ライフサイエンスコーパス: favorable

1 conclusion, the portability scenario is not favorable.

2 y of the offered sensor were also found most favorable.

3 ng the secondary H-bonds from unfavorable to favorable.

4 both kinetically and thermodynamically most favorable.

5 germination when the external conditions are favorable.

6 omerization, is shown to be kinetically less favorable.

7 cating that the first-stage reaction is more favorable.

8 ers, DOAC pretreatment was associated with a favorable 3-month outcome (aOR 1.24; 1.01-1.51).

9 ich the wurtzite phase is energetically more favorable according to the theoretical prediction.

10 These properties appear to underpin the favorable activity and tolerability profiles of effectiv

11 data and as compared with FK506, GNF362 had favorable acute GVHD and GVL properties against MLL-AF9-

12 8 and 2019; these agents also demonstrated a favorable acute safety profile.Supplemental material is

13 Biological in vitro testing revealed favorable ADME and pharmacological profiles for the best

14 lating lipophilicity can be used to engineer favorable ADME properties into both rigid and flexible m

15 ation given its potent in vitro activity and favorable adverse effect profile.

16 x, 0.808 [95% CI, 0.807-0.809]) demonstrated favorable AF discrimination compared to CHARGE-AF (0.806

17 translocation is rapid and thermodynamically favorable after enzyme opening and pyrophosphate release

18 t into this enhancement deriving it from the favorable alignment of interfacial energy levels of DMAS

19 ns may be important resources for pyramiding favorable alleles for improved N and chlorophyll concent

20 ies, thereby suggesting an increasingly more favorable and efficient solution doping process when emp

21 n analysis yields intrinsic strengths of six favorable and four unfavorable atom-atom interactions, e

22 disease, the APOE4 and APOE2 variants confer favorable and poor outcomes in melanoma, respectively.

23 Learning valence-based responses to favorable and unfavorable options requires judgments of

24 We also find a prognostically favorable association between infiltration of mast cells

25 s-spectrum glucose levels, has several other favorable attributes including compact size, simple fabr

26 The synergy of favorable band energy alignment and concerted cascade in

27 nophen/opioid combination may provide a more favorable benefit versus risk ratio than an NSAID regime

28 The most favorable benefit-to-risk profile was observed at a dose

29 During self-assembly, the favorable binding energy competes with the energetic cos

30 erate hundreds of thousands of energetically favorable binding sites for a target ligand.

31 synthesis of novel drug-like molecules with favorable bioactivity and pharmacokinetic properties.

32 Finally, we determined MTP(10)-HDL's favorable biodistribution and safety profile in non-huma

33 Compound 2 exhibited more favorable biological and physicochemical properties than

34 These favorable biological responses to HN warrant studies on

35 Abeta-binding affinity and lipophilicity for favorable blood-brain barrier penetration, while the use

36 or 6-chlorotacrine results in compounds with favorable brain permeability and multiple activities in

37 h selectivity for the thermodynamically less favorable branched isomer.

38 d to socio-economic factors but also provide favorable breeding conditions for mosquitos.

39 The overall process is thermodynamically favorable but faces multiple kinetic barriers along the

40 To date, although a less favorable cardiovascular risk profile for Diclofenac as

41 he placebo group were in one of the two most favorable categories of the pulmonary outcome.

42 quaternary ammonium guests, originating from favorable cation...pai and (+)NC-H...pai interactions.

43 ymus-associated B cells correlated with less favorable changes in clinical symptom measures, steroid

44 r benefits, such as reduced inflammation and favorable changes in extracellular composition, in compa

45 ably, treatment with FMT was associated with favorable changes in immune cell infiltrates and gene ex

46 Dietary prebiotics produce favorable changes in the commensal gut microbiome and re

47 These favorable changes in the in utero environment normalized

48 rug fluoxetine-which also targets 2C-but has favorable chemical properties.

49 adapted first-line treatment of early-stage, favorable, classic Hodgkin lymphoma (ES-HL).

50 ranase recognizes HS substrate and selects a favorable cleavage site.

51 ase inhibitors should be balanced with their favorable clinical benefits compared with tamoxifen.

52 e changes were associated with a safer, more favorable clinical outcome for patients with COVID-19 pn

53 Notably, these patients had a dramatically favorable clinical outcome.

54 74%, respectively; P < .01), as well as more favorable clinical outcomes (96% vs 72%, respectively; P

55 uto, and CAR T recipients, we report overall favorable clinical outcomes for patients with COVID-19 w

56 Despite the generally favorable clinical outcomes of patients with HPV driven

57 The application of GM in RET led to favorable clinical outcomes of root development without

58 of patients, and these were associated with favorable clinical outcomes.

59 fidence interval {CI}, -11.9% to 1.2%]), and favorable clinical response at early follow-up was 61.0%

60 ing the early stage of COVID-19 could induce favorable clinical responses.

61 FO has the potential to be more economically favorable compared to ammonia air stripping or ion excha

62 lation ablation was found to be economically favorable compared with medical management in 95% of sim

63 s in cellular and in vivo models to identify favorable compound properties that can help drive the fu

64 per as a substratum that inherently produces favorable conditions for easy, rapid, and sensitive cont

65 a CA hexamer cavity results in energetically favorable conditions for passive translocation of dNTPs

66 compartmentalize their life cycle to provide favorable conditions for replication and to avoid the li

67 These favorable conditions tend to occur in the vicinity of a

68 survive at low metabolic cost and revive in favorable conditions.

69 subsequent development of progeny under more favorable conditions.

70 Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts

71 We determined the three most favorable conformations of this complex, which we identi

72 xidant and anti-inflammatory activities with favorable consumer's acceptance.

73 y with 90-day functional independence rates (favorable CT = 56% vs favorable CTP = 57%, adjusted odds

74 In favorable CT/unfavorable CTP profiles, EVT was associate

75 al independence rates (favorable CT = 56% vs favorable CTP = 57%, adjusted odds ratio [aOR] = 1.91, 9

76 e major hurdle in an otherwise energetically favorable cycloaddition.

77 Subsets including those with favorable cytogenetics, those lacking a mutation of FLT3

78 tein stability analysis of the VHH-Fcs shows favorable developability features, which enable them to

79 atalytically efficient and thermodynamically favorable diol formation pathway, created by expanding t

80 y be missed by antigen screening, some had a favorable disease course, but some had immunosuppression

81 This favorable diuretic profile may offer significant advanta

82 on the known planar nature of energetically favorable domain boundaries in ferroelectric materials,

83 polynuclear photosensitizers, (ii) the more favorable driving force for electron transfer, character

84 ed and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties

85 Outcomes in the favorable early hypoxia resolution subgroup significantl

86 andens increased in frequency during 30 y of favorable ecological conditions, resulting in genetic an

87 cific GLP-1 RAs and SGLT-2 inhibitors have a favorable effect on certain cardiovascular outcomes.

88 nts on hemodialysis, but have no significant favorable effect on VC progression.

89 ds revealed by Liu and Zhang et al. with the favorable effects (reduced mortality) that were describe

90 Conversely, the favorable effects of CR on health span are mitigated by

91 Overall, our results imply that the favorable effects of PRF membranes in alveolar ridge pre

92 Our results show that bempedoic acid has favorable effects on lipid profile and hsCRP levels and

93 in 2 and is hypothesized to have potentially favorable effects on pathways related to atherothrombosi

94 amics, it is demonstrated that alkalis bring favorable effects.

95 ostructure provides abundant interfaces with favorable electronic structure and coordination environm

96 Favorable electrostatic interactions between the dienoph

97 ynamics simulations confirm the existence of favorable electrostatic interactions between the high ch

98 nal spaces can exploit their confinement and favorable electrostatic interactions to finely control n

99 A favorable end-of-treatment outcome was reported in 86 pa

100 distinct swimming patterns to explore their favorable environments.

101 There was attenuation of favorable excursions in some metabolites in individuals

102 could be introduced as delivery system with favorable features under severe environmental conditions

103 be achieved instead of the thermodynamically favorable five-membered rings under appropriate conditio

104 Rerouted metabolism further promotes favorable fluxes in the TCA cycle and the gluconeogenesi

105 and limited H(2) in the feedstock gas is not favorable for CO(2) hydrogenation to methanol, causing l

106 own rice showed improved textural properties favorable for consumers.

107 sonal variability can also create conditions favorable for flooding, the enhanced precipitation relat

108 ng, which creates under-coordinated Ni sites favorable for H adsorption.

109 dosimetry of (18)F-rhPSMA-7.3 are considered favorable for PET imaging.

110 Low thermal conductivity is favorable for preserving the temperature gradient betwee

111 cells, leading to a protein environment more favorable for protein synthesis.

112 ally more hydrophilic cases were found to be favorable for recovering oil, despite greater interfacia

113 TA-Siglec-9 was safe and biodistribution was favorable for testing of the tracer in larger group of p

114 more hydrated and are electrostatically more favorable for the entry of ions.

115 delayed until host/phage ratio becomes more favorable for the release of progeny.

116 ization, such as gas turbines, make DAC look favorable for these units.

117 or lower prices by offering the drug company favorable formulary placement and fewer utilization cont

118 A favorable free energy pathway of late-stage functionaliz

119 an nudge PHEV drivers toward environmentally favorable fueling behavior.

120 Even though mostly favorable functional outcomes were reported throughout t

121 for the integration of multiple, clinically favorable functions into one suture device.

122 ve of D:A:D score, individuals with the most favorable genetic background may be protected against CK

123 r endangered if climate change leads to more favorable growth conditions.

124 gular yogurt consumption may contribute to a favorable gut microbiome and gut health, but few epidemi

125 rformance of NiO is still limited by lacking favorable H adsorption sites.

126 Because of the favorable half-life of (64)Cu, tracers labeled with this

127 typic analysis indicates that the BnNPC6.C01 favorable haplotype can increase both seed oil content a

128 ams for MRSA in select patients helps elicit favorable host cytokine responses.

129 neighboring nitrogen atoms and maximize the favorable hyperconjugative donation from each nitrogen a

130 has direct antitumor activity and induces a favorable immune microenvironment.

131 Taken together, these results suggest a favorable immune profile induced by ChAdOx1 nCoV-19 vacc

132 A favorable impact on both perceived and objective cogniti

133 Favorable improvements (expressed in common units of SD

134 ld-type-like structures remain energetically favorable in cohesin-depleted cells, potentially as a re

135 The NCB was particularly favorable in high-risk subgroups and those with multiple

136 ding contributions become energetically more favorable in that order for both C(2)H(2) and Si(2)H(2).

137 ibutions to the molecular energy become less favorable in the order dibridged -> trans-bent -> linear

138 enefit for rivaroxaban appeared particularly favorable in the patients with diabetes mellitus (2.7% v

139 dicted to be slightly more thermodynamically favorable in the polymerase relative to these DNA duplex

140 ved by small, drug-like molecules possessing favorable in vitro ADME profiles.

141 (99m)Tc-PHC-102 has previously shown favorable in vivo biodistribution properties in mouse mo

142 genetic polymorphism in in vitro assays, has favorable in vivo characteristics, and is able to accura

143 The results are less favorable in women with failed annuloplasty rings.

144 The favorable incorporation of Mg is attributed to Mg dopant

145 We then combined favorable individual changes to produce combinatorial mu

146 These data were used to assess favorable interactions and then to rebuild models of sea

147 The most favorable interactions are sp(2)O-sp(2)C (lone pair-pai,

148 orroborated by docking results demonstrating favorable interactions between 4-allyl-2,6-dimetoxypheno

149 bolite exchanges to determine evolutionarily favorable interactions between members, a feature missin

150 This autoinhibition is driven by favorable interactions between the DNA-binding surface o

151 with a precisely designed cavity that forms favorable interactions in the drug-protein complex.

152 2019-nCoV RBM (particularly Gln493) provide favorable interactions with human ACE2, consistent with

153 ble, with electron-rich rings providing more favorable interactions.

154 OS probabilities of 0.63, 0.43, and 0.33 for favorable-, intermediate-, and adverse-risk groups, resp

155 ion: (89)Zr-IAB22M2C imaging is safe and has favorable kinetics for early imaging.

156 n Zn(2+) and host O(2-) , which explains the favorable kinetics in PANI-intercalated V(2) O(5) .

157 38a2, the Slc38a1 transporter displayed more favorable kinetics toward the D-enantiomer.

158 unfavorable lipid desolvation, or solely by favorable lipid solvation on the cavities.

159 d the follow-up MLA, and was associated with favorable long-term clinical outcomes, warranting the pe

160 sability early on, whereas others ran a more favorable long-term course.

161 argeting of LM-MDSC could prime the TME in a favorable manner.

162 nanoscale resolution, and micromolding with favorable materials.

163 Patients with lean NAFLD had a more favorable metabolic and histological profile compared wi

164 nt of diabetes, have been shown to possess a favorable metabolic profile and to significantly reduce

165 s in the host signaling networks to create a favorable milieu for survival.

166 d mitigation of Buta toxicity is linked with favorable modifications in energy flux parameters of pho

167 ively interact with one of the receptors are favorable multifunctional chemical entities to treat or

168 ogue locks the system in the in-form while a favorable n-pai* interaction reverses the orientation of

169 Combining favorable nanomedicine designs from individual studies m

170 The primary outcome was favorable neurologic function at 6 months (Glasgow Outco

171 rature management 33 degrees C survived with favorable neurologic outcome, compared with 30% in the t

172 rvive to hospital discharge and survive with favorable neurologic outcomes than patients with pulsele

173 and the secondary outcome was survival with favorable neurological outcome (modified Rankin scale <3

174 enolate Pd complex was found to be the most favorable one, providing a good match with the stereosel

175 Monogenic diseases provide favorable opportunities to elucidate the molecular mecha

176 ifferent statin (or a lower dose) seem to be favorable options for improving statin adherence.

177 These favorable optoelectronic properties suggest CuPbSbS(3) t

178 All compounds devoid of B-H bonds show favorable optoelectronic properties, such as luminescenc

179 conditions for propagation, whether they be favorable or unfavorable, are often transient.

180 municate whether the benefit-risk profile is favorable or unfavorable.

181 ased design led to I-BET469, which possesses favorable oral pharmacokinetic properties, displays acti

182 chemically grafted 4-ABA not only leads to a favorable orientation of BOD as validated by fitting a k

183 ptomatic intracranial hemorrhage (sICH), and favorable outcome (modified Rankin Scale score 0-2) at 3

184 tion mutations, which were associated with a favorable outcome and uniquely observed in DLBCL.

185 aquiline, pretomanid, and linezolid led to a favorable outcome at 6 months after the end of therapy i

186 Patients were classified as having a favorable outcome at 6 months if they had resolution of

187 The favorable outcome derived from the time-to-event Kaplan-

188 breast cancer and are critical to achieve a favorable outcome from cancer.

189 expression is an independent predictor of a favorable outcome in breast cancers.

190 rity (MBEN) have been associated with a more favorable outcome in younger children.

191 Because of the favorable outcome of most patients with CML treated with

192 Here we report a genomic approach to predict favorable outcome to treatment responses thus enabling p

193 ks and the proportion of participants with a favorable outcome, respectively.

194 ts of 1-antigen-mismatched grafts had a less favorable outcome.

195 0%; 95% confidence interval, 83 to 95) had a favorable outcome.

196 n the lower anterior jaw region had the most favorable outcome.

197 eatment with dexamethasone resulted in fewer favorable outcomes and more adverse events than placebo

198 n and diagnosis remains critical to ensuring favorable outcomes for patients.

199 murine tumor models and have been linked to favorable outcomes in patients with cancer.

200 tment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger coh

201 quate numbers of injections are required for favorable outcomes, timely re-treatment of active diseas

202 -driven DLBCL, low CD4, and low DTI had less favorable outcomes.

203 ctral features were evident in patients with favorable outcomes; patients with BSP and unfavorable ou

204 Primary endpoint: favorable overall response (defined by relevant endpoint

205 OCSCC and LUSC patients with a favorable OXPHOG signature demonstrated a dramatic (>2fo

206 diffusion process due to the formation of a favorable pai-complex host-guest interaction.

207 RNAs as essential host factors, suggesting a favorable path during evolutionary adaptation.

208 Our results indicate that the most favorable pathway is a stepwise conjugate addition-Aldol

209 this organic nanocomposite is the result of favorable percolation networks on the nano- and micro-sc

210 The clinical and combined scores showed favorable performance for predicting a poor outcome (AUC

211 al clipping group (n = 349), VASOGRADE had a favorable performance for predicting delayed cerebral is

212 imulation and real data analyses demonstrate favorable performance over existing methods serving simi

213 r >= 150 ng/mL by week 8 was associated with favorable PFS and OS, while having prior episodes of PD

214 cles can deliver potent drug conjugates with favorable pharmaceutical properties.

215 increased in vitro activity, as well as more favorable pharmacokinetic and safety profiles than IP6 a

216 eased potency against the GRK2 subfamily and favorable pharmacokinetic parameters in mice.

217 ravtansine exhibited a manageable safety and favorable pharmacokinetic profile with encouraging preli

218 ic stability across species, and exhibited a favorable pharmacokinetic profile.

219 ilar or higher activity against nSMase2 with favorable pharmacokinetic properties.

220 ad molecules 13, 29, 32, 43, and 51 showed a favorable pharmacokinetics (PK) profile across different

221 g a clinically relevant TLR7 antagonist with favorable pharmacokinetics and 70.8% oral bioavailabilit

222 nclusion: (203)Pb-L1-(203)Pb-L5 demonstrated favorable pharmacokinetics for (212)Pb-based TRT.

223 GW2580, a selective CSF1R inhibitor, showed favorable pharmacokinetics for inhalational treatment an

224 l tetrasulfide to diacyl tetrasulfide due to favorable polar effects.

225 nel and observed that the most energetically favorable pose includes a TPN orientation that coordinat

226 Quite favorable prediction capabilities were observed in the c

227 20), none of the grading scores demonstrated favorable predictive accuracy for DCI (AUC < 0.750).

228 e-nucleotide polymorphism (SNP) represents a favorable predisposing factor leading to HHV-6A/B integr

229 With the favorable probability of benefit in all outcomes, this p

230 ed, neuroimaging core laboratory adjudicated favorable profiles based on predefined criteria (CT:Albe

231 Fifty-eight percent of the patients with favorable profiles on both modalities achieved functiona

232 Favorable profiles on the 2 modalities correlated simila

233 wer FN rates, detection of cancers with more favorable prognoses, and improved performance outcomes v

234 On survival analysis, a favorable prognosis was associated with opsoclonus, fema

235 t, and genetic alterations characteristic of favorable prognosis-with many tumors falling into multip

236 pecially among patients considered to have a favorable prognosis.

237 ertain aneuploidies is in fact linked with a favorable prognosis.

238 high treatment cost and decreased chances of favorable prognosis.

239 NTproBNP <=1000 has favorable prognostic implications in HF, but the prognos

240 also known as (18)F-SDM-8), which displayed favorable properties in monkeys.

241 pecific membrane antigen [PSMA]-7) has shown favorable properties regarding clinical performance and

242 llent air and water stability as a result of favorable radical-radical interactions, and their long-l

243 cilitating their enzymatic reaction rates at favorable reaction conditions.

244 r to play an important role in identifying a favorable response for a drug treatment for major depres

245 The association with a favorable response is even stronger in patients with rad

246 eated with ICB, we are unable to demonstrate favorable response to ICB in patients with PBAF complex

247 The rate of favorable responses was higher in patients with radiolog

248 The persistence of favorable results after 6 months has not been tested in

249 ing trials across phases, we find that early favorable results increase the likelihood of continuing

250 We again reveal favorable results, particularly in extracting wings.

251 e clinical and immunological features, and a favorable risk-benefit profile was maintained for <=96 w

252 pulation-based cohort study of 1386 men with favorable-risk (clinical stage cT1 to cT2bN0M0, prostate

253 ntemporary treatment approaches for men with favorable-risk and unfavorable-risk localized prostate c

254 ose-rate brachytherapy (n = 87) for men with favorable-risk disease and treatment with prostatectomy

255 The PC and GM groups showed favorable root development without inflammation and newl

256 free before DAPT discontinuation at 1 month, favorable safety and effectiveness through 1 year suppor

257 (n = 15) described long-term survival and a favorable safety profile among patients with a history o

258 ntihypertensive drug, guanabenz, which has a favorable safety profile and was recently reported to en

259 At Week 48, DOR at 100 mg had a favorable safety profile compared with EFV or DRV+r and

260 In summary, dabigatran showed a favorable safety profile for secondary VTE prevention in

261 IL-17A and has reported high efficacy with a favorable safety profile in various psoriatic disease ma

262 ib 500 mg once per day was associated with a favorable safety profile, prolonged disease control, and

263 4-6 years postdose 1 was immunogenic with a favorable safety profile.

264 CsA continued to maintain a favorable safety profile.

265 rived xenograft model of colon cancer with a favorable safety profile.

266 esign to only the most stable, energetically favorable sequence possibilities.

267 or chip in untreated serum samples indicated favorable simultaneous detection of picomolar (pM) insul

268 cellular permeability while retaining their favorable spectroscopic and photoreaction properties.

269 of CPR (8 of 8) survived with neurologically favorable status compared with 24% (24 of 102) of ALPS p

270 In favorable subgroups actual 5YS is above 50%.

271 The likelihood of neurologically favorable survival declines with prolonged resuscitation

272 Neurologically favorable survival was significantly higher in UMN-ECPR

273 mational stability of the WW domain due to a favorable synergistic effect that depends on the hydroph

274 n at early times after plasma onset owing to favorable temperatures for molecular formation.

275 lly expressed when larvae oscillated between favorable temperatures, while 614 transcripts were diffe

276 y at the ES(2) site is at least 0.16 eV more favorable than that at the other two potential binding s

277 C cohorts over the entire stage III are less favorable than those published in AJCCv8.

278 using nano-sized polymeric vector induces a favorable therapeutic effect, especially when in combina

279 fluvastatin, and pravastatin showed the most favorable therapeutic index and enhanced the antitubercu

280 th of normal bone marrow cells, suggesting a favorable therapeutic index.

281 timulatory and inhibitory signals to lead to favorable therapeutic outcomes.

282 We find that it is favorable to be freely swimming instead of tethered sinc

283 ety profile compared with EFV or DRV+r and a favorable tolerability profile compared with EFV.

284 narrower distribution are energetically more favorable toward the WGD transition.

285 ) demonstrating improved efficacy and a more favorable toxicity profile are poised to alter the lands

286 rease these biomarkers, demonstrating a more favorable toxicity profile in vivo.

287 , suggesting high diagnostic performance and favorable tracer kinetics for potential therapeutic appl

288 non-genetic mechanisms, can contribute to a favorable transcriptional program employed by tumor cell

289 ight not be a proper predictor of clinically favorable treatment outcome.

290 ns are needed for effective immunotherapy, a favorable tumor immune microenvironment is also critical

291 mary tumors of 5 patients was observed, with favorable tumor-to-background ratios.

292 high in aggressive compared with clinically favorable tumors (median Simpson index of diversity 0.45

293 The noninflammatory phenotype had the most favorable values for all measures.

294 suggest that ligand specificity derives from favorable Van der Waals interactions with a hydrophobic

295 er and had higher creatinine levels and less favorable vital signs.

296 rence between circadian clocks is considered favorable, we propose that hypoxia leads to circadian mi

297 f (hydrophobic) and with sp(2)N are modestly favorable, while sp(2)N interactions with sp(2)N and wit

298 -0.91], P=0.0005), which became increasingly favorable with longer treatment duration.

299 Overall, the safety profile was favorable without long-term side effects.

300 land Journal of Medicine, Wang et al. report favorable ZUMA-2 trial results of CAR T cells for patien