ライフサイエンスコーパス: farnesoid

1 ds resulted in deregulation of ecdysone- and farnesoid-regulated genes, accordingly with the observed

2 eticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and

3 efflux to lumen) and retinoic acid receptor/farnesoid X receptor (cholesterol catabolism).

4 In particular, farnesoid X receptor (FXR) activation that revealed anti

5 notype in SIRT mice correlated with impaired farnesoid X receptor (FXR) activity due to persistent de

6 Nuclear receptor farnesoid X receptor (FXR) acts as a key regulator of bi

7 old, previously described as a key moiety in Farnesoid X receptor (FXR) agonism, herein we report the

8 eatment of mouse or human hepatocytes with a farnesoid X receptor (FXR) agonist GW4064 or bile acids

9 We showed that chronic BAs or farnesoid X receptor (FXR) agonist treatment of primary

10 Farnesoid X receptor (FXR) agonists are emerging as impo

11 tly contribute to hepatocytes, we identified farnesoid X receptor (FXR) agonists as inhibitors of BEC

12 In an effort to develop orally active farnesoid X receptor (FXR) agonists, a series of tetrahy

13 cose cotransporter 2 (SGLT2) inhibitors, and farnesoid X receptor (FXR) agonists, with further novel

14 that GS can act as an antagonist ligand for farnesoid X receptor (FXR) and decrease expression of bi

15 A) are selective and potent agonists for the farnesoid X receptor (FXR) and dual peroxisome prolifera

16 activator of the BA-sensing nuclear receptor farnesoid X receptor (FXR) and epigenetically up-regulat

17 bile acid-activated nuclear hormone receptor farnesoid X receptor (FXR) and G protein-coupled membran

18 Since farnesoid X receptor (FXR) and its natural ligands bile

19 in bile acid homeostasis with a focus on the farnesoid X receptor (FXR) and its potential therapeutic

20 metabolic homeostasis by activating nuclear farnesoid X receptor (Fxr) and membrane G-protein-couple

21 regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors.

22 The ligand-activated transcription factors farnesoid X receptor (FXR) and peroxisome proliferator-a

23 e rodent Sult2A1 gene is also induced by the farnesoid X receptor (FXR) and pregnane X receptor (PXR)

24 The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR)

25 dback loop operated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

26 primarily regulated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

27 id oxidation, and 3) decreased expression of farnesoid X receptor (FXR) and small heterodimer partner

28 Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

29 oxicity in which mithramycin not only alters farnesoid X receptor (FXR) and small heterodimer partner

30 Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

31 Cholestasis activates bile acid receptor farnesoid X receptor (FXR) and subsequently enhances hep

32 key regulators of liver biology: C/EBPalpha, Farnesoid X Receptor (FXR) and telomere reverse transcri

33 that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcription

34 roid metabolism not only share the receptors farnesoid X receptor (FXR) and the G protein-coupled bil

35 Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled rec

36 are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein-coupled rec

37 The farnesoid X receptor (FXR) and the liver x receptors (LX

38 The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-pro

39 Farnesoid X receptor (FXR) and the microRNAs miR-185, mi

40 metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coup

41 ptome, bile acid-activated receptors nuclear farnesoid X receptor (FXR) and transmembrane G-protein-c

42 h mechanisms dependent on the microbiome and farnesoid X receptor (FXR) and type I interferon (IFN) s

43 tor-activated receptor-alpha (PPARalpha) and farnesoid X receptor (FXR) are activated in the fasted a

44 Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that fu

45 ism was likely independent of the microbiome-farnesoid X receptor (FXR) axis.

46 The farnesoid X receptor (FXR) belongs to a family of ligand

47 This ERalpha binding site overlaps the known farnesoid X receptor (FXR) binding site in the SHP promo

48 We have shown that activation of the farnesoid X receptor (FXR) blocks mineralization of bovi

49 the postprandial state, activation of ileal farnesoid X receptor (FXR) by bile salts results in tran

50 contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.

51 ether fibroblast growth factor 19 (FGF19) or farnesoid X receptor (FXR) dependent signaling are invol

52 we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-bet

53 The farnesoid X receptor (FXR) functions as a bile acid (BA)

54 The nuclear receptor farnesoid X receptor (FXR) has been implicated in the co

55 Activation of the farnesoid X receptor (FXR) has indicated a therapeutic p

56 emic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new ther

57 ontrast to mice, human BSEP was regulated by farnesoid X receptor (FXR) in an isoform-dependent manne

58 The function of the farnesoid X receptor (FXR) in DKO mice was lower, reveal

59 ined through positive-feedback antagonism of farnesoid X receptor (FXR) in intestine and liver.

60 CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and ce

61 UCA) in the regulation of the orphan nuclear farnesoid X receptor (FXR) in vivo.

62 nd synthetic (i.e. GW4064) activators of the farnesoid X receptor (FXR) increased FGF21 gene expressi

63 Farnesoid X receptor (FXR) induces fibroblast growth fac

64 We found that farnesoid X receptor (FXR) inhibits expression of gankyr

65 e report that the nuclear bile acid receptor farnesoid X receptor (FXR) inhibits microRNA-34a (miR-34

66 Farnesoid X receptor (FXR) is a bile acid sensor that re

67 Farnesoid X receptor (FXR) is a bile acid sensor that re

68 Farnesoid X receptor (FXR) is a bile acid-activated tran

69 Farnesoid X receptor (FXR) is a bile acid-activated tran

70 Here we show that the farnesoid X receptor (FXR) is a direct regulator of ACE2

71 The farnesoid X receptor (FXR) is a member of the "metabolic

72 Farnesoid X receptor (FXR) is a member of the nuclear ho

73 The Farnesoid X receptor (FXR) is a member of the nuclear ho

74 Farnesoid X receptor (FXR) is a member of the nuclear re

75 The farnesoid X receptor (FXR) is a member of the nuclear re

76 The farnesoid X receptor (FXR) is a member of the nuclear re

77 The farnesoid X receptor (FXR) is a nuclear bile acid recept

78 Farnesoid X receptor (FXR) is a nuclear receptor for bil

79 The farnesoid X receptor (FXR) is a nuclear receptor that ac

80 Farnesoid X receptor (FXR) is a nuclear receptor that ha

81 The farnesoid X receptor (FXR) is a nuclear receptor that pl

82 Farnesoid X receptor (FXR) is a promising target for non

83 Farnesoid X receptor (FXR) is an important regulator of

84 The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcription

85 Farnesoid X receptor (FXR) is considered a therapeutic t

86 ation of bile acid synthesis mediated by the farnesoid X receptor (FXR) is disrupted in the mutant mi

87 igand activated transcription factor nuclear farnesoid X receptor (FXR) is involved as a regulator in

88 Farnesoid X receptor (FXR) is the master regulator of bi

89 The farnesoid X receptor (FXR) is the transcriptional regula

90 rotection conferred by H(2) S was blocked by farnesoid X receptor (FXR) knockdown.

91 s were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and beta-cell

92 The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose h

93 Activation of farnesoid X receptor (FXR) markedly attenuates developme

94 dy, we show that LPS significantly decreases farnesoid X receptor (FXR) mRNA in mouse liver as early

95 Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expr

96 T-beta-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist,

97 cholestasis by altering the activity of the farnesoid X receptor (FXR) or by impairing the structure

98 As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of

99 Intestinal farnesoid X receptor (FXR) plays a critical role in alco

100 The nuclear receptor farnesoid X receptor (FXR) plays a major role in the ent

101 Farnesoid X receptor (FXR) plays a pivotal role in the r

102 Farnesoid X receptor (FXR) plays an important role in ma

103 Farnesoid X receptor (FXR) plays important regulatory ro

104 Activation of the nuclear bile acid receptor farnesoid X receptor (FXR) protects against hepatic infl

105 Two-fold increase of BA-activated farnesoid X receptor (FXR) protein levels were seen in a

106 Constitutive activation of the farnesoid X receptor (FXR) reduces PPARgamma hepatic exp

107 The farnesoid X receptor (FXR) regulates bile acid, lipid an

108 um bile acids, and activation of the hepatic farnesoid X receptor (FXR) regulatory pathway.

109 The nuclear receptor farnesoid X receptor (FXR) shows potent antifibrotic act

110 ase (BSH) activity, inhibition of intestinal farnesoid X receptor (FXR) signaling and decreased tauro

111 ctivation in the liver of SCD mice inhibited farnesoid X receptor (FXR) signaling and its downstream

112 d hepatic macrophages to suppress hepatocyte farnesoid X receptor (FXR) signaling and promote PNAC.

113 d hepatic macrophages to suppress hepatocyte farnesoid X receptor (FXR) signaling and promote PNAC.

114 xamined, and expression of genes involved in farnesoid X receptor (FXR) signaling in the liver and in

115 The farnesoid X receptor (FXR) signaling pathway regulates b

116 Further, dietary TCDF inhibited the farnesoid X receptor (FXR) signaling pathway, triggered

117 SIRT1 iKO mice had reduced intestinal farnesoid X receptor (FXR) signaling via hepatocyte nucl

118 e acid metabolites that inhibited intestinal farnesoid X receptor (FXR) signaling.

119 ctivate small heterodimer partner (SHP) upon farnesoid X receptor (FXR) stimulation by increasing BA

120 Activation of the farnesoid X receptor (FXR) suppressed liver CYP8B1 expre

121 re we report that Foxm1b is the first direct farnesoid X receptor (FXR) target gene known to be invol

122 ntified 7-oxo-DCA as a natural antagonist of Farnesoid X Receptor (FXR) to downregulate FXR signaling

123 that the MDR3 gene is trans-activated by the farnesoid X receptor (FXR) via a direct binding of FXR/r

124 given an intracerebroventricular infusion of farnesoid X receptor (FXR) Vivo-morpholino before AOM in

125 Farnesoid X receptor (Fxr)(-/-), small heterodimer partn

126 Our previous studies have shown that the farnesoid X receptor (FXR), a bile acid-activated nuclea

127 is and mutations in NR1H4, which encodes the farnesoid X receptor (FXR), a bile acid-activated nuclea

128 Farnesoid X receptor (FXR), a key regulator of hepatic e

129 signal through two major receptor pathways: farnesoid X receptor (FXR), a member of the nuclear horm

130 The farnesoid X receptor (FXR), a member of the nuclear horm

131 ne is a highly efficacious antagonist of the farnesoid X receptor (FXR), a nuclear hormone receptor t

132 Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile

133 is strongly up-regulated by agonists of the farnesoid X receptor (FXR), a nuclear receptor for bile

134 and-binding domain (LBD) of human and murine farnesoid X receptor (FXR), a nuclear receptor for bile

135 t studies to serve as a binding site for the farnesoid X receptor (FXR), a nuclear receptor for bile

136 n of hepatic SIRT1 reduces the expression of farnesoid X receptor (FXR), a nuclear receptor that regu

137 is mediated through the bile acid-activated farnesoid X receptor (FXR), a recently characterized mem

138 bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor.

139 sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrahepatic ch

140 This effect was mediated through the farnesoid X receptor (FXR), as demonstrated in Fxr(-/-)

141 In IBD patients, bile acids, their receptor farnesoid X receptor (FXR), IL-33, and eosinophils were

142 The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important transcriptio

143 Expression of nuclear receptors farnesoid X receptor (FXR), LXRalpha, liver receptor hom

144 luding those of nuclear receptors, primarily farnesoid X receptor (FXR), membrane BA receptors, and F

145 mice with intestine-specific knockout of the farnesoid X receptor (FXR), mice that express an FXR tra

146 Farnesoid X receptor (FXR), or NR1H4, protects the liver

147 Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), a

148 Geniposide also down-regulated expression of Farnesoid X receptor (FXR), small heterodimer partner (S

149 herapies include pharmacological agonists to farnesoid X receptor (FXR), the master regulator of hepa

150 Although bile acids activate the farnesoid X receptor (FXR), the mechanism underlying bil

151 Farnesoid X receptor (FXR), the primary bile acid-sensin

152 holesterol, liver X receptors (LXRs) and the farnesoid X receptor (FXR), together with other members

153 n of BSEP gene expression is mediated by the farnesoid X receptor (FXR), which binds as a heterodimer

154 The farnesoid X receptor (FXR), which is activated by bile a

155 ntagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regula

156 al and transactivational regulator of murine farnesoid X receptor (Fxr), which is the primary bile ac

157 An antagonist of bile acid receptor farnesoid X receptor (FXR), Z-guggulsterone, reduced the

158 gulates triglyceride metabolism through both farnesoid X receptor (FXR)-dependent and -independent pa

159 Cholate treatment was associated with a farnesoid X receptor (FXR)-dependent increase in hepatic

160 isk of statins is coupled to the activity of farnesoid X receptor (FXR)-dependent signaling pathways

161 ntracellular bile acids results in repressed farnesoid X receptor (FXR)-FGF15 signalling, leading to

162 pact of sulfated progesterone metabolites on farnesoid X receptor (FXR)-mediated bile acid homeostasi

163 Terminal ileal farnesoid X receptor (FXR)-mediated gene expression and

164 Chenodeoxycholic acid (CDCA) and the farnesoid X receptor (FXR)-specific agonist GW4064 stron

165 acids and transactivated by nuclear receptor farnesoid X receptor (FXR).

166 (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR).

167 GP-BAR1, and nuclear receptors, such as the farnesoid X receptor (FXR).

168 C) acutely enhance insulin secretion via the farnesoid X receptor (FXR).

169 in part through their binding to the nuclear farnesoid X receptor (FXR).

170 y by downregulating the transcription factor farnesoid X receptor (FXR).

171 ve been identified as potent agonists of the farnesoid X receptor (FXR).

172 1 (FIC1)] posttranslationally activated the farnesoid X receptor (FXR).

173 tagonism of the receptor for bile acids, the farnesoid X receptor (FXR).

174 regulated by ligands of the nuclear receptor farnesoid X receptor (FXR).

175 hat bile acids are physiological ligands for farnesoid X receptor (FXR).

176 activating nuclear receptors, including the farnesoid X receptor (FXR).

177 h the bile salt-binding transcription factor farnesoid X receptor (Fxr).

178 in inhibited bile-mediated activation of the farnesoid X receptor (FXR).

179 cirrhosis and liver cancer also have reduced farnesoid X receptor (FXR).

180 molecules that activate the nuclear receptor farnesoid X receptor (FXR).

181 re ligands for the nuclear hormone receptor, farnesoid X receptor (FXR).

182 responses dependent on the nuclear receptor Farnesoid X Receptor (FXR).

183 le acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15.

184 ation and bile acid metabolism by modulating farnesoid X receptor (FXR); we here investigate its role

185 r receptors PPARalpha (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activat

186 Farnesoid X receptor (FXR, NR1H4) is a bile acid-activat

187 The farnesoid X receptor (FXR, NR1H4) is a bile acid-respons

188 Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism i

189 Farnesoid X receptor (FXR, NR1H4) is a member of the nuc

190 gulating the transcriptional activity of the farnesoid X receptor (FXR, NR1H4), otherwise known as th

191 ation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR5 (G-protein-cou

192 The bile acid (BA) nuclear receptor, farnesoid X receptor (FXR/NR1H4), maintains metabolic ho

193 tein directly activated by cAMP 2 (Epac2) or farnesoid X receptor (FXR2) was ruled out by experiments

194 G37) and nuclear hormone receptors including farnesoid X receptor (FXR; also known as NR1H4).

195 The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator

196 The farnesoid X receptor (FXR; NR1H4) is an intracellular bi

197 The farnesoid X receptor (FXR; NR1H4) regulates bile acid an

198 lic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear rec

199 he decreased sensitivity of mice lacking the farnesoid X receptor (FXR; nuclear receptor subfamily 1,

200 1, higher Srepb2 messenger RNA (mRNA), lower farnesoid X receptor (Nr1h4) mRNA, and lower Cyp7a1 mRNA

201 (FGF) 19 levels (a surrogate for intestinal farnesoid X receptor [FXR] activity), patatin-like phosp

202 eptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesi

203 thermore, restoring bile acid homeostasis by farnesoid X receptor activation markedly reduces PTB and

204 In contrast, obeticholic acid (OCA), a farnesoid X receptor agonist and second-line anti-choles

205 The farnesoid X receptor agonist EDP-305 reduces interstitia

206 cilofexor (formerly GS-9674), a nonsteroidal farnesoid X receptor agonist in patients without cirrhos

207 Cilofexor is a nonsteroidal farnesoid X receptor agonist that demonstrated significa

208 t) as monotherapy or combined with TERN-101 (farnesoid X receptor agonist), in patients with presumed

209 5 agonist, INT-777 (50 muM), but not by the farnesoid X receptor agonist, GW4064 (10 muM).

210 Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve

211 Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefi

212 Further understanding of the role of farnesoid X receptor agonists and the potential role of

213 s of BS synthesis-suppressing drugs, such as farnesoid X receptor agonists, is greatest when optimal

214 ated receptor alpha (PPARalpha) and RXRalpha/farnesoid X receptor alpha (FXRalpha) heterodimeric nucl

215 ed receptor alpha (PPARalpha), RXRalpha plus farnesoid X receptor alpha (FXRalpha), liver receptor ho

216 Farnesoid X receptor alpha (FXRalpha, NR1H4) is a bile a

217 n, it appears that retinoid X receptor alpha/farnesoid X receptor alpha and liver receptor homolog 1

218 pathway inhibition induced the expression of farnesoid X receptor alpha, a transcription factor that

219 Bile acids and farnesoid X receptor also inhibited mouse HNF4alpha gene

220 s, has been recently shown to antagonize the farnesoid X receptor and decrease the expression of bile

221 lase most likely resulted from activation of farnesoid X receptor and induction of fibroblast growth

222 the orchestrated regulation mediated by the farnesoid X receptor and small heterodimer partner that

223 tant metabolic regulators acting through the farnesoid X receptor and TGR5 receptor.

224 dulation of bile acid receptors, such as the farnesoid X receptor and TGR5, and transporters, such as

225 drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA-induced gut hormon

226 Bile acids act on several receptors such as Farnesoid X Receptor and the G protein-coupled BA recept

227 The farnesoid X receptor and the liver X receptor (LXR) are

228 imetastatic effects of guggulsterone (GS), a farnesoid X receptor antagonist, are linked to its abili

229 , whereas deletion of the bile acid receptor farnesoid X receptor diminishes the effects of inulin.

230 Ablation of farnesoid X receptor dramatically increases enterohepati

231 rol saturation index, a 2.5-fold increase in farnesoid X receptor expression, a 5-fold increase in LX

232 DCs expressed the farnesoid X receptor for UDCA.

233 is mediated through the retinoid X receptor/farnesoid X receptor heterodimer and is independent of b

234 Interestingly, the expression levels of farnesoid X receptor in liver and intestine were signifi

235 ory factor analysis implicated the bile acid/farnesoid X receptor in some of these processes.

236 These compounds agonized the farnesoid X receptor in vitro, and mice gavaged with the

237 nd suggest that pharmacological targeting of farnesoid X receptor in vivo can be used to reverse the

238 Farnesoid X receptor knockout mice (with a hydrophilic B

239 abetic Patients with NASH Trial (PIVENS) and Farnesoid X Receptor Ligand Obeticholic Acid in NASH Tre

240 ersus placebo-treated patients in the FLINT (farnesoid X receptor ligand obeticholic acid in NASH tri

241 The farnesoid X receptor ligand obeticholic acid in the NASH

242 r-1 null (Tgr5(-/-)) and intestinal-specific farnesoid X receptor null (Fxr(Delta/E)) mice on high-fa

243 In addition, ASBT expression in farnesoid X receptor null mice was unresponsive to bile

244 Furthermore, bile acids and farnesoid X receptor reduced the expression of nuclear H

245 ulation of ASBT by bile acids is mediated by farnesoid X receptor via small heterodimer partner-depen

246 Intestinal farnesoid X receptor was up-regulated after 21 days of C

247 The bile acid receptor FXR (farnesoid X receptor) activates expression of fibroblast

248 The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcripti

249 ry activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our model system to tackle thi

250 otohormones" for the retinoic acid receptor, farnesoid X receptor, and estrogen receptor.

251 ptors, particularly the primary BA receptor, farnesoid X receptor, and small heterodimer partner, whi

252 Bile acid response was mediated by the farnesoid X receptor, as shown by the fact that overexpr

253 d nuclear receptors (i.e., liver X receptor, farnesoid X receptor, estrogen receptor alpha, peroxisom

254 Ablating one receptor, the farnesoid X receptor, in DCs enhanced the generation of

255 4), a small-molecule nonsteroidal agonist of farnesoid X receptor, in patients with nonalcoholic stea

256 of mice with GW4064, a synthetic agonist for farnesoid X receptor, induced SHP expression and decreas

257 1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic g

258 p7b1, and produces partial resistance to the farnesoid X receptor, leading to a lithogenic bile salt

259 d B6J mice, including the bile acid receptor farnesoid X receptor, oxysterol 7alpha-hydroxylase, ster

260 ty to modulate bile acid activated proteins: farnesoid X receptor, vitamin D receptor, pregnane X rec

261 deoxycholic acid, the natural agonist of the farnesoid X receptor, which is a nuclear hormone recepto

262 anscription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduc

263 ed to sustained disruption of the intestinal farnesoid X receptor-fibroblast growth factor 15 axis, a

264 Thus, farnesoid X receptor-mediated regulation was preserved.

265 pd3 expression was attenuated in LCA-treated farnesoid X receptor-null mice that are resistant to LCA

266 15 (FGF15), a target gene of the BA receptor farnesoid X receptor.

267 ogenous bile acids, indicating activation of farnesoid X receptor.

268 alized using a sensor based on the zebrafish farnesoid X receptor.

269 binding to the mammalian bile acid receptor farnesoid X receptor.

270 ired early growth response factor-1, but not farnesoid X receptor.

271 gene expression is regulated by the nuclear farnesoid X receptor.

272 factor-kappaB (NF-kappaB) rather than by the farnesoid X receptor.

273 dependent of the nuclear bile acid receptor, Farnesoid X receptor.

274 The farnesoid X receptor/bile acid receptor (FXR) is a recen

275 The farnesoid X receptor/fibroblast growth factor axis and i

276 receptor (LXR)/retinoid X receptor (RXR) and farnesoid X receptor/RXR nuclear receptor signaling amon

277 Farnesoid X receptor; Small Heterodimer Partner double k

278 l, a coffee diterpene, is a known agonist of farnesoid X receptors (FXR), which are involved in chole

279 me proliferator-activated receptors (PPARs), farnesoid X receptors (FXRs), liver X receptors (LXRs),

280 ated receptor (clofibrate or linoleic acid), farnesoid X-activated receptor (farnesol or juvenile hor

281 xpressed in human livers and is regulated by farnesoid X-activated receptor (FXR) in response to FXR

282 Farnesoid X-activated receptor (FXR) is a key transcript

283 tamins and are physiological ligands for the farnesoid X-activated receptor (FXR), a member of the nu

284 iferator activated receptors (PPARs) and the farnesoid X-activated receptor (FXR), on the development

285 d to isolate genes that are regulated by the farnesoid X-activated receptor (FXR, NR1H4).

286 The farnesoid X-activated receptor (FXR; NR1H4) is a member

287 e proliferator-activated receptor and of the farnesoid X-activated receptor accelerate epidermal barr

288 or-alpha ligand, and juvenile hormone III, a farnesoid X-activated receptor activator, markedly accel

289 eroxisome proliferator-activated receptor or farnesoid X-activated receptor activators, or by an acti

290 eroxisome proliferator-activated receptor or farnesoid X-activated receptor are involved in this gluc

291 Farnesoid X-activated receptor mRNA was not detected in

292 that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methylt

293 and transfected with expression plasmids for farnesoid X-receptor (FXR), short heterodimer partner (S

294 d to isolate genes that are regulated by the farnesoid X-receptor (FXR, NR1H4).

295 To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol

296 t that overexpression of a dominant-negative farnesoid X-receptor eliminated the bile acid mediated d

297 cation was linked with liver X receptors and farnesoid X/liver X receptor signaling pathways.

298 regulation is provided by bile acids through farnesoid-X-receptor (FXR) (NR1H4).

299 nd obeticholic acid (OCA, 6-a-ethyl-CDCA), a farnesoid-X-receptor (FXR) agonist, as preventive treatm

300 antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR).