ライフサイエンスコーパス: exquisite

1 CANCE STATEMENT The vertebrate retina has an exquisite ability to adjust information processing to ev

2 three-dimensional hydrogel scaffolds have an exquisite ability to promote tissue repair.

3 under different oxygen conditions, providing exquisite adaptation to different conditions encountered

4 hese conformers hybridize to each other with exquisite affinity, sequence selectivity, and level of o

5 These results demonstrate exquisite and diverse sensitivity to TBX5 dosage in hete

6 al that Atm deficiency is associated with an exquisite and genotype-specific sensitivity against PARP

7 An exquisite and supremely accessible exhibition of classic

8 an had been thought but the cell has evolved exquisite antiprion systems that rapidly eliminate most

9 aintaining a healthy body weight requires an exquisite balance between energy intake and energy expen

10 S), involving the semaphorin domain, confers exquisite binding affinity for HER2 and enables MET(N375

11 d C-terminal modifications that preserve the exquisite biological activity of acid 1 and offer the op

12 Inspired by biology, exquisite biomolecular nanoarchitectures have been forme

13 We showed that these exquisite biosensors report on changes in cholesterol re

14 que biophysical fingerprint characterized by exquisite Ca(2+) selectivity, store-operated gating, and

15 Exquisite catalyst control allows for the preparation of

16 This is the result of exquisite catalyst controlled regioselectivity enabling

17 lavin-dependent 'ene'-reductases (EREDs) are exquisite catalysts for effecting stereoselective reduct

18 Using an exquisite cell imaging approach based on DNA nanosensors

19 The exquisite cell-type specificity of global lncRNA express

20 This highlights the exquisite cell/tissue-specific actions of the ERalpha su

21 n or mismetallation, suggesting the need for exquisite cellular control of Mn-dependent metabolic pro

22 eactions are few in number, they demonstrate exquisite chemo- and stereo-selectivity.

23 ding the enzymes largely responsible for the exquisite chemodiversity of more than 80000 terpenoid na

24 Purpose Owing to its exquisite chemotherapy sensitivity, most patients with m

25 Some (e.g. plasmepsin V) have exquisite cleavage sequence specificity; others are fair

26 show that this preference is not key to this exquisite CN selectivity.

27 y which this tripartite coupling enables the exquisite cochlear filtering has yet to be articulated i

28 The exquisite complementarity between glucuronic acid and it

29 ly fast rate of C-C bond formation driven by exquisite complementarity of the reacting pai systems.

30 y between these two phase transitions yields exquisite composition fluctuations and a coexistence of

31 Thus, the exquisite connectivity of ChCs not only mediates directi

32 tivity and visual experience can sculpt this exquisite connectivity.

33 tractor during catalysis, in contrast to the exquisite control achieved with the enzymatically genera

34 These observations exploit the exquisite control afforded by electrochemistry in contra

35 The exquisite control afforded by the DNA origami technology

36 lation as a metabolic rheostat that mediates exquisite control of aerobic glycolysis.

37 , DAH7PS and CM from M. tuberculosis provide exquisite control of aromatic amino acid biosynthesis, n

38 e to address challenging issues that require exquisite control of fundamental radical processes.

39 the activities of other ion channels lead to exquisite control of intracellular ion concentrations in

40 Photonic crystals enable exquisite control of light propagation in integrated opt

41 tly regulated processes, nature demonstrates exquisite control of light-matter interactions at variou

42 Exquisite control of the chain folding in PSCs allows us

43 Our system provides exquisite control of the level, timing, and cell-type sp

44 nd Pd(II) single sites on zeolite Y, with an exquisite control of the Lewis acidity, to catalyze diff

45 ced to achieve maximum therapeutic effect by exquisite control of the molecular structure.

46 he development of inexpensive catalysts with exquisite control on their electronic and structural fea

47 This is usually achieved by exquisite control over atomic positions in crystalline s

48 hough it is not known how cells maintain the exquisite control over caspase activity in order to reta

49 a dynamic cobalamin binding site and exerts exquisite control over coordination geometry, reactivity

50 the dye over a range of compositions enables exquisite control over dye quantum behavior, leading to

51 Plants display exquisite control over gene expression to elicit appropr

52 iments in Rydberg atomic gases have achieved exquisite control over non-local interactions, allowing

53 Yet, this exquisite control over selectivity comes at an operation

54 mplex type of material, nanocomposites, with exquisite control over structural and chemical parameter

55 The hydrogel allows exquisite control over the chemical and physical in vitr

56 xial growth in an alcoholic solvent, we show exquisite control over the dimensions and dispersity of

57 High selectivity and exquisite control over the outcome of reactions entice c

58 In addition, the approach allows exquisite control over the patterned substrate/crystal l

59 trapping 'tags' for downstream modification, exquisite control over the site of subsequent modificati

60 and promises new opportunities for achieving exquisite control over the surface chemistry and propert

61 ly available methodologies arguably lack the exquisite control required for producing metal-organic f

62 ge pro-inflammatory activation must be under exquisite control to avert unbridled inflammation.

63 obial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environm

64 llenges requiring tissue regeneration, where exquisite coordination of gene expression is essential.

65 ent production of a signed language requires exquisite coordination of sensory, motor, and cognitive

66 homeostasis and organismal survival through exquisite coupling of oxidative phosphorylation, a promi

67 tforward preparation, stoichiometric use and exquisite cysteine selectivity of the carbonylacrylic re

68 acterized by reduced SIRT6 expression and an exquisite dependence on Lin28b for tumor growth.

69 educes cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second po

70 The exquisite dependency on CRAF kinase in KRAS mutant tumor

71 tissue characterization ability and provides exquisite detail about myocardial structure and composit

72 xities of cell biology have been analyzed in exquisite detail and much is known about how these organ

73 al. (2017) offer new insights by mapping in exquisite detail chromatin accessibility dynamics as mou

74 surement of phenotypic outcomes to match the exquisite detail emerging at the molecular level.

75 behavior and ecology of adult mosquitoes in exquisite detail on complex resource landscapes generate

76 llular behaviour can now be characterised in exquisite detail using live single-cell imaging experime

77 sing of rotatory optic flow is understood in exquisite detail, how they process translatory optic flo

78 s we describe the immune system in ever more exquisite detail, we might find that no matter how succe

79 forms with phenotypes of early G1 mutants in exquisite detail.

80 acterize these neurons' upstream circuits in exquisite detail.

81 lant species and its mechanisms are known in exquisite detail.

82 enzymes involved have been characterised in exquisite detail.

83 ding innumerable fault features displayed in exquisite detail.

84 Using the exquisite diagnostic power of NMR chemical shifts, Byun

85 ons that exhibit extensive CAG expansion and exquisite disease vulnerability.

86 substrate scope under mild conditions and an exquisite divergence in site selectivity that can be eas

87 Proton therapy generates even more exquisite dose distribution in some patients, thus poten

88 onate homopolymers and block copolymers with exquisite efficiency and control.

89 Topological insulators give rise to exquisite electronic properties because of their spin-mo

90 nction, and biochemically relevant for their exquisite enzymatic cyclization mechanism.

91 displaced to the bladder wall, represents an exquisite example of morphogenetic apoptosis, requiring

92 One of the most exquisite examples of membrane remodeling is myelination

93 tertiary ophthalmology centre with bilateral exquisite eye pain, inability to open the eyes, photosen

94 In particular, the exquisite Fe/Co system displays tuneable optical and mag

95 pe-specific transcriptional programming with exquisite fidelity is essential for normal development.

96 To understand the molecular basis of this exquisite fine specificity, we undertook Ala substitutio

97 ite via subtle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential met

98 ion in neural circuits, which often requires exquisite fine-tuning of inhibitory connections.

99 crimination among very similar analytes, and exquisite fingerprinting of extremely similar mixtures o

100 ade and reactive oxygen signalling, provides exquisite flexibility to both perceive and respond to bi

101 ly sample their mechanical environment using exquisite force sensors such as talin, whose folding sta

102 Although exquisite fossil and geological records provide insight

103 The exquisite Gal((13)C(6)) modified Tn are then recognized

104 it has become clear that animals can exhibit exquisite graded specification to their movements.

105 and no protection from obesity but retained exquisite hepatic insulin sensitivity.

106 ic structural analyses reveal much about the exquisite hexameric core structure of Orai channels.

107 ng phylogenetic trunks which may explain the exquisite immunotherapy sensitivity of dMMR tumours.

108 kely a major contributor responsible for the exquisite inhibitor selectivity.

109 pecific stable isotope tracers has permitted exquisite insight into amino acid, fatty-acid and carboh

110 conventional procedures and give access and exquisite insight into on-surface tetrapyrrole chemistry

111 k-Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoreg

112 Exploiting the exquisite intrinsic optical absorption contrast of circu

113 cation of AKR1C3 inhibitors that demonstrate exquisite isoform selectivity for AKR1C3 over the other

114 The exquisite isoform selectivity of lynx1 interactions prov

115 LOU064 exhibits an exquisite kinase selectivity due to binding to an inacti

116 Compound 5 potently binds to RIP1 with exquisite kinase specificity and has excellent activity

117 We propose that the exquisite kinetic control of telomerase activity may pla

118 In a brain slice, RhoVR-Halos provide exquisite labeling of defined cells and can be imaged us

119 nd a full-length monoclonal antibody with an exquisite level of control over the site of conjugation.

120 ic alkyl bromides are well accommodated with exquisite levels of retention over isomerization.

121 With the realization that bacteria achieve exquisite levels of spatiotemporal organization has come

122 Exactin shows exquisite macromolecular specificity to FX activation as

123 We show that Dnmt5 displays exquisite maintenance-type specificity in vitro and in v

124 s human host for over 50 000 years and is an exquisite manipulator of the human immune response.

125 d electron microscopy traditionally requires exquisite manual skills and is tedious and unreliable.

126 The findings identify an exquisite mechanism of metered secretory output that pre

127 t also present a new tool to investigate the exquisite mechanism of PPIs.

128 ity pocket in the n-Src domain, providing an exquisite mechanism where multiple motifs are used combi

129 her survival and remarkable recovery to both exquisite medical critical care and support she received

130 s both a nutrient and a signal directing the exquisite microbiota-pathogen relationships within the g

131 Drosophila melanogaster, a fruit fly, is an exquisite model organism to understand neurotransmission

132 FM combines exquisite molecular discrimination capacities with high

133 member of the Hha protein family, acts as an exquisite molecular sensor of solvent ionic strength.

134 The exquisite nanoscale shape control of this inherently bio

135 rates or adhesive ligands(1), for instance), exquisite nanostructures (composed of peptides(2), prote

136 Their exquisite NPC-typical sorting selectivity and strong int

137 The exquisite periodicity of their firing has led to the sug

138 The human eye is an exquisite photodetection system with the ability to dete

139 n, we describe a novel strategy that enabled exquisite point mutation discrimination with isothermal

140 g blood vessel morphogenesis that highlights exquisite post-translational regulation of mVEGFR1 in it

141 ists as well as drug developers due to their exquisite potency and selectivity, not just against prey

142 Compound 8 has exquisite potency at PDE4B, good selectivity over PDE4D,

143 Despite the exquisite potential of siRNA as a therapeutic, the mecha

144 This work demonstrates the exquisite power of combining cell-type-specific perturba

145 , both specified and radially patterned with exquisite precision during embryonic development.

146 plexity in GTPase signaling patterns enables exquisite precision over the control of cellular process

147 mponents self-assemble at the nanoscale with exquisite precision-a key to their biological success in

148 chaeological metal artifacts offers the most exquisite preservation through a mechanism unexplored on

149 ated by a rich record of fossils, often with exquisite preservation, but current analyses conflict ov

150 NMR residual dipolar couplings (RDCs) are exquisite probes of protein structure and dynamics.

151 Despite their exquisite programmability, DNA-based walkers are challen

152 ic subunit of V-ATPase with high potency and exquisite proteomic selectivity as revealed by fluoresce

153 Lysosomal cathepsins regulate an exquisite range of biological functions, and their dereg

154 remarkable machines capable of performing an exquisite range of functions, many of which depend cruci

155 unique class of mesoionic dipoles displaying exquisite reactivity towards both copper-catalyzed and s

156 Recent studies in mammalian brain reveal an exquisite refinement of KCh subcellular localization.

157 R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting

158 d complex at high resolution to explain this exquisite regioselectivity remains unfulfilled.

159 h no easily observable recognition motif and exquisite regioselectivity.

160 These findings explain the exquisite regulation of CMG disassembly and provide a ge

161 While the exquisite regulation of lncRNA transcription can provide

162 taxin-1, SNAP-25 and synaptobrevin, allowing exquisite regulation of neurotransmitter release.

163 indings highlight the physiological need for exquisite regulation of neutral lipid storage within adi

164 ese results advance our understanding of the exquisite regulatory control of the lifetime of rod PDE6

165 er the decades, many studies have shown that exquisite regulatory mechanisms at multiple levels contr

166 Apart from this, boronic acids exhibit an exquisite reversible coordination profile that can be ex

167 produce and structurally manipulate, exhibit exquisite SARs, are nontoxic, and elicit improved and qu

168 , biorecognition ligands that are capable of exquisite selective binding, and seamless integration at

169 ng Michael adducts in a couple of hours with exquisite selectivities (up to 98% ee).

170 several showing submicromolar inhibition and exquisite selectivity against P. falciparum parasites (3

171 a next-generation RIP2 inhibitor possessing exquisite selectivity and potency.

172 rinic acetylcholine receptor (mAChR) achieve exquisite selectivity by occupying a dynamic pocket abse

173 ariety of unbiased pai-systems proceeds with exquisite selectivity by the combination of a Ni catalys

174 molar (nmol/L) target affinity and exhibited exquisite selectivity for polySia structures.

175 cause the proton concentration is minuscule, exquisite selectivity for protons over other ions is cri

176 operativity with acetylcholine, and retained exquisite selectivity for the M1 mAChR.

177 e) promotes a high-affinity interaction with exquisite selectivity for this sequence.

178 This molecule displays potent activity, an exquisite selectivity for Vps34 with excellent propertie

179 To discover the principles underlying the exquisite selectivity LuxN has for its ligand, we identi

180 Here, we reveal the structural basis for the exquisite selectivity of CENP-N for centromeres.

181 from binding to convertases and explain the exquisite selectivity of eculizumab for human C5 and how

182 Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate

183 ibitor with low nanomolar in vitro activity, exquisite selectivity on a panel of methyl reader and wr

184 de screen of 468 protein kinases, HS-243 had exquisite selectivity toward both IRAK-1 (IC(50) = 24 nm

185 ophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.

186 Our data highlight the exquisite selectivity with which members of the KRAB-ZFP

187 These processes require exquisite selectivity, but the individual roles of most

188 (NCys) that proceeds with fast kinetics and exquisite selectivity, thereby enabling facile modificat

189 mbine remarkable affinity (K(i) < 30 nM) and exquisite selectivity.

190 markable capabilities to combat disease with exquisite selectivity.

191 ct transistors (SiNW FETs) typically display exquisite sensitivities, but their bioanalytical impleme

192 The exquisite sensitivity and frequency discrimination of ma

193 o the cochlear amplifier, which provides the exquisite sensitivity and frequency selectivity of the m

194 Medical diagnostic assays provide exquisite sensitivity and precision in the diagnoses of

195 ospray-ionization mass spectrometry with its exquisite sensitivity and specificity offers the prospec

196 ings because of their low time to result and exquisite sensitivity and specificity.

197 Its exquisite sensitivity enables time-lapse optical biopsie

198 n this same reductionist tradition but offer exquisite sensitivity in space and time along with the a

199 The exquisite sensitivity of BRCA-deficient cells to 3' bloc

200 Despite the exquisite sensitivity of cHL to PD-1 checkpoint blockade

201 l Disorder of Glycosylation (CDG) due to the exquisite sensitivity of glycosyltransferases to Mn conc

202 The exquisite sensitivity of neurons at each processing stag

203 These studies highlight the exquisite sensitivity of the cellular response to low-le

204 The sharp frequency tuning and exquisite sensitivity of the mammalian cochlea is due to

205 ple micelle or vesicle models, indicating an exquisite sensitivity of the protein to the complex lipi

206 of an active process that might underlie the exquisite sensitivity of the sacculus to mechanical stim

207 We demonstrate exquisite sensitivity of the striatum to IFN-alpha, impl

208 We document exquisite sensitivity of Vgamma9Vdelta2 T cells, which r

209 bacilli DNA input material, having shown its exquisite sensitivity over a conventional gel based read

210 As a consequence, these tumors display an exquisite sensitivity to agents inducing proteotoxic str

211 er and manifested as cardiac fibrosis and an exquisite sensitivity to alcohol, leading to sudden arrh

212 lonic (YAMC) epithelial cells demonstrate an exquisite sensitivity to both toxins with phenotypes tha

213 ue clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analog

214 The results reveal an exquisite sensitivity to diameter and substantially larg

215 ut the molecular mechanisms underlying their exquisite sensitivity to different forces within the mem

216 gy-dependent repair (HDR)(5,6) and confer an exquisite sensitivity to inhibitors of poly (ADP-ribose)

217 th good QY, long fluorescence lifetimes, and exquisite sensitivity to local structural changes.

218 testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are

219 Our data indicate that Dnf2 exhibits exquisite sensitivity to the membrane composition, thus

220 Due to this exquisite sensitivity, (th)G appears ideal for monitorin

221 dvantages for metabolite analysis, including exquisite sensitivity, high speed and reproducibility, a

222 vidual cellular metabolite profiles with its exquisite sensitivity, large dynamic range, and ability

223 Our sense of hearing boasts exquisite sensitivity, precise frequency discrimination,

224 f appraising, on a short time scale and with exquisite sensitivity, the occurrence and the magnitude

225 ction together to mediate thermosensation of exquisite sensitivity.

226 Macrophages are exquisite sensors of tissue homeostasis that can rapidly

227 ed proteases in biotechnology because of its exquisite sequence specificity.

228 bility, folding and function required by the exquisite serpin mechanism of action.

229 neural signal transduction and must maintain exquisite signal fidelity while also accommodating the p

230 us of movements (tics) and high performance (exquisite singing).

231 dines to Boc-protected 2-aminopyridines with exquisite site selectivity and chemoselectivity.

232 s is the pairing of powerful reactivity with exquisite site selectivity.

233 The simplicity and exquisite site-selectivity of the aza-Michael ligation d

234 luding the use of ethylene as substrate, and exquisite site-selectivity pattern for both alpha-olefin

235 cid-containing amino acid into proteins with exquisite site-specificity and homogeneity, overcoming i

236 Ubiquitin ligases exert exquisite spatial and temporal control over protein stab

237 Iteratively executed with exquisite spatial and temporal control, the selective is

238 developments show how MAPK pathways perform exquisite spatial and temporal signal processing and und

239 netic memory across mitotic generations with exquisite spatial fidelity.

240 is endowed by unique features, including an exquisite spatial nonlocality.

241 ct this to be one of many examples where the exquisite spatial organization of the eukaryotic cell en

242 s and characterization in imaging mode, with exquisite spatial resolution and high sensitivity, has s

243 With exquisite spatial selectivity and capability for depth p

244 oom body modulate synaptic transmission with exquisite spatial specificity, allowing individual neuro

245 temporally specific manner and thereby exert exquisite spatiotemporal control over its protein bindin

246 Light activation of a degrader to achieve exquisite spatiotemporal control over protein stability

247 production and cell entry and emphasize the exquisite spatiotemporal regulation governing adenovirus

248 titative characterization demonstrated their exquisite specificity and high affinity, and they perfor

249 stry, biology, and medicine because of their exquisite specificity and sustained duration of inhibiti

250 1R-FRed mouse provides a novel reporter with exquisite specificity for cells of the MPS.

251 a CD4(dim) CD8(+) phenotype, both exhibiting exquisite specificity for conserved epitopes of JCV larg

252 he ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational dock

253 eferred TCRalphabeta pairing that determined exquisite specificity for the D(b)PA224 epitope from inf

254 rk of kinase-substrate interactions provides exquisite specificity in cell signaling pathways, but al

255 As therapeutics, they combine the exquisite specificity of antibodies, enabling discrimina

256 culate that this coupling contributes to the exquisite specificity of Dnmt5 via mechanisms related to

257 How the exquisite specificity of high-avidity T cells is achieve

258 and provide a molecular explanation for the exquisite specificity of PA function.

259 SEA-4 plays a dominant role in dictating the exquisite specificity of the ch28/11 antibody.

260 u5Ac in R. gnavus that is underpinned by the exquisite specificity of the sialic transporter for 2,7-

261 t the molecular mechanisms that underlie the exquisite specificity of these signaling pathways are in

262 These data highlight the exquisite specificity that conserved RNA-binding protein

263 ous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display

264 Integrin alphavbeta8 binds with exquisite specificity to latent transforming growth fact

265 erizes additional PV-specific enhancers with exquisite specificity within distinct brain regions.

266 However, as a result of this exquisite specificity, it is blind to changes that may b

267 Although both tests have exquisite specificity, RT-QuIC has a sensitivity of 92 t

268 Yet, even for therapeutics with exquisite specificity, the sequence of events following

269 temporal expression during neurogenesis with exquisite specificity.

270 ght chain into presynaptic compartments with exquisite specificity.

271 he substrate-binding centre to achieve their exquisite specificity.

272 dually bind different basic amino acids with exquisite specificity.

273 ing, with both classes of enzymes displaying exquisite specificity.

274 tional off-target proteins, confirming their exquisite specificity.

275 ic structure, constituting the foundation of exquisite spin-valley-electronic, topological, and many-

276 ion converge on GRPR neurons and thus map an exquisite spinal circuitry hard-wired for converting inn

277 ic photochemical cascade whose mechanism and exquisite stereoselectivity were informed by computation

278 erior mechanical properties, are amenable to exquisite strain manipulation with a broad tunability in

279 shielded by organic ligands possessing both exquisite structural aesthetics and intriguing propertie

280 mum freezing efficiency, bacteria must exert exquisite, subangstrom control of the distance between I

281 Here, we show that Orn exhibits exquisite substrate preference for diribonucleotides.

282 erases in the purine salvage pathway exhibit exquisite substrate specificity despite the chemical sim

283 re domains of the protein, thereby providing exquisite substrate specificity.

284 (-1)s(-1), a K(M) for triuret of 20 muM, and exquisite substrate specificity.

285 ition, solution-processed nanocrystals allow exquisite surface engineering.

286 P reveal a tight interaction that depends on exquisite surface shape and charge complementarity betwe

287 MX2, and TRIM25, which may contribute to the exquisite susceptibility of these cells to SIV infection

288 These data demonstrate exquisite targeting of distinct commensal bacteria by mu

289 fferences in processing speed highlights the exquisite temporal calibration required for accurate per

290 cells and tissues, and its execution demands exquisite temporal coordination of functionally diverse

291 Exquisite temporospatial control of the GREM1-BMP intera

292 histone deacetylase inhibitors providing an exquisite therapeutic vulnerability.

293 Tissue clearing methods promise to provide exquisite three-dimensional imaging information; however

294 ds as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for n

295 rticles are versatile materials that provide exquisite, tunable control over the sequestration and de

296 f the groups would open up possibilities for exquisite tuning of the siting and performance of subseq

297 Here, by developing an exquisite ultra-sensitive NGS (USNGS) platform "EasyMF"

298 Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a

299 ances marking fluorescent HSPCs have allowed exquisite visualization of HSPCs in the caudal hematopoi

300 diated mitochondrial fusion accounts for the exquisite vulnerability of Purkinje neurons in pcd mice.