ライフサイエンスコーパス: family

1 RH, adipokinetic hormone (AKH) and corazonin family.

2 henotypic targets of the essential mir-35-42 family.

3 uR1 and mGluR5, members of the group I mGluR family.

4 hibitor of the first bromodomains of the BET family.

5 12 new receptors from the unclosed cryptand family.

6 and fine-scale niche transitions within the family.

7 INSENSITIVE3-LIKE (EIL) transcription factor family.

8 the A Disintegrin And Metalloprotease (ADAM) family.

9 nding member of a novel secondary metabolite family.

10 securing resources and defending oneself and family.

11 case of this phenomenon is KRAS from the RAS family.

12 gion as the genetic cause of disease in this family.

13 therapeutic targeting of proteins of the NSD family.

14 functions of individual members of the FABP family.

15 iption factor of the orphan nuclear receptor family.

16 three affected siblings of a consanguineous family.

17 ts focus on care of the child and the larger family.

18 pharmacologically targeted membrane protein family.

19 life-long care, with implications for their families.

20 riety of glycoside hydrolases from different families.

21 nal Utah suicides unrelated to the discovery families.

22 for children with critical illness and their families.

23 urgical intervention were discussed with the families.

24 manually curated into 116 different protein families.

25 ilation of varying degrees aggregates within families.

26 e' and this included 139 genes from 33 toxin families.

27 nic KDELR2 variants as a cause of OI in four families.

28 le pattern of crossover regions in six human families.

29 resent in all affected siblings in three PCa families.

30 y amongst poor subsistence farmers and their families.

31 of variation than the majority of other gene families.

32 peptide interactions across multiple protein families.

33 isorders transmission in clinically affected families.

34 naldehyde into RA by aldehyde dehydrogenases family 1, subfamily A (ALDH1as), such as ALDH1a1, ALDH1a

35 The patient from Family 2 had a milder clinical phenotype and reduced exo

36 l fusion-fission-related gene solute carrier family 25 member 46 (Slc25a46) and treated them with neu

37 ic cohort comprised 452 individuals from 411 families (66 genes).

38 ransmembrane segment 6 (TM6) not observed in family A GPCRs.

39 led from 10 plots hosting 10 different plant families across three forest environments (Terra Firme,

40 lu200 with residues conserved across the Dio family anchor the loop's N-terminus to the active site S

41 mes were prospectively recorded for 111 farm families and 129 non-farm families enrolled in the Wisco

42 thousands of Americans each year, devastates families and entire communities, and cripples the health

43 sis in a broad range of flowering land plant families and in both monocots and dicots.

44 r 90 putative bacterial and archaeal genomic families and nearly 300 previously unknown genera, many

45 r animals may reveal additional new compound families and signaling paradigms.

46 and dental care for children from low-income families and support nondental primary care providers de

47 member of the papain-like cysteine protease family and an iteratively acting ATP-grasp protein.

48 rehensive phylogenetic analysis of the Cdc14 family and comparing the conservation of active site str

49 s profile hidden Markov models of each smORF family and deep learning models that better generalize t

50 IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections.

51 an interferon-inducible chemokine of the CXC family and is increased in cGVHD.

52 Zn(2+)/H(+) antiporter that belongs to SLC30 family and plays an essential role in regulating Zn(2+)

53 nd NLP-22 belong to the RPamide neuropeptide family and share sequence similarities with neuropeptide

54 Therapies targeting the IFN family and T-cell-activating factors may therefore be of

55 ith widespread, lasting impacts on children, families, and communities.

56 or specific segregation within the high-risk families, and for association of variants with predicted

57 ured registered organ donors, deceased donor families, and transplant recipients.

58 ommon IL-10R2, belongs to the IL-10 cytokine family, and is critically involved in tissue regeneratio

59 e thus present the fold of the CirpT protein family, and provide detailed mechanistic insights into i

60 e between HIV-1 RT and a broad-spectrum UCAA-family aptamer.

61 While both protein families are membrane scaffolds appreciated for their ro

62 In addition, some compounds from this family are able to undergo click-and-release reactions,

63 gical targeting of DUBs establish the enzyme family as targetable and provide a framework for other D

64 We highlight PGC1alpha, SRF and the MEF2 family as transcription factors that may potentially med

65 ng highly conserved genomic regions make pan-family assays robust and resilient to mutation.

66 er local ancestries for all individuals in a family, assuming (contrary to fact) they are unrelated,

67 Recent structures of family B GPCR-G(s) protein complexes reveal a disruption

68 concentrations in dragonflies differed among families but were correlated (r(2) > 0.80) with each oth

69 tly conserved recombinase and transposon Tn3 family but with a difference: the 'bla(TEM-1B) type' pro

70 lated significantly with numbers of affected families (but not for dominant disease).

71 hat have been identified in several foldamer families can serve as scaffolds for the predictable spat

72 REMM(5) scores were calculated from personal/family cancer history.

73 The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and

74 the founding member of carbohydrate esterase family CE18.

75 Although Hsp70 family chaperones have been extensively examined for the

76 ttern is explained by color variation within families: Chick coloration increases with position in th

77 factor, functions with both SWI/SNF and ISWI family chromatin remodelers to allow recruitment of Pol

78 r of voltage-gated potassium channels (K(V)1 family) clinically approved for the symptomatic treatmen

79 ound in plastid-targeted protein-coding gene families compared with Arabidopsis, but an additional 20

80 The PDE4 family comprises four subtypes, PDE4A, B, C, and D.

81 The Arabidopsis (Arabidopsis thaliana) SnRK2 family comprises the abscisic acid (ABA)-activated prote

82 treatment barriers including, alcohol abuse, family conflicts, and mental health issues.

83 studies suggested that members of a songbird family-corvids-also evolved complex cognitive skills but

84 understanding the role of each immunophilin family, cyclophilins, FK506 binding proteins (FKBPs), an

85 inescence is found within ostracods from the family Cypridinidae, which use their luminescence for de

86 In this large, population-based, family database, the risk of PC varied by cancer FH and

87 helial sodium channel (ENaCs), these channel families display very different functional characteristi

88 tionary trajectories are accompanied by gene-family diversification and homoeolog expression divergen

89 Here we identify two consanguineous families, each with two affected family members presenti

90 We report here the identification of a gene family encoding for three small plastidial proteins of t

91 pecific skills or experience, 6) patient and family engagement is important, and 7) program evaluatio

92 orded for 111 farm families and 129 non-farm families enrolled in the Wisconsin Infant Study Cohort b

93 014), particularly due to an increase in the family Enterobacteriaceae (p = 0.002) and Escherichia co

94 Ten-eleven translocation (TET) family enzymes (TET1, TET2, and TET3) oxidize 5-methylcy

95 us iron/manganese superoxide dismutase (SOD) family exemplifies this deficit, as the specific metal u

96 -6.6) of 2420 and 65 (2.7%, 2.1-3.4) of 2420 families experienced moderate and severe food insecurity

97 s, but positively associated with aspects of Family & Friend Relationships.

98 and differentiated five common carbapenemase families from Enterobacterales and P. aeruginosa colonie

99 sects were caught, representing at least 100 families from thirteen orders.

100 These individuals belong to the same family from Northeastern Brazil, which has 28 consanguin

101 indicate that multiple members of the CslF/H family fulfil important functions during grain developme

102 nd heat-induced auxin biosynthesis via YUCCA family genes are synergistically required to maintain fl

103 in the largest mammalian glycosyltransferase family, GT31, but little is known about the structure, s

104 RAC1, a Rho family GTPase, is an essential mediator of HDAC6 functio

105 hanisms involved in fear transmission within families have been scarcely investigated in humans.

106 gen-presenting cells, we show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppres

107 -11) per SD increase in PRS), independent of family history and smoking risk factors (odds ratio(PRS+

108 A family history of AD was a strong risk factor for AD.

109 Marfan syndrome or bicuspid aortic valve, a family history of AD was associated with an RR of 6.56 (

110 e extended model included menopausal status, family history of breast cancer, body mass index, hormon

111 regnancy, abortion, or breastfeeding; and no family history of breast cancer.

112 A testing: self-reported Jewish ancestry and family history of breast, ovarian, prostate, or pancreat

113 anted in UM patients with strong personal or family history of cancers, or both.

114 a positive family history of PD, a positive family history of dementia, non-smoking, low alcohol con

115 Family history of disease can provide valuable informati

116 how to best combine case-control status and family history of disease.

117 moking cessation or in aiding persons with a family history of HNC to evaluate their risks.

118 s per day, was a high school graduate, had a family history of HNC, and was non-Hispanic white.

119 Family history of pancreatic cancer and high-grade IPMN

120 e <0.05) was found between PD and a positive family history of PD, a positive family history of demen

121 ex, dyslipidemia, hypertension, smoking, and family history of premature cardiovascular disease contr

122 ory and smoking risk factors (odds ratio(PRS+family history+smoking), 1.24 [95% CI, 1.14-1.35]; P(PRS

123 -(1) medical history, (2) physical exam, (3) family history, (4) diagnostic phenotypic testing, and (

124 13) interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HE

125 ry; and "optimal control," healthy without a family history.

126 diagnoses; "CHD-related," healthy with a CHD family history; and "optimal control," healthy without a

127 e found notable contractions in several gene families in J. hindsii, including disease resistance-rel

128 nds; the inclusion of ICU patients and their families in rounds-based discussions; and incorporation

129 a should focus on engagement of patients and families in the development process and provision of res

130 now find a role for the APP family in neuronal excitability, synaptic plasticity, an

131 the knowledge about the role of this protein family in other physiological processes and species rema

132 tic protein MCL1, another member of the BCL2 family, in intestinal homeostasis in mice.

133 The SWI/SNF chromatin remodeler family includes the BAF and PBAF complexes.

134 ith autism spectrum disorder (ASD) and their families, including the presence of autoantibodies react

135 electronic structures of this metallocenate family, including an unexpected high-spin S = 3/2 ground

136 netically reprograms members of the TGF-beta family, including neuronal regeneration-related protein

137 f the genes of the echinocandin biosynthetic family indicated that most of the predicted proteins of

138 Therefore, members of the RSL1/RFA family interact with ABA receptors at plasma membrane, c

139 this Perspective we present key islet miRNA families involved in T2D pathogenesis including miR-200,

140 aramount importance toward understanding BEX family involvement in neurodevelopment and cell death.

141 However, this family is divided into three classes and, though the reg

142 ividual, or sets of, bromodomains within the family is required.

143 r of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developi

144 vestigator Award, MSK's Ludwig Center, Weiss Family Kidney Research Fund, Novartis, The Sidney Kimmel

145 Previous studies with various Src family kinase biosensors showed that the nuclear kinase

146 disordered SH4 and Unique domains of the Src family kinase Hck.

147 Src family kinase Lck plays critical roles during T cell dev

148 The Src family kinases (SFKs) Src, Lyn, and Fyn are essential fo

149 for taxonomic identity (particularly at the family level) as a predictor of body nutrient content, i

150 rimental trials, growth rates differed among family lineages, and the highest mortality under OA occu

151 GTPase-signaling small molecule ras homolog family member A (RhoA).

152 orylation and activation of Ras homolog gene family member A.

153 s deficit, as the specific metal used by any family member cannot be predicted.

154 olreductase (GILT), and lymphocyte antigen 6 family member E (LY6E), the three cellular proteins iden

155 source of the epidermal growth factor (EGF) family member NEUREGULIN1 (NRG1).

156 , 28,062 (48.8%) had a survey completed by a family member or close contact.

157 Phosphorylation of the FAK family member Pyk2 at tyrosine 402 is decreased in NK92

158 ally redundant with that of another TGF-beta family member, activin A.

159 emonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostati

160 The coronavirus family member, SARS-CoV-2 has been identified as the cau

161 0%) responded preintervention and 129 of 226 family members (57.1%) responded postintervention.

162 At 90-day follow-up, 131 of 226 family members (58.0%) responded preintervention and 129

163 ese results highlight the importance of PARP family members and ADPRylation in gene regulation, mRNA

164 detectable in antibody-seronegative exposed family members and convalescent individuals with a histo

165 e potential, as well as staff and subsequent family members exposure to severe acute respiratory synd

166 Family members had significantly higher mean polygenic l

167 natural peptide ligand for the ErbB protein family members HER3 and HER4.

168 Of 37 family members of positive individuals, 17 (35%) were al

169 sanguineous families, each with two affected family members presenting with progressive heart valve d

170 immune cells isolated from the patients and family members to characterize any immune defects.

171 uit their own novel and divergent kinesin-14 family members to form neocentromeres.

172 istructured interviews and focus groups with family members, clinicians, and managers.

173 TET catalytic domains (hTETCDs) from the TET family members, especially for hTET3CD, significantly at

174 cturally similar to the immunosuppressive B7 family members, yet how they regulate and coordinate alp

175 on coupling of opioid receptors to Galphai/o family members.

176 ld, leaving many grieving the sudden loss of family members.

177 increase support for their parents and other family members.

178 ture, substrate recognition, or catalysis by family members.

179 function is likely conserved in other DUF328 family members.

180 28 consanguineous marriages and 59 genotyped family members.

181 for the patient but especially for affected family members.

182 0.01] and Actinobacteria [p = 0.02]) and two families (Moraxellaceae [p < 0.001] and Pseudomonadaceae

183 ivity = 0.90, specificity = 0.88), and CDKN2 family mutations (sensitivity = 0.76, specificity = 0.86

184 The monospecific family Mysteriomorphidae was recently described based on

185 rning models that better generalize to smORF families not seen in the training set, resulting in pred

186 s of interest, and lack of consultation with families of affected children.

187 ndertook exome sequencing in three unrelated families of Caucasian, Turkish and French-Canadian ethni

188 th high scores across three broad diagnostic families of disorders (externalizing, internalizing, tho

189 umulation of primary metabolites and on four families of glycosylated aroma precursors (GAPs) at the

190 ery of the new RE-hpt-MOF-1 and RE-ken-MOF-1 families of MOFs highlights the great opportunities exis

191 e mutant behaves differently between the two families of papillomaviruses.

192 In this study, several families of peptides, selected for the ability to partit

193 is approach will be widely applicable to all families of porous ions and represents a new and powerfu

194 inct set of substrates, including PE and PPE families of proteins, named for conserved Pro-Glu and Pr

195 s including trehalose metabolism and various families of transcription factors (TFs) were differentia

196 We also classified families of transcription factors that are increasingly

197 SOX6 belongs to a family of 20 SRY-related HMG-box-containing (SOX) genes

198 covery of p53-like binders to MDM2, and to a family of 3-19 nM-affinity, alpha/beta-peptide-based bin

199 in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in

200 eri RNA ligase (NgrRnl) exemplifies the Rnl5 family of adenosine triphosphate (ATP)-dependent polynuc

201 ) formation and are members of the RsbQ-like family of alpha,beta-hydrolases.

202 nium permease (MEP)/Rhesus glycoprotein (Rh) family of ammonia (NH(3)/NH(4) (+)) transporters has bee

203 iosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators.

204 i Takeichi for the discovery of the cadherin family of Ca(2+)-dependent cell-cell adhesion proteins,

205 The mononuclear phagocyte system (MPS) is a family of cells including progenitors, circulating blood

206 Here, we report that octopus arms use a family of cephalopod-specific chemotactile receptors (CR

207 insect antiviral immunity and explain how a family of cGAS-STING evasion enzymes evolved from viral

208 The Speckled Protein (SP) family of chromatin 'readers' in humans consists of SP10

209 Although LSH belongs to a family of chromatin remodeling proteins, it remains unkn

210 Examining a large family of circuit models with non-identical neurons and

211 e structures through application of the wide family of click transformations.

212 IL-1beta is the most studied of the IL-1 family of cytokines, including 11 members, among which a

213 s belonging to the type-B Response Regulator family of cytokinin response activators.

214 The unique family of DPC-specific proteases Wss1/SPRTN targets DPC

215 Together, our results point to a family of functional human microproteins that play criti

216 Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and periphe

217 rotein-coupled receptors (GPCRs) are a large family of integral membrane proteins responsible for cel

218 Oligoadenylate synthetases (OASs) are a family of interferon-inducible enzymes that require doub

219 ng with proteins and nucleic acids, the vast family of mammalian circRNAs is proposed to influence ma

220 vation of non-trivial surface states in this family of materials are not ubiquitous.

221 article equivalents, making them a promising family of materials to investigate.

222 We report seven members of this new family of materials.

223 several polycyclic members of the rhodonoid family of meroterpenoids.

224 nesis by controlling processing of the let-7 family of microRNAs.

225 n be tuned from weak to strong to generate a family of models that spans a continuum from critical dy

226 ies of fifteen lanthanides are an intriguing family of MOFs from the standpoint of both structure and

227 proteins (sHsps) compose the most widespread family of molecular chaperones.

228 Here, we identify a family of over 30 enzymes, which are homologous to mamma

229 tode Caenorhabditis elegans produces a broad family of pheromones, known as the ascarosides, that are

230 and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emer

231 The BET family of proteins consists of BRD2, BRD3, BRD4, and BRD

232 The NF-kappaB family of proteins is important for the cell to mediate

233 culocyte binding-like protein homolog (PfRh) family of proteins play a pivotal role in merozoite inva

234 It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers

235 The evolution of a strategy to access the family of rearranged spongian diterpenoids harboring a c

236 A new family of robust, non-toxic, water-compatible ruthenium(

237 rt of this strategy is expression of a broad family of salivary proteins, called Evasins, to neutrali

238 oblasts leads to robust activation of the B2 family of SINEs in a cell-autonomous manner.

239 cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker channels.

240 hm of discrete field theories belongs to the family of structure-preserving geometric algorithms, whi

241 rostate tissue and is related to the B7/CD28 family of T-cell immune checkpoint markers.

242 lasses that both require a member of the Eag family of T6SS chaperones for export.

243 Members of the NF-kappaB family of transcription factors are key drivers of infla

244 ondrial homeostasis as controlled by the PGC family of transcriptional activators is required for ang

245 rk showcases the possibility of developing a family of transition metal polychalcogenides functioning

246 thienopyrrolo[3,2,1-jk]carbazoles enrich the family of triarylamine donors and constitute a novel bui

247 ARS-CoV-2), is a member of the Coronaviridae family of viruses that can cause respiratory infections

248 catalyzed by the LytR-CpsA-Psr (LCP) enzyme family, offers a unique extracellular target for the dev

249 ffects on TF binding sites from different TF families on a cancer-type basis.

250 bers of the light-harvesting complex protein family participate in multiple processes connected with

251 two distinct lineages of parvoviruses (PVs, family Parvoviridae; subfamily Hamaparvovirinae) infect

252 he association between colorectal testing in family physicians and their patients was examined using

253 Patients were assigned to family physicians based on billing claim frequency, and

254 Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic and

255 We found gene families potentially involved in the degradation of the

256 3 (Arrdc3) is a member of the alpha-arrestin family previously linked to human obesity.

257 Whole genome sequencing in multiplex families, proband-parent trios, and case-control cohorts

258 TRIM family proteins play integral roles in the innate immune

259 ate the complex interactome of HSP chaperone family proteins under normal and stress conditions.

260 s poorly, likely because its cofactors, MAP7-family proteins, are slow in populating these ends.

261 e receptor 4 and prime the nod-like receptor family pyrin domain-containing 3 inflammasome in naive n

262 es with studies of its regulation of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome.

263 ditions (HOMEChem campaign) and (2) a single-family residence when vacant (H2 campaign).

264 omes belong to the commonly algae-associated families Rhodobacteraceae and Flavobacteriaceae.

265 s from a subset of genera within the figwort family (Scrophulariaceae).

266 s of a common B. burgdorferi paralogous gene family, share 59% similarity.

267 ness leads to stromal cell-mediated TGF-beta family signaling relying on the induction and utilizatio

268 ir is mediated through the inhibition of Rac family small GTPase 1 and cell division cycle 42 activat

269 and ovarian cancer and were adjusted for the family-specific ascertainment schemes.

270 Family studies have identified a heritable component to

271 d heritability, is high, with estimates from family studies in EUR of 0.75-0.83 and from SNP based st

272 hibitors with high potency and excellent JAK family subtype selectivity.

273 r fruits species representative of Myrtaceae family such as Syzygium cumini, Syzygium malaccense, Eug

274 Here, we study the seahorse and pipefish family (syngnathids) that have evolved male pregnancy ac

275 ally within polygynous and patrilineal royal families that are headed by god-kings(5,6).

276 otype of an evolutionarily diversified large family that fine-tunes osmoregulation but is likely to f

277 binding proteins (RBPs) are a large protein family that plays important roles at almost all levels o

278 We tested the efficacy of APTi with two gene families, the actin-dependent motor, myosin XI (a,b), an

279 der Thysanoptera were restricted to a single family, the Thripidae, resulting in a biased view of the

280 h other, enabling adjustment to a consistent family to facilitate spatial comparisons among sampling

281 s, we resequenced two 3-4 generation nuclear families (totaling 29 individuals) of olive baboons (Pap

282 were detected at lower rates and zinc finger family transcripts were of poorer quality.

283 Here we describe a strategy utilizing pan-family viral assays to improve early accessibility of la

284 During hospitalization, family visits inside or outside the patient's room were

285 Approximately 1000 M(2) families were screened for the segregation of pale-green

286 onates per isofamily for a total of 114 F(2) families were screened with a diagnostic concentration o

287 ted genes overall (with prevalence rates per families) were as follows: ABCA4 (20.8%), USH2A (9.1%),

288 nomy, the impact of living in quarters among families who are the most at risk, and factors including

289 ptive mutations (FDR 5%), six of which reach family-wise error rate (FWER) significance (p < 1.25E-06

290 the threshold to find a particular level of family-wise significance may need to be established usin

291 In Palestinian families with no prior history of hearing loss, we estim

292 used for downstream structure prediction on families with the longest length sequences (16S and 23S

293 We report a second family with 2 siblings with a homozygous frameshift muta

294 aimed to molecularly characterize the first family with a dominant GSD.

295 variants and one in-frame deletion) and one family with a missense variant inherited from the affect

296 There was one family with macular dystrophy, nine with cone-rod dystro

297 Here, we present a family with two siblings displaying an autosomal recessi

298 Here we explore different gene pairs and families within the context of the endoplasmic reticulum

299 which is not feasible for students who have family, work, or housing commitments.

300 dbirth is devastating for the mother and her family, yet data regarding incidence and contemporary tr