ライフサイエンスコーパス: explant

1 percent of patients within Milan criteria on explant.

2 three viral regulatory proteins following TG explant.

3 as not readily detected until 16 hours after explant.

4 system using axillary shoots as the initial explant.

5 largest viable tumor and number of tumors on explant.

6 ted patients are now 2.26+/-0.97 years after explant.

7 Of 3439 patients, 802 (23%) had cPR on explant.

8 such as collagen-I and -IV, were retained in explants.

9 egenerant variation compared with the source explants.

10 There were no deaths and 2 early explants.

11 nificantly induced in ZIKV-infected placenta explants.

12 promoted axon outgrowth from fetal thalamic explants.

13 port vascular anastomoses in cultured kidney explants.

14 oride (LiCl) treatment in the in vitro tooth explants.

15 during 24-day in vitro culture of cartilage explants.

16 e and prevented epidermal disruption in skin explants.

17 adermal injections into primary, human, skin explants.

18 microvascular sprouting assay using choroid explants.

19 d by SDS PAGE and by qRT-PCR in ex-vivo bone explants.

20 get genes were upregulated in Rspo2-depleted explants.

21 , a result confirmed in human term placental explants.

22 d midbody abscission in NSCs within cortical explants.

23 asion, leading to colonization of peritoneal explants.

24 between paired PPR lesional and nonlesional explants.

25 reased the permeability of anchoring villous explants.

26 associated with vascular dysmorphia in lung explants.

27 had a surgical revision and 94 (26.1%) were explanted.

28 20 tube exposure cases (90%) underwent tube explant, 1 underwent tube revision, and 1 re-epitheliali

29 .30) and in the subgroup that underwent tube explant (15.9 +/- 5.5 mmHg to 15.2 +/- 10.4 mmHg, P = 0.

30 Overall, 19 patients were explanted (19/36, 52.3% of those receiving the protocol)

31 extran added apically to Myo5b KO intestinal explants accumulated in intracellular inclusions.

32 tformin treatment on male diabetic placental explant activated AMPK and stimulated PGC-1alpha express

33 Lung tissue was explanted after the animals were killed, and ablation zo

34 C types of mouse and rat organotypic retinal explants after 1 to 3 weeks in tissue culture, under mod

35 w frequency component of NLC, within in situ explants, agrees with previously reported results on iso

36 rtantly, our approach enables researchers to explant and reuse these valuable probes, a transformativ

37 Two patients were explanted and 1 lost to follow-up.

38 Afterward, the LV was explanted and pressurized ex vivo, and the multiaxial le

39 (2019) use lgCMN explants and a newly developed patient-derived xenograft

40 ffects against resident host T cells in skin explants and against a keratinocyte-derived cell line.

41 ed ROS or PGZ (6-6000muM) was mixed with fat explants and cultured.

42 e most strikingly different patterns between explants and during dedifferentiation.

43 PAHSAs inhibited lipolysis directly in WAT explants and enhanced the action of insulin to suppress

44 Treatment of intestinal explants and enteroids with Dyngo resulted in accumulati

45 po2 inhibited elongation of Xenopus ectoderm explants and Erk1 activation in response to FGF.

46 cting tracts can innervate mouse spinal cord explants and evoke contractions of adjacent muscle in a

47 Explants and hiPSCs were then pulsed with BET inhibitors

48 F-kappaB, specifically using 1(st) trimester explants and HTR-8/ SVneo cell line models.

49 Using mouse embryonic pancreatic explants and human induced pluripotent stem cells (hiPSC

50 C single cells and MCAs to murine peritoneal explants and impaired MCA survival and mesothelial clear

51 n adult lateral ventricle ChP in whole-mount explants and in awake mice.

52 l cells, in both ex vivo respiratory mucosal explants and in vitro primary equine respiratory epithel

53 mechanically-regulated in ex vivo cartilage explants and in vivo joint cartilage.

54 erentiation and adverse remodeling in aortic explants and in vivo.

55 nt increased PL expression in human placenta explants and JEG3 trophoblast cells.

56 as used to infect equine respiratory mucosal explants and primary equine respiratory epithelial cells

57 elivered RNA in resident cells in human skin explants and, we explore a more modular delivery system

58 man serum, primary cell cultures, and tissue explants), and largely abolishes the development of VC i

59 RNA sequencing, lineage tracing, whole-organ explant, and live-cell imaging, we show that homeostatic

60 Indication, time-to-surgical-explant, and year of surgical explantation were not asso

61 ng and increased shoot morphogenesis of stem explants, and in BY2 cultures cell size was reduced.

62 g gene transfer methods in neonatal cochlear explants, and in vivo in adult mice.

63 c stress (US) was imposed on in vitro potato explants, and provides clues to the temporal dynamics in

64 cterized biomaterials of known stiffness and explanted animal tissue models, we first established exp

65 cumulation at the aortic side of leaflets of explanted aortic valves.

66 (DAP) and for the callus induction from this explant, as compared to 23 DAP and mature embryos.

67 sed bacterial survival in CFA-exposed airway explants, ASL, and AMPs.

68 f freshly isolated human PVR membranes in an explant assay.

69 ession of Shh signaling activity in vitro in explant assays appears to induce supernumerary cusp form

70 Pancreatic grafts were explanted at 6 weeks for histological analyses.

71 Eleven (6.7%) of these patients were explanted at a later date.

72 d cases of keratoconus were more prone to be explanted because of a loss of the initial improved visu

73 In mouse explants, BET protein inhibition further led to increase

74 ost tissues when e-scaffolds were applied to explant biofilms.

75 BCG2) content and clonogenic capacity in the explants but had opposite effects on isolated cells.

76 notypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tissue obt

77 Tissue explants can be used to investigate adipose regulation i

78 ion derived from vortexing and sonication of explanted cardiovascular implantable electronic devices

79 subsets and HIV-1 replication in ex vivo RM explant challenge experiments revealed an inverse correl

80 On human lung parenchymal explants, chloroquine concentration clinically achievabl

81 Compared with the no-explant cohort, the explant cohort was significantly younger (mean age 73.7

82 Compared with the no-explant cohort, the explant cohort was significantly you

83 Fold outgrowth was superior from LL explants compared to explants from the buccal mucosa (BM

84 In retinal explants, compound 12j protected retinal neurons from hi

85 Ex vivo studies with mouse cochlear explants confirm the low levels of ototoxicity predicted

86 Explanted corneae are highly needed for the surgical man

87 Explanted corneae from the Institute of Anatomy are a va

88 oting therapy ex vivo and in vivo using lung explant culture and transplacental prenatal therapy in t

89 Results from explant culture assays indicate that disruption of palat

90 han unmodified Dex over 2 weeks in cartilage explant culture models of OA.

91 both 5alpha-dihydrotestosterone and adrenal explant culture supernatant induce nuclear translocation

92 Chemical ablation of dopamine receptors in explant culture with the neurotoxin 6-hydroxydopamine at

93 esses can be perturbed in mutant mice and in explant culture, mimicking the defects associated with c

94 (INK4a)-expressing chondrocytes in cartilage explant culture.

95 f numerous patterning systems in vivo and in explant culture.

96 he regression of vascular vessels in retinal explants cultured in a high glucose microenvironment.

97 luble molecules were measured in a subset of explant cultures (n = 26).

98 In explant cultures of embryonic kidney rudiments, retinoic

99 Here we employ explant cultures of human fetal organs (adrenals, gonads

100 Employing murine cochlear organoid and explant cultures to model mitotic and nonmitotic mechani

101 al lung development was tested in mouse lung explant cultures.

102 Explanted degenerate bioprosthetic valves were examined

103 Cytokine-induced biochemical cartilage explant degradation occurs near the sides, top, and lesi

104 man in vitro studies using placental villous explants demonstrated that increased HIF-1alpha resultin

105 vitro experiments in human cells and retinal explants demonstrated the molecular mechanism of action

106 effects on the growth of axons from retinal explants derived from different quadrants of the retina.

107 andem mass spectrometry proteomics of kidney explants digested with ADAMTS5, identified multiple kidn

108 Together, these data suggest that zebrafish explants do not undergo bona fide self-organization, but

109 ted device leads and from samples taken from explanted/donor hearts.

110 ual cell divisions from time-lapse movies of explanted Drosophila larval brains, comparing wild-type

111 ibroblasts and macrophages in initial tissue explants during organoid formation.

112 Nodal signaling emerges that is required for explant elongation via the planar cell polarity (PCP) pa

113 ury to keratinocytes in vitro and human skin explants ex vivo, and mice in vivo generate microvesicle

114 normal human keratinocytes in vitro and skin explants ex vivo, we found that SP rapidly depleted XPB

115 tinocytes from NLP exposed to IL-17 and skin explants exposed to common fungal antigens responded wit

116 In explanted failing LVs that were homozygous for PDE3A DEL

117 atomic failure: among them, 36 (29.75%) were explanted for spontaneous extrusion (overall extrusion r

118 regenerated from either protoplasts or stem explants for copy number changes by comparison of Illumi

119 We used hepatocytes and mouse tumor explants for studies of incorporation of radiolabeled ch

120 s, reminiscent of tissues derived from mouse explanted foregut-midgut culture.

121 Hut78 cells and from primary CD4(+) T cells explanted from SIV(mac)239-infected RhMs.

122 f metformin were examined in human placental explants from a subgroup of diabetic women and in a mous

123 Human aganglionic colon explants from children with HSCR were cultured with GDNF

124 taining sEVs is detected in cultured colonic explants from colitic mice, GSDMD deficiency substantial

125 Using ex vivo skin explants from cutaneous MF tumors as well as Sezary cell

126 trophoblast cell lines and anchoring villous explants from first-trimester placentas infected with ZI

127 Explants from healthy and failing human hearts were comp

128 TG explants from latently infected, but not uninfected, TG

129 brotic cardiac tissue obtained from surgical explants from patients with hypertrophic cardiomyopathy,

130 hways, and maintained viable crypts in colon explants from patients with inflammatory bowel disease (

131 from latency using trigeminal ganglion (TG) explants from Swiss Webster mice latently infected with

132 th was superior from LL explants compared to explants from the buccal mucosa (BM), HP, and transition

133 TG explants from the latently infected mice shed significan

134 Here, direct incubation of leaf explants from the non-medicinal plant Arabidopsis thalia

135 odels, and altered effector T cells in colon explants from UC patients grown ex vivo.

136 Explants from uncomplicated pregnancies (n = 6) cultured

137 permitted detection of reactivating virus in explanted ganglia and cryosections of DRG and the sacral

138 Explanted grafts demonstrated similar insulin secretory

139 Explanted grafts were assessed for ex vivo function and

140 ical explantation (hazard ratio: 4.03 vs. no-explant group; 95% confidence interval: 1.81 to 8.98).

141 In the LVAD explanted group, 38% of the patients achieved peak cardi

142 Degree of tumor necrosis found on explant has been associated with recurrence and overall

143 the setting of cirrhosis with <60% of liver explants having hepatitis.

144 Methods We analyzed the explanted heart histology for all patients who underwent

145 th ex-vivo amyloid fibrils purified from the explanted heart of this patient.

146 Microscopic analysis of the explanted heart revealed desmin aggregates and the absen

147 Colony formation assay from explanted heart tubes and genetic lineage tracing with t

148 Sections of the explanted heart were analyzed with antibodies specific t

149 Patients were followed to device explant, heart transplantation, or death.

150 psies (n=2), and cardiac tissue samples from explanted hearts (n=13).

151 We identified 4 explanted hearts in the context of transplant that recei

152 cardiac MRI with histological findings from explanted hearts of patients who underwent cardiac trans

153 were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and

154 Within otherwise naive zebrafish blastoderm explants, however, Nodal induces C and E in a largely PC

155 gle AF drivers were mapped simultaneously in explanted human atria (n=11) by subsurface near-infrared

156 raphy using a fresh cardiac thrombus from an explanted human heart.

157 de during high-resolution optical mapping in explanted human hearts depress intranodal SAN conduction

158 e rapid detection of pathogens in situ in an explanted human lung.

159 This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu a

160 by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine.

161 xed and paraffin-embedded tissues from fresh explanted human lungs of patients with PVOD (n = 19), PA

162 ions in PET-positive, CT-negative regions of explanted human specimens as evidenced by (18)F-fluoride

163 Ex vivo transduction of mouse organotypic explants identified Anc80L65 from a set of other adeno-a

164 litated closure in 15%, and planned surgical explant in 5%.

165 Consecutive cases of ICRSs explanted in the last 10 years were reviewed.

166 y block of transduction channels of cochlear explants in culture.

167 agents such as Cas9 and single guide RNAs to explants in culture.

168 RETREAT was superior to Milan criteria (explant) in predicting HCC recurrence by the net reclass

169 In Xenopus explants, in the presence of Wnt5a, these receptor clust

170 Growth-factor stimulation of explants increased the expression of p16(Ink4a) at both

171 ine and mediated pathological damage to skin explants independently of T cells.

172 etic corticosteroid dexamethasone stimulated explant-induced reactivation from latency.

173 oteins, which enhanced virus shedding during explant-induced reactivation from latency.IMPORTANCE Her

174 fected-cell protein 0 (ICP0) and ICP4 during explant-induced reactivation.

175 l regulatory proteins during early stages of explant-induced reactivation.

176 cy, indicating that GR activation stimulated explant-induced reactivation.

177 lysis of neuronal function in rodent retinal explants is useful for the study of early damage due to

178 Various models based on tissue explants, isolated cardiomyocytes, skinned myofibrils, a

179 otocol being explanted within 18 months (pre-explant left ventricular ejection fraction, 57+/-8%; end

180 rapaxar, an FDA-approved PAR1 antagonist, on explanted lesional skin from patients with psoriasis.

181 In patient-derived CaP explants, lestaurtinib increased AR target gene expressi

182 %) and complete pathological response in the explanted liver specimen in 183 of 188 nodules (97.3%) a

183 ver biopsies from ARLD patients; (2) 20 ARLD explant livers; (3) 213 liver biopsies with non-ARLD inj

184 patients by histological examination of the explanted livers using hematoxylin and eosin (H&E) and T

185 ense perisinusoidal mature elastic fibres in explanted livers.

186 to mature elastic fibres usually present in explanted livers.

187 Studies of explanted lungs from patients with drug-resistant tuberc

188 identified regarding the gene expression of explanted lungs with PVR, compared with controls.

189 Exposure of peptide-siRNA NP to cartilage explants markedly suppressed p65 activation, an effect t

190 tablish a physiologically relevant cartilage explant model for testing the induction and elimination

191 e we describe an ex vivo cultured human skin explant model in which we have characterized pathologica

192 This study establishes a cartilage explant model of senescence induction and senolytic clea

193 Using a novel explant model, we find that clemastine is also effective

194 d antiviral efficacy in a primary human lung explant model.

195 ZIKV infection in an ex vivo human placental explant model.

196 matory signaling receptors in a human tonsil explant model.

197 ent of acantholysis in a neonatal mouse skin explant model.

198 n vitro human graft-versus-host disease skin explant model.

199 opment, in a clinically relevant, human skin explant model.

200 level in non-small cell lung cancer (NSCLC) explant models after treatment with clinically relevant

201 mparison of the Transwell model against skin explant models would increase the validity of this metho

202 e xenograft and patient-derived breast tumor explant models.

203 riction in other systems, arrested the molar explant morphogenesis at the bud stage.

204 VEGF-C expanded the lymphatic population in explanted mouse embryonic kidneys.

205 d recovery tests were conducted on cartilage explants (N = 10), and the resulting mechanical properti

206 he center of full-thickness porcine gingival explants (n = 31).

207 Using intact tissue explants, Ncad+ MCAs were also shown to efficiently rupt

208 ation and was feasible and reproducible with explants occurring in all 6 participating sites.

209 Strikingly, explant of latently infected dorsal root ganglia reveale

210 Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8

211 Application of GDNF to cultured explants of aganglionic bowel from children with HSCR in

212 GDNF application to cultured explants of human aganglionic bowel induced proliferatio

213 adian rhythms in peripheral cells and tissue explants of the master clock in the suprachiasmatic nucl

214 Culturing primary neuron explants on planar microelectrode arrays (MEAs) has emer

215 and did not vary by either time to surgical explant or TAVR era, or between patients with versus wit

216 Angiogenic rescue experiments in ventricular explants, or in primary human endothelial cells, indicat

217 Importantly, explant organization requires polarized inheritance of m

218 s to develop a long-term OvC patient-derived explant (OvC-PDE) culture strategy in which architecture

219 rtery thromboses and adherent hMSCs found on explanted oxygenator fibers.Conclusions: Endobronchial h

220 ion of LRP1 protein was also demonstrated in explanted PASMC from patients with PAH and accompanied b

221 Lesions were categorized on the basis of explant pathologic findings as either completely (100%)

222 a retrospective cohort study using national explant pathology data from 2012 to 2015.

223 The 15 ongoing explanted patients are now 2.26+/-0.97 years after expla

224 further validated using the patient-derived explant (PDE) model.

225 subsequent gene delivery experiments to the explanted porcine heart utilized an autologous blood rec

226 hibition of pSTAT phosphorylation in colonic explants post-oral dose but low systemic exposure and no

227 ere, we show that zebrafish embryonic tissue explants, prepared prior to germ layer induction and lac

228 Explanted probes displayed a small increase in noise com

229 operating within the 15 DAP immature embryo explant provides key molecular hints as to why this stag

230 The time from SBRT to explant ranged from 12 to 250 days.

231 continuous-flow LVAD, 16 patients with LVAD explanted (recovered patients), and 24 heart transplant

232 odal-signaling levels, is highly variable in explants, reminiscent of embryos with reduced Nodal sign

233 e, both Sulfs rendered infarcted mouse heart explants responsive to the angiogenic effects of HS-bind

234 applying YIGSR to E13.5 EdnrB(NCC-/-) colon explants resulted in 80%-100% colonization of the hindgu

235 Atoh1 and Gfi1 in cultured neonatal cochlear explants resulted in numerous ectopic HC-like cells (HCL

236 xposure of first trimester placental villous explants resulted in secretion of inflammatory cytokines

237 of CNN3 in lens epithelial cell cultures and explants results in actin stress fiber reorganization, s

238 s apoptosis in radical prostatectomy ex vivo explant samples.

239 cytokine responses in vivo and in human IBD explant samples.

240 ta from beta-NGF stimulated cartilage callus explants show a promotion in markers associated with end

241 Skeletal muscle stem (satellite) cell explants show that Auf1 transcription is activated with

242 Finally, placental explants showed a significant increase in CORIN producti

243 Liver explants showed fibrosis ranging from mild to severe.

244 HHV-6 was detected in liver explants significantly more often and in higher quantiti

245 Explanted small bronchi isolated from human lung tissue

246 Last, we stained for monocytes in explanted stenotic aortic human valves.

247 Using explant studies, lineage tracing, and clonal analysis, w

248 significantly increased in ex vivo cartilage explants subjected to increasing load magnitude and in i

249 ta-hydroxysteroid dehydrogenase 1 mRNA in HG explants suggests glucose involvement in blubber cortiso

250 lly active dose of KAFAK to bovine cartilage explants, suppressing pro-inflammatory interleukin-6 (IL

251 bility of patient breast tumor samples in an explant system.

252 cles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids.

253 led system that uses large porcine GI tissue explants that are functionally maintained for an extende

254 ed tissue; however after the first week post-explant, there was a decrease in mechanical properties i

255 A prospective study was performed using an explant tissue model with ex vivo inferior turbinate muc

256 from formalin-fixed paraffin-embedded liver explant tissue.

257 Explanted tissue was tested for contractile responses to

258 nd tissue biomechanics were evaluated on the explanted tissue.

259 osterone synthesis in human fetal testicular explants to an extent greater than that seen with indivi

260 Such analysis requires explants to be imaged under conditions that maintain bot

261 ) were tested in HIV-1-infected human tonsil explants to compare levels of inhibition of HIV-1 infect

262 In this study, we utilized PPR skin biopsy explants to integrate both differentially expressed gene

263 ates 3-dimensional cultures and normal human explants to knock down IL17RA mRNA by 63% and 66%, respe

264 established organotypic cell cultures of AT explants to study the impact of cytokine treatment on lo

265 d to an increase in mucociliary clearance in explanted tracheae that was Trpm5- and M3R-mediated.

266 eq databases in conjunction with mouse gonad explant transfection assays, we identified TCF/LEF-bindi

267 ure results from either a vitreous sample or explanted tube shunt.

268 e revision in the anti-VEGF group included 5 explanted tubes for recurrent erosions.

269 samples) and in six SCLC patient-derived CTC explant tumors.

270 DCs migrated out of human skin explants upon inoculation of the skin with B. miyamotoi.

271 By comparison, 33 regenerants from stem explants used for Agrobacterium-mediated transformation

272 On explant, vascular invasion was found in 23.7% of AC-DS v

273 The median time to surgical explant was 212 days, whereas 8.8% and 70.9% underwent s

274 Time to surgical explant was calculated from the index TAVR discharge to

275 EHV1 binding to and infection of mucosal explants was greatly enhanced upon destruction of the re

276 Conversely, virus shedding from TG explants was significantly impaired when they were incub

277 ng nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates

278 By imaging epithelial cells in intact ChP explants, we observed calcium activity and secretory eve

279 Histopathological data of HCC at explant were recorded.

280 Organotypic culture and human tumour explants were allowed to grow long-term (14-35 days) and

281 In the control group, all explants were composed of tumor.

282 Colonic explants were cultured and preserved ex vivo for 35 days

283 Bovine full-depth articular cartilage explants were loaded to 2.5 MPa (physiological) or 7 MPa

284 Tissue explants were mechanically minced into 1 mm(3) pieces to

285 In the experimental group, explants were microscopically devoid of tumor cell, and

286 rthritis in vitro, human articular cartilage explants were placed in culture and treated with IL-1bet

287 n and migration of epicardial cells in heart explants were reduced in nrp1a mutants.

288 ificantly more GR-positive neurons following explant when treated with dexamethasone.

289 cally, this was validated in patient-derived explants where enzymatic inactivation of IKBKE reduced c

290 was detected in TG neurons at 8 hours after explant whereas infected-cell protein 0 (ICP0) and ICP4

291 n, but few patients recover sufficiently for explant, which has focused attention on stem cells to au

292 real-time, in situ detection of bacteria in explanted whole human Cystic Fibrosis lungs.

293 ns of 20E support prolonged proliferation in explanted wing discs in the absence of insulin, incident

294 Stimulation of normal-weight bone explant with recombinant resistin increased the Type I c

295 Endocrine development was enhanced in explants with higher expression of insulin and maturatio

296 support of this, stimulation of nonlesional explants with IL-1beta resulted in transcriptomic and pr

297 Here, we treated brain explants with the organophosphate compound paraoxon and

298 study period, 121 ICRSs (119 patients) were explanted, with an explantation rate of 5.60%.

299 different degrees of ototoxicity in cochlear explants, with gentamicin C2b being the least and gentam

300 36) of patients receiving the protocol being explanted within 18 months (pre-explant left ventricular