome not observed with the exonu

256 lease domain, with R301 pointing towards the exonuclease site.

257 erase site and for hydrolytic editing in the exonuclease site.

258 transfer pathway between the polymerase and exonuclease sites displays additional kinetic states not

259 r strand transfer between the polymerase and exonuclease sites.

260 The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induce

261 rcoma-associated herpesvirus (KSHV) alkaline exonuclease SOX, encoded by open reading frame 37 (ORF37

262 destruction is the virally encoded alkaline exonuclease SOX.

263 nergy path connecting the polymerization and exonuclease states of E. coli replicative DNA polymerase

264 merase I inhibitor camptothecin, loss of WRN exonuclease stimulates fork inactivation and accumulatio

265 a manganese binding site in the vestigial 3' exonuclease subdomain and a non-catalytic water-bridged

266 In the absence of 3' exonucleases, such as ExoI, these 3' flaps can be conver

267 rted into 5' flaps, which are degraded by 5' exonucleases, such as ExoVII and RecJ.

268 5' end was more stable in the presence of 5'-exonuclease than an oligonucleotide of the same sequence

269 simple, and each reaction used 0.04 U of T5 exonuclease that cost 0.25 US cents.

270 replication depends on a proofreading 3'-5' exonuclease that is associated with the replicative DNA

271 Human EXOG (hEXOG) is a 5'-exonuclease that is crucial for mitochondrial DNA repair

272 um tuberculosis (Mtb) uses its intrinsic PHP-exonuclease that is distinct from the canonical DEDD exo

273 from Saccharomyces cerevisiae is a 3' -> 5' exonuclease that is responsible for 5' end degradation i

274 gest potential lead inhibitors for the DEDDh exonucleases that may pave the way for designing nucleas

275 transcriptional modifications, by miRs and 3'exonucleases that process PLD2 mRNA, thus increasing PLD

276 that DIS3L and DIS3L2 are critical 3' to 5' exonucleases that regulate miRNA stability, with the add

277 s process, identifying conserved PARN-family exonucleases that trim piRNAs to their mature size in si

278 R 3' end processing likely involves multiple exonucleases that work in parallel and/or sequentially,

279 ucleoplasm, La binds to and protects from 3' exonucleases, the ends of precursor tRNAs, and other tra

280 r processing is co-opted by cellular non-Cas exonucleases, thereby offsetting the need for Cas4.

281 sbuvir terminated RNA resists removal by the exonuclease to a substantially higher extent than RNA te

282 e exchange occurs in vivo, allowing Poldelta exonuclease to prevent catastrophic accumulation of Pole

283 EcMutH, EcUvrD, EcSSB and one of four ssDNA exonucleases to accomplish excision.

284 er, some noncoding RNA classes use endo- and exonucleases to achieve functionality.

285 This ensures the pruning of exposed ends by exonucleases to aptly sized substrates for integration i

286 uencing, an approach that combines ChIP with exonuclease treatment to pinpoint regulatory elements in

287 damage or down-regulation of the cytoplasmic exonuclease TREX1 enhances ISG expression in BLM-deficie

288 We show that the DNA exonuclease Trex1 is induced by radiation doses above 12

289 DNA fragments and that the cytoplasmic 3'-5' exonuclease Trex1 is required for their degradation.

290 We show that the cytoplasmic exonuclease TREX1, which promotes the resolution of dice

291 The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifyi

292 EJ repair event (i.e., expression of the 3' exonuclease Trex2).

293 improved by an average of 1.4-fold with the exonuclease, Trex2.

294 and binding inhibits aptamer digestion by T5 exonuclease, where the extent of this inhibition correla

295 also PRNPIP and PINT1), a putative 3'-5' RNA exonuclease, which preferentially associates with DENV-2

296 this requirement is due to cytoplasmic ssDNA exonucleases, which inhibit natural transformation.

297 This reinforced structure blocks the 5'-->3' exonuclease Xrn1 for the production of pathogenic subgen

298 required for their degradation by the 5'->3' exonuclease Xrn1 to enact opposing effects on the UPR.

299 mediate both processes, including the 5'-3' exonuclease Xrn1, are responsible for a cross-talk betwe

300 ption termination is mediated by the nuclear exonuclease XRN2.