ライフサイエンスコーパス: fasting-induced

1 This fasting-induced 3D genome reorganization requires inhibi

2 Bioluminescence imaging demonstrated that fasting induced a 7-fold increase in p21 expression in l

3 omain of the CREBH protein is the site where fasting-induced acetylation/deacetylation occurs.

4 Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate

5 the inhibition of mTORC1 is required for the fasting-induced activation of PPARalpha (peroxisome prol

6 ed nadir corticosterone as well as a blunted fasting-induced activation of the axis.

7 Fasting-induced adipocyte factor (Fiaf), a member of the

8 occludin) and limiting triglyceride storage (fasting-induced adipocyte factor).

9 e differentiation-related protein (ADRP) and fasting induced adipose factor (FIAF) mRNA in cultures k

10 receptor (PPAR)-gamma angiopoietin-related, fasting induced adipose factor, and hepatic fibrinogen/a

11 Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for fu

12 Moreover, GF knockout mice lacking fasting-induced adipose factor (Fiaf), a circulating lip

13 udies of gnotobiotic knockout mice that lack fasting-induced adipose factor (Fiaf), a fibrinogen/angi

14 Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor), a protein inhibitor of

15 clude adipsin, adiponectin, aP2, caveolin-1, fasting-induced adipose factor, fat-specific gene 27 (FS

16 Here, we show that fasting-induced AgRP neuronal activation is associated w

17 essure overload stimulation and show reduced fasting-induced atrophy.

18 ation of Akt in skeletal muscle and impaired fasting-induced atrophy.

19 e of endogenous spermidine synthesis reduced fasting-induced autophagy in yeast, nematodes and human

20 Furthermore, E2 treatment suppresses fasting-induced c-Fos activation in AgRP and NPY neurons

21 fect on neuropeptide expression, C75 blocked fasting-induced c-Fos expression in the arcuate nucleus

22 Fasting-induced caloric restriction reduces androgen rec

23 Fasting-induced changes in Brummer expression and, conse

24 elin regulates leptin and insulin secretion, fasting-induced changes in serum levels of leptin and in

25 In contrast to findings in mice, fasting-induced changes in the hypothalamic-pituitary-ad

26 hormone pulse frequency but had no effect on fasting-induced changes in thyroid-stimulating hormone p

27 ontrast to the short-term effects of C75 on "fasting-induced" changes of hypothalamic orexigenic and

28 However, the fasting-induced decrease in baseline blood glucose conce

29 ent increases in gene transcription and that fasting-induced decreases in leptin can regulate this CR

30 verall, our data indicate that physiological fasting-induced downregulation of GRK2 in the liver is k

31 The partial mimicking of these fasting-induced effects in ad libitum-fed rats after GLP

32 well with its ability to interfere with the fasting-induced effects on the expression of key orexige

33 organizes liver chromatin, exposing numerous fasting-induced enhancers.

34 nding protein1 (RRBP1) is required to enable fasting-induced ER sheet-mitochondria interactions and t

35 Fasting-induced exopher elevation requires the intestina

36 tonomous factors that sense and activate the fasting-induced exopher response revealed that DAF16/FOX

37 of PGC-1alpha to the Cyp7A1 promoter and the fasting-induced expression of CYP7A1 mRNA.

38 Decreasing the fasting-induced fall in leptin by leptin administration

39 echanism of how ageing impaired intermittent fasting induced fat loss.

40 lpha-dependent genes and overcomes defective fasting-induced fatty acid oxidation and lipid accumulat

41 Here, we report fasting-induced Fibroblast Growth Factor-21 (FGF21) sign

42 os immunoreactivity and appeared to suppress fasting-induced Fos immunoreactivity by about 35% (altho

43 We discovered a fasting-induced four-fold increase in length and abundan

44 ation of lipid metabolism and contributes to fasting-induced free fatty acid mobilization.

45 ppl) was identified as an astrocyte-specific fasting-induced gene.

46 Herein, we identified previously unknown fasting-induced, glucagon-mediated inhibitory effect of

47 d syndrome led to the discovery of the novel fasting-induced, glucogenic, and orexigenic hormone name

48 ode in the liver mitochondria that regulates fasting-induced gluconeogenesis and energy homeostasis.

49 represents the main mechanism implicated in fasting-induced GRK2 degradation in the liver in vivo.

50 of total myocardial lipid mass; and 3) acute fasting-induced hemodynamic dysfunction.

51 itro approaches, we found that p16 modulates fasting-induced hepatic fatty acid oxidation (FAO) and l

52 suggest that KLF15 and BTG2 are mediators of fasting-induced hepatic FGF21 expression.

53 we show that p16(Ink4a) deficiency enhances fasting-induced hepatic glucose production in vivo by in

54 ficiency of the Tgr5 gene in mice alleviated fasting-induced hepatic lipid accumulation.

55 etylation, and its functional involvement in fasting-induced hepatic lipid metabolism.

56 Double knockout mice were protected against fasting-induced hepatic steatosis (a model of enhanced e

57 ermore, the suppressive effects of leptin on fasting-induced hepatic steatosis are absent in mice lac

58 Here, we show that fasting-induced hepatic steatosis is under genetic contr

59 in determining bile acid composition and in fasting-induced hepatic steatosis through a novel mechan

60 eptin receptors from AGRP neurons diminishes fasting-induced hepatic steatosis.

61 Here we identify arginase 2 (Arg2) as a fasting-induced hepatocyte factor that protects against

62 ce to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary

63 These data establish FGF21 as a fasting-induced hormone in humans and indicate that FGF2

64 Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose pr

65 , our findings identify the neural basis for fasting-induced HPA axis activation and uncover a unique

66 essing neurons trigger and are essential for fasting-induced HPA axis activation.

67 ing three distinct hunger states of satiety, fasting-induced hunger, and leptin-induced hunger suppre

68 ee compared to homeostatic conditions due to fasting-induced hyperexcitability of N/OFQ neurones.

69 ulin tolerance but showed markedly increased fasting-induced hyperphagia (P < 0.001).

70 Also, fasting-induced hyperphagia and after acute or chronic p

71 The POMC transgene attenuated fasting-induced hyperphagia in wild-type mice.

72 nduction of mitoNEET in alpha-cells leads to fasting-induced hypoglycemia and hypersecretion of insul

73 of which is similar to the life-threatening, fasting-induced hypoglycemia observed in infants treated

74 trols and, as a result, delayed the onset of fasting-induced hypoglycemia.

75 ls with streptozotocin completely blocks the fasting-induced hypoglycemia/hypertriglyceridemia, sugge

76 sting whereas its inhibition attenuated both fasting-induced & hypoglycemic feeding.

77 In this study, we show that fasting-induced hypoleptinemia in (NZB x NZW)F(1) lupus-

78 the activin receptor ALK7 in BAT resulted in fasting-induced hypothermia due to exaggerated catabolic

79 Loss of neuropeptide Y prevents a fasting-induced increase in epinephrine release and resu

80 rotransmitters from sympathetic neurons, the fasting-induced increase in plasma ghrelin was blocked.

81 culating leptin levels did not eliminate the fasting-induced increase in quadriceps UCP3 expression.

82 ity of sIPSCs in POMC neurons as well as the fasting-induced increase in sIPSC frequency.

83 nd found that nesfatin-1 fully abolishes the fasting-induced increase in the reward value of sucrose.

84 BNP inhibited the fasting-induced increase in total and acylated ghrelin c

85 e its effect in lean mice, C75 prevented the fasting-induced increase of hypothalamic NPY and AgRP mR

86 in) administered to fasted men prevented the fasting-induced increase of sOB-R levels, and pharmacolo

87 4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates c

88 Prolonged fasting induced lipid deposition in livers of control mi

89 t (hLrp1(-/-)) mice were more susceptible to fasting-induced lipid accumulation in the liver.

90 iobasal hypothalamus (MBH), display impaired fasting-induced lipolysis accompanied by a decreased nor

91 We found that Relish is required to restrain fasting-induced lipolysis, and thus conserve cellular tr

92 JMJD8 suppresses fasting-induced lipophagy and reduces energy production

93 ediated silencing of hepatic Fsp27 abolishes fasting-induced liver steatosis in the absence of change

94 ting-induced white adipose tissue lipolysis, fasting-induced liver triglyceride accumulation, fasting

95 However, fasting induced metabolic alterations might interfere wi

96 Overall, our report identifies HSDL2 as a fasting-induced mitochondrial protein that links nutriti

97 Fasting-induced mitophagy was lost in CBK mice, indicati

98 mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in v

99 Fasting-induced muscle atrophy was also compromised in f

100 rain-derived neurotrophic factor (BDNF) is a fasting-induced myokine that controls metabolic reprogra

101 n parallel to, lipid signaling also promotes fasting-induced neuronal exopher elevation.

102 , chronic hyperglycemia is associated with a fasting-induced paradoxical increase in glucose-potentia

103 Here, we show that fasting induced PGC-1alpha deacetylation in skeletal mus

104 Fasting-induced PPARalpha activation was drastically pre

105 We have identified a fasting-induced protein hormone that modulates hepatic g

106 ciency blunted C-Fos induction in the PVH by fasting-induced re-feeding, and insulin and NPY induced

107 perleptinemic while fasting, did not exhibit fasting-induced reductions in temperature.

108 Fasting-induced refeeding is unchanged in younger Y5R-nu

109 Compound 38 temporarily reduces fasting-induced refeeding of mice, thereby emulating the

110 ing-induced liver triglyceride accumulation, fasting-induced refeeding, and fasting-induced regulatio

111 accumulation, fasting-induced refeeding, and fasting-induced regulation of the adipostatic and hypoth

112 hus, in lean mice C75 seems to interrupt the fasting-induced signals that activate expression of NPY

113 e, we found that this hypothalamic-specific, fasting-induced SIRT1 regulation is altered in leptin-de

114 neurons is both necessary and sufficient for fasting-induced spinogenesis and excitatory synaptic act

115 Here we show that entry into mouse torpor, a fasting-induced state with a greatly decreased metabolic

116 ice from five other inbred strains developed fasting-induced steatosis like the C57BL/6J mice.

117 hat regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased en

118 resistant to acetaminophen hepatotoxicity or fasting-induced steatosis.

119 However, PGC-1alpha knockout did not prevent fasting-induced suppression of CYP2R1 in the liver, indi

120 ng of alpha-MSH every 6 hr for 3 d prevented fasting-induced suppression of pro-TRH in the PVN but ha

121 CART prevented fasting-induced suppression of pro-TRH in the PVN when a

122 act fed GH release; however, it reversed the fasting-induced suppression of pulsatile GH secretion.

123 ization, and importantly, it counteracts the fasting-induced suppression of TNF-alpha release, result

124 r5, Bmi1, or HopX expression, contributed to fasting-induced survival.

125 Here, we identified a fasting-induced switch in leukocyte migration that prolo

126 alleled by an increase in spines, suggesting fasting induced synaptogenesis and spinogenesis.

127 um TH levels, both CAR agonist treatment and fasting induced the expression of CAR target genes (nota

128 In PPARalpha+/+ mice, fasting induced the hepatic and cardiac expression of PP

129 Glucocorticoid receptor blockade prevented fasting-induced tissue Angptl4 expression and WAT TG hyd

130 rons are required for the full expression of fasting-induced torpor in both female and male mice, the

131 no]-2S-2-propa nol oxalate] severely blunted fasting-induced torpor in control mice, whereas other AR

132 ed the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and

133 In ob/ob mice, fasting-induced torpor was completely reversed by leptin

134 eptor gamma coactivator 1-alpha (PGC1A) is a fasting-induced transcriptional coactivator.

135 se effects are associated with inhibition of fasting-induced up-regulation and down-regulation, respe

136 effect seems to be due to inhibition of the fasting-induced up-regulation of expression of hypothala

137 completely blocked food intake and prevented fasting-induced up-regulation of hypothalamic AgRP and N

138 ibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptide

139 Thus, fasting-induced WAT TG hydrolysis requires glucocorticoi

140 that the MC3-R(-/-) mouse exhibits defective fasting-induced white adipose tissue lipolysis, fasting-