ライフサイエンスコーパス: fate determination

1 targets of PNT participate in the posterior fate determination.

2 tem cell maintenance, niche interactions and fate determination.

3 3 is reorganized during development and cell fate determination.

4 otrusion, migration, proliferation, and cell-fate determination.

5 ell proliferation, differentiation, and cell fate determination.

6 Shh morphogen gradient and influencing cell fate determination.

7 n epigenetic control of SE activity for cell fate determination.

8 etwork (GRN), corresponding to specific cell fate determination.

9 nt-triggered mitochondrial dynamics and cell fate determination.

10 translation is an important feature of cell-fate determination.

11 xplore the functional role of Jagged in cell-fate determination.

12 ne expression, chromatin structure, and cell fate determination.

13 cadherins required for NC migration and cell fate determination.

14 merged as important factors influencing cell fate determination.

15 l to study neural stem cell self-renewal and fate determination.

16 e and actin cytoskeleton is critical for TGC fate determination.

17 Nkx2.1, for lung epithelial progenitor cell fate determination.

18 s to regulate embryonic development and cell fate determination.

19 th embryonic stem cell self-renewal and cell fate determination.

20 aining immune homeostasis by regulating cell fate determination.

21 s modelling lineage differentiation and cell-fate determination.

22 ngolipids function in neural stem cell (NSC) fate determination.

23 ive in the stem cell niche that oversees SSC fate determination.

24 nects DNA damage signaling to SirT1 and cell fate determination.

25 are critical regulators of lymphoid lineage fate determination.

26 a classical embryologic model to study cell fate determination.

27 ides a prototypic example of collective cell fate determination.

28 ich endogenous secretion contributed to cell fate determination.

29 up210 in gene expression regulation and cell fate determination.

30 ctions of the Hippo signaling cascade in HSC fate determination.

31 ulatory network that guides progressive cell fate determination.

32 le in controlling embryonic neural stem cell fate determination.

33 ory T cells (T(reg) cells) and controls cell fate determination.

34 as well as its function in C. albicans cell fate determination.

35 re involved in embryonic patterning and cell fate determination.

36 omosome copy number could contribute to cell-fate determination.

37 olarity signaling mechanism in mammalian HSC fate determination.

38 on of gene expression during vertebrate cell-fate determination.

39 by ADAM10 is critical to hematopoietic cell-fate determination.

40 *-124 can have an instructive role in neural fate determination.

41 ptors and a requirement for thrb in red cone fate determination.

42 re cell surface molecules essential for cell fate determination.

43 -5 plays an instructive role in male gonadal fate determination.

44 or suppression, and monocyte/macrophage cell fate determination.

45 important for CD8 T-cell effector or memory fate determination.

46 ith proper heterochromatin assembly and cell fate determination.

47 lls, leads to a complete loss of proper cell fate determination.

48 lineage-specific reorganization during cell-fate determination.

49 d to cell signaling, cell survival, and cell fate determination.

50 n P11.p is concordant with the timing of HCG fate determination.

51 initiates morphogenesis and prosensory cell fate determination.

52 reciprocal negative regulation of CD4 T cell fate determination.

53 mechanisms of early neural and retinal cell fate determination.

54 to achieve complete IL-12-dependent Th1 cell-fate determination.

55 oliferation, death and morphogenesis to cell fate determination.

56 rmination cascade involved in embryonic cell fate determination.

57 development is a process of progressive cell fate determination.

58 ociated with tissue differentiation and cell fate determination.

59 e crucial for lineage specification and cell fate determination.

60 icity and dissect mechanisms underlying cell fate determination.

61 ouple leaf morphogenesis with epidermal cell fate determination.

62 al for controlling further amplification and fate determination.

63 f cancer cell biology: inflammation and cell-fate determination.

64 t of H3K27me3-mediated silencing during cell fate determination.

65 r-mediated transcription attenuation in cell fate determination.

66 ling and unravel the complexity of stem cell fate determination.

67 nal transduction in cells are vital for cell fate determination.

68 to allow ample time for DNA repair and cell fate determination.

69 des new insights into the mechanisms of cell fate determination.

70 cell proliferation, differentiation and cell fate determination.

71 roteomic dynamics during the process of cell fate determination.

72 F signaling to balance self-renewal and cell fate determination.

73 t couple metabolism to pluripotency and cell fate determination.

74 from metabolism to redox homeostasis to cell fate determination.

75 al to transcriptional reprogramming and cell fate determination.

76 t of EpiLCs, the epigenome is reset for cell fate determination.

77 n of quiescent cells and/or a switch in cell-fate determination.

78 ling activation and cause a gradient of cell fate determination along the direction of flow.

79 f misexpressing NeuroD genes on retinal cell fate determination also suggested shared and divergent f

80 ted early gene modules expressed long before fate determination although being clearly associated wit

81 naling is a cellular pathway regulating cell-fate determination and adult tissue homeostasis.

82 rm the basis for understanding not only cell fate determination and cellular homeostasis in the norma

83 signatures that lead to each retinal cell's fate determination and development challenging.

84 rious adult stem cells, but its role in cell fate determination and differentiation during liver deve

85 f the transcriptional networks regulating HC fate determination and differentiation is crucial not on

86 7 (H3K27me3) regulates gene repression, cell-fate determination and differentiation.

87 We elucidate the role of Jagged in cell-fate determination and discuss its possible implications

88 Numb functions in progenitor cell fate determination and early development, but it is also

89 t critical genes acting in the steps of cell fate determination and early differentiation of various

90 r Wnt/beta-catenin signaling in granule cell fate determination and for Wnt/PCP signaling in controll

91 e role of CD28 in gammadelta T cell effector fate determination and function.

92 upporting distinct pathways for human T cell fate determination and homeostasis.

93 As (miRNAs) are important regulators of cell fate determination and homeostasis.

94 tes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate ce

95 ting protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

96 independent role of DOT1L in modulating cell-fate determination and in transcriptional elongation con

97 Notch1 regulates binary cell fate determination and is critical for angiogenesis and

98 stone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple canc

99 tally changed our view on developmental cell-fate determination and led to a cascade of technological

100 ascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue

101 ionarily conserved process critical for cell fate determination and maintenance of gene expression du

102 Notch receptors mediate binary cell fate determination and may regulate the function of BM-d

103 rved across metazoans, including neural cell fate determination and migration, axon guidance, synapto

104 res coordination of cell proliferation, cell fate determination and morphogenetic movements.

105 associated with key factors central to cell fate determination and neural tube patterning.

106 d their disruption leads to abnormalities in fate determination and neuronal positioning.

107 and the signaling pathways that control cell fate determination and organism development.

108 ial players in development by acting on cell fate determination and progression towards cell differen

109 ional dominance' model of photoreceptor cell fate determination and provide insights into the pathoge

110 nce of single-cell analyses in understanding fate determination and provide new insights into the spe

111 ERECTA-mediated signaling in growth and cell-fate determination and reveal a role for ERECTA-LIKE2 in

112 mous function of Shox2 in osteogenic lineage fate determination and skeleton patterning.

113 duced signaling provides a switch for neural fate determination and specification of neurotransmitter

114 and signaling molecules involved in neuronal fate determination and specification.

115 -catenin and are critically involved in cell fate determination and stem/progenitor self-renewal.

116 t the importance of metabolic cues in T cell fate determination and suggest that metabolic modulation

117 synthetic biology framework to approach cell fate determination and suggests a landscape-based explan

118 roteasome pathway is necessary for hair cell fate determination and survival.

119 roblastic cell-cell interactions affect cell fate determination and the organization of skeletal musc

120 al taste system: embryonic chemosensory cell fate determination and the specification of lingual mech

121 ion of gene expression is essential for cell fate determination and tissue development.

122 s during animal development, regulating cell fate determination and tissue growth in a variety of tis

123 ed us to identify key genes involved in cell fate determination and to obtain new insights about a sp

124 essential roles in cell proliferation, cell fate determination and tumorigenesis by regulating the e

125 viding cell population just upstream of cell fate determination and updates previous models of spindl

126 entify an epigenetic mechanism governing BAT fate determination and WAT plasticity.

127 as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that

128 (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developin

129 ndocannabinoids regulate cell proliferation, fate determination, and migration.

130 e WNT7A-PAX6 axis in corneal epithelial cell fate determination, and point to a new strategy for trea

131 e is suppressed via Nkx2-5 during mesodermal fate determination, and that the Gata1 gene is one of th

132 ential for many aspects of development, cell fate determination, and tissue homeostasis.

133 al to ensure proper lineage commitment, cell fate determination, and ultimately, organogenesis.

134 y transcription factors that regulate T cell fate determination are methylated on arginine.

135 nate models of Notch pathway control of cell fate determination are presented.

136 development, extracellular cues guiding cell fate determination are provided by morphogens.

137 ovement, Balbiani body formation, and oocyte fate determination are selectively blocked by low levels

138 aling has been described in neuro/glial cell fate determination as well as in modulating neurogenesis

139 NOTCH receptors have been implicated in cell fate determination, as well as maintenance and different

140 a1 appears to act as a balancing molecule in fate determination at a critical juncture of T-cell diff

141 enance, but may have a critical role in cell-fate determination at the initiation stage.

142 inating enzymes (DUBs) help control neuronal fate determination, axonal pathfinding and synaptic comm

143 isms that underlie proneural induction, cell fate determination, axonal targeting, dendritic branchin

144 As (miRNAs) are important in regulating cell fate determination because many of their target mRNA tra

145 in key auto-regulatory proteins can control fate determination between latency and productive replic

146 Cell-fate determination between the three phenotypes is in fa

147 cellular metabolism both contribute to cell fate determination, but their interplay remains poorly u

148 Thus, excess beta-catenin can alter cell fate determination by both direct and paracrine mechanis

149 Cell fate determination by lateral inhibition via Notch/Delta

150 e balance between stem cell self-renewal and fate determination by regulating the expression of stem

151 monstrate that stochastic and permanent cell fate determination can be achieved through initializing

152 Several models of cell fate determination can be invoked to explain how single

153 st 5-6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulator

154 d a passive component or "passenger" of cell-fate determination, cell metabolism is now starting to t

155 ting a model of a stochastic process of cell fate determination coupled with dynamic patterns of clon

156 ordination between morphogenic movements and fate determination critically influences organogenesis.

157 multiple cellular processes, including cell fate determination, development, differentiation, prolif

158 onsists of several processes, including cell fate determination, differentiation, and maturation.

159 ic aspects of retinal development, including fate determination, differentiation, morphological devel

160 relationship between PCP signaling and cell fate determination during asymmetric division of neural

161 Cell polarization is linked to fate determination during asymmetric division of plant s

162 -mediated Wnt signaling in proliferation and fate determination during cerebral cortical development.

163 he AMPK pathway as a novel regulator of cell fate determination during differentiation.

164 ers in the control of proliferation and cell fate determination during differentiation.

165 al factors that play essential roles in cell fate determination during early embryogenesis and ontoge

166 conserved signaling cascade crucial for cell fate determination during embryogenesis.

167 Notch signaling pathway mediates cell-fate determination during embryonic development, wound h

168 ch signal transduction pathway controls cell fate determination during metazoan development.

169 ctyostelium homologue of GSK3 (gskA) in cell fate determination during morphogenesis of the fruiting

170 e signaling have all been implicated in cell fate determination during neurogenesis, our findings pro

171 Histone protein modifications control fate determination during normal development and dediffe

172 for the EMS1 receptor kinase to signal cell fate determination during plant sexual reproduction.

173 e Hedgehog (Hh) pathway is required for cell-fate determination during the embryonic life, as well as

174 d Numbl in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesi

175 e mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-

176 ifications, but their specific roles in cell fate determination events are poorly understood.

177 The cell fate determination factor Dachshund was cloned as a domi

178 Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis,

179 es advantage of this knowledge and uses cell fate determination factors to convert one lineage into a

180 rength and environmental cues, but how these fate-determination factors are transcriptionally regulat

181 RNA sequencing revealed key factors of fate determination for HCRT (Peg3, Ahr1, Six6, Nr2f2, an

182 Unbalanced neurogenic fate determination found in complete CB(1)(-/-) mice and

183 ly pathways, that are involved in their cell-fate determination from pre-specified embryonic foregut.

184 change in splicing isoforms of Numb, a cell-fate determination gene.

185 of the let-7 miRNA family control many cell-fate determination genes to influence pluripotency, diff

186 The process of cell fate determination has been depicted intuitively as cell

187 nscription factors that drive megakaryocytic fate determination have been identified and experimental

188 erlying transcriptional mechanism for neural fate determination, HOE-140 induced up-regulation of Not

189 lays a crucial role in the control of T cell fate determination; however, the precise regulatory mech

190 tic metabolism, cell cycle progression, cell fate determination, immune function, and inflammatory re

191 ablish that PBX1 regulates adult neural cell fate determination in a manner beyond that of its hetero

192 gulation of nuclear architecture during cell-fate determination in a mouse cell line.

193 y provides a general model for niche-induced fate determination in adult tissues.

194 gnaling makes critical contributions to cell fate determination in all metazoan organisms, yet remark

195 in regulating somatic and reproductive cell fate determination in Arabidopsis anthers.

196 Notch signaling governs binary cell fate determination in asymmetrically dividing cells.

197 novel role of ETBR in NPCs and mitochondrial fate determination in cerebral ischemia, and in improvin

198 g the molecular control of cell lineages and fate determination in complex tissues is key to not only

199 early events in a program of secretory cell fate determination in developing murine airways.

200 rom mouse skin results in a marked change in fate determination in epidermal progenitor cells, leadin

201 riptomes over time and applied this to study fate determination in hematopoiesis.

202 of early embryonic stem cell state and cell fate determination in humans.

203 the mechanisms at play during the first cell-fate determination in mammalian embryos have been debate

204 Proper cell fate determination in mammalian gonads is critical for t

205 e Foxp3 CNS elements (CNS1-3) in T(reg) cell fate determination in mice.

206 r balance between neural and mesodermal cell fate determination in mouse embryos and ESCs.

207 s a critical factor required for proper cell fate determination in S. pombe.

208 are dispensable for primitive and adult HSC fate determination in steady-state and stress hematopoie

209 f the MOF/FAO/OXPHOS axis in regulating cell fate determination in stem cells.

210 Cell fate determination in the asymmetric bacterium Caulobact

211 ped beyond growth to encompass specific cell-fate determination in the context of blood development.

212 oles for the enzymes in regulating adipocyte fate determination in the developing mammary gland.

213 intrinsic competence act in concert for cell fate determination in the developing vertebrate retina.

214 lent mating-type region is critical for cell fate determination in the form of mating-type switching.

215 cle 7 (Cdc7) has been shown to regulate cell fate determination in the initial phase of transforming

216 nd common roles for the three miRNAs in cell-fate determination in the inner ear, and these principle

217 ne modifications are integral to normal cell fate determination in the mammalian lens.

218 ne whether beta-catenin regulates basal cell fate determination in the mouse trachea.

219 standing of the molecular mechanisms of cell fate determination in the nervous system requires the el

220 rinting as a critical determinant of lineage fate determination in the thymus.

221 tical analysis predicts that stochastic cell fate determination in this case can only be realized whe

222 o control cytoplasmic Cdc42 activity and HSC fate determination in vivo.

223 mportant regulator of EGFR activity and cell fate determination in vivo.

224 uired for cranial neural crest formation and fate determination in Xenopus.

225 RP6 appeared to be critical for granule cell fate determination, in vivo knockdown of PCP core protei

226 region of genes involved in Lgr5+ stem cell fate determination, including Lgr5, Tgfb1 and Tgfbr2, fo

227 Fate determination is confined to a critical development

228 d signaling pathway and its function in cell fate determination is crucial in embryonic development a

229 When the process of cell-fate determination is examined at single-cell resolution

230 Cell-fate determination is influenced by interactions between

231 whether other regulatory events support cell-fate determination is less well understood.

232 , but its role in brain development and cell fate determination is less well understood.

233 ly accepted that the process of retinal cell fate determination is under tight transcriptional contro

234 le receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated.

235 hat RAS-induced senescence represents a cell fate determination-like process characterised by a uniqu

236 en recognition (DNA sensing) pathways, viral fate determinations (lytic or latent), and to anticipate

237 cally constricting cells, downstream of cell fate determination mechanisms.

238 d could provide powerful mechanisms for cell fate determination more broadly.

239 Despite this early fate determination, multiple cell types can be replaced

240 This reveals a role for nmy-2 in cell fate determination not obviously linked to the primary p

241 plant morphogenesis, hormone signaling, cell fate determination, nutrient deficiency, nitrogen metabo

242 the factors that regulate proliferation and fate determination of adult neural stem cells and descri

243 These findings confirm that fate determination of cIN subgroups is crucially influen

244 the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that

245 ve selection results in a change in the cell fate determination of developing iNKT cells, with a bloc

246 gnaling-mediated lateral inhibition and cell fate determination of external sensory organs.

247 4 methylation activity of these complexes in fate determination of hematopoietic stem and progenitor

248 vide a connection between metabolism and the fate determination of ISCs.

249 Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly co

250 xample of two relevant genes involved in the fate determination of mesenchymal progenitors, and can b

251 ates transcriptional complexes to direct the fate determination of multipotent mesenchymal stem cells

252 gamma-Secretase regulates fate determination of neural progenitor cells.

253 ecially mTORC2, in iNKT cell development and fate determination of NKT17 cells.

254 How the differentiation and fate determination of PDGFRbeta(+) cells are regulated,

255 ic regulation responsible for the asymmetric fate determination of XCI remain elusive.

256 nal regulators involved in cell identity and fate determination, often dysregulated in cancer.

257 which enables direct study of quadruple cell fate determination on an engineered landscape.

258 initially identified for their roles in cell fate determination or signaling during development can h

259 of Sox2 in promoting proliferation and cell fate determination, our data demonstrate that Sox2 plays

260 Attenuation of FOX function by the cell fate determination pathway has broad implications given

261 ellipse, encodes a key component of the cell fate determination pathway involved in Drosophila eye de

262 How these unusual cell-fate determination patterns are generated is unclear.

263 Here we identify a stochastic cell fate determination process that operates in Bacillus sub

264 itted precursor thymocytes are screened by a fate-determination process mediated via T cell receptor

265 ighlight the influence of cell morphology on fate determination processes.

266 factors are critical regulators of cellular fate determination, proliferation, and differentiation.

267 potent morphogens that are involved in cell fate determination, proliferation, apoptosis and adult t

268 ether this function is linked to its role in fate determination remains unclear.

269 Cell fate determination requires faithful execution of gene e

270 e data reveal Bcl-3 as a regulator of B cell fate determination, restricting the MZ path and favoring

271 le for how cells acquire competence for cell fate determination, resulting in the context-dependent r

272 s family GTPases play a pivotal role in cell fate determination, serving as molecular switches to con

273 Cs in a variety of cancers and controls cell fate determination, survival, proliferation, and the mai

274 oundation for studies of when and where cell fate determination takes place.

275 er of TCR binding, signaling, and functional fate determination that can differentially specify outco

276 ant for cellular homeostasis, signaling, and fate determination that is implicated in several disease

277 s suggest a conserved mechanism for neuronal fate determination that might operate during asymmetric

278 Despite its critical involvement in cell fate determination, the enrichment of germline determina

279 r detrusor smooth muscle and urothelial cell fate determination, the mutants have significantly lower

280 Here we review progress in understanding LCN fate determination, their nonradial migration to the cor

281 mplicate AMSH as a key modulator of receptor fate determination through its action on components of t

282 pathways, suggest that Adam10 regulates cell fate determination through the activation of Notch signa

283 dle during cell division is crucial for cell fate determination, tissue organization, and development

284 lular organisms actively regulate their cell fate determination to cope with changing environments or

285 genesis, and cellular stress that links cell fate determination to disease pathology.

286 esis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic form

287 tant for diverse processes ranging from cell fate determination to synaptic plasticity; however, so f

288 Foxp3 transcription, which is essential for fate determination towards TH17 cells.

289 ses, including embryo development, stem cell fate determination, trichome branching, leaf morphogenes

290 to exhibiting spiral cleavage and early cell fate determination, trochozoans typically undergo indire

291 muscular junction formation, and neuron cell fate determination, typically during the pupal stage of

292 regulates PDGFRbeta(+) cell differentiation/fate determination via gpihbp1.

293 In studies of photoreceptor fate determination, we found that Blimp1 (Prdm1) is expr

294 ore the role of Shh and other factors in cIN fate determination, we generated a reporter line such th

295 To further evaluate its role in cell fate determination, we investigated INSM1 effects on cel

296 urther examine the role of Olig2 in NG2 cell fate determination, we used genetic fate mapping of NG2

297 rstanding the mechanisms underlying neuronal fate determination will provide important insights into

298 cts of the gene miranda that is required for fate determination with GFP.

299 Thus, the APC/C coordinates cell-fate determination with the cell cycle through the modul

300 sease states with opposing responses in cell fate determination, yet its contribution in pro-survival