ライフサイエンスコーパス: feedback loop

1 10 to reduce nAcRbeta2 mRNA levels (negative feedback loop).

2 a inside the tumor mass, creating a positive feedback loop.

3 ance-dependent manner, indicating a positive feedback loop.

4 volution of the photodeposit in a continuous feedback loop.

5 ial dysfunction and IL-6 exist in a positive feedback loop.

6 cruit T cells to the skin through a positive-feedback loop.

7 e, thus creating a self-reinforcing negative feedback loop.

8 (NF)-kappaB activation as part of a negative feedback loop.

9 neurons, forming a transcriptional positive feedback loop.

10 expression in macrophages through a positive feedback loop.

11 IL-10 production in ILC2s through a positive feedback loop.

12 translation, thereby constituting a negative feedback loop.

13 of FlrA is down-regulated through a negative feedback loop.

14 the recruitment of each other in a positive feedback loop.

15 1 to inhibit its activity and close the core feedback loop.

16 in cells overlying LRP, creating a negative feedback loop.

17 s its own gene expression through a positive feedback loop.

18 y and promoting ATM activation in a positive feedback loop.

19 plifies amphiregulin signaling in a positive feedback loop.

20 tionally conserved transcription-translation feedback loop.

21 tion has two roles in the circadian negative feedback loop.

22 oncanonical NF-kappaB, creating a continuous feedback loop.

23 between voltage and Ca2+, forming a delayed feedback loop.

24 ntributes to induction of IRF5 in a positive-feedback loop.

25 ght modulator and a spectrometer providing a feedback loop.

26 s apoptosis in part by blocking the MDM2-p53 feedback loop.

27 family enter people into a proclimate social feedback loop.

28 ight act as signaling molecules in a complex feedback loop.

29 03 locus is directed by SNAIL2 in a negative-feedback loop.

30 specific positive Delta-like 4 (Dll4)-Notch1 feedback loop.

31 eby contributes to a complex mechanochemical feedback loop.

32 a substrate for an ultrashort autoregulatory feedback loop.

33 t-transcriptionally, establishing a positive feedback loop.

34 urther Mg(2+)-uptake completing a regulatory feedback loop.

35 f genes in oncogenic pathways via a positive feedback loop.

36 via PP2A inhibition, and thereby rescues the feedback loop.

37 put owing to disruption of the MDM2-negative feedback loop.

38 trol neuronal firing frequency in a negative feedback loop.

39 ytoskeletal structures through a biophysical feedback loop.

40 strocytic Ca(2+) and resulting in a positive-feedback loop.

41 gulates IL-12 secretion by DCs in a positive feedback loop.

42 al regulation between p63 and PABPN1 forms a feedback loop.

43 ulates PDLSCs activities by fine-tuning this feedback loop.

44 to autoregulate GH secretion via a negative-feedback loop.

45 ts production of LDL receptors, completing a feedback loop.

46 accelerating mass recruitment in a positive feedback loop.

47 utoregulation of GH secretion via a negative-feedback loop.

48 ng with transcription factors to form hybrid feedback-loop.

49 stems are composed of countless interlocking feedback loops.

50 d via transcriptional-translational negative feedback loops.

51 h interlocking transcriptional-translational feedback loops.

52 thin cortico-striato-thalamo-cortical (CSTC) feedback loops.

53 interactions or act as embedded sensors for feedback loops.

54 wn signaling output via positive or negative feedback loops.

55 from transcriptional and post-translational feedback loops.

56 of motor circuits or extrinsic sensorimotor feedback loops.

57 (s) are upregulated independently of protein feedback loops.

58 rmful mutations, can be achieved via protein feedback loops.

59 A-seq, to identify novel such autoregulatory feedback loops.

60 n by intracellular transcription-translation feedback loops.

61 clocks keep time via ~ 24 h transcriptional feedback loops.

62 regulating transcription- and chromatin-gene feedback loops.

63 hat microRNA-144 targets Dicer in a negative feedback loop, affecting global canonical microRNA expre

64 malformations-3), participate in a negative feedback loop among RhoA and its cytoskeletal effectors

65 sue damage and thereby results in a positive feedback loop, amplifying GBM necrosis development to it

66 y network composed of a fast-acting positive feedback loop and a delayed negative feedback loop, medi

67 patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop

68 This transcriptional feedback loop and associated network functions to variou

69 peractivation of YAP unbalances the YAP-SOX9 feedback loop and confers CSC-like features in ESCC, sug

70 ly enhancing plaque targeting via a positive feedback loop and dual action of cholesterol deposition

71 BP5 response to NF-kappaB through a positive feedback loop and was present in individuals with a hist

72 , icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcome

73 nt to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intri

74 ytes was found to be more complex, involving feedback loops and other receptor tyrosine kinases.

75 ms are generated by transcriptional negative feedback loops and require histone modifications and chr

76 ons for the switching properties of positive feedback loops and that these differences decrease with

77 ctivity results from a dysregulated positive feedback loop, and can be suppressed by overexpression o

78 ary by individual, be a key mechanism of the feedback loop, and help characterize network connections

79 atelets, cleaves coagulation proteins within feedback loops, and cleaves fibrinogen into fibrin, whic

80 rol through small molecules that act on both feedback loops, and we find that changes to the paramete

81 A physiological consequence of this positive feedback loop appears to be decreased GBM cell migration

82 poral properties of the recurrent inhibitory feedback loop are compatible with a role in reducing phy

83 at changes to the parameters of the negative feedback loop are much stronger inputs for shifting phas

84 ms such as tumor heterogeneity and adaptable feedback loops are prevalent issues facing cancer therap

85 There is also an important positive feedback loop as T(b) influences BMR(1-3).

86 mplexity of these nonlinear interactions and feedback loops at different levels of abstraction-from g

87 atin domains maintained by a self-templating feedback loop based on nucleosomes bearing the histone H

88 n models including as many as three putative feedback loops based on known biochemistry.

89 A feedback loop between Amazonian BVOCs and the trends of

90 These results revealed a negative feedback loop between appressorium formation and cell cy

91 aracterized in flowering plants, involving a feedback loop between class I KNOX genes and cytokinin [

92 Furthermore, a negative-feedback loop between Cxcl12 and its clearance receptor

93 A positive feedback loop between cytoskeletal signaling and membran

94 hese findings establish that pRPA provides a feedback loop between DNA resection and the DDR.

95 ssion via TGFbeta-SMAD2 signaling, forming a feedback loop between hypoxia and the matrix.

96 have previously identified an autoregulatory feedback loop between iASPP and p63, which is critical i

97 Overall these results suggest a positive feedback loop between lamellar disruption and cellular d

98 al inhibition of Bcl6, suggesting a positive feedback loop between MLL and BCL6.

99 In our model, contraction mediates a feedback loop between myosin-induced flow and advection-

100 The negative feedback loop between NMDARs and SK channels was blunted

101 that early-life stress initiates a positive feedback loop between peripheral inflammatory cells and

102 We identified a positive-feedback loop between PPARD and interferon gamma signali

103 This negative feedback loop between pressure and transport allows the

104 We and others previously reported a feedback loop between PROX1 and vascular endothelial gro

105 Here, we describe a transcriptional feedback loop between the biosynthesis and repertoire of

106 Model analysis further predicted a negative feedback loop between the persistent and resurgent gatin

107 We identified a regulatory feedback loop between the TF Foxa2 and a downstream lncR

108 duced by beta-catenin, triggering a positive feedback loop between the two proteins.

109 Thus, our study unravels a regulatory feedback loop between TORC1 and the Fab1 complex that co

110 New research suggests that a social feedback loop between young male zebra finches and adult

111 ar to facilitate this crosstalk and positive-feedback loops between multiple types of immune cells an

112 ct effects and by the disruption of positive-feedback loops between tumour cells and the bone microen

113 ical modeling, demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1

114 m negative translational and transcriptional feedback loops by the introduction of probabilistic time

115 Independent of the initiating event, this feedback loop can catastrophically propagate intramural

116 Lastly, we show that modulating this feedback loop can generate significant phenotypic divers

117 cal integration occurring through a positive feedback loop centred on FGF20, which induces cell aggre

118 hat governs circadian repression, leading to feedback loop closure.

119 and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status va

120 ocks are driven by transcription/translation feedback loops composed of positive transcriptional acti

121 h demonstrates that a negative MYC-eIF2alpha feedback loop constitutes a targetable vulnerability of

122 otential pathogenic mechanism that acts as a feedback loop contributing to the progression of IIM.

123 Initiation activates a feedback loop, controlled by a second hitherto unrecogni

124 We demonstrate that this autoregulatory feedback loop controls cell migration in cSCC by blockin

125 ically, we demonstrate how density-dependent feedback loops couple population growth and antibiotic e

126 In the negative feedback loop driving fungal and animal circadian oscill

127 d methods, suggesting an amplifying positive feedback loop due to increasing gRNA dosage.

128 activation in a microglia-astrocyte positive feedback loop during brain inflammation.

129 e when miR-144 represses Dicer in a negative-feedback loop during erythropoiesis.

130 f Brachyury is supportive of a Wnt-Brachyury feedback loop during PAE in S. kowalevskii, establishing

131 The recurrent feedback loop effectively carried frequencies up to 100

132 provides a temporal compartmentalization of feedback loops, enabling duration-dependent desensitizat

133 sm offers robustness to a dynamic epigenetic feedback loop ensuring long-term centromere inheritance.

134 en becomes self-sustained through a positive feedback loop established among the tumor-secreted facto

135 a simple model capable of capturing the key feedback loop: evolutionary history shapes tradeoff stre

136 el activity, thereby establishing a positive feedback loop for PI(4,5)P(2) microdomain compartmentali

137 However, experimentally establishing this feedback loop for the control of expression relationship

138 diates body temperature decrease, a negative feedback loop for thermoregulation.

139 ngage in early metabolism, which created the feedback loop for transcription and cell formation.

140 ed via the environment offer new pathways of feedback loops for population regulation.

141 B signaling network to test the necessity of feedback loops for responses to pulsatile and continuous

142 Thus, we propose a feedback loop formed by CtBP, cholesterol, and TGF-beta

143 , we present a novel mechanism of a positive feedback loop, formed by a reciprocally activating kinas

144 pool through a transcriptional-translational feedback loop from the synaptic terminal to the nucleus.

145 These feedback loops from muscle contraction and mechano-trans

146 The feedback loop further enables prolonged production of Bi

147 rway collapsibility, chemoreceptive negative feedback loop gain, and arousal threshold.

148 A feedback-looped heating system, utilizing a 980-nm fiber

149 eas that have captured both elements of this feedback loop-host-pathogen dynamics and cultural transm

150 hanical load regimes and altered dynamics of feedback loops, illustrate that the waiting time distrib

151 ur studies reveal a surprising role for this feedback loop in maintaining synaptic vesicle pools in t

152 Overall, our results reveal a negative feedback loop in the miRNA pathway mediated by the trans

153 ownregulation of Sox2, suggesting a negative-feedback loop in the tooth.

154 Depletion of Zeb1 disrupts this positive feedback loop in the tumor perivascular niche, which eve

155 d our results are consistent with a positive feedback loop in which amino acids bound to self-assembl

156 can be generated by a time-delayed negative feedback loop in which Plk4 inactivates the interaction

157 This closes a feedback loop in which senescence acts as a crosspoint f

158 We also identified a positive feedback loop in which TGF-beta signaling promotes expre

159 y regulate endocytic trafficking by creating feedback loops in cells to enhance tumor progression.

160 ities in the active cytoskeleton network and feedback loops in the biochemical network of activators

161 s are building blocks of "mini-homeostasis": feedback loops in which one component responds to a stim

162 ated mechanism relies on the inhibition of a feedback-loop in the JNK-pathway by the immune effector

163 gulate their expression levels by a negative feedback loop, in which RBP binds its own pre-mRNA and c

164 illator relies on a negative transcriptional feedback loop, in which the PERIOD (PER) and TIMELESS (T

165 EBPdelta as a link that engages two positive feedback loops, in part by directly targeting the IL-6 r

166 These perspectives represent two halves of a feedback loop: individual behaviour scales up to define

167 ic feedback loop and a long-range inhibitory feedback loop interact.

168 We describe an optical feedback loop involving both partners of the association

169 This redistribution likely involves a feedback loop involving the DNA methyltransferase, CHROM

170 wn, our results suggest the possibility of a feedback loop involving these two genes, with the CTNNB1

171 substrate (MARCKS) and two newly considered feedback loops involving the lipid, phosphatidic acid (P

172 ngle-molecule characterisation intertwine, a feedback loop is generated between disciplines, providin

173 nock-in mouse in which the p53-Mdm2 negative feedback loop is genetically disrupted.

174 This negative feedback loop is mediated by two translation inhibitors,

175 the membrane voltage is a global signal, the feedback loop is then a delayed global feedback (DGF) lo

176 This positive feedback loop is thought to be important for the establi

177 nd suggest that the function of the positive feedback loop is to stabilize the oscillations while lin

178 hosphorylation, regulated via a Ca(2+)-based feedback loop, is an important component in the adaptati

179 es can trap populations within a reinforcing feedback loop known as the extinction vortex, in which s

180 symptoms influencing each other by creating feedback loops, leading to a self-sustained syndromic co

181 r, disruption of the Falcor-Foxa2 regulatory feedback loop leads to altered cell adhesion and migrati

182 signaling is regulated by a robust negative feedback loop mediated by TBK1 and IKKepsilon.

183 ere, we uncovered an NFIB-calpain 1-positive feedback loop mediated through CAST and calcineurin.

184 one (GH) secretion is controlled by negative-feedback loops mediated by GH-releasing hormone (GHRH)-

185 ositive feedback loop and a delayed negative feedback loop, mediated by upregulation of ubiquitin-spe

186 itions are mediated by a mutually inhibitory feedback loop-microRNA-200/ZEB-driven by the levels of t

187 the endopeptidase PepO suppresses the ComRS feedback loop, most likely by degrading the XIP/ComS fee

188 endent pool of CDK1-CCNB1 creates a positive feedback loop necessary for timely recruitment of MPS1 t

189 the deep ocean to the atmosphere, a positive feedback loop not included in most future projections of

190 ned in cSCC, epigenetic dysregulation of the feedback loop occurs at the microRNA level by a previous

191 imiting further glucose uptake in a negative feedback loop of "glucose-dependent" insulin resistance.

192 cells, which is likely to create a positive feedback loop of cellular senescence within the adipocyt

193 testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-m

194 ed executive functioning creates a potential feedback loop of diabetic dysglycaemia leading to brain

195 actor in spatially coordinating the negative feedback loop of its own genetic circuit.

196 A TaVrt2-mediated positive feedback loop of TaVrn1 during vernalization was propose

197 s period driven by transcription-translation feedback loops of specific genes, which are referred to

198 physiologically-based model of the two main feedback loops of the mammalian molecular clock, which p

199 nt interpretation could be altered by adding feedback loops or morphogen cascades to receiver cell re

200 This feedback loop orchestrates the dual control of fat oxida

201 hanical load regimes and altered dynamics of feedback loops, presenting the same variation of pattern

202 by interlocked transcriptional-translational feedback loops, producing oscillations in the expression

203 disparate triggering of a cytokine negative feedback loop promotes tuning of macrophage responses in

204 -loop mechanism for a classic autoregulatory feedback loop proposed ~25 years ago.

205 nce mediated by FOXM1-Nedd4-VDAC2/3 negative feedback loop provides an initial framework for creating

206 The resulting positive feedback loops rapidly lock larvae into evolving greater

207 and that a general and conserved Hsp70-HSF1 feedback loop regulates cellular proteostasis in yeast.

208 However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood.

209 properties, such approaches lack an internal feedback loop required for automatic manipulation.

210 aling and activate Dyn1 to create a positive feedback loop required for rapid recycling of EGFR and b

211 These YAP-dependent feedback loops result in a switch-like change in the sig

212 K3beta) signaling pathway through a positive-feedback loop, resulting in N-Myc stabilization.

213 configuration is realized through a built-in feedback loop rooted in the photothermal and mechanical

214 cadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and pos

215 sFceRI contributes to a negative regulatory feedback loop that aims at preventing overshooting respo

216 be a GC-specific, AKT-kinase-driven negative feedback loop that attenuates BCR signaling.

217 et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in

218 nstitutes a potentially detrimental positive feedback loop that can only be attenuated through the re

219 terone-induced miRs may represent a negative feedback loop that contributes to a form of aldosterone

220 onstitute a previously unrecognized negative feedback loop that contributes to CD8 T cell adaptations

221 ion, suggesting the presence of a regulatory feedback loop that controls p53 levels and functions dur

222 ock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior t

223 Social interaction can be seen as a dynamic feedback loop that couples action, reaction, and interna

224 RPEL-family rhoGAPs thus provides a negative feedback loop that couples Rac activity to actin dynamic

225 ivity of these proteins, creating a negative feedback loop that dampens upstream BCR signaling.

226 M129A regulated both PERK and eIF2alpha in a feedback loop that differentially channeled the UPR outp

227 between Spd-2, Polo and Cnn form a positive feedback loop that drives the dramatic expansion of the

228 to an unexpected CDK9-dependent compensatory feedback loop that elevated Pol II pause release rates a

229 induces VCP expression, creating a positive feedback loop that enhances degradation.

230 dependent proton secretion, and is part of a feedback loop that ensures acidification of the luminal

231 nd Hsp90, in turn, participate in a negative feedback loop that ensures appropriate coordination of t

232 ncer cell signaling through a self-enforcing feedback loop that expands the glycocalyx and furthers c

233 Their combination constitutes a positive feedback loop that exponentially amplifies their antimic

234 revealing a MUS81-triggered and ATR-mediated feedback loop that fine-tunes MUS81 activity at replicat

235 These mutants thus appear to lack a negative feedback loop that inhibits DSB formation when homologs

236 ult C. elegans males employ a neuroendocrine feedback loop that integrates food detection and genetic

237 the basis for the formation of the negative feedback loop that interrelates cell volume and its cont

238 s FBP1 and PRC2 are part of a novel negative feedback loop that is deregulated in liver and kidney ca

239 microglial phagocytosis provides a negative feedback loop that is necessary for the long-term mainte

240 apeutic strategies that disrupt the positive feedback loop that leads to persistent airway constricti

241 able motif, i.e., a self-sustaining positive feedback loop that maintains an associated state, we int

242 inflammatory signaling, and an ATF4-mediated feedback loop that maintains de-differentiation.

243 ubsides, placing the receptors in a negative-feedback loop that may contribute to the resolution of t

244 to collided ribosomes to initiate a negative-feedback loop that prevents new ribosomes from translati

245 -1alpha expression, which creates a positive feedback loop that promotes FLT-1 expression leading to

246 orylation at Ser(384) constitutes a negative feedback loop that regulates DSB repair.

247 nctionally coupled, forming a local negative feedback loop that restrains the excitatory effect evoke

248 form a functional Ca(2+) -dependent negative feedback loop that restrains the excitatory effect on me

249 ms are driven by a transcription-translation feedback loop that separates anabolic and catabolic proc

250 Here, we identify a neuroendocrine feedback loop that sex-specifically regulates odr-10 in

251 tive pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents

252 ity, suggesting that Zta may contribute to a feedback loop that would limit its own expression, thus

253 olecular systems built from self-reinforcing feedback loops that can spontaneously switch between her

254 gulatory networks involving self-stabilizing feedback loops that convert small differences into long-

255 ted by interlocked transcription-translation feedback loops that establish cell-autonomous biological

256 ck consists of transcriptional/translational feedback loops that generate rhythms.

257 SARS-CoV-2 infections could create positive feedback loops that increase ACE2 levels and facilitate

258 s interlocking transcriptional-translational feedback loops that regulate gene expression and consequ

259 ving as the frequency-selecting element in a feedback loop, the phase noise at the extremum amplitude

260 y, however, instead of generating a negative feedback loop, the signals oppositely polarize, establis

261 pendent lasR induction initiating a positive feedback loop through the small RNA, Lrs1.

262 urthermore, it unravels an activity-mediated feedback loop through which neuronal activation during C

263 ight junctions, which establishes a positive feedback loop to accommodate lumen growth.

264 lling and experimental data demonstrated the feedback loop to act as a scalable converter of unimodal

265 esterol (7-DHC) accumulation form a positive feedback loop to amplify innate immune responses to cont

266 e proof-of-concept illustrated here, using a feedback loop to couple in situ material characterizatio

267 switch protein, thereby providing a positive feedback loop to ensure successful completion of the vir

268 lncRNA Falcor functions within a regulatory feedback loop to fine-tune the expression of Foxa2, main

269 tivity, demonstrating an unexpected positive feedback loop to persistently promote pain.

270 sembly to PI3K activation to form a positive feedback loop to support lateral membrane extension.

271 IL1beta and TNFalpha established a feedback loop to upregulate ARG2 expression via p38 and

272 rate the control strategy involving multiple feedback loops to yield two successive division cycles.

273 PM mice than negative feedback or OVX (open feedback loop) trains in all three animal models, but th

274 lock consists of a transcription-translation feedback loop (TTFL) composed of CLOCK-BMAL1 transcripti

275 ining transcriptional-translational negative feedback loop (TTFL) in which the negative regulators Pe

276 e arm of the clock transcription-translation feedback loop (TTFL), causes down-regulation of c-MYC, a

277 characterised transcriptional/translational feedback loop (TTFL), whilst the SCN circuit as a whole

278 ll-autonomous, transcriptional/translational feedback loops (TTFLs), active in all tissues.

279 acellular transcription-translation negative feedback loops (TTFLs).

280 e propose a model based on a double-negative feedback loop, vertically transmitted via the entero-mam

281 Chemotherapeutic drugs triggered a positive feedback loop via ATM/E2F1/STAT signaling, amplifying th

282 addition, this approach reveals a molecular feedback loop via the COP1/SPA E3 ubiquitin ligase compl

283 ng in the plaques by establishing a positive feedback loop via the reciprocal regulation of SR-A and

284 that AN may arise from pathological positive feedback loops: voluntary food restriction activates SIR

285 th both in vitro and in vivo, and a negative feedback loop was discovered between DGAT1, PEDF, and GM

286 In 4T1BR5 cells, there was a positive feedback loop whereby astrocytic BDNF induced cancer cel

287 ed glucocorticoid secretion, demonstrating a feedback loop whereby stressful stimuli activate RFRP ne

288 ment initiation occurring through a positive-feedback loop wherein surface-deposited C3b participates

289 d investigated the JNK-AP-1-RUNX1 regulatory feedback loop, which can be modulated by VEGF.

290 and Bub1 form a distance-dependent positive feedback loop, which spatiotemporally may act as a tensi

291 ta-catenin and Tspan8 are part of a positive feedback loop, which sustains a high Tspan8 expression l

292 se interactions form an engine-like positive feedback loop, which sustains a shared elongation rate f

293 tion factor forms a positive transcriptional feedback loop with Notch3 that is critical in CCA.

294 effector acquisition which forms a negative feedback loop with T-bet to preserve the identity of CCR

295 the aorta, which participates in a positive feedback loop with the impaired vascular mitochondrial f

296 ecific movements is maintained by a positive feedback loop with the thalamus.

297 m a regulatory system consisting of negative feedback loops with time delays and that BMP9 would trig

298 servations that define positive and negative feedback loops within the network.

299 egative arm of the transcription/translation feedback loop without affecting period length.

300 These data suggest that signaling feedback loops work to restrain or maintain cellular lys