ライフサイエンスコーパス: farnesyl diphosphate

1 phate, generating the 15-carbon product (E,Z-farnesyl diphosphate).

2 C]isopentenyl diphosphate incorporation into farnesyl diphosphate.

3 t only GGPP but also its metabolic precursor farnesyl diphosphate.

4 in atoms and the isoprenoid portion of bound farnesyl diphosphate.

5 E)-alpha-bisabolene as the sole product from farnesyl diphosphate.

6 he enzyme-peptide complex was not trapped by farnesyl diphosphate.

7 out a gene for biosynthesis of the precursor farnesyl diphosphate.

8 ith binding and utilization of the substrate farnesyl diphosphate.

9 addition to trichodiene when incubated with farnesyl diphosphate.

10 phate substrates neryl diphosphate and 2z,6z-farnesyl diphosphate.

11 tosolic and reported to act on the 15-carbon farnesyl diphosphate.

12 ion mixtures of L-tryptophan with geranyl or farnesyl diphosphate.

13 lly phosphorylated to farnesyl phosphate and farnesyl diphosphate.

14 as altered templates for the cyclization of farnesyl diphosphate.

15 he total hydrocarbons obtained using (2E,6E)-farnesyl diphosphate.

16 g to the synthesis of farnesene isomers from farnesyl diphosphate.

17 Incubation of farnesyl diphosphate (1) with Penicillium roqueforti ari

18 Incubation of farnesyl diphosphate (1) with the W308F or W308F/H309F m

19 ion of the recombinant protein, SAV_76, with farnesyl diphosphate (1, FPP) in the presence of Mg(2+)

20 erea, catalyzes the multistep cyclization of farnesyl diphosphate (2) to the tricyclic sesquiterpene

21 color catalyzes the multistep cyclization of farnesyl diphosphate (2, FPP) to the tricyclic sesquiter

22 Incubation of (1R)-[1-(2)H]farnesyl diphosphate (2b) with recombinant presilphiperf

23 Cyclization of [13,13,13-(2)H(3)] farnesyl diphosphate (2d) gave [14,14,14-(2)H(3)]-3d, th

24 Through the addition of prenyl transferases, farnesyl diphosphates, (2E,6E)-FDP and (2Z,6Z)-FDP, were

25 alogues of geranyl diphosphate (3-ClGPP) and farnesyl diphosphate (3-ClFPP), respectively.

26 diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate i

27 yme active site, we conclude that folding of farnesyl diphosphate alone does not always dictate the s

28 e synthase (FPPS) catalyzes the synthesis of farnesyl diphosphate, an important precursor of sterols,

29 cco, alone and complexed separately with two farnesyl diphosphate analogs were analyzed.

30 Addition of a farnesyl diphosphate analogue causes no detectable chang

31 Here, the synthesis of a benzophenone-based farnesyl diphosphate analogue containing a stable phosph

32 Farnesyl diphosphate analogues with fluorine at C2 and C

33 Eleven farnesyl diphosphate analogues, which contained omega-az

34 The assays use [(3)H]farnesyl diphosphate and [(3)H]geranylgeranyl diphosphat

35 rase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a t

36 resulted in reduction in the k(cat)/K(m) for farnesyl diphosphate and formation of varying proportion

37 isoprenoid mevalonate pathway-intermediates, farnesyl diphosphate and geranylgeranyl diphosphate, als

38 catalyze the attachment of lipid groups from farnesyl diphosphate and geranylgeranyl diphosphate, res

39 functional, catalyzing the formation of both farnesyl diphosphate and geranylgeranyl diphosphate.

40 The sensitivity to feedback inhibition by farnesyl diphosphate and its sulfur-containing analog, f

41 ; the K(i) values were 46 and 45 micro M for farnesyl diphosphate and its thio analog, respectively.

42 omega,Z-neryl diphosphate yielding omega,E,Z-farnesyl diphosphate and omega,Z,Z-farnesyl diphosphate,

43 Both farnesyl diphosphate and peptide substrates can be accom

44 anisms, is subject to feedback regulation by farnesyl diphosphate and related compounds.

45 adds seven more isoprene units to omega, E,Z-farnesyl diphosphate and releases decaprenyl diphosphate

46 the cell membrane that synthesizes omega,E,Z-farnesyl diphosphate and the other present in the cytoso

47 over experiments with the yeast enzyme using farnesyl diphosphate and the short peptide RTRCVIA as su

48 was inactive, whereas the LSU produced GPP, farnesyl diphosphate, and geranylgeranyl diphosphate (GG

49 diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylgeranyl diphosphate, to

50 quitination and degradation was derived from farnesyl diphosphate, and thus implied conservation of a

51 required for the conversion of mevalonate to farnesyl diphosphate are found in the peroxisome.

52 To examine if specific pools of farnesyl diphosphate are made for zealexin synthesis we

53 useful for identifying enzymes that utilize farnesyl diphosphate as a substrate.

54 The use of (2Z,6E)-farnesyl diphosphate as an alternate substrate for recom

55 e-catalyzed synthesis of sesquiterpenes from farnesyl diphosphate as high-value natural products with

56 cell-free extracts from grand fir stem with farnesyl diphosphate as substrate indicated that the con

57 FDS-1 and FDS-2 synthesized farnesyl diphosphate as the final chain elongation produ

58 picture of the conformation of enzyme-bound farnesyl diphosphate at the active site of presilphiperf

59 o be involved in isopentenyl diphosphate and farnesyl diphosphate biosynthesis leading to AN were not

60 essarily reflect the original orientation of farnesyl diphosphate bound in the corresponding enzyme a

61 osphate bound and with the product mimic E,E-farnesyl diphosphate bound.

62 ntha x piperita) and can be synthesized from farnesyl diphosphate by a cell-free extract of peppermin

63 s an isomerization to form a tighter FTase*--farnesyl diphosphate--BZA2-B complex.

64 Recombinant Mg25 converted farnesyl diphosphate (C(15)) predominantly to beta-cubeb

65 gh either geranyl diphosphate (C10) or trans-farnesyl diphosphate (C15), to yield monoterpenes and se

66 he active site which can be modeled as bound farnesyl diphosphate carried through the enzyme purifica

67 ation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isoprenyltransfe

68 rapping experiments revealed that the enzyme-farnesyl diphosphate complex was efficiently trapped by

69 otion that the inhibitor binds to the FTase--farnesyl diphosphate complex which then undergoes an iso

70 pressed C-terminal domain of SC9B1.20 had no farnesyl diphosphate cyclase activity.

71 ogenes lacking conserved motifs required for farnesyl diphosphate cyclase activity.

72 examined the resultant impacts on different farnesyl diphosphate-derived metabolites.

73 r elongation factor, interacts directly with farnesyl diphosphate during rubber biosynthesis.

74 ed with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1) (P =

75 emethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transferase 1)) via novel

76 ll interfering RNA showed that inhibition of farnesyl-diphosphate farnesyl transferase (squalene synt

77 Squalene synthetase (farnesyl-diphosphate:farnesyl-diphosphate farnesyltransf

78 coamplified genes from this region including farnesyl-diphosphate farnesyltransferase (FDFT1), arylam

79 enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate

80 10-geranyl diphosphate (GDP) and only 4% C15-farnesyl diphosphate (FDP) in the presence of Co(2+) or

81 in order of increasing potency at inhibiting farnesyl diphosphate (FDP) synthase (their intracellular

82 zes the metal-dependent cyclization of (E,E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene

83 idago canadensis catalyzes the conversion of farnesyl diphosphate (FDP) to the plant sesquiterpene (+

84 Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP was not a substrate for

85 e conversion of the isoprenoid intermediate, farnesyl diphosphate (FDP), to sesquiterpene phytoalexin

86 products from its natural substrate (2E,6E)-farnesyl diphosphate (FDP).

87 ur, which in turn facilitates cyclization of farnesyl diphosphate for the exclusive formation of tric

88 while FPS1 (GRMZM2G168681) made most of the farnesyl diphosphate for the vital respiratory co-factor

89 at FPS3 (GRMZM2G098569) produced most of the farnesyl diphosphate for zealexins, while FPS1 (GRMZM2G1

90 sensitive method was developed for measuring farnesyl diphosphate (FPP) accumulation in a mutant stra

91 Certain farnesyl diphosphate (FPP) analogs are potent inhibitors

92 ld in a ternary complex with an enzyme-bound farnesyl diphosphate (FPP) analogue, indicating that the

93 Here, the syntheses of two new farnesyl diphosphate (FPP) analogues containing photoact

94 Farnesyl diphosphate (FPP) analogues have proven to be b

95 a non-sterol isoprenoid signal derived from farnesyl diphosphate (FPP) and a sterol-derived signal a

96 trates for modification with the isoprenoids farnesyl diphosphate (FPP) and anilinogeranyl diphosphat

97 Farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

98 In plants, farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

99 The polyisoprenoid diphosphates farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

100 GGTase-I discriminates against farnesyl diphosphate (FPP) at the product turnover step

101 lyl diphosphate (DMAPP) to the C(15) product farnesyl diphosphate (FPP) by addition of two molecules

102 ly synthesizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl dipho

103 in the assay buffer increases the potency of farnesyl diphosphate (FPP) competitive inhibitors.

104 ous or monitor pyrophosphate release and not farnesyl diphosphate (FPP) creation.

105 zyme, the fact that the isoprenoid substrate farnesyl diphosphate (FPP) forms part of the binding sit

106 We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive

107 tep in its biosynthesis, condensation of two farnesyl diphosphate (FPP) molecules to dehydrosqualene,

108 sor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules.

109 (E,E)-farnesyl diphosphate (FPP) principally produced small am

110 A cDNA encoding farnesyl diphosphate (FPP) synthase (FPPS) has been clon

111 -regulated transcription of the gene for rat farnesyl diphosphate (FPP) synthase (geranyl-diphosphate

112 ntly demonstrated that mevalonate kinase and farnesyl diphosphate (FPP) synthase are localized predom

113 Farnesyl diphosphate (FPP) synthase catalyzes the consec

114 Sterol-regulated transcription of the farnesyl diphosphate (FPP) synthase gene is dependent on

115 control of promoters derived from either the farnesyl diphosphate (FPP) synthase, 3-hydroxy-3-methylg

116 ethylglutaryl coenzyme A (HMG-CoA) synthase, farnesyl diphosphate (FPP) synthase, and the low density

117 transfer of a 15-carbon farnesyl group from farnesyl diphosphate (FPP) to a conserved cysteine in th

118 transfer of a 15-carbon farnesyl moiety from farnesyl diphosphate (FPP) to a cysteine residue near th

119 nsfer of the hydrophobic farnesyl group from farnesyl diphosphate (FPP) to cellular proteins such as

120 ase) catalyzes the transfer of farnesyl from farnesyl diphosphate (FPP) to cysteine residues at or ne

121 irst is the condensation of two molecules of farnesyl diphosphate (FPP) to form a cyclopropylcarbinyl

122 AsDMS catalyzes the class II cyclization of farnesyl diphosphate (FPP) to form drimenyl diphosphate,

123 talyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphospha

124 an initial condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphospha

125 yzes the ionization-dependent cyclization of farnesyl diphosphate (FPP) to form the bicyclic eremophi

126 nthesis-the condensation of two molecules of farnesyl diphosphate (FPP) to form the cyclopropylcarbin

127 talyzes the condensation of two molecules of farnesyl diphosphate (FPP) to give presqualene diphospha

128 Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by p

129 trichodiene synthase-catalyzed conversion of farnesyl diphosphate (FPP) to trichodiene at 15 degrees

130 6 complexed with farnesyltransferase (FTase)-farnesyl diphosphate (FPP) were determined, and they pro

131 te presqualene diphosphate (PSPP) from trans-farnesyl diphosphate (FPP) with reduced production of sq

132 hosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), and geranylgeranyl diphospha

133 The universal sesquiterpene precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dep

134 -carbon geranyl diphosphate (GPP), 15-carbon farnesyl diphosphate (FPP), or 20-carbon geranylgeranyl

135 de, and L-739,750 peptidomimetic with either farnesyl diphosphate (FPP), or a nonreactive analogue.

136 sphates were good alternative substrates for farnesyl diphosphate (FPP).

137 ates containing a C-terminal "CaaX" motif by farnesyl diphosphate (FPP).

138 volving rupture of the carbon-oxygen bond in farnesyl diphosphate (FPP).

139 synthase, RcG/FPPS1, producing both GPP and farnesyl diphosphate (FPP).

140 sphate (GPP) and between IPP and GPP to give farnesyl diphosphate (FPP).

141 atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).

142 and a sesquiterpene, nerolidol, derived from farnesyl diphosphate (FPP).

143 Toxoplasma gondii possesses a bifunctional farnesyl diphosphate (FPP)/geranylgeranyl diphosphate (G

144 to an allylic diphosphate initiator, such as farnesyl diphosphate (FPP, 1), in the presence of a diva

145 te synthase (FPS) catalyzes the synthesis of farnesyl diphosphate from isopentenyl diphosphate and di

146 In summary, we report the first bifunctional farnesyl-diphosphate/geranylgeranyl-diphosphate synthase

147 n adds a further seven isoprene units to E,Z-farnesyl diphosphate in a processive manner to generate

148 Zealexins are produced from farnesyl diphosphate in microgram per gram fresh weight

149 ne cyclase that catalyzes the cyclization of farnesyl diphosphate in the first committed step of the

150 ta-caryophyllene and alpha-humulene from E,E-farnesyl diphosphate in trichomes of leaf but not of ste

151 f the tomato sesquiterpene synthases use z,z-farnesyl diphosphate in vitro as well, or more efficient

152 TCs from Dictyostelium discoideum converted farnesyl diphosphate into (2S,3R,6S,9S)-(-)-protoillud-7

153 Two methyltransferases successively modify farnesyl diphosphate into a C(17) diphosphate precursor,

154 produced protein catalyzed the conversion of farnesyl diphosphate into over 15 sesquiterpenes in simi

155 features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pent

156 hese results established that cyclization of farnesyl diphosphate involves displacement of the diphos

157 As farnesyl diphosphate is also a precursor for many compou

158 A possible metabolic fate for farnesyl diphosphate is its conversion to farnesol, then

159 alytic efficiency is greatest when omega,E,Z-farnesyl diphosphate is used as the allylic acceptor, su

160 In M. smegmatis, the omega,E, Z-farnesyl diphosphate is utilized by a membrane-associate

161 The product of this enzyme, omega,E,Z-farnesyl diphosphate, is an intermediate for the synthes

162 l cation, the product of 11,1-cyclization of farnesyl diphosphate, is the product of the first commit

163 The product, omega,E, Z-farnesyl diphosphate, is the putative substrate of the s

164 -cadinene (5%) with the native C15 substrate farnesyl diphosphate (Km approximately 0.6 microM; Vrel

165 tic roles in enhancing the reactivity of the farnesyl diphosphate leaving group.

166 ion that following the initial ionization of farnesyl diphosphate, minimal enzymatic intervention may

167 of 6.2 +/- 0.5 x 10(-3) s(-1) and a K(m) for farnesyl diphosphate of 62 +/- 8 nM.

168 yl diphosphate, neryl diphosphate, omega,E,E-farnesyl diphosphate, omega,E,Z-farnesyl diphosphate, or

169 e synthase from Aspergillus terreus cyclized farnesyl diphosphate only to (+)-aristolochene (4).

170 d by human PGGTase-I with either (S)-[1-(2)H]farnesyl diphosphate or (S)-[1-(2)H]GGPP.

171 osphate (2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate or DATFP-FPP) inhibits mevalonate-d

172 vine brain cytosol in the presence of either farnesyl diphosphate or geranylgeranyl diphosphate, GST-

173 e, omega,E,E-farnesyl diphosphate, omega,E,Z-farnesyl diphosphate, or omega,E,E,E-geranylgeranyl diph

174 fuels and the rapid engineering of microbial farnesyl diphosphate-overproducing platforms for the pro

175 of a catalytically competent ternary enzyme-farnesyl diphosphate-peptide complex.

176 nzymes, acetoacetyl-CoA thiolase (thiolase), farnesyl diphosphate phosphatase, and farnesal dehydroge

177 This partitioning of farnesyl diphosphate production between growth and defen

178 omega,E,Z-farnesyl diphosphate and omega,Z,Z-farnesyl diphosphate, respectively.

179 cells overexpressing Rv2361c incubated with farnesyl diphosphate showed a 10-fold increase of [(14)C

180 Binding of the substrate farnesyl diphosphate similarly may trigger this conforma

181 may be significantly more selective for the farnesyl diphosphate substrate than the active site bind

182 the abilities of all the mutants to bind the farnesyl diphosphate substrate were similar to that of t

183 o as well, or more efficiently than, the e,e-farnesyl diphosphate substrate.

184 a2 T cells as a consequence of inhibition of farnesyl diphosphate synthase (a key enzyme of the meval

185 eactions, chimeric proteins constructed from farnesyl diphosphate synthase (chain elongation) and chr

186 Farnesyl diphosphate synthase (FDPS) catalyzes the conve

187 stimulate Vgamma2Vdelta2 cells by inhibiting farnesyl diphosphate synthase (FDPS) in the mevalonate p

188 Farnesyl diphosphate synthase (FDPS), a mevalonate pathw

189 y unrecognized beta2AR regulators, including farnesyl diphosphate synthase (FDPS).

190 nts of the first two enzymes in the pathway, farnesyl diphosphate synthase (FDS) and carotenoid synth

191 The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl

192 Farnesyl diphosphate synthase (FPPase) catalyzes chain e

193 ISPP and GSPP were substrates for avian farnesyl diphosphate synthase (FPPase).

194 esized and evaluated as substrates for avian farnesyl diphosphate synthase (FPPase).

195 r therapeutic agents involving inhibition of farnesyl diphosphate synthase (FPPS) and geranylgeranyl

196 alysis and pharmacophore modeling studies of farnesyl diphosphate synthase (FPPS) inhibition, human V

197 n between cell growth inhibition and E. coli farnesyl diphosphate synthase (FPPS) inhibition.

198 They function by inhibiting the enzyme farnesyl diphosphate synthase (FPPS), but the details of

199 to the isoprene biosynthesis pathway enzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphos

200 r possible binding to the allosteric site in farnesyl diphosphate synthase (FPPS).

201 s modulated by the lipid biosynthesis enzyme farnesyl diphosphate synthase (FPPS).

202 Farnesyl diphosphate synthase (FPS) catalyzes the synthe

203 ted mutagenesis to transform wild-type avian farnesyl diphosphate synthase (FPS) into synthases capab

204 of the x-ray structure of homodimeric avian farnesyl diphosphate synthase (geranyltransferase, EC 2.

205 ylgeranyl diphosphate synthase (LiGGPPS) and farnesyl diphosphate synthase (LiFPPS).

206 related Z-prenyl diphosphate synthases, E,Z-farnesyl diphosphate synthase (Rv1086) and decaprenyl di

207 n at the low nanomolar level of the T. cruzi farnesyl diphosphate synthase (TcFPPS).

208 neryl diphosphate synthase1 (NDPS1) and Z,Z-farnesyl diphosphate synthase (zFPS), which are encoded

209 e levels of geranyl diphosphate synthase and farnesyl diphosphate synthase activities did not correla

210 y by the targeted overexpression of an avian farnesyl diphosphate synthase along with two versions of

211 expression in either compartment of an avian farnesyl diphosphate synthase and an appropriate terpene

212 ylamines were found to be weak inhibitors of farnesyl diphosphate synthase and caused accumulation of

213 Unlike farnesyl diphosphate synthase and geranylgeranyl diphosp

214 a subgroup of prenyltransferases, including farnesyl diphosphate synthase and geranylgeranyl diphosp

215 Z-Farnesyl diphosphate synthase catalyzed the addition of

216 Farnesyl diphosphate synthase catalyzes the sequential c

217 Farnesyl diphosphate synthase catalyzes the sequential h

218 compounds revealed that the active site of Z-farnesyl diphosphate synthase differs substantially from

219 sphate synthase differs substantially from E-farnesyl diphosphate synthase from pig brain (Sus scrofa

220 We screened 26 bisphosphonates against a farnesyl diphosphate synthase from Plasmodium vivax, fin

221 ncer cells to pitavastatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeran

222 In plants the presence of farnesyl diphosphate synthase isozymes offers the possib

223 at of the chain elongation prenyltransferase farnesyl diphosphate synthase rather than squalene synth

224 We have now purified Z-farnesyl diphosphate synthase to near homogeneity using

225 Inhibitors of the Z-farnesyl diphosphate synthase were designed and chemical

226 ogen-containing bisphosphonates that inhibit farnesyl diphosphate synthase were effective in inhibiti

227 re excellent competitive inhibitors of avian farnesyl diphosphate synthase with KI = 1.0 +/- 0.12 muM

228 iguration, indicating that Rv1086 (omega,E,Z-farnesyl diphosphate synthase) and Rv2361c act sequentia

229 l diphosphate synthase (but not, apparently, farnesyl diphosphate synthase) to favor the production o

230 gen-containing BPs (N-BPs) was identified as farnesyl diphosphate synthase, an enzyme in the mevalona

231 lglutaryl coenzyme A synthase and reductase, farnesyl diphosphate synthase, and squalene synthase.

232 res of one sulfonium bisphosphonate bound to farnesyl diphosphate synthase, finding that it binds exc

233 nate (MVA) pathway by a bifunctional geranyl/farnesyl diphosphate synthase, RcG/FPPS1, producing both

234 3-hydroxy-3-methylglutaryl-CoA reductase or farnesyl diphosphate synthase, reduced endometrial organ

235 ar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, which also contains two a

236 similar in some respects to that of dimeric farnesyl diphosphate synthase, which is not a cyclase.

237 (nBPs) are bone-specific agents that inhibit farnesyl diphosphate synthase.

238 IP and DMAP can also competitively inhibit farnesyl diphosphate synthase.

239 her gene involved in cholesterol metabolism, farnesyl diphosphate synthase.

240 Farnesyl-diphosphate synthase (FPPS) catalyzes the synth

241 nd characterization of two Toxoplasma gondii farnesyl-diphosphate synthase (TgFPPS) homologs.

242 is of the pathway revealed that two enzymes, farnesyl-diphosphate synthase and geranylgeranyl-diphosp

243 e CRISPR/Cas9 knockouts of each of the three farnesyl diphosphate synthases (FPS) in Z. mays and exam

244 synthesize long-chain trans-polyisoprene via farnesyl diphosphate synthases (FPSs).

245 noterpene synthases and three that preferred farnesyl diphosphate, the substrate for sesquiterpene sy

246 Farnesyl diphosphate, the substrate for squalene synthas

247 mutant proteins retained the ability to bind farnesyl diphosphate, they were found to have lost essen

248 Addition of both peptide and farnesyl diphosphate to give the product complex causes

249 nene synthase, catalyzing the cyclization of farnesyl diphosphate to pentalenene, the parent hydrocar

250 zes the conversion of two molecules of (E,E)-farnesyl diphosphate to squalene via the cyclopropylcarb

251 by aspartate beta352 and the diphosphate of farnesyl diphosphate to stabilize the developing charge

252 zes the covalent attachment of the 15-carbon farnesyl diphosphate to the C terminus of regulatory pro

253 e a fully functional cyclase which converted farnesyl diphosphate to the identical sesquiterpene alco

254 e synthase that catalyzes the cyclization of farnesyl diphosphate to the novel tricyclic hydrocarbon,

255 catalyze the Mg(2+)-dependent conversion of farnesyl diphosphate to the sesquiterpene alcohol (4S, 7

256 odiene synthase catalyzes the cyclization of farnesyl diphosphate to the sesquiterpene hydrocarbon tr

257 ent metal ion-dependent cyclization of [1-3H]farnesyl diphosphate to these same sesquiterpene olefins

258 step in HA biosynthesis is the conversion of farnesyl diphosphate to trichodiene (TD), a volatile org

259 , whereas VoTPS1 catalyzes the conversion of farnesyl diphosphate to valerena-1,10-diene.

260 c activity with native substrates (H-Ras and farnesyl diphosphate) to about 50% of that of the zinc-c

261 on of the universal sesquiterpene precursor, farnesyl diphosphate, to form the bicyclic hydrocarbon a

262 e universal sesquiterpene cyclase substrate, farnesyl diphosphate, to form the bicyclic hydrocarbon a

263 istry revealed that all of the overexpressed farnesyl diphosphate was in the omega,E, Z-configuration

264 ations of isotopically pure [2-(2)H(1)](E,E)-farnesyl diphosphate with recombinant patchoulol synthas

265 Incubation of farnesyl diphosphate with recombinant yeast squalene syn

266 scherichia coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as the domi

267 substrates neryl diphosphate (NPP) and 2Z,6Z-farnesyl diphosphate (Z,Z-FPP).

268 beetle protein extracts, but only when (Z,E)-farnesyl diphosphate [(Z,E)-FPP] was offered as a substr

269 squiterpene synthases, exclusively using Z-Z-farnesyl-diphosphate (zFPP) in plastids, probably arisen