ライフサイエンスコーパス: extrinsic factor

1 bility as a function of any intrinsic and/or extrinsic factor.

2 in) by accounting for possible variations in extrinsic factors.

3 lgorithm to identify osteogenic cocktails of extrinsic factors.

4 on scheme that accounts for the variation in extrinsic factors.

5 ve dysfunction is assumed to be due to valve-extrinsic factors.

6 hich this intrinsic dichotomy is enhanced by extrinsic factors.

7 is accomplished by a myriad of intrinsic and extrinsic factors.

8 o deregulation of various cell intrinsic and extrinsic factors.

9 tly to those of other vertebrates to certain extrinsic factors.

10 interactions between cell intrinsic and cell extrinsic factors.

11 ein activities and is typically regulated by extrinsic factors.

12 the coordinated action of many intrinsic and extrinsic factors.

13 complex interplay between cell intrinsic and extrinsic factors.

14 e of an arbor is the result of intrinsic and extrinsic factors.

15 le requires regulation by many intrinsic and extrinsic factors.

16 ate of primitive HPCs, might be modulated by extrinsic factors.

17 nder the influence of distinct intrinsic and extrinsic factors.

18 nce of hexokinase function in the absence of extrinsic factors.

19 a may mediate its lymphopoietic function via extrinsic factors.

20 ic cell fates can involve both intrinsic and extrinsic factors.

21 t reactivity of the subject as well as other extrinsic factors.

22 ted to selection influenced by intrinsic and extrinsic factors.

23 by complex interactions among intrinsic and extrinsic factors.

24 widely and depend on intrinsic (genetic) and extrinsic factors.

25 -midgut boundary organoids in the absence of extrinsic factors.

26 loss of peripheral NKT cells is due to cell-extrinsic factors.

27 ormation and its modulation by intrinsic and extrinsic factors.

28 growth of thalamic axons in response to cell-extrinsic factors.

29 been the inability to control intrinsic and extrinsic factors.

30 ed by a variety of interacting intrinsic and extrinsic factors.

31 de that cancer risk is heavily influenced by extrinsic factors.

32 -layer and seven-layer MoS2 to exclude other extrinsic factors.

33 inguish between the effects of intrinsic and extrinsic factors.

34 an be predicted by a number of intrinsic and extrinsic factors.

35 uch of the leukemia signature is mediated by extrinsic factors.

36 In each case, these extrinsic factors act as molecular switches to facilitat

37 simple model in which transient exposure to extrinsic factors acting through known pathways initiate

38 Through the interplay of intrinsic and extrinsic factors, adult neurogenic niches ensure neuron

39 Intrinsic and extrinsic factors affect individuals, which lead to spat

40 We examined intrinsic and extrinsic factors affecting phrenic motoneuron (PMN) exc

41 in epidemiological parameters; intrinsic and extrinsic factors affecting population dynamics; provide

42 However, tumor-extrinsic factors also contribute to resistance.

43 genesis is regulated by interactions between extrinsic factors and intrinsic transcriptional cascades

44 , we provide an update on HSC-intrinsic and -extrinsic factors and processes that were recently disco

45 In this review, we discuss how intrinsic and extrinsic factors and the extensive cross-talk between c

46 Extrinsic factors and the interactions of neurons with s

47 out evolution, whether it can be affected by extrinsic factors, and its role in regulating dynein fun

48 Thus, T cell-extrinsic factors appear to promote the increased Th1, T

49 ctors in HC specification suggests that cell extrinsic factors are also crucial to their development.

50 Intrinsic rather than extrinsic factors are likely to play the critical roles

51 However, the extrinsic factors are poorly understood.

52 lly susceptible to failure, or whether other extrinsic factors are responsible that distort scientist

53 Chief among the extrinsic factors are the environmental cues of hematopo

54 pecies, the importance of species traits and extrinsic factors as determinants of establishment in ex

55 one formation was probably due to osteoblast-extrinsic factors, as Atp6v02 was not expressed in osteo

56 to chemical and solid-state structure or to extrinsic factors, as device architecture.

57 indicates that the gut microbiome is a tumor-extrinsic factor associated with antitumor response to a

58 ark Service units and examined intrinsic and extrinsic factors associated with the variation in Hg co

59 ect and illuminates the complex influence of extrinsic factors at the molecular level in breast cance

60 In aged subjects, the influence of extrinsic factors becomes increasingly more important.

61 le, in identifying hallmarks associated with extrinsic factors, biomarkers and therapeutics targets.

62 gated the relationship between intrinsic and extrinsic factors (breed group according to size/weight,

63 Here, we examined the effects of cell-extrinsic factors (buffer environment) and cell-intrinsi

64 elopment is influenced by both intrinsic and extrinsic factors, but the precise contribution of each

65 test the relative roles of intrinsic versus extrinsic factors by challenging the developmental poten

66 mature infants and ameliorating the risks of extrinsic factors by the use of prophylactic antibiotics

67 e trauma in mice could be explained by these extrinsic factors, by utilizing an increasing severity o

68 thway activation, provide evidence that cell extrinsic factors can contribute to the development of m

69 is evident that integration of intrinsic and extrinsic factors can dictate subtype heterogeneity, and

70 or after the terminal cell division and that extrinsic factors can influence fate choices.

71 It is known that intrinsic and extrinsic factors can influence the mating success.

72 he available structural examples of how such extrinsic factors can modulate the way in which a DNA-bi

73 mples reveal a variety of ways in which such extrinsic factors can significantly extend the repertoir

74 R) stress, whether triggered by intrinsic or extrinsic factors, can be resolved by the unfolded prote

75 and residual solvent molecules are the major extrinsic factors causing changes of charge-state distri

76 iological catch bonds because it requires an extrinsic factor-competitor proteins-rather than a speci

77 within the lung, we predicted intrinsic and extrinsic factors contribute to development of poor memo

78 ures indicated that both cell-intrinsic and -extrinsic factors contribute to the aberrant migratory p

79 s alone cannot demonstrate that ecological ("extrinsic") factors contribute to such isolation.

80 epigenetic features, and cell intrinsic and extrinsic factors contributing to exhaustion and how thi

81 rs, such as patient severity of illness, and extrinsic factors contributing to the development of nos

82 n a cell autonomous manner, after quiescence extrinsic factors control the reactivation of neuroblast

83 s and MCF-7 indicate that both intrinsic and extrinsic factors cooperate to ultimately determine the

84 Here, we demonstrate that cell-extrinsic factors coordinate with the epigenetic regulat

85 hese findings suggest that IL-6 serves as an extrinsic factor counteracting CD4(+) T-cell-mediated im

86 Genes and orthologous intrinsic and extrinsic factors critical for embryonic pituitary gonad

87 rands and a [Formula: see text] scaling when extrinsic factors drive the individual vortices.

88 supply, angiogenesis, and matrix turnover to extrinsic factors due to infection and continued trauma,

89 t intrinsic factors act synergistically with extrinsic factors during RGC genesis and development.

90 ies, or spurred on by some other large-scale extrinsic factor (e.g., climate change) remains to be de

91 t of intrinsic traits (e.g. weaning age) and extrinsic factors (e.g. precipitation seasonality within

92 sources, which may be further compounded by extrinsic factors (e.g., diet, psychosocial stressors, o

93 rinsic lyrical and acoustic characteristics, extrinsic factors (e.g., publisher influence and support

94 sic factors (eg, the tendency to sickle) and extrinsic factors (eg, the capacity of the reticuloendot

95 Extrinsic factors, endocrine mechanisms, and behavioral

96 ver naive CD8+ T cells, suggesting that cell-extrinsic factors enhance memory CD8+ T cell proliferati

97 Our data suggest that RNA binding is the extrinsic factor essential for the assembly of HEV nativ

98 nary history) play more important roles than extrinsic factors (experimental treatment and environmen

99 haematopoietic cells and bone cells could be extrinsic factors for each other.

100 between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and disse

101 etween genotype and phenotype indicates that extrinsic factors frequently impact the severity of gene

102 study, we assessed the paracrine effects of extrinsic factors from haematopoietic cells on human mes

103 mply embryo-autonomous processes but require extrinsic factors from maternal tissues.

104 Both extrinsic factors from the neuronal environment and intr

105 etween intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple featu

106 However, extrinsic factors from these perivascular cells that reg

107 ion to depend on thrombopoietin (TPO), a key extrinsic factor, from E16.5 onward in the developing li

108 How these intrinsic and extrinsic factors govern the activity of excitatory and

109 While certain extrinsic factors have been implicated, little is known

110 ical, a mixture of chemicals, and associated extrinsic factors (i.e., mechanical irritation) in the o

111 To test whether extrinsic factors impact development of Math1-null (Math

112 Intrinsic and extrinsic factors impact observed age-related changes an

113 cell precursor frequency as a possible cell-extrinsic factor impacting T cell programming in a model

114 cluding Leptin Receptor and other blood cell-extrinsic factors in adipocytes and endothelium that reg

115 The role of extrinsic factors in maintaining self-renewal of embryon

116 esting that they are short-lived and require extrinsic factors in order to persist.

117 le tools for studying the discrete action of extrinsic factors in organogenesis, and allow for the di

118 ed in evolutionary biology, gives primacy to extrinsic factors in producing morphological variation,

119 nts and the importance of both intrinsic and extrinsic factors in shaping animal curiosity.

120 n the importance of both cell-intrinsic and -extrinsic factors in shaping disease progression and pat

121 Together, these observations suggest that extrinsic factors in the bone marrow that decline with a

122 studying roles of cell-cell interactions and extrinsic factors in the development of the Drosophila n

123 tion of the cell-intrinsic timer, indicating extrinsic factors in the embryo may regulate the segment

124 illations underlying the wave pattern, while extrinsic factors in the embryo tune this timer's durati

125 actors within myeloid progenitors along with extrinsic factors in the microenvironment may foster clo

126 n-specific T cells can be compensated for by extrinsic factors in the presence of CTLA-4 expression b

127 lded an intriguing mix of both intrinsic and extrinsic factors in the readout of cell phenotype.

128 To determine if extrinsic factors in the retinal micro-environment are r

129 c clock-type mechanism; however, the role of extrinsic factors in the temporal control of cell-cycle

130 insic alterations of cellular metabolism and extrinsic factors in the tumor microenvironment, cancer

131 Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food palatability,

132 Intrinsic molecular programs and extrinsic factors including proinflammatory molecules ar

133 erformances, which are often plagued by many extrinsic factors, including chemical disorder at the se

134 y which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal

135 r integrity can be affected by intrinsic and extrinsic factors, including genetic predisposition, the

136 ned by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the envir

137 otein components) or can be brought about by extrinsic factors, including the cytoskeleton.

138 s population age structure and mobility, and extrinsic factors, including weather systems and habitat

139 ctivity of certain brain regions) as well as extrinsic factors (infections).

140 FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outc

141 We examine the extent to which intrinsic and extrinsic factors influence reproductive phenology in ma

142 Many intrinsic and extrinsic factors influence signaling along this axis, m

143 titioning reactions) appears to be the major extrinsic factor influencing the extent of protonation a

144 Intrinsic and extrinsic factors influencing succession and their healt

145 However, differentiation of hPSCs with extrinsic factors is a slow, step-wise process, mimickin

146 3 induction, but how the production of these extrinsic factors is controlled remains poorly understoo

147 The distribution of extrinsic factors is estimated using the maximum entropy

148 as well as relationships with intrinsic and extrinsic factors is important both for theoretical and

149 The evidence for a role of extrinsic factors is strongest for development of rodent

150 the disk surface, as well as surface-related extrinsic factors, is decisive for the asymmetric format

151 ynamics of a protein, induced by an array of extrinsic factors, is of central importance in producing

152 -LDH, thus stabilization due to intrinsic or extrinsic factors leads to decreased activity.

153 s is primarily driven by host genetics or by extrinsic factors like dietary intake.

154 heterogeneity, caused by both intrinsic and extrinsic factors, limits our ability to build digital t

155 ited MEK/ERK signaling, suggesting that cell-extrinsic factors maintain ERK activation in vivo.

156 In contrast, we show that if extrinsic factors maintain variation in behaviour, high

157 egulatory network of cell-intrinsic and cell-extrinsic factors maintains the epigenetic homeostasis o

158 We suggest that the variation in extrinsic factors may account for the observed wider-tha

159 t and raise the interesting possibility that extrinsic factors may instruct cortical progenitors to b

160 Cell intrinsic and cell extrinsic factors mediate asymmetric cell divisions duri

161 olation of spinal V3 interneurons, combining extrinsic factor-mediated differentiation and magnetic a

162 , the full complement of axon-intrinsic and -extrinsic factors mediating eye-specific segregation in

163 f Th17 cell lineage plasticity in which cell-extrinsic factors modulate Th17 cell fates through diffe

164 These data indicate that both intrinsic and extrinsic factors modulate the sensitivity of hippocampa

165 , while subsequent explanations incorporated extrinsic factors more consistently.

166 egulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined.

167 e that anthropophagy was better explained by extrinsic factors (namely, local host availability and i

168 We hypothesized that a tumor-extrinsic factor, notably tumor-associated macrophages,

169 tivity to force and binding geometry and the extrinsic factor of competitor protein concentration.

170 phincteric muscle function, and as the first extrinsic factor of skeletal myogenesis in the murine es

171 n risk, yet while most studies (78%) include extrinsic factors of some kind (e.g., geographic or bioc

172 the relative contributions of intrinsic and extrinsic factors on observed tick burdens.

173 s illustrate the strong influence of epitope-extrinsic factors on TCD4+ responses and memory.

174 e the mechanistic influence of intrinsic and extrinsic factors on the Abeta aggregation network.

175 ata offer insight into the impact of epitope-extrinsic factors on the resulting TCD4+ responses.

176 ction sites, highlighting cell-intrinsic and extrinsic factors optimizing antigen surveillance at ste

177 ir fitness may depend on inherited variants, extrinsic factors or distributions of fitness effects.

178 posed to different environmental conditions (extrinsic factors), or inconsistencies in reporting (mea

179 w the most recent findings on how neutrophil extrinsic factors participate in the formation of NETs.

180 We found that the extrinsic factors play a critical role in maintaining th

181 y between cell-intrinsic mechanisms and cell-extrinsic factors produced by the microenvironment.

182 e the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia

183 nd survival of plasma cells (PCs) depends on extrinsic factors provided in specialized niches.

184 Its manipulation by extrinsic factors provides synchronized access to multip

185 Our results show that extrinsic factors qualitatively and quantitatively affec

186 -glial cell-fate segregation, especially how extrinsic factors regulate cell-fate changes, are poorly

187 Both intrinsic and extrinsic factors regulate each retinal cell type.

188 indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation

189 he complex nature of the mechanisms by which extrinsic factors regulate signal transduction and cell-

190 Both cell-intrinsic and -extrinsic factors regulate the proliferation of progenit

191 ain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional st

192 We also show that while extrinsic factors related to climate were poor predictor

193 influenced by intrinsic neuronal factors and extrinsic factors related to myelination.

194 t postmitotic cell fate plasticity driven by extrinsic factors remains controversial.

195 esolvated species; the ease of altering such extrinsic factors renders ESI-MS an appropriate method b

196 in the identification of dynein subunits and extrinsic factors required for preassembly of dynein com

197 nce of such a pattern, albeit insensitive to extrinsic factors, requires a balance between intrinsic

198 ibbean, I sought to reveal the intrinsic and extrinsic factors responsible for avian sensitivities to

199 However, the identity of CD8 T cell-extrinsic factor(s) and mechanism(s) that contribute to

200 X2 protein in neural crest is to regulate an extrinsic factor(s) required for development of the opti

201 ium was swapped between cultures showed that extrinsic factors secreted by activated fibroblasts unde

202 Extrinsic factors seem to play a major role in the devel

203 ptomics along with in vitro modeling of cell-extrinsic factor signaling.

204 they are affected by changes in intrinsic or extrinsic factors.SIGNIFICANCE STATEMENT Multisensory in

205 In contrast, extrinsic factors significantly influenced ID MMEs, with

206 xplore the mechanism of cellular response to extrinsic factors, specific loss of function mutations w

207 gests that OA progression may be mediated by extrinsic factors such as altered joint loading.

208 e processes are highly regulated and require extrinsic factors such as chromatin remodelers and histo

209 stems locally and over short time spans, but extrinsic factors such as climate and oceanographic and

210 h inherent or intrinsic features rather than extrinsic factors such as context or relations.

211 uge potential to create REF PMM by improving extrinsic factors such as controlling the microstructure

212 Extrinsic factors such as diet and host immunity are ins

213 ammation and repair after activation by cell-extrinsic factors such as host-derived cytokines.

214 rmine if insulin resistance is the result of extrinsic factors such as hyperinsulinemia primary skele

215 at Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenos

216 via genetic vulnerability to SVD and/or via extrinsic factors such as hypertension, smoking and diab

217 NA contacts made by DNA recognition domains, extrinsic factors such as ligand binding, homo- and hete

218 ments is usually assumed to be determined by extrinsic factors such as limb biomechanics and feedback

219 Such biosensors can sense extrinsic factors such as nutrient or oxygen deprivation

220 In HCM patients, extrinsic factors such as obesity are independently asso

221 ion, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient a

222 Typically, extrinsic factors such as strain profiles, grain size or

223 ligand pairs points to a predominant role of extrinsic factors such as surface topography and accessi

224 the intrinsic properties of kinesin-13s and extrinsic factors such as their associated proteins resu

225 e ecologists, we discussed the intrinsic and extrinsic factors such as virus receptor engagement, ada

226 aving sufficient resolution to determine the extrinsic factors (such as perisynaptic astroglia) and t

227 we discuss recent studies demonstrating that extrinsic factors, such as ambient temperature, can modu

228 ddition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interact

229 sic factors, such as sequence variation, and extrinsic factors, such as crowding effects.

230 alterations and the targeting of tumor-cell-extrinsic factors, such as growth factors.

231 A variety of extrinsic factors, such as in-utero and infant malnutrit

232 viability, the tissue microenvironment, and extrinsic factors, such as microbial products and cytoki

233 an incomplete understanding of the roles of extrinsic factors, such as non-radiative recombination a

234 abolic programmes and also describe how cell-extrinsic factors, such as nutrients and regulatory T ce

235 ough this latter relationship may arise from extrinsic factors, such as resource heterogeneity, that

236 size and number might be influenced by local extrinsic factors, such as the availability of canal spa

237 owever, current research suggests that other extrinsic factors, such as the microbiome, may play a ro

238 Extrinsic factors, such as the Western diet and alcohol,

239 an eventually be removed from the product by extrinsic factors, such as translocating polymerases, bu

240 ntrinsic properties of the immune system and extrinsic factors, such as vaccination.

241 Regional sex differences suggest that extrinsic factors, such as water depth, contribute to be

242 Thus, TACE serves as a lymphocyte extrinsic factor that is essential for normal T developm

243 velopmentally regulated CaR, is an important extrinsic factor that modulates the intrinsic lung devel

244 Previously we identified IGFBP2 as an extrinsic factor that supports ex vivo expansion of hema

245 malian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated sig

246 e is critically dependent upon intrinsic and extrinsic factors that act to regulate stem cell behavio

247 requirements by incorporating intrinsic and extrinsic factors that affect susceptibility, adequately

248 Additional simulations reveal that extrinsic factors that affect the kinetics of fast or sl

249 xplosion of information on the intrinsic and extrinsic factors that are responsible for the first pha

250 imarily supports T cell function by inducing extrinsic factors that can be shared by CD40L-deficient

251 n little synthesis of these effects with the extrinsic factors that can shape biodiversity over large

252 fects of numerous cancer cell-intrinsic and -extrinsic factors that cannot be fully captured in cultu

253 Here, we identified intrinsic and extrinsic factors that cause FVIII to form aggregates.

254 being invested in defining the intrinsic and extrinsic factors that control stem cell maintenance and

255 ave provided insights into the intrinsic and extrinsic factors that control stomatal development.

256 of great interest to identify intrinsic and extrinsic factors that control the selection process.

257 l location of sensors for both intrinsic and extrinsic factors that disrupt energy and/or nutrient ho

258 ta shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8(+) ILL differentiation.

259 Our understanding of the intrinsic and extrinsic factors that enable PSCs to self-renew and to

260 t a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of thes

261 ess has provided a framework for identifying extrinsic factors that establish proliferation rate and

262 fferentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell

263 Extrinsic factors that impact iNKT cell development and

264 tative evaluation of potential intrinsic and extrinsic factors that impact vitamin C degradation in a

265 Identifying the intrinsic and extrinsic factors that make some species especially vuln

266 eatment, focusing on the tumor-intrinsic and extrinsic factors that may account for such a heterogene

267 availability, which additionally depends on extrinsic factors that may be rare or widespread at the

268 requires scrutiny of tumours' intrinsic and extrinsic factors that may impact host antitumour immuni

269 While various studies have identified extrinsic factors that modulate phagocytosis in health a

270 Herein, we review the intrinsic and extrinsic factors that promote the sensitivity of cancer

271 e, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the

272 In particular, we focus on the intrinsic and extrinsic factors that regulate microbiota oscillations

273 However, little is known about the extrinsic factors that regulate nucleic acid vaccine res

274 However, extrinsic factors that regulate self-renewal of satellit

275 To identify the extrinsic factors that regulate the conversion from a no

276 lowing ORN injury, the precise intrinsic and extrinsic factors that regulate this dynamic process hav

277 The intrinsic and extrinsic factors that regulate vertebrate photoreceptor

278 Several extrinsic factors that stimulate ex-vivo expansion of he

279 s a solid understanding of the intrinsic and extrinsic factors that underlie purchase motivation.

280 re essential to understand the intrinsic and extrinsic factors that underlie social patterns.

281 , PTHrP provides an excellent example of the extrinsic factors that, through their network of activit

282 Because our system has reduced extrinsic factors, the changes we saw in the GABAergic n

283 Relative to other extrinsic factors, the effects of hydrodynamic flow fiel

284 Although influenced by both intrinsic and extrinsic factors, the genetic mechanisms coordinating t

285 rn of bristle curvature is a product of both extrinsic factors-the socket cell and the inner pupal ca

286 ponent of expression variability arises from extrinsic factors thought to influence multiple genes si

287 Angptl3, as an extrinsic factor, thus supports the stemness of HSCs in

288 The methodology using intrinsic and extrinsic factors to adjust for nosocomial infections sh

289 ive responses to a wide array of genetic and extrinsic factors to maintain contractile function.

290 the relative contributions of intrinsic and extrinsic factors to the functional specification of dif

291 nt to disentangle the relative importance of extrinsic factors vs. species characteristics for the es

292 rtex differentiation depends on intrinsic or extrinsic factors, we generated models of gonadal inters

293 ce, we found that both ILC-intrinsic and ILC-extrinsic factors were responsible for this ILC dysregul

294 n individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell

295 of the interplay of stem cell-intrinsic and extrinsic factors will set the stage for improving cell

296 It is particularly unclear how multiple extrinsic factors with contrasting effects among seasons

297 and activation of immune cells, the role of extrinsic factors within the microenvironment in immunos

298 essments of edoxaban included endogenous and extrinsic factor Xa activity and edoxaban concentration.

299 reinitiating coagulation without input from extrinsic factor Xase activity.

300 ion is thought to require both intrinsic and extrinsic factors, yet few intrinsic gene products have