ライフサイエンスコーパス: expedient

1 Expedient access to a highly functionalized 2-pyrrolidin

2 This platform provides expedient access to a range of derivatives through subse

3 This methodology enables expedient access to a variety of 1,2,3-triazoles from al

4 he diverse and modular technology allows for expedient access to a wide variety of cyclic peptides fr

5 under mild reaction conditions and provides expedient access to complex spirocyclic molecular archit

6 ally mild conditions and provides direct and expedient access to complex terpenoid motifs.

7 merization (ROP) of cyclic (di)esters offers expedient access to diverse PHA microstructures, includi

8 his simple and efficient methodology enabled expedient access to functionalized 3D frameworks that ca

9 ermediates, followed by hydrolysis, provides expedient access to ketones and esters.

10 is approach with a modular synthesis enabled expedient access to more than a dozen designed derivativ

11 ffords valuable indole derivatives, enabling expedient access to novel heterocyclic analogues not eas

12 The method gives an expedient access to propargylic amines in good to excell

13 idine/benzoxazine heterocycles, providing an expedient access to quinazolin-4(3H)-ones, N-aryl-2-aryl

14 Besides offering expedient access to seldom studied boryl metal carbenes,

15 f tri- and tetracyclic carbazoles, including expedient access to several natural products and anti-ca

16 ot, two-step process, this chemistry enables expedient access to synthetically versatile alpha'-chira

17 th a catalytic amount of Yb(OTf)(3) provides expedient access to tetrahydroquinoline derivatives.

18 In addition to providing expedient access to the 2-oxo-1,2-dihydrospirobenzo[d][1

19 An expedient access to the first optically pure ruthenium c

20 This work offers general and expedient access to this class of little studies electro

21 Despite their synthetic significance, expedient access to this difunctionalization is rare.

22 ized via oxidative gold catalysis, providing expedient access to various substituted N- or O-heterocy

23 An expedient, accurate, and cost-efficient test was develop

24 The Blood-mCIM should facilitate expedient administration of antimicrobial therapy target

25 this assay to be a relatively economical and expedient alternative that will likely facilitate studie

26 ore, the developed system is well suited for expedient analysis of low-level plutonium in urine of ex

27 An expedient and concise Ugi-based approach for the rapid a

28 In this work, we disclose expedient and efficient access to this class of syntheti

29 We report herein an expedient and efficient synthesis of chiral polysubstitu

30 novel computational approach that permits an expedient and exhaustive assessment of hundreds of minim

31 In this work, we report an expedient and general one-pot procedure for the synthesi

32 hemists in this regard, we have developed an expedient and general strategy for the ortho-arylation o

33 ge of homologous alkenylamine salts provides expedient and high-yielding routes to commercially valua

34 were classified as serotypes 6A and 6C by an expedient and highly accurate serotype 6C-specific PCR a

35 Our protocol is expedient and practical and is carried out under microwa

36 An expedient and reliable method for accessing reactive alp

37 In the process, a more expedient and reliable synthesis of 1 and its analogues

38 The expedient and scalable approach to cardiotonic steroids

39 An expedient and scalable synthesis of a versatile new anal

40 The expedient and stereoselective syntheses of small librari

41 ce of providing relief to patients in a more expedient and systematic manner.

42 Expedient and thorough research-based evaluation of pati

43 contexts was widely considered as episodic, expedient and unrepresentative of early Homo toolkits.

44 ish list for optogenetic approaches to allow expedient application of this technology.

45 This expedient approach enables the synthesis of a range of p

46 We herein report a rational and expedient approach to access a library of 27 oligosaccha

47 this potential, even though it offers a more expedient approach to addressing environmental change th

48 nsformation, thereby providing a modular and expedient approach to building structural complexity in

49 titution, which led to the development of an expedient approach to densely functionalized cyclic 1,3-

50 kene feedstocks with aldehydes represents an expedient approach to the generation of new and structur

51 An expedient approach to the synthesis of 4-azaspiro[2.3]he

52 ns is herein proposed for the first time for expedient assessment of the kinetics of lead bioaccessib

53 An expedient asymmetric total synthesis of aspidophytine is

54 is concept has been demonstrated through the expedient, asymmetric total syntheses of six well-known

55 er, microfluidic system was found to be more expedient because of attaining small and uniform sized s

56 Neurological signs may serve as expedient bedside measures that are potentially useful i

57 and concomitant C-H annulation constitute an expedient cascade strategy for the construction of multi

58 T) polyamide from epsilon-caprolactam, lacks expedient chemical recyclability, while low-ceiling temp

59 tial structural simplification permitted the expedient chemical synthesis and rapid discovery of MTSB

60 amples from multiple sources and would be an expedient choice when whole genome assembly from the rea

61 This trial suggests that expedient clinical trials can be implemented in low-inco

62 g and various human cancers, we have used an expedient combination of genetic analysis and pharmacolo

63 efficient targeting and recycling of Mfd and expedient conflict resolution.

64 ly unbiased cyclopropanes, which enables the expedient construction of a host of structurally diverse

65 Early diagnosis and the most expedient coronary reperfusion method at each point of c

66 ctive agar (BCSA) has been recommended as an expedient culture method for the isolation of rapidly gr

67 2 pandemic has brought to light the need for expedient diagnostic testing.

68 Our synthesis features the expedient diazene-directed assembly of two advanced frag

69 Herein, an expedient divergence strategy for tandem dehydrogenative

70 Here, we describe an expedient, divergent synthesis to prepare defined HS gly

71 ership with local inhabitants, represents an expedient, efficient, and cost-effective strategy for co

72 An expedient enantioselective total synthesis of epicoccin

73 ring and genome editing into a practical and expedient endeavor for academic, industrial and clinical

74 The method provides an expedient entry to a variety of secondary and tertiary a

75 construction of molecular complexity and the expedient exploration of a pharmaceutically relevant and

76 A facile nonlithographic method for expedient fabrication of microfluidic devices of poly(di

77 d richly functionalized cyclic alkenes in an expedient fashion.

78 nstruction of highly complex molecules in an expedient fashion.

79 Expedient five-step syntheses of a cyclic bis(benzimidaz

80 An expedient, five step synthesis of caprolactam 1 is repor

81 ides a suite of plotting methods and enables expedient, flexible and interactive visualization of com

82 r -alkyl halide reagents, and it enables the expedient formation of quaternary centers from easily av

83 gh level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical

84 rone (2Z,4E,6Z,8E)-tetraenoate motif, and an expedient fragment-assembly procedure.

85 A robust and expedient gas quenching method is developed for the solu

86 The described method enables expedient generation of polycyclic molecules including m

87 isomer interconversion is showcased through expedient glycan synthesis, including one-step glycodive

88 Such expedient growth is driven by several factors including

89 ients (73%) were men, and 226 (69%) required expedient hemorrhage control.

90 ique within reach, but CE also represents an expedient highly efficient separation inlet for MS, capa

91 cine candidates could therefore represent an expedient improvement in the challenge to induce human F

92 -carboxylate (Imi) have been obtained by the expedient in-peptide cyclization of ( S)- or ( R)-alpha,

93 This expedient information gain may be useful in time-sensiti

94 These studies feature an expedient installation of the B16-oxidation based on B14

95 equipment is not available, and permits the expedient isolation of individual members of multigene o

96 Although this chiral uniformity may be expedient, it is not a chemical necessity, as demonstrat

97 perimentation (HTE) assay proved crucial for expedient ligand evaluation.

98 rm goals to assist in realizing, in the most expedient manner, the potential utility of cell transpla

99 relevant sulfur(VI) chemical entities in an expedient manner.

100 s engineered to express a foreign gene is an expedient means for generating novel mutant nonviral pro

101 re nonlinear responses exist, and provide an expedient means of designing traditional experiments to

102 eld BioSeeq thermocycler shows promise as an expedient means of forward diagnosis of infection in the

103 c-SpCA presents a robust and computationally expedient means of measuring heteromeric interactions in

104 in developing a useful, but computationally expedient, means of modeling proteins.

105 CCT provides a rapid (6 minutes), clinically expedient, measure of color vision for quantifying norma

106 clear and organelle genomes, and provides an expedient mechanism for F(1) hybrid seed production.

107 Direct labeling of RNA is an expedient method for labeling large quantities (e.g. mic

108 The microtiter dish assay is a more expedient method for measuring transport into membrane v

109 We report herein an expedient method for the regioselective synthesis of ind

110 A highly efficient and expedient method for the synthesis of 4,5-disubstituted

111 ve historically relied on open burning as an expedient method of volume reduction and treatment of so

112 s is rarely undertaken, and a dependable and expedient method that can correctly assign biological se

113 screening method, it offers a convenient and expedient methodology for visualizing hepatotoxicity in

114 ubstrates have been synthesized employing an expedient methodology that incorporates phosphorylated n

115 Herein, we report a general and expedient methodology to access a variety of unusual deo

116 Although a variety of expedient methods are established for simple alkenes, se

117 are apparent deviations in hydration status; expedient methods such as skinfold predictions will be m

118 Here we introduce the host insect as an expedient model environment for microswimmer research, a

119 y, we have established D. melanogaster as an expedient model system to study the effects of radiation

120 r-acceptor pai-conjugated system facilitates expedient molecular packing, consistent morphology, and

121 rip and co-planar waveguide lines, which are expedient, narrowband, and low-efficiency transducers, a

122 cross-coupling described herein provides an expedient new method for the construction of boron-conta

123 ide transfer equilibria, taking advantage of expedient new synthetic procedures for Ru and Ir hydride

124 r levels into Brassica food is considered an expedient nutritional strategy that can be achieved thro

125 hat the effects can be avoided by the simple expedient of epitope separation.

126 ment of differential receptors by the simple expedient of mixing slightly different amphiphiles (i.e.

127 rb metalloenzyme activity through the simple expedient of modifying the helical pitch adjacent to the

128 By the simple expedient of removing the bacterial DNA complement, we s

129 c bromide and methyl formate provides for an expedient one-flask synthesis of complex oxasilacyclopen

130 An expedient one-pot protocol for the synthesis of function

131 An expedient one-pot rhodium catalyzed C-H bond functionali

132 This process represents an expedient, operationally simple method for the construct

133 Herein we report an expedient organocatalytic ring-opening polymerization of

134 hemical C-C activations were accomplished by expedient oxidative rhodium(III) catalysis.

135 , simple isolation of viral RNA permits more expedient pathogen detection by downstream real-time rev

136 ient samples is of the outmost importance to expedient patient care.

137 MWASs were fabricated using a technically expedient, photoinitiated polymerization reaction whereb

138 IFOSs were fabricated using a technically expedient, photoinitiated polymerization reaction whereb

139 fficient reverse-genetics protocol that uses expedient pooling and hybridization strategies to identi

140 An expedient, practical, and enantioselective route to the

141 Its synthetic potential is demonstrated by expedient preparation of dihydrofuran-3-ones containing

142 Application to peptides allowed expedient preparations of alpha-amino boronic acids, oft

143 A remarkably expedient process for the simultaneous purification and

144 A simple and an expedient process to prepare 5-aryl-1-benzyl-1H-imidazol

145 This expedient protocol covers a broad scope of readily avail

146 , or with a functionalized arylstannane gave expedient regiospecific access to a wide range of functi

147 idis serogroups is crucial for judicious and expedient response to cases of meningococcal disease, in

148 xibility offered by the catalysis enables an expedient revision of the reported structure of diplobif

149 Expedient RNA folding must avoid the formation of undesi

150 cohol over its hydroxyl group would offer an expedient route to expand the chemical space of alcohols

151 nd C-H bond of the other arene to provide an expedient route to multifluorinated biaryls.

152 Here we report expedient routes to 1,3- and 1,2-disubstituted cubane bu

153 The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarboli

154 erefore, a plausible strategy for facile and expedient staining would be to target components of the

155 ghtforward approach provides a promising and expedient strategy for continuously converting diverse p

156 rofunctionalization of alkenes represents an expedient strategy for converting feedstock olefins into

157 An expedient strategy for the synthesis of polycyclic small

158 we report an iron-catalyzed, convenient, and expedient strategy for the synthesis of styrene and naph

159 antibiotic pentamycin was accomplished by an expedient strategy involving a highly stereoselective as

160 This expedient strategy is also applicable to alpha,beta-unsa

161 ur findings establish a novel and clinically expedient strategy to generate allogeneic or autologous

162 d halogenated natural products, resulting in expedient structure validation or revision.

163 We report the expedient, structure-guided evolution of weak physiologi

164 mmediately respond to the more metabolically expedient sugar, glucose, would seem advantageous for en

165 This catalytic reaction allows expedient syntheses of broadly useful substituted indoli

166 Expedient syntheses of C(8) substituted 1-azabicyclo[3.3

167 Finally, this work has facilitated expedient syntheses of pharmaceutically active compounds

168 th dienes and dienophiles, which enables the expedient syntheses of structurally diverse natural prod

169 se the versatility of this method, we report expedient syntheses of the rare sugars l-ristosamine, l-

170 An expedient synthesis corroborating the proposed structure

171 An Fe(III)-catalyzed expedient synthesis of 13-aryl-13H-indeno[1,2-l]phenanth

172 d practical one-pot sustainable approach for expedient synthesis of 2-arylimino-2H-chromenes by two-c

173 Also, the first expedient synthesis of 2-arylnaphthoquinones via the rea

174 ve C-H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarins is unveiled.

175 We have described an expedient synthesis of a key building template, 33, for

176 An expedient synthesis of a linear triquinane illustrates t

177 ion of a naturally occurring steroid and the expedient synthesis of a medicinally relevant drug lead.

178 The reaction also facilitated the expedient synthesis of a range of analogues via the use

179 gh selective downstream manipulation and the expedient synthesis of a saturated hydrocarbon analogue

180 A catalytic, two-step protocol for the expedient synthesis of anti-2,4-disubstituted tetrahydro

181 Herein, we report an expedient synthesis of aryl sulfonyl ureas 4 and 5 from

182 An expedient synthesis of enantiomerically pure threo-beta-

183 Altogether, this platform enables the expedient synthesis of four pharmaceutical analogues, al

184 The compatibility with bioactive motifs and expedient synthesis of pharmaceutically relevant molecul

185 of simple or functionalized alkynes for the expedient synthesis of propargylic ethers with excellent

186 We show the utility of the new method by the expedient synthesis of racemic melphalan in four steps t

187 hnology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol.

188 compared to the pyrazolopurine lead, and the expedient synthesis of the new tricyclic systems allowed

189 Expedient synthesis, spectroscopic, solid state structur

190 Expedient synthetic approaches to the highly functionali

191 Using this expedient synthetic strategy, the diverse C7-silylated i

192 d provides a direct route to streamlined and expedient targeted protein analysis.

193 Here we report a simple and expedient technique for physical mapping of BAC inserts.

194 44-42 ka cal BP assemblages are based on an expedient technology dominated by bipolar knapping, with

195 An expedient, template-free, high-yield, and solventless ro

196 direct route to palladium porphyrins is more expedient than the four steps of the traditional synthes

197 Although politically expedient, the scientific basis and conservation value o

198 eneficial to their learning, and some simply expedient to completing assignments with as little work

199 l processes occurring in the apoplast, it is expedient to develop methods to study its contents.

200 Yet it has also proved politically expedient to invoke climate change as an exogenous force

201 A simple expedient to prevent such reactions when an excess of re

202 e results point to sulfur substitution as an expedient tool to tailor the chain-breaking antioxidant

203 ility of this new method were highlighted in expedient total syntheses of the Turkish tobacco natural

204 The expedient total synthesis involves a one-pot sequential

205 rasubstituted alpha-amino acids including an expedient total synthesis of the antiepileptic drug leve

206 The expedient total synthesis resulting in unambiguous proof

207 is a promising neuromodulation approach for expedient translation to individuals with SCI and potent

208 e (+)-scabrol A have been accomplished in an expedient unified approach starting from d-(+)-malic aci

209 r cells to myeloid cells in particular is an expedient used by cancer cells to control the immune mic

210 We highlight how expedient vaccine delivery to high-risk groups is critic

211 We show that, compared to the more expedient vacuum-slab model, direct level alignment thro

212 erzmanowician sites and is best explained by expedient visits of short duration by small, mobile grou

213 rding to standard disease classification for expedient visualization.

214 We did this via the simple expedient way of simultaneously using two redox probes:

215 known loci in other populations would be an expedient way to evaluate the generalizability of the cu

216 Standard RDEs become, however, less expedient when the studied electrode process is a comple

217 e-based definition is more reliable but less expedient, whereas the urine output based definition is