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1 f acetyl-CoA carboxylase and polyunsaturated fatty acid biosynthesis.
2 , from the TCA cycle for use in HCMV-induced fatty acid biosynthesis.
3 tion of the malonyl-CoA precursor of de novo fatty acid biosynthesis.
4 d gluconeogenesis but funneled directly into fatty acid biosynthesis.
5 cation: autophagy, actin polymerization, and fatty acid biosynthesis.
6 an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis.
7 which catalyzes the first enzymatic step of fatty acid biosynthesis.
8 etoxifying reactive carbonyls and regulating fatty acid biosynthesis.
9 biosynthesis and 5 genes specify aspects of fatty acid biosynthesis.
10 ylCoA carboxylase (ACC), the first enzyme in fatty acid biosynthesis.
11 yses the first committed step in prokaryotic fatty acid biosynthesis.
12 r enzymes at the first major branch point in fatty acid biosynthesis.
13 antibacterial activity through inhibition of fatty acid biosynthesis.
14 AtpC, RpoA, and several proteins involved in fatty acid biosynthesis.
15 pathways: glycerophospholipid metabolism and fatty acid biosynthesis.
16 g the chain-elongation reaction of bacterial fatty acid biosynthesis.
17 oth of which are involved in cholesterol and fatty acid biosynthesis.
18 (also known as BCCP), which is required for fatty acid biosynthesis.
19 me that catalyzes the last reductive step of fatty acid biosynthesis.
20 st reductive step in the elongation cycle of fatty acid biosynthesis.
21 PDC provides acetyl-CoA and NADH for de novo fatty acid biosynthesis.
22 noyl reductase enzyme from type II bacterial fatty acid biosynthesis.
23 esis and the less well exploited pathway for fatty acid biosynthesis.
24 ondensing enzyme that plays central roles in fatty acid biosynthesis.
25 w antibacterial compounds are the enzymes of fatty acid biosynthesis.
26 otein that is an essential cofactor in plant fatty acid biosynthesis.
27 yzes the first committed reaction of de novo fatty acid biosynthesis.
28 ntify a potential regulatory role of ACPS in fatty acid biosynthesis.
29 P) is then active as the central coenzyme of fatty acid biosynthesis.
30 biosynthetic process that closely parallels fatty acid biosynthesis.
31 te genes encoding enzymes of cholesterol and fatty acid biosynthesis.
32 ACP) synthase III (FabH or KS III) enzyme of fatty acid biosynthesis.
33 where they activate genes of cholesterol and fatty acid biosynthesis.
34 CoA from acetyl CoA, a rate-limiting step in fatty acid biosynthesis.
35 y participate in determining the products of fatty acid biosynthesis.
36 ltienzyme complex involved in branched-chain fatty acid biosynthesis.
37 tion of genes encoding enzymes of sterol and fatty acid biosynthesis.
38 e that catalyzes the first committed step of fatty acid biosynthesis.
39 lesterol biosynthesis, the LDL receptor, and fatty acid biosynthesis.
40 ffect of 25-hydroxycholesterol on sterol and fatty acid biosynthesis.
41 atty acid degradation and as an activator of fatty acid biosynthesis.
42 that BPL-1 is required for efficient de novo fatty acid biosynthesis.
43 (ACP) with acetyl-CoA in plant and bacterial fatty acid biosynthesis.
44 ulation of fatty acid oxidation, rather than fatty acid biosynthesis.
45 ters for key enzymes of both cholesterol and fatty acid biosynthesis.
46 ier protein) (holo-ACPP) in an early step of fatty acid biosynthesis.
47 hat controls the first rate-limiting step in fatty acid biosynthesis.
48 scription factors regulating cholesterol and fatty acid biosynthesis.
49 ase) catalyzes the committed step of de novo fatty acid biosynthesis.
50 th exogenous fatty acids and de novo type II fatty acid biosynthesis.
51 directly confer sensitivity to inhibitors of fatty acid biosynthesis.
52 and may also require increasing the flux of fatty acid biosynthesis.
53 ion relevant to understanding polyketide and fatty acid biosynthesis.
54 e the multidomain protein can participate in fatty acid biosynthesis.
55 correlated with a decrease in branched-chain fatty acid biosynthesis.
56 ricarboxylic acid metabolism (TCA) cycle and fatty acid biosynthesis.
57 tions in either amino acid concentrations or fatty acid biosynthesis.
58 acetyl-CoA to the cytosol for the essential fatty acid biosynthesis.
59 ete down-regulation of proteins required for fatty acid biosynthesis.
60 reconstituted in vitro by coupling Gcs with fatty acid biosynthesis.
61 ds of the Arabidopsis (Arabidopsis thaliana) fatty acid biosynthesis 1 (fab1) mutant contain a 35% to
62 ression of several hepatic genes involved in fatty acid biosynthesis, 2) elevated postprandial fatty
63 Importantly, the rate-limiting enzyme of fatty acid biosynthesis, acetyl-CoA carboxylase 1 (ACC1)
64 ed in lignan synthesis, cell elongation, and fatty acid biosynthesis, all of which have important rol
66 production, including 9% to 19% of carbon to fatty acid biosynthesis and 32% to 46% of carbon to amin
67 sing enzymes, is a key catalyst in bacterial fatty acid biosynthesis and a promising target for novel
68 of the acyl carrier protein (ACP) as used in fatty acid biosynthesis and a range of other metabolic e
70 mellitus in animals leads to a reduction of fatty acid biosynthesis and an upregulation of an altern
72 ee interconnected pathways (innate immunity, fatty acid biosynthesis and cholesterol biosynthesis) in
73 ion factor FadR regulates genes required for fatty acid biosynthesis and degradation in an opposing m
74 rward loop regulating the transition between fatty acid biosynthesis and degradation in V. cholerae O
75 air C. elegans fertility identified genes in fatty acid biosynthesis and ethanolamine utilization pat
76 y relevant drug target, we demonstrated that fatty acid biosynthesis and FabI activity are essential
77 g an intermediate in the pathways of de novo fatty acid biosynthesis and fatty acid elongation, malon
79 for essential biosynthetic processes such as fatty acid biosynthesis and haem biosynthesis, the two l
80 a transporter genes that are associated with fatty acid biosynthesis and intracellular lipid traffick
81 e for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for
82 es the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for
83 et, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gr
84 ein reductase (ENR) is involved in bacterial fatty acid biosynthesis and is the target of the antibac
86 C1), an enzyme with crucial roles in de novo fatty acid biosynthesis and lipogenesis and essential fo
88 ostatic cancers exhibit increased endogenous fatty acid biosynthesis and overexpress certain enzymes
90 inate the acyl-acyl carrier protein track of fatty acid biosynthesis and play an essential role in de
92 ter, this suggests a functional link between fatty acid biosynthesis and R1128 biosynthesis in the en
94 modulated energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to o
96 ivity, avoiding the detrimental reduction in fatty acid biosynthesis and the concomitant detrimental
97 ATP(lo)pyruvate(lo) conditions triggered fatty acid biosynthesis and the formation of cytoplasmic
98 at least two genes required for unsaturated fatty acid biosynthesis and the gene encoding the transc
101 ion of WRINKLED1, a key regulator of plastid fatty acid biosynthesis, and a microalgal lipid droplet
102 high-resolution structural information about fatty acid biosynthesis, and a new strategy is required
103 ic pathways, primary bile acid biosynthesis, fatty acid biosynthesis, and biosynthesis of unsaturated
104 se, the major enzyme required for endogenous fatty acid biosynthesis, and carcinoma lines are growth
105 and cell cycle progression, anti-apoptotic, fatty acid biosynthesis, and endoplasmic reticulum stres
106 colysis, the tricarboxylic acid (TCA) cycle, fatty acid biosynthesis, and nucleotide biosynthesis.
107 ght into the regulation of a crucial step in fatty acid biosynthesis, and provide a plausible explana
108 espiration (aerobic and anaerobic), genes of fatty acid biosynthesis, and the principal genes of amin
109 he pentose phosphate pathway, nucleotide and fatty acid biosynthesis, and the tricarboxylic acid cycl
112 xy-3-methylglutaryl-coenzyme A reductase and fatty acid biosynthesis are known to be inhibited by the
114 s, and they suggest how microbes could alter fatty acid biosynthesis as an immune evasion mechanism.
115 t pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related
116 m the SREBP-1c-mediated regulation of common fatty acid biosynthesis, as well as by peptide uptake an
117 regulation, metabolism of alpha-glucans, and fatty acid biosynthesis, as well as genes affecting cell
118 identified genes involved in cholesterol and fatty acid biosynthesis, as well as genes involved in fa
120 cc2 background, because when ACC2 is absent, fatty acid biosynthesis becomes dependent on translation
121 oited for fuel and chemical production, with fatty-acid biosynthesis (beta-ketoacyl-ACP synthases) at
122 have previously shown that the difference in fatty acid biosynthesis between cancer and normal cells
123 have shown previously that the difference in fatty acid biosynthesis between cancer and normal cells
124 enzyme that catalyzes the committed step in fatty acid biosynthesis: biotin-dependent conversion of
125 tually divided into two blocks of reactions (fatty acid biosynthesis (Block A), lipid assembly (Block
126 enzymes FabA and FabZ catalyze a key step in fatty acid biosynthesis; both dehydrate hydroxyacyl fatt
127 ith acidic environments (F1F0-ATPase system, fatty acid biosynthesis, branched chain amino acids meta
128 fragment increases mRNAs encoding enzymes of fatty acid biosynthesis, but not sterol or isoprenoid bi
129 o detected in vivo by monitoring the rate of fatty acid biosynthesis by [(14)C]acetate labeling of ce
132 SIII) initiates straight- and branched-chain fatty acid biosynthesis by catalyzing the decarboxylativ
133 ases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase I (FAS I)
134 Applying this approach to study the rates of fatty acid biosynthesis by single cells of S. aureus gro
138 olites that are generated or utilized during fatty acid biosynthesis can significantly influence gene
139 The long-chain (>=C(20)) polyunsaturated fatty acid biosynthesis capacity of fish varies among sp
140 The genes encoding the components of type II fatty acid biosynthesis cluster at a single location wit
141 expressed candidate genes for straight-chain fatty acid biosynthesis confirmed their role in acylsuga
142 d with lipid droplets and that inhibitors of fatty acid biosynthesis decreased VLS formation or viral
143 lar level of malonyl-CoA, an intermediate in fatty acid biosynthesis, depends on its rate of synthesi
145 n biotin biosynthesis, protein synthesis and fatty acid biosynthesis, DNA repair, electron transfer,
146 panded gene families involved in unsaturated fatty acid biosynthesis, DNA repair, photoprotection, io
149 e transcription of genes encoding enzymes of fatty acid biosynthesis, e.g. fatty-acid synthase (FAS).
150 -ACP substrate bound to the Escherichia coli fatty acid biosynthesis enoyl reductase enzyme (FabI), b
151 ethylglutaryl-CoA (HMG-CoA) synthase and the fatty acid biosynthesis enzyme FabH, allow assignment of
152 adjacent to the active site cavities of the fatty acid biosynthesis enzymes and the high degree of s
153 ive expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that fatty acid d
157 ey enzymes involved in the type II bacterial fatty acid biosynthesis (FASII) pathway and are putative
159 DX1 in redox metabolism and carbohydrate and fatty acid biosynthesis, for FDX2 in anaerobic metabolis
160 mal peptide synthase family, and mycolic and fatty acid biosynthesis gene families were disproportion
161 ene, encoding a transcriptional regulator of fatty acid biosynthesis genes, contained 54.5% of these
163 (MCAT), a mitochondrial protein involved in fatty acid biosynthesis, has now been identified as resp
164 h a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of the
166 Dihomo-gamma-linolenic acid also inhibited fatty acid biosynthesis in 3T3-L1 preadipocytes and sele
167 Although coordination of astaxanthin and fatty acid biosynthesis in a stoichiometric fashion was
169 es the first committed and regulated step in fatty acid biosynthesis in bacteria and thus is a prime
171 sation reaction in the initiation of type II fatty acid biosynthesis in both Gram-positive and Gram-n
172 to identify potential feedback regulation of fatty acid biosynthesis in Brassica napus embryo-derived
173 arter units for straight- and branched-chain fatty acid biosynthesis in cell extracts of Streptomyces
175 ere is an associated increase in the rate of fatty acid biosynthesis in DENV-infected cells, and de n
176 nection between the regulator of unsaturated fatty acid biosynthesis in E. coli, FabR, thioesterase e
180 arrier proteins (ACPs) are the scaffolds for fatty acid biosynthesis in living systems, rendering the
184 scriminates against the streptomycete ACP of fatty acid biosynthesis in preference to RedQ, an ACP of
185 consistent with previous in vivo analyses of fatty acid biosynthesis in S. collinus, which suggested
187 In the current model of medium-chain (C8-14) fatty acid biosynthesis in seeds, specialized FatB acyl-
188 otein reductase enzyme FabI is essential for fatty acid biosynthesis in Staphylococcus aureus and rep
189 initiating both straight- and branched-chain fatty acid biosynthesis in Streptomyces and that the rat
190 diated transformation of fibroblasts induces fatty acid biosynthesis in the absence of significant ch
191 nses acetyl-CoA with malonyl-ACP to initiate fatty acid biosynthesis in the dissociated, type II fatt
192 nfirm the earlier speculation that elevating fatty acid biosynthesis in the leaf would lead to an inc
193 uted throughout North America and implicates fatty acid biosynthesis in the pathogenesis of macular d
194 yl-ACP synthase III (KASIII) which initiates fatty acid biosynthesis in the type II dissociable fatty
196 itor, cerulenin, markedly reduces tumor cell fatty acid biosynthesis in vivo; (d) fatty acid synthase
197 ns in ACC1 and FAS1, two genes important for fatty acid biosynthesis in yeast; ACC1 encodes acetyl co
200 boxylase (ACC), the key regulatory enzyme in fatty acid biosynthesis, in the arcuate nucleus (Arc) an
202 fatty acids is blocked by the addition of a fatty acid biosynthesis inhibitor, the organism is rende
203 ells treated with either excess SCFAs or the fatty acid biosynthesis inhibitors cerulenin and 5-(tetr
205 ate that this enzyme has a universal role in fatty acid biosynthesis, irrespective of the plant speci
209 nes, showed that the expression of genes for fatty acid biosynthesis is elevated in PI126449 glands,
212 s been replaced and the essential process of fatty acid biosynthesis is initiated by plasmid-based ex
215 loroplast accD locus, which is necessary for fatty acid biosynthesis, is essential in Arabidopsis but
216 , mtACP, as a key component of mitochondrial fatty acid biosynthesis, is important in generating the
217 which encodes the rate-controlling enzyme of fatty acid biosynthesis, is shown to be regulated by cel
218 Enoyl reductase (ENR), an enzyme involved in fatty acid biosynthesis, is the target for antibacterial
219 ACC catalyzes the first step in de novo fatty acid biosynthesis known to be downstream of the SR
220 oteins encoded in O-island 138, a cluster of fatty acid biosynthesis-like genes located adjacent to a
221 e cobamides biosynthesis, sterol metabolism, fatty acid biosynthesis, lipid metabolism, carotenoid me
222 imiting enzyme in long-chain polyunsaturated fatty acid biosynthesis, mediates the signature pattern
224 ction of ACC, the rate-controlling enzyme of fatty acid biosynthesis, occurs in the liver in response
226 l carrier protein (ACP), which allows native fatty acid biosynthesis of the Escherichia coli host to
227 bacterial metabolism is primarily fueled by fatty acids, biosynthesis of sugars from intermediates o
231 trols the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique reg
232 cancer, TGF-beta signaling, FoxO signaling, fatty acid biosynthesis, p53 signaling and apoptosis.
235 al structures for the enzymes of the type II fatty acid biosynthesis pathway can now be exploited in
239 ase enzyme in the Mycobacterium tuberculosis fatty acid biosynthesis pathway, we predicted its possib
242 uction of key enzymes of the cholesterol and fatty acid biosynthesis pathways, and thus membrane lipi
243 ses; among these are inhibitors of bacterial fatty acid biosynthesis, peptidoglycan synthesis, and di
245 f biosynthetic pathways in Escherichia coli: fatty acid biosynthesis, phospholipid biosynthesis, lipo
246 coenzyme A carboxylase (ACCase) function and fatty acid biosynthesis, plants with reduced or increase
248 insights through quantitative exploration of fatty acid biosynthesis processes for optimal biofuels,
249 A carrying fatty acids reduced the amount of fatty acid biosynthesis proteins to the same extent as p
250 the discovery of two genes encoding Type II fatty acid biosynthesis proteins: ACP (acyl carrier prot
251 ductase catalyses the last reductive step of fatty acid biosynthesis, reducing an enoyl acyl carrier
252 ductase catalyses the last reductive step of fatty acid biosynthesis, reducing the enoyl group of a g
253 and that drugs that regulate cholesterol and fatty acid biosynthesis regulate the replication of the
254 An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a m
255 duct inhibitors of the condensation steps in fatty acid biosynthesis, represent new classes of compou
258 characterization of the viral modulation of fatty acid biosynthesis revealed that a key enzyme in th
259 n implicated as a physiological inhibitor of fatty acid biosynthesis since acyl-ACP degradation by th
260 he level of malonyl-CoA (the intermediate of fatty acid biosynthesis) specifically in the Arc and inc
263 oorganisms, are made by a process resembling fatty acid biosynthesis that allows the suppression of r
264 represses genes involved in cholesterol and fatty acid biosynthesis that are transcriptionally regul
265 zymatic function for M. tuberculosis CitE in fatty acid biosynthesis that is analogous to bacterial c
266 his mutant lacks FabH, an enzyme involved in fatty acid biosynthesis that previously was thought to b
267 arboxylase (ACC) catalyzes the first step of fatty acid biosynthesis, the synthesis of malonyl-CoA fr
268 ependently; one is in fabZ, a dehydratase in fatty acid biosynthesis; the other is in thrS, the Thr-t
269 WRI1 target genes involved in glycolysis and fatty acid biosynthesis; these genes were down-regulated
270 pantothenamides is due to the inhibition of fatty acid biosynthesis through the formation and accumu
271 MV targets ACC1, the rate-limiting enzyme of fatty acid biosynthesis, through multiple mechanisms.
272 s associate with acyl-ACP as a mechanism for fatty acid biosynthesis to coordinate the expression, Fe
273 gent response enzyme SpoT appears to monitor fatty acid biosynthesis to govern transmission trait exp
274 This functional redundancy allows limited fatty acid biosynthesis to occur in the absence of heter
275 proteins (plastid-localized intermediates of fatty acid biosynthesis) to release 3-ketoacids and that
277 etabolism, Porstmann et al. demonstrate that fatty acid biosynthesis, under the transcriptional contr
278 ), a key enzyme initiating bacterial type II fatty acid biosynthesis, usually involve incubation of r
279 ntiseptic triclosan, which are inhibitors of fatty acid biosynthesis, validates this pathway as a tar
284 sis of central pathway architecture, E. coli fatty acid biosynthesis was re-cast into three modules:
285 conversion of malonyl-CoA to malonyl-ACP for fatty acid biosynthesis was shown to be active with TcmM
287 tive in producing primers for branched-chain fatty acid biosynthesis, was bypassed with one of a seri
288 coli acyl carrier protein (ACP), involved in fatty acid biosynthesis, was not bound to DltD and thus
289 accumulation of intermediate metabolites of fatty acid biosynthesis, we then questioned whether prot
290 acetyl-phosphate and subsequently leading to fatty acid biosynthesis were consistently upregulated du
291 fast light-responding genes in, for example, fatty acid biosynthesis were identified and allocated to
292 Proportions of bacterial genes involved in fatty acid biosynthesis were lower in feces from patient
293 acyl-acyl-carrier-proteins (intermediates in fatty acid biosynthesis) were hydrolyzed and decarboxyla
294 anges in proteins and transcripts related to fatty acid biosynthesis, whereas proteins and transcript
295 ly distinct from all known ketoreductases of fatty acid biosynthesis, which instead belong to the sho
296 els for known SREBP target genes involved in fatty acid biosynthesis, which led to significantly high
298 ied out the initial condensation reaction of fatty acid biosynthesis with acetyl-coenzyme A (acetyl-C
300 l-CoA carboxylase (ACC) and thereby inhibits fatty acid biosynthesis with submicromolar potency.