ライフサイエンスコーパス: familial risk

1 unctional neural system mechanism related to familial risk.

2 oach allows for a very precise definition of familial risk.

3 g an additive effect of CACNA1C variation on familial risk.

4 uneus in the left hemisphere, independent of familial risk.

5 cancer risk for women across the spectrum of familial risk.

6 s were not detected in a large group at high familial risk.

7 l abnormalities as compared to youth with no familial risk.

8 lity genes explain less than half the excess familial risk.

9 k, and the remaining 91% were considered low familial risk.

10 re age 5 years is therefore a marker of high familial risk.

11 on of breast cancer in women who are at high familial risk.

12 sability in the proband appears to influence familial risk.

13 etrial cancer in Lynch syndrome), and assess familial risk.

14 le full siblings and cousins as a measure of familial risk.

15 ectomy, 1003 had previous CRC, and 224 had a familial risk.

16 ailable evidence relates to children at high familial risk.

17 nset adolescent depression in individuals at familial risk.

18 s, which individually account for >1% of the familial risk.

19 te that can explain approximately 33% of the familial risk.

20 CRC (oncology clinic cohort), unselected for familial risk.

21 d common genetic variants that contribute to familial risk.

22 s a systems-level endophenotype or marker of familial risk.

23 cer in young men and is notable for its high familial risks.

24 ntified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 n

25 The pattern of familial risks across different levels of relatedness su

26 ocytic lymphoma (CLL) has one of the highest familial risks among cancers.

27 Familial risk analysis examined the risks in first-degre

28 Patterns of familial risk analysis suggest that the association betw

29 Familial risk analysis was used to clarify the relations

30 ma were detected in 1156 adults at increased familial risk and 0 cases were detected in 161 average-r

31 connectivity mediated a relationship between familial risk and a neuropsychological measure of impuls

32 investigate telomere length in connection to familial risk and disease expression in bipolar disorder

33 rts are well under way, precise estimates of familial risk and heritability are lacking.

34 at estimated summary statistics of aggregate familial risk and heritability for each disorder.

35 -onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed

36 dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, bu

37 or most cancer types, there were significant familial risks and the cumulative risks were higher in m

38 relatively low incidence of lymphoma, modest familial risk, and the lack of a screening test and asso

39 e top ninth percentile were assigned as high familial risk, and the remaining 91% were considered low

40 ion of disease, to estimate the magnitude of familial risks, and to identify families at high risk of

41 s captured by FHR-P and by a transdiagnostic familial risk approach (TDFR-P) based on parental inpati

42 en siblings and offspring in the patterns of familial risk are intriguing and should be investigated

43 s with CLL and the effects of sex and age on familial risk are unknown.

44 These familial risks are elevated for multiple lymphoma subtyp

45 tios for undiagnosed diabetes, using average familial risk as referent, were 1.7 (95% confidence inte

46 1/2 gene mutations with an appropriate brief familial risk assessment tool.

47 ncreased risk of major depression beyond the familial risk associated with a depressed proband.

48 ornia pregnant women participating in a high-familial risk autism spectrum disorder cohort.

49 tivity with predicted absolute breast cancer familial risk based on pedigree data and with BRCA1 and

50 We found high familial risks between some concordant histologic subtyp

51 ismatch repair gene mutations for predicting familial risk, but not for predicting sensitivity to PAR

52 Imaging-based screening in groups at high familial risk can detect pancreatic adenocarcinoma with

53 o disengage default-mode regions in those at familial risk carrying the risk haplotype.

54 d caregiver reports and grouped according to familial risk category derived from G1 and G2 depression

55 The Familial Risk-Colorectal Cancer: European Society for Me

56 We wanted to test whether familial risks differ in ALL diagnosed in the very early

57 C have been identified, including those with familial risk due to germline mutations, a history of pa

58 ssional personality traits may be a specific familial risk factor for anorexia nervosa.

59 ivity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure

60 of hypertension in pregnancy may be a novel familial risk factor for future hypertension.

61 iety on the State-Trait Anxiety Inventory, a familial risk factor for offspring anxiety.

62 he dorsal anterior cingulate appears to be a familial risk factor for the development of PTSD followi

63 e in PTSD is an acquired characteristic or a familial risk factor.

64 del incorporates self-reported lifestyle and familial risk factors and mammographic density to estima

65 nd schizophrenia is not the result of shared familial risk factors and may be causal.

66 9%) who received CPM had no major genetic or familial risk factors for contralateral disease.

67 we know little about the relationship of the familial risk factors for premenstrual symptoms and majo

68 premorbid neurodevelopmental impairments and familial risk factors for schizophrenia are prominent in

69 nia from other psychotic syndromes, and take familial risk factors into consideration.

70 enia have considered individuals with either familial risk factors or prodromal symptomatology.

71 Mammograms, age, lifestyle, and familial risk factors were collected at study entry.

72 identifying these genetic and environmental familial risk factors, which may serve as targets for in

73 95% CI=2.61-4.70), even after accounting for familial risk factors.

74 simonious score were similar irrespective of familial risk factors.

75 D and learning disabilities is due to shared familial risk factors.

76 dence that these 2 disorders may have shared familial risk factors.

77 range of sociodemographic, psychiatric, and familial risk factors.

78 omen and premenopausal women with genetic or familial risk factors.

79 portant eye diseases and their behavioral or familial risk factors.

80 ximum age 38 years) to examine perinatal and familial risk factors.

81 nitively unimpaired older adults at elevated familial risk for AD (N = 172, 120 females, 52 males; me

82 manic symptoms across two groups of youth at familial risk for AD: Offspring of parents with BD (n =

83 f female individuals with ADHD are at higher familial risk for ADHD than the siblings of affected mal

84 ngs suggest that these volumes are linked to familial risk for ADHD.

85 larly depression, in youth across a range of familial risk for affective disorders.

86 use disorder are increased in those at high familial risk for alcoholism.

87 s (54 boys and 58 girls), of whom 81 were at familial risk for ASD and 31 were typically developing l

88 in a cohort of 24-month-olds at high and low familial risk for ASD reduced this confound; we reported

89 behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approa

90 in a cohort of 104 infants with and without familial risk for autism by virtue of having an older si

91 data were collected from 270 infants at high familial risk for autism spectrum disorder and 108 low-r

92 the newly emerging literature on infants at familial risk for autism to shed light on this issue.

93 e outcome due to the inclusion of infants at familial risk for autism.

94 measure brain volume in 6-month-olds at high familial risk for autism.

95 ngitudinal study of infants with and without familial risk for autism.

96 Individuals at high familial risk for BD homozygous for the DGKH risk haplot

97 Examining this circuitry in youth at familial risk for BD may provide further insight into th

98 ication and guide interventions for youth at familial risk for BD.

99 shortened telomere length is associated with familial risk for BD.

100 Results suggest familial risk for bipolar disorder, and presumably genet

101 r quantity of alcohol use only in those with familial risk for bipolar disorder.

102 scent-onset bipolar disorder and in youth at familial risk for bipolarity.

103 or assessing the probability that a youth at familial risk for BPSD will develop new-onset BPSD withi

104 predict the 5-year onset of BPSD in youth at familial risk for BPSD.

105 have not considered the heterogeneity of the familial risk for breast cancer in a systematic way.

106 d FHS7 identified thousands of patients with familial risk for breast cancer, indicating a substantia

107 g Nordic twins, there was significant excess familial risk for cancer overall and for specific types

108 processing in 36 prereading children with a familial risk for DD (n = 18, average age = 66.50 mo) co

109 Familial risk for depression affects neural mechanisms u

110 Children at familial risk for depression exhibited atypical function

111 ased on rs-fcMRI, individuals at high vs low familial risk for depression showed increased DMN connec

112 t episodes of depression (i.e., daughters at familial risk for depression) or with no history of psyc

113 er ill persons who have either a high or low familial risk for depression.

114 dividuals, aged 11-60 years, at high and low familial risk for depression.

115 hed with persons who were at higher or lower familial risk for developing depression based on being b

116 eurobiological abnormalities associated with familial risk for developing mental illnesses are largel

117 Six "healthy" co-twins, who carry a maximal familial risk for developing MS, showed subclinical neur

118 ves do not have MDD but who are at increased familial risk for developing the illness.

119 In the present nation-wide study we describe familial risk for GCA and for GCA and TA with any other

120 The familial risk for GCA was 2.14, 2.40 for women and non-s

121 onnaire (hereafter, FHS7 positive) assessing familial risk for hereditary breast and ovarian cancer (

122 of depressive illness in individuals at high familial risk for major depression, possibly by expandin

123 Bipolar Disorder, or persons at high or low familial risk for Major Depressive Disorder, our method

124 nition-related neural pathways through which familial risk for MDD leads to depression and interperso

125 By studying individuals at high familial risk for MDD, we aimed to identify potential bi

126 and discrete brain structural correlates of familial risk for mental disorders.

127 enter, acceleration cohort study of youth at familial risk for mood disorders and controls with yearl

128 [3.6] years; 203 [51.5%] female), youths at familial risk for mood disorders showed overall no diffe

129 These analyses provide strong evidence that familial risk for neuropsychiatric disease becomes more

130 e for a positive association between genetic/familial risk for non-affective psychosis and four pheno

131 Moreover, there was no evidence of increased familial risk for non-right-handedness.

132 parate twin modeling analyses confirmed that familial risk for OCD was largely attributable to additi

133 nducted predominantly in populations at high familial risk for pancreatic adenocarcinoma were include

134 nction of panic disorder diagnosis, sex, and familial risk for panic.

135 Familial risk for PD in children and adolescents may be

136 risk loci that explain approximately 33% of familial risk for prostate cancer (PrCa), their function

137 youths, reflecting a connectome signature of familial risk for psychotic illness.

138 The familial risk for rheumatoid arthritis was similar in pa

139 ory neurofunctional mechanisms in persons at familial risk for schizophrenia.

140 ive symptoms was not associated with genetic/familial risk for schizophrenia.

141 g that personality might be one indicator of familial risk for substance use disorders during this de

142 aspects of atypical activation as markers of familial risk for the condition from those that are auti

143 nctional endophenotype of autism, related to familial risk for the condition shared between individua

144 renia (Sz) and have been associated with the familial risk for the disorder.

145 ate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry popu

146 ty loci, explaining approximately 30% of the familial risk for this disease, have now been identified

147 Our results suggest that some familial risks for carcinoma will be evident only throug

148 ne mutation risk group (n = 134) than in the familial risk group (n = 330 [for pancreatic cancer, haz

149 sive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03).

150 iated with mental disorders across the three familial risk groups.

151 BRCA mutation carriers and women with a high familial risk (> 20% lifetime risk) for breast cancer we

152 .3%) of 345 individuals classified as having familial risk had a previously unrecognized pancreatic c

153 on morbidity and mortality in groups at high familial risk has not been studied, and no data are avai

154 twin concordance, and ethnic differences in familial risks have established that CD and UC are compl

155 ly developing infants, either at High or Low familial Risk (HR or LR, respectively) for developing Au

156 s in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static im

157 Path-analysis models indicate that increased familial risk impacted offspring's brain function in two

158 ced nodal influence was associated with high familial risk in (1) those who had never had MDD at the

159 tions and provide more rigorous estimates of familial risk in a population-based study.

160 a modest effect on the risk of HL; however, familial risk in NLPHL has not been previously examined.

161 ing the Finnish registries and evaluated the familial risk in NLPHL.

162 The familial risk in sisters (9.4-fold; 95% CI, 5.9- to 14-f

163 ty loci, explaining approximately 25% of the familial risk in this disease, have now been identified.

164 ate standardized incidence ratios (SIRs) for familial risks in ALL in three diagnostic age-groups: 0-

165 Data on familial risks in penile and vulvar/vaginal cancers and

166 In contrast to women with genetic or familial risk, in HL survivors breast MRI was not more s

167 at onset has been associated with increased familial risk, increased clinical severity, and distinct

168 lected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD,

169 er classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteri

170 al health resilience in young people at high familial risk is an internationally recognised priority.

171 offspring support other data indicating that familial risk is genetically determined.

172 Population-level familial risk is not known.

173 Some of the unexplained familial risk is presumably due to high-penetrance mutat

174 The remainder of the unexplained familial risk is presumably due to other high-penetrance

175 ly representing one of the pathways in which familial risk is translated into the SCZ phenotype.

176 one-third of colon cancers exhibit increased familial risk, likely related to inheritance.

177 was obtained for CO(2) hypersensitivity as a familial risk marker for PD in children and adolescents.

178 de (CO(2)) sensitivity is postulated to be a familial risk marker of panic disorder (PD).

179 The overlap in familial risk may reflect shared genetic susceptibility.

180 s largely untested, and other factors (e.g., familial risk) may confound exposure effects.

181 adjusting for early childhood disorders and familial risk (odds ratio 2.0, 95% CI 1.2-3.1).

182 elevated levels of aggression, impulsivity, familial risk of aggression, and abnormalities in neurob

183 psychosocial factors, brain functioning, and familial risk of alcohol misuse.

184 ve neuroimaging study of 106 infants at high familial risk of ASD and 42 low-risk infants, we show th

185 ive brain-imaging studies of infants at high familial risk of ASD might identify early postnatal chan

186 In this cohort study of children with high familial risk of ASD, placental and cord serum metabolis

187 analyses, we further adjusted for aggregate familial risk of AUD by including family genetic risk sc

188 cokinetic effects (eg, absorption rates), or familial risk of AUDs.

189 Studies of infants at high familial risk of autism can provide insight into the ear

190 on to social stimuli in newborns with a high familial risk of autism.

191 roups consisted of young individuals at high familial risk of BD (n=81) and a comparison group of hea

192 died 98 young unaffected individuals at high familial risk of BD and 58 healthy controls using functi

193 nset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths).

194 affected with bipolar disorder (BP), at high familial risk of BP, and at low risk to identify endophe

195 genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations.

196 ility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic

197 s would account for just 0.32% of the excess familial risk of breast cancer.

198 family cancer cohort studies, 2 enriched for familial risk of breast cancer.

199 Literature on familial risk of carcinomas in situ (CISs) is limited be

200 We aimed to provide the familial risk of classical Hodgkin lymphoma (HL) by rela

201 Moreover, given the strong familial risk of CLL, we further subset our GWA analysis

202 oscopy screening in individuals at increased familial risk of colorectal cancer (CRC) is suboptimal,

203 A proportion of the familial risk of common cancers may be attributable to v

204 families (7-9 generations) with significant familial risk of completed suicide.

205 We compared 27 individuals without a familial risk of dependence who had been using cocaine r

206 order (MDD) is common in individuals at high familial risk of depression and is associated with poor

207 Effect sizes between familial risk of depression and neurocognitive test perf

208 ight be present in young people at increased familial risk of depression but with no personal history

209 salivary cortisol levels in young people at familial risk of depression but with no personal history

210 dings suggest that young people at increased familial risk of depression have altered neural represen

211 Children and adults with or without familial risk of depression were included.

212 ssed individuals, and 30 individuals at high familial risk of developing depression underwent functio

213 on and otherwise healthy individuals at high familial risk of developing depression.

214 significant thinner cortex associated with a familial risk of developing depressive illness.

215 is the first to demonstrate that children at familial risk of developing MDD are characterized by acc

216 1) with a model (model 2) that also included familial risk of diabetes (average, moderate, and high).

217 hysical activity of sedentary individuals at familial risk of diabetes.

218 We examined familial risk of disease in relation to age at onset in

219 Familial risk of early ischemic stroke almost doubled wh

220 Almost all previous studies of familial risk of epilepsy have had potentially serious m

221 Previous studies on familial risk of ischemic stroke have supported genetic

222 As familial risk of lung disease is better defined, referra

223 s was conducted in unaffected individuals at familial risk of mood disorder (n = 70) and comparison s

224 11 initially unaffected young adults at high familial risk of mood disorders and 93 healthy control s

225 association between zBMI and age in youth at familial risk of mood disorders and controls while accou

226 ts from the general population (enriched for familial risk of mood disorders) in Nova Scotia, Canada,

227 rum CA-125 measurement in women at increased familial risk of ovarian cancer is ineffective in detect

228 ng chemopreventive strategy in women at high familial risk of ovarian cancer.

229 even loci explained approximately 13% of the familial risk of PDB.

230 inconsistent; family studies have identified familial risk of postpartum depression, whereas systemat

231 Despite the higher familial risk of postpartum psychosis among full sibling

232 d with literacy (sub)skills or influenced by familial risk of reading difficulty and children's home

233 87 years) in a cohort of individuals at high familial risk of schizophrenia (n = 142) and control sub

234 ynonymous variants associated with increased familial risk of suicide death.

235 gether account for an additional 4-6% of the familial risk of TGCT.

236 Compared with individuals at low familial risk of the development of depression, high-ris

237 nd these account for approximately 9% of the familial risk of the disease.

238 t these explain only a small fraction of the familial risk of the disease.

239 cancer, explaining approximately 14% of the familial risk of the disease.

240 25 variants explain approximately 16% of the familial risk of this breast cancer subtype.

241 ling, stratified by sex and age, to estimate familial risk of tooth loss as well as estimates of heri

242 embolism (VTE) clusters in families, but the familial risk of VTE has not been determined among adopt

243 y study of HAE, which aimed to determine the familial risk of VTE.

244 We investigate the familial risks of cancers of the breast and ovary, using

245 Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumo

246 thermore, new light is shed on the different familial risks of seminoma and nonseminoma.

247 osure effects during emerging adulthood from familial risk on control/salience network cortical thick

248 er in young men and have an unusually strong familial risk, only one low-frequency susceptibility gen

249 The association was not modified by familial risk or BRCA mutation status (P interactions >0

250 There were no differences in familial risk or heritability between male and female pa

251 development of depression, as a function of familial risk or, in the absence of familial risk, stres

252 hird-generation offspring of depressed (high familial risk) or nondepressed (low familiar risk) proba

253 ccount for more than a small fraction of the familial risk, perhaps because the responsible variation

254 uctured clinical interviews blinded to their familial risk; putamen structure, neuronal integrity, an

255 To estimate the familial risk ratio (lambda) of sarcoidosis in sibs and

256 The familial risk ratio for childhood obesity when a parent

257 To identify potential familial risk-related FNC changes, we compared age-relat

258 ver, approximately two-thirds of the overall familial risk remain unexplained.

259 risk of postpartum psychosis, the extent of familial risk remains to be determined.

260 : 2.2, 6.3) for those with moderate and high familial risk, respectively.

261 Time-to-event analyses were used to estimate familial risk (risk of cancer in an individual given a t

262 A familial risk score was calculated for each subject.

263 fic difference was detected, with females at familial risk showing a rapid peripubertal increase in b

264 The familial risk status of the subjects and greater EEG sen

265 the probability of onset by PGS quartile and familial risk status.

266 ction of familial risk or, in the absence of familial risk, stressful life events.

267 High-familial-risk subjects had more melanomas diagnosed at a

268 ears) had slightly (nonsignificantly) higher familial risk than the total sample, although this was s

269 The model predicted familial risks that were consistent with those reported

270 The familial risk to CD is composed of 2 discrete dimensions

271 Bipolar disorder in individuals at familial risk typically unfolds in a progressive clinica

272 Increased familial risk was associated with reduced nodal influenc

273 For hematologic cancers, higher familial risk was evident for Asian/Pacific Islanders (S

274 Familial risk was higher in full (relative risk, 1.64; 9

275 First, high familial risk was indirectly associated with future depr

276 Second, high familial risk was indirectly associated with future inte

277 Residual familial risk was modeled by a hypothetical recessively

278 The highest familial risk was observed among first-degree relatives

279 test, p=0.006), but higher than expected if familial risk was simply polygenic.

280 Familial risks were even higher when multiple relatives

281 Although familial risks were highest at ages below 60 years, most

282 ng 1335 ALL patients diagnosed before age 5, familial risks were increased for esophageal (4.78), bre

283 evelopmental trajectories in infants at high familial risk who go on to develop ASD.

284 velop MDD from healthy controls and those at familial risk who remain well.

285 tical thickness mediated the associations of familial risk with inattention, visual memory, and clini

286 carry deleterious BRCA mutations as in high familial-risk women who are noncarriers, but occurs at a