ライフサイエンスコーパス: exosome

1 compared to naturally secreted exosomes (SEC-exosomes).

2 on, inflammatory response, and extracellular exosome.

3 hich encodes a structural subunit of the RNA exosome.

4 PROMPTs are degraded by the nuclear exosome.

5 es BMMO HuR expression and its transfer into exosome.

6 s partly attenuated through ILK knockdown in exosomes.

7 mbly, but it is not itself incorporated into exosomes.

8 patients, MTEX accounted for 23-66% of total exosomes.

9 ese membrane scaffolds for the production of exosomes.

10 bearing a specific sequence (EXO motif) into exosomes.

11 c and neuronal functions and are reported in exosomes.

12 intercellular communication when secreted as exosomes.

13 by increasing secretory miR-23c level in the exosomes.

14 lpha-synuclein and syntenin-1) from neuronal exosomes.

15 heir activation leads to robust secretion of exosomes.

16 hosphorylation in cells, and associated with exosomes.

17 e and precise isolation of subpopulations of exosomes.

18 anding both autocrine and paracrine roles of exosomes.

19 the sorting and delivery of tetraspanins to exosomes.

20 enhances peripheral insulin sensitivity via exosomes.

21 gh release of extracellular vesicles such as exosomes.

22 port, and analysis of electroactive drugs in exosomes.

23 ed exosomal protein biomarkers of the target exosomes.

24 ty in a paracrine manner through circulating exosomes.

25 hich having masses in the range expected for exosomes.

26 cluding immune cells, can secrete and uptake exosomes.

27 y be specific to microvesicles as opposed to exosomes.

28 organelles generate the final content of the exosomes.

29 nal and hypothalamic peptides in addition to exosomes.

30 NA profiling was performed on plasma-derived exosomes.

31 irm that these samples have been enriched in exosomes.

32 nt a method for stimulating the secretion of exosomes.

33 ILK-enriched exosomes activated NF-kappaB (nuclear factor kappaB) pat

34 an exosome core component, or components of exosome adaptor complexes, we identify ~2900 transcripti

35 ifying Cproteins in plasma astrocyte-derived exosomes (ADEs) of subjects with sports-related TBI (sTB

36 Small extracellular vesicles called exosomes affect multiple autocrine and paracrine cellula

37 ble to selectively recover cancer-associated exosomes, allowing for important insights into patient d

38 etry analysis revealed wild-type EPC-derived exosome and IL-10 knockout EPC-derived exosome contain d

39 lar nanoporation produced up to 50-fold more exosomes and a more than 10(3)-fold increase in exosomal

40 on of sEVs corresponding to both traditional exosomes and a novel subset of vesicles containing both

41 uch fusions can be detected in tumor-derived exosomes and could potentially represent an early detect

42 DNs was enriched for those that bind to VCaP exosomes and discriminate them from exosomes derived fro

43 ng analytical efforts to separate and purify exosomes and exosome subpopulations.

44 Moreover, miR-26a is down-regulated in serum exosomes and islets of obese mice.

45 In addition, extracellular vesicles (EVs), exosomes and microvesicles, containing cargo mediators,

46 zing the physical and chemical properties of exosomes and other EVs.

47 n clearance by preventing it release through exosomes and promoting lysosomal degradation of misfolde

48 all extracellular vesicles (sEVs), including exosomes and small microvesicles, represent an understud

49 ship between expression of IRS-1 in L1CAM(+) exosomes and systemic IR as assessed by homeostatic mode

50 ive to combine the targeting capabilities of exosomes and the bio-orthogonal potential of Pd nanopart

51 rthermore, we discuss the role of lncRNAs in exosomes and their function in drug resistance, and ther

52 Viruses can spread in exosomes and thereby avoid immune recognition(3).

53 and their subpopulations (micro-vesicles and exosomes), and microRNAs (miRNA-21-3p, miRNA-150-5p, and

54 as small molecules, proteins, nanoparticles, exosomes, and amyloid fibrils.

55 o be enriched in astrocytes and secreted via exosomes, and antipsychotics were shown to control its c

56 including microRNA, circulating tumor cells, exosomes, and cell-free DNA, and discuss the opportunity

57 R4 was required for the protective effect of exosomes, and exosomal HSP70 interacted with TLR4 on hai

58 ial repair by upregulating ILK enrichment in exosomes, and ILK-mediated activation of NF-kappaB pathw

59 ed proteolytically by BACE1, is released via exosomes, and is a potent diffusible inhibitor of regene

60 ery using M1 macrophages, macrophage-derived exosomes, and macrophage-membrane-coated nanoparticles a

61 s mainly in the size range closer to that of exosomes, and that the average alpha-syn concentrations

62 onfirms the notion that mRNA products of the exosome are direct substrates for DcpS.

63 Exosomes are also a promising class of novel drug delive

64 Exosomes are attractive as nucleic-acid carriers because

65 Exosomes are cell-secreted microvesicles that play impor

66 Exosomes are emerging as new regulators of intercellular

67 Plasmatic exosomes are extracellular vesicles involved in the inte

68 Human milk (HM) exosomes are highly enriched in microRNAs (miRNAs), whic

69 Exosomes are highly enriched in tetraspanins (TSPNs) and

70 Exosomes are lipid bilayer-enclosed EVs of 30-150 nm in

71 Exosomes are nanosized (30-150 nm) extracellular vesicle

72 Exosomes are naturally derived 50-150 nm nanovesicles th

73 Although the protein constituents of these exosomes are often glycosylated, a large-scale character

74 The identified genes and exosomes are potential therapeutic targets for stopping

75 secretion, and uptake of immune cell-derived exosomes are regulated by intracellular proteins and ext

76 Exosomes are secreted extracellular vesicles carrying di

77 Exosomes are small EVs with growing recognition for thei

78 Exosomes are small extracellular vesicles involved in ma

79 Cellular nanoporation may enable the use of exosomes as a universal nucleic-acid carrier for applica

80 essed the clinical utility of serum neuronal exosomes as biomarkers across the spectrum of Parkinson'

81 1 carries its cargo, at most, to the site of exosome assembly, but it is not itself incorporated into

82 Here, we show that both standard and exosome-associated preparations of AAV8 vectors can effe

83 in recipient cells, whereas ILK knockdown in exosomes attenuates NF-kappaB activation and reduces inf

84 target kinase for improving progenitor cell exosome-based cardiac therapies.

85 w that caveolin-1 (Cav1) centrally regulates exosome biogenesis and exosomal protein cargo sorting th

86 multiprotein ESCRT complex participating in exosome biogenesis.

87 gnore whether these work together to control exosome biology.

88 multiplex characterizations of NSCLC-derived exosomes by bioaffinity interactions of antibodies and d

89 his work, we intend to isolate and visualize exosomes by combining an affinity-based method and passi

90 th dissipation monitoring (QCM-D), to detect exosomes by exploiting their surface protein profile.

91 from a triblock copolymer which encapsulates exosomes by polymeric self-assembly and maintains their

92 ells is increased relative to late endosomal exosomes by reducing growth regulatory Akt/mechanistic T

93 Mechanistically, secretion of exosomes by these spheres was essential for enhancing su

94 protein, and have shown that PDL1-expressing exosomes can inhibit antitumour immune responses.

95 Immune cell-derived exosomes can mediate crosstalk between innate and adapti

96 d to investigate if modification of specific exosome cargo can rescue reparative activity.

97 miRNAs and FMR1, play a significant role in exosome cargo loading and enhanced secretion during cell

98 trical stimulus that promotes the release of exosomes carrying transcribed mRNAs and targeting peptid

99 d from fly to human, is described here, with exosomes carrying unique cargos, including the GTPase Ra

100 The limitations and scarcity of current exosome characterization approaches have led to a growin

101 alcium leads to release of chelation-induced exosomes (CI-exosomes) from OVCAR-3 EOC cells.

102 Schwann cell-derived exosomes communicate with dorsal root ganglia (DRG) neur

103 Yet, little is known about how these exosomes compare to those that are continuously released

104 selectively process or degrade RNAs, the RNA exosome complex dictates the levels of RNAs comprising m

105 our analysis to different mutants of the RNA exosome complex, we explore how substrate channeling thr

106 cleolyticly shortened from the 3' end by the exosome complex.

107 s emphasize the potential value of different exosome components in distinguishing between healthy, pr

108 G198D mutation prevents binding to other RNA exosome components, resulting in protein and complex ins

109 stic analyses have demonstrated that the RNA exosome confers expression of a differentiation regulato

110 identified a significant proportion of host exosome constituents.

111 rived exosome and IL-10 knockout EPC-derived exosome contain different protein expression pattern.

112 HIV-associated saliva exosomes contain the HIV trans-activation response eleme

113 ith human alpha-synuclein preformed fibrils, exosomes containing alpha-synuclein released by microgli

114 d C2BBe1 and intestinal organoids to secrete exosomes containing viral components and have the abilit

115 The TAR RNA in HIV-associated exosomes contributes to enhancing KSHV infectivity throu

116 Cell-to-cell communication by exosomes controls normal and pathogenic processes(1,2).

117 By depleting an exosome core component, or components of exosome adaptor

118 Still, the nuclear exosome could have protein-coding (pc) gene-specific reg

119 nce in the field suggests that tumor-derived exosomes could be responsible for mediating systemic imm

120 PTs are sources of small interfering RNAs in exosome-deficient mutants, perhaps explaining why plants

121 or tumor-stroma interactions through a novel exosome-dependent ECM deposition mechanism.

122 Exosomes derived from both hDPSCs and MDPCs upregulated

123 tested with human serum samples spiked with exosomes derived from healthy human serum and a prostate

124 study investigated the therapeutic effect of exosomes derived from healthy Schwann cells (SC-Exos) on

125 to VCaP exosomes and discriminate them from exosomes derived from LNCaP prostate cancer cells.

126 By this way, the exosomes derived from normal lung and NSCLC cells can be

127 Image analysis of fluorescent labeled exosomes derived from three cell lines injected systemic

128 Furthermore, compared to the OVX group, exosomes, derived from the loading group, promoted the a

129 There is a growing need for cancerous exosome detection towards potential non-invasive cancer

130 lectrochemical and electrical biosensors for exosomes detection in the field of cancer and other dise

131 CI-exosomes display a unique miRNA profile compared to natu

132 rends, challenges and future perspectives of exosome-driven POCT in liquid biopsy have been discussed

133 IL-10 (interleukin-10) deficient-EPC-derived exosome dysfunction in myocardial repair and to investig

134 Plasma endothelial-derived exosomes (EDEs) were enriched by two-step immunoabsorpti

135 s of the protein and RNA content of captured exosomes enable further molecular analysis of exosomes,

136 antibody against EGFR, blocks HIV-associated exosome-enhanced KSHV infection.

137 ogy and herein report an increased number of exosomes enriched for L1CAM, a marker predominantly expr

138 hat an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regener

139 Exosomes, extracellular vesicles (EVs) of endosomal orig

140 alpha-toxin through the release of ADAM10 on exosomes-extracellular vesicles of endosomal origin.

141 glycan microheterogeneity within the urinary exosomes, finding on average 5.9 glycans per site.

142 nanomedicine including CRISPR nanoparticle, exosomes for the treatment of BC/TNBC and other molecula

143 ize-based subpopulations (e.g., exomeres and exosomes) for further analysis.

144 An alternate exosome formation mechanism, which is conserved from fly

145 rane scaffolds appreciated for their role in exosome formation, composition, and activity, we current

146 Herein, we identify exosomes from autologous breast cancer cells that show e

147 of 1) rapid isolation and identification of exosomes from both malignant and healthy cells and 2) mu

148 Exosomes from cancer cells have great potential to be ap

149 Release of Rab11-positive exosomes from cancer cells is increased relative to late

150 sential step in the formation and release of exosomes from cells that is critical for intracellular c

151 Monocyte exosomes from coinfected persons increased in microRNA (

152 Transplantation of splenocytes and serum exosomes from elafin-overexpressing HFD-treated donor mi

153 ggested that miR-16 and miR-148a enriched in exosomes from FAK-null CAFs contribute to the reduced tu

154 Isolated exosomes from heat-shocked utricles were sufficient to i

155 ression profiles in first week postpartum HM exosomes from HIV-1 infected and uninfected control moth

156 G DNA induce the secretion of ADAM10-bearing exosomes from human cells as well as in mice.

157 Exosomes from IAA/DNP-treated or untreated cells had sim

158 underlying mechanism of loss of function of exosomes from inflamed EPCs is still obscure.

159 Exosomes from macrophages exposed to diabetic milieu (hi

160 After long-term exposure to inject exosomes from MKN-45 cells, mice developed an immunosupp

161 n size and shape to previously characterized exosomes from other organisms and that these EVs contain

162 neomycin, whereas inhibition or depletion of exosomes from the extracellular environment abolished th

163 The composition of ESCRT complexes in exosomes from VCaP versus LNCaP cells might constitute a

164 to release of chelation-induced exosomes (CI-exosomes) from OVCAR-3 EOC cells.

165 0 deficiency/inflammation alters EPC-derived exosome function, content and therapeutic effect on myoc

166 r showed that FAK ablation in CAFs decreased exosome functions to promote tumor cell migration and ot

167 microglial proinflammatory cytokines, these exosomes further increased protein aggregation in neuron

168 er in vivo studies showed that CBSA/siS100A4@Exosome had a higher affinity toward lung in comparison

169 own whether diabetic milieu affects cellular/exosome-HuR and its implications on cardiac inflammation

170 talytically active subunit Rrp44/Dis3 of the exosome in budding yeast (Saccharomyces cerevisiae) is c

171 However, the role of beta-cell-derived exosomes in metabolic homeostasis is poorly understood.

172 ay between the immune system and circulating exosomes in metastatic breast cancer (MBC).

173 Furthermore, addition of astrocytic exosomes in neuronal cultures resulted in a significant

174 able alternative method for the detection of exosomes in scarce resource settings.

175 lin receptor substrate-1 (IRS-1) in L1CAM(+) exosomes in subjects with MDD as compared with age- and

176 y, by purifying microglia/macrophage derived exosomes in the CSF of Parkinson's disease patients, we

177 s initial study, we describe the analysis of exosomes in the serum of healthy subjects, intraductal p

178 xosomes enable further molecular analysis of exosomes, including Western blot and quantitative polyme

179 enous tumor exosomal PD-L1 and tumor-derived exosome-induced PD-L1 are two of the most notable mechan

180 The biogenesis of exosomes involves their origin in endosomes, and subsequ

181 The RNA exosome is a multisubunit protein complex involved in RN

182 The RNA exosome is an essential ribonuclease complex required fo

183 reveal that saliva containing HIV-associated exosomes is a risk factor for the enhancement of KSHV in

184 Accurate biological characterization of exosomes is an important step toward clinical applicatio

185 uncoating of HAV particles contained in the exosomes, is mainly responsible for exo-HAV infectivity

186 s sites developed after mice were exposed to exosomes isolated from all three gastric cancer cell lin

187 was demonstrated by stereotaxic injection of exosomes isolated from alpha-synuclein preformed fibrils

188 the tumor environment was investigated using exosomes isolated from gastric cancer cell lines MKN-28,

189 Moreover, exosomes isolated from the muscle of trained mice displa

190 tracellular vesicles (sEVs, formerly termed "exosomes") isolated at ~100 000g are known, a wide range

191 Furthermore, treatment with CI- and SEC-exosomes leads to differential biophysical and functiona

192 fluorescent tag allows visualization of the exosome lifecycle, including multivesicular body (MVB) t

193 KD2 and PKHD1 genes, are abundant in urinary exosome-like vesicles (ELVs) where they form the polycys

194 g lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different mode

195 The capsid-free viral RNA in the exosome lumen, but not the endosomal uncoating of HAV pa

196 mon membrane origin, and utilization of host exosome machinery for virion assembly and egress.

197 CD81 exosome marker-normalized ADE levels of classical pathwa

198 agentless impedimetric assay of two internal exosome markers (alpha-synuclein and syntenin-1) from ne

199 es that carry HSP70 in addition to canonical exosome markers and other proteins.

200 GSDMD and IL-1beta colocalize with the exosome markers CD63 and ALIX intracellularly, and GSDMD

201 Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represen

202 and containing a defined set of constitutive exosome markers.

203 Hence, immune cell-secreted exosomes may have applications in cancer diagnosis and i

204 ding of how inflammation may alter stem cell-exosome-mediated cardiac repair and identifies ILK as a

205 ects on breast cancer cell migration through exosome-mediated delivery.

206 L1 are two of the most notable mechanisms of exosome-mediated resistance against antitumor immunity a

207 C4-membrane attack complex and ROS regulates exosome-mediated, ethanol-induced beta-endorphin neurona

208 vation and gene expression, monocyte-derived exosome micro-ribonucleic acid (miRNA) expression, plasm

209 Extracellular vesicles, including exosomes/microvesicles (EMVs), have been described as se

210 new insights into how gastric cancer derived exosomes modulate the immune response to promote lung tu

211 re into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MT

212 able to reach a limit of detection of 10(5) exosomes muL(-1) directly in human serum, when performin

213 ived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX).

214 (8)) participate in cargo delivery from exosomes of hepatitis A virus (HAV)-infected cells (exo-

215 evealed that miR-214-3p was increased in the exosomes of the bone-losing ovariectomized (OVX) mice, w

216 used to introduce a therapeutic load inside exosomes often involve disruption of their membrane, whi

217 In this study, the impact of tumor secreted exosomes on immune function in the tumor environment was

218 endothelial progenitor cell (EPC) and their exosomes on myocardial repair, although the underlying m

219 odies and then used to immobilize and enrich exosomes on their surfaces using antigen-antibody affini

220 rent forms of extracellular PDL1, such as on exosomes or as a freely soluble protein, and have shown

221 Tumor cells secrete PD-L1 through exosomes or splice variants, which has been described as

222 erive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma mem

223 Inhibition of the exosome pathway decreased EV-A71 replication and release

224 Therefore, we establish that the host exosome pathway is intrinsic for HCMV maturation, and re

225 ediated by previously unreported pDC-derived exosomes (pDCexos), that were also produced by pDCs unde

226 We characterized an exosome population averaging 100 +/- 50 nm in diameter a

227 ental factors contribute to heterogeneity in exosome populations and how different exosome population

228 ity in exosome populations and how different exosome populations mediate diversity in stromal cell be

229 ess of alpha-synuclein in neuronally derived exosomes predates the clinical presentation of Parkinson

230 ystemically into C57BL/6 mice revealed these exosomes primarily localize to the lungs.

231 urther, qRT-PCR analysis with the same serum exosomes processed for EXO-NGS, we observed two long non

232 (ii) The accumulation of exosomes produced by cells in which the gene encoding hn

233 Melanoma patients' plasma contains exosomes produced by malignant and normal cells.

234 (i) hnRNPA2B1 is not a component of exosomes produced in HEp-2 or HEK293T cells.

235 we show that hnRNPA2B1 is not a component of exosomes produced in HEp-2 or HEK293T cells.

236 Compared with bulk electroporation and other exosome-production strategies, cellular nanoporation pro

237 Transferred exosomes protect host cells in vitro by serving as scave

238 ndings underpin future investigation of host exosome proteins as important modulators of HCMV replica

239 Thus, we selected a panel of exosome proteins for knock down, and confirmed that loss

240 We demonstrate that exosomes purified from the saliva of HIV-positive patien

241 ngle bead for an accurate fluorescence-based exosome quantification.

242 Exosomes reflect heterogeneous biological changes associ

243 crease of brain nSMase2 activity and related exosome release have been implicated in various patholog

244 nvestigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator,

245 on to infectious microvesicles, CD9-positive exosomes released from PV-infected cells are also infect

246 validate this acquisition, we characterized exosomes released from uninfected cells, and demonstrate

247 erived, breast and pancreatic cancer-derived exosomes, respectively, when the correct aptamer sequenc

248 ficient glioma mouse models, mRNA-containing exosomes restored tumour-suppressor function, enhanced i

249 The controlled release of odontogenic exosomes resulted in a reparative dentin bridge formatio

250 lumenal vesicles at endosomes (the source of exosomes) revealed general and domain-specific effects o

251 g speckle association correlate with reduced exosome RNA degradation and larger Ser2p CTD-modified RN

252 miRNA profile compared to naturally secreted exosomes (SEC-exosomes).

253 ale) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors,

254 However, little is known about the role of exosome-secreted miRNAs in the regulation of glutamate r

255 Exosome secretion by cells is a complex, poorly understo

256 ological synapse and plays a crucial role in exosome secretion.

257 ts, even from cells with low basal levels of exosome secretion.

258 c and resulted in a 3 to 16-fold increase in exosome secretion.

259 CBSA/siS100A4@Exosome self-assembled nanoparticles formed homogeneous

260 or genes are overrepresented among loci with exosome-sensitive antisense RNAs, suggesting a potential

261 e active TSSs, alternative TSSs that produce exosome-sensitive transcripts typically do not contribut

262 tes (TSSs) from within pc genes that produce exosome-sensitive transcripts.

263 Lastly, profiling of miRs from CAF exosomes showed alterations of several exosomal miRs in

264 ILK knockdown in IL-10 knockout EPC-derived exosome significantly rescued their reparative dysfuncti

265 ly depends on cell communication mediated by exosomes, small vesicles generated within multivesicular

266 efforts to separate and purify exosomes and exosome subpopulations.

267 ings expand the number of genes encoding RNA exosome subunits linked to human disease while also sugg

268 tor (NgR1)-interacting Nogo-66 domain on the exosome surface.

269 persed element-1 family, through the nuclear exosome targeting-mediated nuclear degradation.

270 -infected cells can secrete HCV RNA carrying exosomes that can infect cells in a receptor independent

271 se to heat stress, inner ear tissue releases exosomes that carry HSP70 in addition to canonical exoso

272 se to infection, facilitating the release of exosomes that serve as decoys for bacterially produced t

273 release small extracellular vesicles (sEVs, exosomes) that contain lipids and proteins, RNA, and DNA

274 The unique biogenesis of exosomes, their ubiquitous production by all cell types,

275 defective in nuclear RNA decay including the exosome to reassess the existence of Arabidopsis PROMPTs

276 ty of small secretory microvesicles known as exosomes to influence neuronal and glial function via th

277 is a Rab27b effector protein with a role in exosome transport and is encoded by the EXPH5 gene.

278 xO1 is decreased in the liver of trained and exosome-treated mice.

279 rization, whereas IL-10 knockout EPC-derived exosome treatment showed diminished and opposite effects

280 rdial infarction (MI), wild-type EPC-derived exosome treatment significantly improved left ventricle

281 Protection was independent of exosomes under the conditions tested.

282 esicular body (MVB) trafficking, MVB fusion, exosome uptake and endosome acidification.

283 protein FMR1 and directs miRNA loading into exosomes via interaction with components of the ESCRT (e

284 The in vivo significance of these exosomes was demonstrated by stereotaxic injection of ex

285 llular vesicle (EV) preparation enriched for exosomes were directly determined for the first time by

286 Exosomes were efficiently extracted from patient sera us

287 egulatory proteins in MTEX, non-MTEX and HDs exosomes were evaluated by on-bead flow cytometry.

288 In this design, target exosomes were firstly captured by latex beads via aldimi

289 The increased IRS-1 levels in L1CAM(+) exosomes were greater in subjects with MDD and were asso

290 Plasma exosomes were isolated and separated by immunocapture in

291 Exosomes were isolated from plasma by ExoQuick solution

292 We further showed exosomes were mainly taken up by natural killer cells an

293 are transported in body fluids often within exosomes, which are small cell-derived vesicles that fun

294 controlled, tunable release of cell-derived exosomes, which maintains their advantageous physiologic

295 esence of alpha-synuclein oligomer in CD11b+ exosomes, which were able to induce alpha-synuclein aggr

296 imulates release from Rab11a compartments of exosomes with pro-tumorigenic functions, which we propos

297 Functionally, exosomes with the Nogo-66 domain on their surface potent

298 Exosomes, with an average diameter of ~100 nanometers, a

299 Although the RNA exosome would be expected to control diverse biological

300 Studies of exosomes would be facilitated by a method for increasing