ライフサイエンスコーパス: feedback regulation

1 cytokines, which induced SOCS3 for negative-feedback regulation.

2 of wild type levels as a result of disturbed feedback regulation.

3 tream target of FoxOs in NVP-BEZ235-mediated feedback regulation.

4 n specifying network outputs and fine-tuning feedback regulation.

5 omplex, providing for both reinforcement and feedback regulation.

6 es and pulsatility, and is not responsive to feedback regulation.

7 nded the model to explore mechanisms of Atf3 feedback regulation.

8 1 in DKO mice, suggesting impaired bile acid feedback regulation.

9 immunizations to bypass TE-mediated negative feedback regulation.

10 sis and is therefore subjected to allosteric feedback regulation.

11 ing opens calcium-activated ion channels for feedback regulation.

12 of COPD status, possibly reflecting negative feedback regulation.

13 orption and vitamin A production by negative feedback regulation.

14 uence specificity reflecting its efficacy in feedback regulation.

15 were similarly regulated by TCRbeta-mediated feedback regulation.

16 GluR1, thereby constituting a useful form of feedback regulation.

17 ally after genetic removal of a key negative-feedback regulation.

18 r loss of mRNA, suggesting the potential for feedback regulation.

19 /E)L sequence that is essential for negative feedback regulation.

20 mutation causes a defect in telomere length feedback regulation.

21 ription, consistent with previously reported feedback regulation.

22 s is required to integrate the weight-growth feedback regulation.

23 ules at the same site for the most efficient feedback regulation.

24 ial gene expression patterns and ABA pathway feedback regulation.

25 volve by optimizing the strength of negative-feedback regulation.

26 ly caused by the lack of proteasome-mediated feedback regulation.

27 receptor-mediated signaling and its negative feedback regulation.

28 n is controlled by a BCO1-dependent negative feedback regulation.

29 Negative feedback regulation also constrains the range of QS outp

30 e also provide evidence of auto-, para-, and feedback regulation among these factors at the transcrip

31 etwork interactions that correspond to known feedback regulations among multiple network species and

32 IGCR1 is also required for feedback regulation and allelic exclusion of proximal V(

33 ssue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signali

34 SHP2 inhibition blocks this feedback regulation and growth-promoting IR signaling, p

35 citrate synthase (HCS), is the target of the feedback regulation and is strongly inhibited by l-lysin

36 el mechanism of PI3K-AKT inhibition-mediated feedback regulation and may identify FoxO as a novel bio

37 The feedback regulation and mechanical-biochemical integrati

38 en concentrations via hypothalamic-pituitary feedback regulation and prolonged ligand half-life.

39 s the protein at a constant rate without any feedback regulation, and any form of feedback (positive,

40 -translational modifications, its metabolite feedback regulation, and its enzyme organization is high

41 -translational modifications, its metabolite feedback regulation, and its enzyme organization.

42 erating multiple states is an alternative to feedback regulation, and its general principle should be

43 ture on expression variability and implicate feedback regulation as an effective mechanism to ensure

44 mics and plant development and reveals tight feedback regulation at both the transcriptional and prot

45 t the hypothesis that ABA signaling is under feedback regulation at the level of isoprenylcysteine me

46 We found that positive feedback regulation at the sre1(+) promoter increases th

47 metabolism in cardiomyocytes, and a negative feedback regulation between CBS and CSE in the heart.

48 ing sequence of CCN1) disrupted the positive-feedback regulation between CCN1/alpha6beta1 and nuclear

49 echanical stimuli and suggest activity-based feedback regulation between components of caveolae and t

50 and TNF-alpha in RA monocytes, suggesting a feedback regulation between IL-7/IL-7R and TNF-alpha cas

51 ression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFAT

52 Together, our findings suggest that positive feedback regulation between Lhx8, TrkA, and NGF is an im

53 ether, these findings demonstrate a negative feedback regulation between TRIM21 and HuR, which may pl

54 ic analysis reveals no evidence for negative feedback regulation, but provides evidence that the choi

55 , cyclic ADPR, H(2)O(2), NAADP, and negative feedback regulation by AMP and permeating protons (pH).

56 hing is subject to a dual and interdependent feedback regulation by chemoreceptors.

57 iosynthesis in B. fragilis and is subject to feedback regulation by CMP-Kdo.

58 hTR-/hTERT-E1A mRNA differential, evidencing feedback regulation by E1A.

59 metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related

60 We further demonstrate feedback regulation by finding that ZBP1 physically asso

61 (2+)-dependent inactivation, a fast negative feedback regulation by incoming Ca(2+) ions, which depen

62 response to 2-APB, and strikingly different feedback regulation by intracellular Ca(2+).

63 GTPCH-1 undergoes negative feedback regulation by its end-product BH(4) via interac

64 ax2 seedlings, which could indicate negative feedback regulation by KAR/SL signaling.

65 The lacustrine Si:C atomic ratio is negative feedback regulation by phytoplankton, which may result i

66 hese results also explain the known negative feedback regulation by PTEN on its own synthesis through

67 s of several protein cofactors is subject to feedback regulation by riboswitches.

68 trate that PI3K/AKT signals enforce positive-feedback regulation by suppressing PTEN function.

69 crassa, by removing the endogenous negative feedback regulation by the circadian oscillator.

70 tic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast grow

71 tive distal nephron (ASDN) is under negative-feedback regulation by the renin-angiotensin-aldosterone

72 Negative feedback regulation correlated with increased systemic T

73 , we classify these observations as negative-feedback regulation due to the deficient BMP antagonism

74 l3 complexes also provide essential negative feedback regulation during both thymocyte development an

75 to models of stochastic gene expression and feedback regulation elucidates that isolated lineages, a

76 GE expression is under negative feedback regulation; endogenous GE expression is upregul

77 s and also demonstrate the important role of feedback regulation for the polarization toward distinct

78 Moreover, our data suggest a feedback regulation in amiR-cpgi plants that fine-tunes

79 RT6, revealing the existence of LD and FOXO3 feedback regulation in colonic cells.

80 pha and indicate the existence of a positive feedback regulation in excitotoxicity involving calpain

81 (2+) signaling axis could enforce a positive feedback regulation in gastric cancer progression.

82 Our research underscores the importance of feedback regulation in generating robust and adaptable b

83 tial firing and shape calcium influx through feedback regulation in mature neurons.

84 Chellamuthu et al. now identify a feedback regulation in plant nitrogen metabolism through

85 ing for NMD and demonstrate that reversal of feedback regulation in response to NMD perturbation is c

86 hich ubiquitin ligases cooperate and provide feedback regulation in the clearance of misfolded protei

87 Our findings support a model of feedback regulation in which RNase L and TTP target SRF

88 Thus, our studies identify a compensatory feedback regulation in which the activation of Akt is in

89 terminals, show two types of Ca2+-dependent feedback regulation-inactivation (CDI) and facilitation

90 n but then undergo various forms of negative feedback regulation including voltage- and calcium-depen

91 We further demonstrate how this negative feedback regulation insulates alternative sigma factor a

92 his constitutes a complete endocrine system; feedback regulation involving amino acids regulates alph

93 ty in cell cycle activity to double-negative feedback regulation involving CDK2, p21, and E3 ubiquiti

94 observed sarcomere length-dependent positive feedback regulation is a key determinant in the length-d

95 We suggest that sRNA-mediated feedback regulation is a network design feature that per

96 -STAT activation due to loss of LNK negative feedback regulation is a novel mechanism of MPN pathogen

97 ork replete with interpathway cross-talk and feedback regulation is broadly appreciated, kinetic data

98 Feedback regulation is conferred by different branches o

99 that the resulting tissue selective negative feedback regulation is essential to establish sex-specif

100 Evidence is provided that positive feedback regulation is independent from commensal germs

101 ndent Cav-1 phosphorylation in eNOS negative feedback regulation is investigated.

102 This feedback regulation is responsible for the transient act

103 matory cytokine signaling through a negative feedback regulation loop involving down-regulation of TL

104 the existence of an ATAF2-BAS1/SOB7-BR-ATAF2 feedback regulation loop, as well as a light-ATAF2-BAS1/

105 construction of kinase-substrate network and feedback regulation loops downstream of SDF-1/CXCR4 sign

106 sis is maintained in part by transcriptional feedback regulation loops that control the expression of

107 e nature of this complex and interconnecting feedback regulation makes it difficult to dissect the mo

108 Feedback regulation may occur when the concentration of

109 n gastric cancer cells, enforcing a positive feedback regulation mechanism.

110 In addition to classic feedback regulation mediated by a rise in extracellular

111 of purine precursors is under tight negative feedback regulation mediated by adenosine and guanine nu

112 We specifically tested the role of feedback regulations mediated by G1- and SG2M-phase cycl

113 elease probability, and we suggest that this feedback regulation might be required to maintain synaps

114 data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate sy

115 Thus feedback regulation of a shared component can restrict t

116 regulated by Sir-based silencing, providing feedback regulation of a silencing protein by silencing.

117 Feedback regulation of adaptive immunity is a fundamenta

118 ss was blocked by HSL inhibition, suggesting feedback regulation of adipocyte lipolysis via CD36 traf

119 Negative feedback regulation of ALAS-1 by the end product heme is

120 lts yield new insights into the mechanism of feedback regulation of an enzyme central to lysine biosy

121 orylation, implicating a role for Srx in the feedback regulation of AP-1 activity.

122 erve to override the autoinhibitory negative feedback regulation of ARF2 on its own transcription and

123 f Egr1 was lost, demonstrating that negative feedback regulation of Atf3 by Atf3 itself is implausibl

124 de-reactive CD4(+) Treg involved in negative feedback regulation of autoimmunity use a highly limited

125 These results reveal a novel negative feedback regulation of BCR signaling by HPK1-mediated ph

126 Negative feedback regulation of bile acid synthesis mediated by t

127 (FGF19) plays a crucial role in the negative feedback regulation of bile salt synthesis.

128 Overall, GABA(B) receptors do contribute to feedback regulation of bipolar cell transmitter release.

129 We also demonstrate that feedback regulation of both the activity and the abundan

130 ncy seemed to reflect disruption of negative feedback regulation of c-MPL signaling by the E3 ligase

131 Phosphorylation-mediated negative feedback regulation of cAMP levels by phosphodiesterase

132 Ca(2+)/CaM mediates a negative feedback regulation of Cav1.2 by incoming Ca(2+) ions (C

133 Feedback regulation of cell lineage dynamics alone howev

134 Feedback regulation of cell lineage progression plays an

135 ablishes that the ORMDL proteins mediate the feedback regulation of ceramide biosynthesis in mammalia

136 ns, when crossed into a line lacking calcium feedback regulation of cGMP synthesis, produced much lar

137 lifetime in normal rods are also dampened by feedback regulation of cGMP synthesis.

138 Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cel

139 ith increased PCSK9 expression, suggesting a feedback regulation of cholesterol on LASER expression.

140 n multiple cytokines by both feedforward and feedback regulation of common signaling intermediates an

141 d that all three pigmentation genes exercise feedback regulation of conidiation.

142 The mechanism suggests feedback regulation of Ctf19c assembly and unanticipated

143 We have investigated the feedback regulation of cytokine-induced iNOS expression

144 TRPC3 channels also provide negative feedback regulation of cytosolic Ca(2+), mediated by a C

145 it through degradation, suggesting negative feedback regulation of damage-induced cell-cycle checkpo

146 Interestingly, the feedback regulation of DBL-1/BMP signaling by collagens

147 We now identify feedback regulation of DBL-1/BMP through analysis of fou

148 The type of feedback regulation of DGKepsilon by PA depends on the p

149 S by IFN-I meditates the subsequent positive feedback regulation of DNA-triggered IFN-I production.

150 with elevated AVP release compromises normal feedback regulation of ENaC in Adx mice in response to c

151 Thus, loss of paracrine ATP feedback regulation of ENaC in Cx30(-/-) mice disrupts n

152 The negative feedback regulation of epidermal growth factor receptor

153 Studying negative feedback regulation of Erk in genetic experiments at thr

154 c signaling by strong activation of negative feedback regulation of Erk signaling.

155 Feedback regulation of Ero1p through reduction and oxida

156 demonstrate a key role for integrins in the feedback regulation of excitatory synaptic strength.

157 nds appeared to act by reducing the negative feedback regulation of FAAH activity by free ethanolamin

158 er-expression of PDAT1, indicating a lack of feedback regulation of FAS in tgd1-1.

159 l of this research was to identify potential feedback regulation of fatty acid biosynthesis in Brassi

160 activity through inhibition of CYP1 disturbs feedback regulation of FICZ levels, with potential detri

161 DNA.RNA triplex formation may participate in feedback regulation of genes in cis.

162 factor 1 (IGF1) resistance, and a defect in feedback regulation of GH.

163 in cocaine-evoked neuronal activity-mediated feedback regulation of glutamatergic synapses.

164 tions, nongenomic effects may play a role in feedback regulation of GnRH secretion.

165 biquitin ligase component and a mechanism of feedback regulation of GPCR signaling.

166 ted degradation significantly contributes to feedback regulation of HMGCR in vivo Results of these st

167 paired glucocorticoid receptor (GR)-mediated feedback regulation of HPA function, since cocaine self-

168 ultiple mechanisms contribute to the overall feedback regulation of HVA-mediated I(Ca) by estradiol.

169 These data indicate that feedback regulation of immediate-early and early genes o

170 are metabolic hormones that provide natural feedback regulation of immune function.

171 hat this "FOXO-to-FOXO" signaling occurs via feedback regulation of ins-7 insulin gene expression.

172 gnaling pathway that is involved in negative feedback regulation of insulin action.

173 Our findings show that feedback regulation of insulin gene expression coordinat

174 Negative feedback regulation of insulin signaling involves ubiqui

175 excitation-transcription coupling or normal feedback regulation of ion channels blocked by PAHs.

176 Inhibition of PKC relieves negative feedback regulation of IP3 accumulation and, thereby, sh

177 Thus, feedback regulation of IR trafficking and function by cl

178 promoter region, which indicated a positive feedback regulation of KPNB1 expression mediated by the

179 These spinal reflexes could contribute to feedback regulation of locomotor body undulations and to

180 gest novel molecular mechanisms for negative-feedback regulation of MAVS by vIRF-1 during virus repli

181 +-activated K+ (BK) channels encode negative feedback regulation of membrane voltage and Ca2+ signali

182 hieved through metabolite sensing coupled to feedback regulation of metabolic enzyme activity or expr

183 ition, it was demonstrated that the negative feedback regulation of miR-146 on NF-kappaB activation m

184 We found coordinated positive feedback regulation of mRNA for ZEB1 and beta-tubulin is

185 ning the complex with UNAM for the efficient feedback regulation of murein biosynthesis and by primin

186 S-Nitrosylation mediates the feedback regulation of N-type channels by NO.

187 This defective feedback regulation of NF-kappaB by IkappaBalpha not onl

188 e demonstrate that the IkappaBalpha-mediated feedback regulation of NF-kappaB has an essential role i

189 ogical significance of IkappaBalpha-mediated feedback regulation of NF-kappaB, we generated mice harb

190 el mechanism by which HS suppresses negative-feedback regulation of Nlrp3 inflammasome to enhance IL-

191 EGFR activation without the feedback regulation of normal degradation leads to uncon

192 ular quality control pathways to bring about feedback regulation of normal proteins is a unifying the

193 Short-term feedback regulation of Ntcp by primary bile salts has no

194 ovided a novel approach to understanding the feedback regulation of olfactory signal transduction pat

195 Atf3 is required for negative feedback regulation of other genes, but is itself subjec

196 adeoff is most likely mediated by allosteric feedback regulation of phosphofructokinase and ADP-gluco

197 ating the proposed ephaptic mechanism for HC feedback regulation of photoreceptor Ca(2+) channels, ou

198 signal via yet unknown target proteins in a feedback regulation of photosynthesis.

199 ious work has shown that there is reciprocal feedback regulation of PI3K and AR signaling in PCa, sug

200 d a key role for tachykinins in the positive feedback regulation of platelet aggregation and thrombus

201 s its transcriptional activity, suggesting a feedback regulation of PPARgamma transcriptional activit

202 the NEDA neurons, may facilitate homeostatic feedback regulation of prolactin release.

203 these dopamine/GABA neurons had no effect on feedback regulation of prolactin secretion.

204 but these neurons are not necessary for the feedback regulation of prolactin secretion.

205 volvement of cis-carotenoid metabolites in a feedback regulation of PSY1 gene expression.

206 extent of the anaerobic response by negative feedback regulation of RAP2.12.

207 lso function in mammals and mediate an early feedback regulation of receptor signaling.

208 gonist-stimulated EC monolayers via negative-feedback regulation of Rho signaling, stimulation of act

209 ents included the discovery of translational feedback regulation of ribosomal protein synthesis and t

210 ntially physiologically significant negative feedback regulation of RyR activity on Na(v)1.4 properti

211 PS25) in MDM2-mediated p53 degradation and a feedback regulation of S25 by p53.

212 sclosed a role for sphingolipids in negative feedback regulation of serine metabolism, we investigate

213 s upstream of 5-HT neurons provides negative feedback regulation of serotonergic firing to modulate a

214 tudies have identified an important negative feedback regulation of SLP-76 by HPK1 (hematopoietic pro

215 (cells are "on" or "off") is predicated upon feedback regulation of SOS.

216 Orm protein phosphorylation mediating feedback regulation of SPT activity occurs in response t

217 ent in a signaling pathway that mediates the feedback regulation of starch breakdown by sucrose, pote

218 n or eye results from abrogation of negative feedback regulation of STAT6 activation and CCR7 express

219 uctase (HMGR) both possess SSDs required for feedback regulation of sterol-related genes and sterol s

220 ial step of telomerase activation as well as feedback regulation of telomerase by telomere length, wh

221 PhuS-dependent flux of heme through HemO to feedback regulation of the cell surface signaling system

222 Y repressor complex is critical for negative feedback regulation of the circadian clock of mammals.

223 ly nuclear import of PER/CRY in the negative feedback regulation of the circadian clock.

224 nes in a stepwise manner by initial positive feedback regulation of the Etv1 gene itself followed by

225 Ralpha signaling pathways to convey estrogen feedback regulation of the female hypothalamic-pituitary

226 In agreement with homeostatic feedback regulation of the GA biosynthetic pathway, we f

227 oint to activated Cdc42 providing a positive feedback regulation of the GEF activity of p220.

228 We also found evidence for TRA-1 feedback regulation of the global sex-determination path

229 exogenous cortisol further established that feedback regulation of the hypothalamic-pituitary-adrena

230 resistance, provides novel insights into the feedback regulation of the Lia system, and demonstrates

231 a striking photosynthetic phenotype in which feedback regulation of the light reactions was strongly

232 This is the first evidence of feedback regulation of the menaquinone biosynthesis path

233 including small RNAs that mediated negative feedback regulation of the miRNA pathway and miR390-depe

234 The mechanism involves cooperative feedback regulation of the near-terminal pathway enzyme

235 y identify cell type-specific differences in feedback regulation of the PI3K pathway.

236 the mouse BCR is subject to general negative feedback regulation of the receptor proteins, as well as

237 predicts a role for calcium in the negative feedback regulation of the ROP1 activity.

238 vascular fibrotic responses through negative feedback regulation of the TGF-beta pathway.

239 and is thought to be important for negative feedback regulation of the Th1 response.

240 emonstrate cell type specific differences in feedback regulation of the ubiquitous PI3K pathway.

241 defect in thymic HPC homing, suggesting the feedback regulation of thymic progenitor homing by thymi

242 have characterized the ontogeny of negative feedback regulation of thyrotrope function and examined

243 To investigate whether GABA is involved in feedback regulation of TIDA neurons, we examined the phy

244 pose tissue to liver and a possible negative feedback regulation of tissue inflammation that may inst

245 lation of Ron by LPS could provide classical feedback regulation of TLR signaling.

246 on of corticotropin-releasing factor and its feedback regulation of TLR4 expression, likely contribut

247 Feedback regulation of transcription factor NF-kappaB by

248 tory loops of the circadian clock consist of feedback regulation of transcription/translation circuit

249 Disruption of this uORF stops the ascorbate feedback regulation of translation and results in increa

250 ne that is required for T4-mediated negative feedback regulation of TSH expression.

251 er fertilization and that TH-driven negative feedback regulation of tshb transcription appears in the

252 Here, we sought to identify possible feedback regulation of VEGFR2 by calpain via its substra

253 These data implicate calpain/PTP1B negative feedback regulation of VEGFR2, in addition to the primar

254 ered a capacity for intensive, and specific, feedback-regulation of miRNA targeting activity directly

255 2-ERK signaling pathway and demonstrated the feedback regulation on MEK, ERK1/2, delta-catenin, and P

256 ddition, c-Myc was shown to exert a positive feedback regulation on ROCK by increasing RhoA mRNA expr

257 they help establish GA homeostasis by direct feedback regulation on the expression of GA biosynthetic

258 her genes, but is itself subject to negative feedback regulation possibly by autorepression.

259 An entirely new level of feedback regulation -- post-transcriptional regulatory m

260 However, the underlying mechanisms of such feedback regulation remain incompletely understood.

261 hibitors is associated with loss of negative feedback regulation, resulting in phosphorylation and ac

262 tate of insulin resistance due to a negative feedback regulation, resulting in reduced Akt phosphoryl

263 high sterol levels, recapitulating the same feedback regulation seen at the endogenous LDLR locus.

264 Presumably, this considerable degree of feedback regulation serves to promote a robust and stabl

265 f the transcription factor required for this feedback regulation, sterol regulatory element-binding t

266 e by SA and is thus a key part of a negative feedback regulation system of SA levels during senescenc

267 ely result from a disturbance in the complex feedback regulation system of the HPG axis, which involv

268 nd conversion to retinoids is under negative feedback regulation that adapts this process to the actu

269 ent characteristic features for each form of feedback regulation that can aid in their identification

270 These data identify positive feedback regulation that couples age-dependent MMP-1-cat

271 the identification of an additional level of feedback regulation that depends on the negative transcr

272 the molecular underpinnings of this positive feedback regulation that enhances neuronal sensitivity t

273 mponents could establish a means of positive feedback regulation that maintains an active growth site

274 -466l expression within human macrophages, a feedback regulation that most likely prepares for homeos

275 ion and degradation is an important negative feedback regulation that specifically terminates Akt act

276 ne protein Crumbs and bypassing the negative feedback regulation that targets the same expanded enhan

277 rform a systematic analysis of mechanisms of feedback regulation that underlie short-term adaptation

278 Negative feedback regulation, that is the ability of a gene to re

279 ific isoform expression and by BET-dependent feedback regulation through distal regulatory elements.

280 trate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the

281 appaB activation is controlled by a negative feedback regulation through the ubiquitin editing enzyme

282 CNS-derived serotonin synthesis and central feedback regulation to control HSC numbers.

283 -TCF/LEF complexes may function primarily in feedback regulation to control levels of beta-catenin an

284 his finding points to a remarkable degree of feedback regulation to create resilience in the auxin re

285 g cell fate decisions, often employ positive feedback regulation to establish and stabilize new cellu

286 Thus, the embryo rewires its feedback regulation to meet two different developmental

287 transport and Cl-dependent tubuloglomerular feedback regulation to occur over a wider Cl concentrati

288 We conclude that positive feedback regulation to up-regulate Sre1 precursor synthe

289 of the PTR is transcriptional-translational feedback regulation (TTR), common to all circadian syste

290 The forward feedback regulation we describe here between GIV and STA

291 To identify components critical for this feedback regulation, we performed a genetic screen for A

292 of stochastic gene expression with nonlinear feedback regulation, we reveal the relationship between

293 an unexpected component of opioid-dependent feedback regulation, where low levels of opioid receptor

294 the PITX2 and Wnt pathway exerts a positive feedback regulation, whereas frizzled receptors generate

295 ERalpha is involved in the estrogen negative feedback regulation, whereas hypothalamic ERalpha is nec

296 Interestingly, TNF-alpha has a feedback regulation with TLR5 expression in RA monocytes

297 Lack of transcriptional and translational feedback regulation within the CLPPR gene family indicat

298 ity, potential novel functions for PTEN, and feedback regulation within the pathway.

299 Ls may function as signals to provide direct feedback regulation within the plant to calibrate defens

300 at targeted mutants with defects in negative feedback regulation yielded a fully viable arrhythmic st