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1 upregulated in metastatic cells and detected extracellularly.
2 n, suggesting that expansin and GH5 function extracellularly.
3 the cytoplasm, in the periplasmic space, or extracellularly.
4 al water in the spin-dried sample, intra- or extracellularly.
5 f the fact that the mutant C termini project extracellularly.
6 proteins, being important to kill pathogens extracellularly.
7 e SPI2 and maintain virulence by replicating extracellularly.
8 rmined binding site of SR141716A but extends extracellularly.
9 by the presence of VEGFA intracellularly or extracellularly.
10 M-2 was reversed by reducing agents that act extracellularly.
11 gluconate, pyruvate, and acetate) accumulate extracellularly.
12 that some obscurin kinase isoforms localize extracellularly.
13 de exosomes, which are nanovesicles secreted extracellularly.
14 ributes to the enhanced trafficking of MMP-9 extracellularly.
15 capsid proteolysis (uncoating) is initiated extracellularly.
16 howed no fluorescent signal either intra- or extracellularly.
17 ost of the FFA produced by E. coli are found extracellularly.
18 livering multiple types of membrane capsules extracellularly.
19 oforms in the effective trafficking of MMP-9 extracellularly.
20 on when administered intracellularly but not extracellularly.
21 appeared in acidic vesicles and was released extracellularly.
22 an ectonucleotidase, and generates adenosine extracellularly.
23 pressing anchorless PrP-sen may be occurring extracellularly.
24 .6 recognizes an ASP epitope that is exposed extracellularly.
25 omer efficiently, and it does not accumulate extracellularly.
26 t innate inflammatory mediator when released extracellularly.
27 alert the host of infection both intra- and extracellularly.
28 the cell surface with the Gla domain exposed extracellularly.
29 thogen, Y. enterocolitica survives primarily extracellularly.
30 these cutaneous infections appears to occur extracellularly.
31 S. mitis appear to release mitilysin extracellularly.
32 ts, suggesting that bile acids regulate ENaC extracellularly.
33 iological functions both intracellularly and extracellularly.
34 pression of oligomeric Abeta either intra or extracellularly.
35 h and function by sequestering these ligands extracellularly.
36 ucose is converted into lactate and released extracellularly.
37 lasm to the cell surface, and to be secreted extracellularly.
38 hat CAT processes Cm intracellularly but not extracellularly.
39 iation pathways regulate toxicity intra- and extracellularly.
40 ested that quaternary amines can bind to two extracellularly accessible sites, one of them located at
41 metry fills this gap, it is limited to sites extracellularly accessible, when the key region for gati
43 or targeted and site-specific delivery of an extracellularly active drug and an intracellular functio
44 GI is a multifunctional dimeric protein that extracellularly acts as a cytokine [autocrine motility f
45 esistance of disulfide bonds to reduction by extracellularly added DTT and Triton X-114 detergent pha
48 ed lipids inhibits cell penetration, whereas extracellularly administered pure oxidized lipids enhanc
51 choline and its breakdown product G3P occurs extracellularly allowing other bacteria to benefit from
52 In contrast, large microbes triggered ROS extracellularly, amplifying IL-1beta expression to recru
53 toxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by
54 -inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to th
55 detection of bacteria that typically reside extracellularly and demonstrate that this microbial sens
56 s, adult transgenic mice released more IL-33 extracellularly and exhibited robust type 2 immune respo
57 HSA)-based therapeutic (KH-1) that functions extracellularly and exhibits pleiotropic effect on multi
58 use yeast use invertase to hydrolyze sucrose extracellularly and import the resulting monosaccharides
59 c1 mutant strain is almost exclusively found extracellularly and in a hyperencapsulated form, and its
61 In the second mechanism, Dab2 is released extracellularly and interacts with the pro-aggregatory m
62 acroscopic and single-channel currents using extracellularly and intracellularly applied methanethios
63 dase that has been proposed to function both extracellularly and intracellularly to activate oncogeni
64 is a bioactive lipid that can function both extracellularly and intracellularly to mediate a variety
67 rate that a sub-population of Alix localizes extracellularly and regulates integrin-mediated cell adh
68 prise glycerol and FFA formation and release extracellularly and the diversion of glucose carbons to
69 functional matrix biogenesis is coordinated extracellularly and thus reflects the cooperative action
70 whether IAPP toxic oligomers form intra- or extracellularly and whether vaccination to induce anti-t
72 ns can be expressed both intracellularly and extracellularly, and extracellular galectins mediate the
73 m is fibronectin independent, can take place extracellularly, and is demonstrated to be direct in vit
74 shock protein 90 beta (HSP90beta) is present extracellularly, and its interaction with the hemopexin
75 t the sites of inflammation, both intra- and extracellularly, and large numbers of bacteria were obse
76 was localized on the cell surface, activated extracellularly, and required propeptide processing befo
77 hod takes advantage of the unique ability of extracellularly applied Abeta oligomers to rapidly induc
79 erometry that SERT has the capacity to clear extracellularly applied DA in the hippocampal CA3 region
81 -to-basal fluid transport in response to the extracellularly applied membrane-permeable cGMP analog p
83 ositions 106, 107, and 109 indeed react with extracellularly applied MTS probes, but not to intracell
84 S1-S2 linker of WT Kv1.5 could be cleaved by extracellularly applied proteinase K (PK), an N-terminal
86 selectivity filter are easily accessible to extracellularly applied sulfhydryl reagents and select f
87 n unprecedented level of detail by examining extracellularly applied tubular system markers in skelet
89 obility group box 1 (HMGB1) is a NF released extracellularly as a late mediator of lethality in sepsi
91 42) fragments are found intracellularly, and extracellularly as amyloid plaques, in Alzheimer's disea
92 that upon keratinocyte damage icIL-1Ra1 acts extracellularly as an antagonist of the alarmin IL-1alph
93 t stony corals precipitate calcium carbonate extracellularly as aragonite in a calcifying medium betw
94 lularly as part of fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precu
95 an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage
96 tive globular proteins, which then aggregate extracellularly as insoluble fibrils, damaging the struc
99 xed circular (RC) DNA genome can be secreted extracellularly as virions after envelopment with the vi
100 iral envelope proteins, leading to secretion extracellularly as virions, or (ii) disassembly (uncoati
101 ) stimulated further activation of caspase-1 extracellularly, as well as intracellularly after phagoc
102 wild-type HSV-1(F) virus intracellularly and extracellularly at late times postinfection, with the ex
105 anner by which amyloidogenic proteins spread extracellularly, become seeded, oligomerize, and are tak
106 ched polyethylene imine coated Ag NPs/mL the extracellularly bound Ag varied from 79 to 560 fg and ce
108 duces an autoregulatory peptide that matures extracellularly but functions intracellularly to regulat
109 icated that both GGT1 and GGT2 are localized extracellularly but have different physical or chemical
111 he actions of AEA were apparent when applied extracellularly but not during intracellular dialysis.
112 synthesis and metabolism intracellularly and extracellularly, but also in the macroenvironment via di
113 tic transmission and plasticity when applied extracellularly, but induced synaptic depression and LTP
115 mpeding the reuptake of bicarbonate produced extracellularly by CA9 could exacerbate the intracellula
119 s infection by distinct effector mechanisms: extracellularly by neutralization and intracellularly by
120 r intracellularly by furin-like proteases or extracellularly by plasmin or matrix metalloproteinases.
121 hat the precursor of NGF (proNGF) is cleaved extracellularly by plasmin to form mature NGF (mNGF) and
122 tudy, we demonstrate that LOXL2 is processed extracellularly by serine proteases, generating a 65-kDa
123 e mechanism of VEGF/Fn synergism is mediated extracellularly by the formation of a novel VEGF/Fn comp
124 x, and secreted pro-myostatin can be cleaved extracellularly by the proprotein convertase furin.
126 eted as a 46-kDa proenzyme that is activated extracellularly by the removal of an approximately 10-kD
127 el suggests that oligomerization is mediated extracellularly by unoccupied ligand-binding sites and t
128 ts show that some cationic molecules applied extracellularly can powerfully inhibit both sodium chann
130 d to the loss of the accessory toxins may be extracellularly complemented by inoculation of the defec
131 IP4a indicate that the N terminus is exposed extracellularly, consistent with a transmembrane KISD.
132 ning the reducing-end probe, both intra- and extracellularly, consistent with the importance of vesic
133 r geminin, in vitro, providing evidence that extracellularly delivered SMoC-geminin can have an antip
134 point to a possible mechanism through which extracellularly delivered ssRNA contributes to CNS damag
138 y phage particles were composed of up to 41% extracellularly derived N, while proteins of the infecte
142 d proteins were detected in cell lysates and extracellularly, either as soluble proteins or in lympho
143 of presynaptic NMDARs depressed unitary and extracellularly evoked EPSCs at L4-L2/3 synapses, accomp
144 on method has the advantage of being able to extracellularly excite any neuron in a network regardles
145 , unique to Dictyostelia, mostly consists of extracellularly exposed and secreted proteins, with role
146 cyclable enzyme via direct immobilization of extracellularly expressed SrtA in the fermentation super
147 in the intact salamander retina, we recorded extracellularly from a population of ganglion cells with
148 ed to the extracellular space or it may form extracellularly from adenine nucleotides released from i
149 hese results indicate that adenosine, formed extracellularly from adenine nucleotides, plays a major
150 ity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons (PNs) in male
151 al plasticity in the AF pathway by recording extracellularly from individual M/T cells and presumed g
152 -dependent vestibular behaviors by recording extracellularly from neurons in the vestibular nuclear c
155 dine (4-AP)-evoked network activity recorded extracellularly from substantia gelatinosa (SG) of young
157 - and OFF-ganglion cells (GCs) were recorded extracellularly from their axon terminals in the medial
159 Thus, cholesteryl ester hydrolysis can occur extracellularly in a specialized compartment, a lysosoma
160 ased increased amounts of phosphorylated tau extracellularly in an isoform-dependent manner by a hepa
161 RTN CO(2)-activated neurons were recorded extracellularly in anaesthetized intact or vagotomized r
162 l transfer of information occurs, RNAs found extracellularly in animals are candidate molecules that
163 er, we have determined that it can also grow extracellularly in animals, in the lumen of the gallblad
165 ely dilute population of miRNAs can be found extracellularly in body fluids such as human blood plasm
166 otoreceptor degeneration) rats were recorded extracellularly in flattened eye cup preparations, to as
167 nt procyclin, while in the mammal it resides extracellularly in its bloodstream form (BF) and is dens
168 l cells and putative stellate cells recorded extracellularly in layer II of the medial entorhinal cor
170 side hydrolases are public goods transported extracellularly in outer membrane vesicles allowing for
172 es as an inflammatory cytokine when secreted extracellularly in psoriatic lesions and is involved in
173 and multicellular organisms, and is produced extracellularly in response to external stresses and int
176 n (RT-PCR), and it was subsequently released extracellularly in Tat-expressing and HIV-infected astro
178 ulate and dense-core cells, and it was found extracellularly in the morula fibrillar matrix and assoc
182 ten house small-molecule-producing symbionts extracellularly in their mesohyl, providing the host wit
183 re found as intact membrane-bound structures extracellularly in tissue sites of eosinophil-associated
184 which soluble proteins aggregate and deposit extracellularly in tissues as insoluble fibrils, causing
186 male rats, trigeminal ganglia were explored extracellularly in vivo to identify the corneal neurons
188 ording CST-evoked focal synaptic potentials, extracellularly, in the cervical enlargement of cats bef
189 In contrast, 11,12-EET (5 microm) applied extracellularly increased KATP currents by 520% in mesen
192 study, alpha-MSH, instead of being delivered extracellularly, is targeted to the endoplasmic reticulu
195 The presence of dsRNA, intracellularly or extracellularly, leads to the induction of innate inflam
196 regulator of the Toll pathway and functions extracellularly, likely by blocking the proteolytic acti
198 g properties of Cav1.3 channels, the largely extracellularly localized alpha2delta2 subunit moreover
199 c accessory proteins, like HrpZ1, may not be extracellularly localized, resulting in disabled translo
201 that the FhaB prodomain is required for the extracellularly located mature C-terminal domain (MCD) o
204 ost-translational modification mostly occurs extracellularly, making these chemical events prime drug
205 tion of the trivalent cation La(3+) (50 muM) extracellularly markedly prolongs the lag that precedes
206 g the early preictal phase, synchronous with extracellularly measured recurrent field potentials (FPs
207 this organism digests these polysaccharides extracellularly, mutants lacking this ability are outcom
208 ether fibrils are initially formed intra- or extracellularly, nor it is understood what determines wh
209 ellularly on infected macrophages as well as extracellularly on bacterial growth with very low toxici
211 port that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus
212 yloid-beta (Abeta) oligomers, either applied extracellularly or accumulated intraneuronally, is an im
214 yruvate, a concentration that can only exist extracellularly or in cell culture media, 95% eliminatio
218 binding affinity and selectivity of the more extracellularly positioned Na(+) binding site (Na1 site)
219 and compartmentalized analysis of intra- and extracellularly produced oxidants, respectively, using a
220 ream actions of GrB occur intracellularly or extracellularly, producing apoptotic cytotoxicity or non
221 ective sodium channel inhibitor when applied extracellularly, producing more potent inhibition than l
222 6-0-endosulfatase that is present and active extracellularly, providing a further mechanism to genera
223 w spatiotemporal ensemble spiking is encoded extracellularly, providing a window for efficient, LFP-b
224 molar ratios, provided that they were added extracellularly rather than being overexpressed in the c
225 els, as determined by their ability to block extracellularly recorded action potentials in three prep
229 valent use, the proper interpretation of the extracellularly recorded local field potential (LFP) is
230 aken place in recent years in the use of the extracellularly recorded local field potential (LFP) to
231 ically defined neuronal characteristics from extracellularly recorded physiological signatures has be
232 nt (20-40%) decrease in the amplitude of the extracellularly recorded postganglionic compound action
235 ntial (LFP) and multiunit activity (MUA) are extracellularly recorded signals that describe local neu
237 ments of the NMDA dependent component in the extracellularly recorded stratum radiatum CA(1) field po
240 types the mTOR inhibitor rapamycin activates extracellularly regulated kinases (Erk1/2) signaling.
241 at all tested strains maximally produce, and extracellularly release, TpeL at the late-log or early-s
242 tigates the molecular mechanism of action of extracellularly released HMGB1 in airway epithelial cell
243 to better control the deleterious effects of extracellularly released neutrophil serine proteases and
244 n mRNA generates a truncated, nonfunctional, extracellularly released protein that binds to but does
246 um hydrolyzes the Wnt palmitoleoylate adduct extracellularly, resulting in inactivated Wnt proteins t
248 time reverse transcription-PCR shows that an extracellularly secreted form of tTLL, tTLLs, is transie
249 l identification and characterization of 908 extracellularly secreted proteins will advance our under
250 t study to demonstrate that expression of an extracellularly secreted tolloid-like metalloproteinase
251 ask whether nutrients that must be digested extracellularly select for the evolution of undifferenti
252 usion proteins are successfully secreted and extracellularly self-assemble into amyloid nanofibre net
255 arising from the intracellular hydration of extracellularly supplied CO2, overall CA activity in the
258 so by measuring the correlated diffusion of extracellularly tagged transmembrane neurotrophin recept
261 can efficiently catalyze the click reaction extracellularly, thereby enabling in situ anticancer dru
262 Eosinophils release their granule proteins extracellularly through exocytosis, piecemeal degranulat
263 o vesicle carrier intermediates and released extracellularly through incompletely understood mechanis
265 intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of
267 respond uniformly to osmotic shocks applied extracellularly, thus confirming sensitivity toward chan
270 trate that the N terminus of BAI1 is cleaved extracellularly to generate a truncated receptor and a 4
271 Sulf2 (XtSulf2), which like XtSulf1, can act extracellularly to inhibit BMP4 and FGF4 signalling.
272 synthesized by certain microbes and released extracellularly to inhibit the growth of other microbes.
275 ecreted inactive pro-KLKs are then activated extracellularly to mature peptidases by specific proteol
276 led compounds, we confirm NMN is metabolized extracellularly to NR that is then taken up by the cell
277 secreted enzymes attack the polysaccharides extracellularly to remove the side-chains, exposing the
278 esponse in the neck connectives was recorded extracellularly to reveal the precise response-timing of
279 gineered Zn2+-binding site that was situated extracellularly to the predicted common binding pocket.
280 sms by which bacterial nucleic acids traffic extracellularly to trigger the modulation of host immune
281 Using FLAG-tagged constructs that expressed extracellularly truncated APP, Notch-1, or CD44, we foun
282 We demonstrated that episomal expression of extracellularly truncated CpsA causes a dominant-negativ
283 igh-mobility group box 1 (HMGB1) is released extracellularly upon cell necrosis acting as a mediator
286 onas and Acinetobacter transferred electrons extracellularly via electron shuttles, and the consequen
288 s of uric acid either intracellularly and/or extracellularly, we found that uric acid depletion subst
289 ial intracellularly, and motor neuron spikes extracellularly, we show that initiation of motor neuron
290 zyme acid sphingomyelinase (ASM) is released extracellularly when cells are wounded in the presence o
291 and Te as nanoparticles, intracellularly and extracellularly, when grown with selenite or tellurite.
292 n kinase isoform that contains SK1 localizes extracellularly, where it undergoes N-glycosylation.
293 found in CCh fibroblasts intracellularly and extracellularly, whereas only proMMP-1 was found intrace
294 cal inhibition of the PCSK9-LDLR interaction extracellularly will increase hepatic LDLR expression an
295 e de novo IL-12-like activities by combining extracellularly with p35 released from other cells.
296 s, which are frequently studied by recording extracellularly with penetrating microelectrodes inserte
299 ous effects on presumptive MT cells recorded extracellularly, with an overall modest increase in rest
300 ASMase residing within lysosomes is released extracellularly within seconds to hydrolyze sphingomyeli