ライフサイエンスコーパス: female-specific

1 s not to determine sex or to be functionally female specific.

2 wild type, Sxl would seem to be functionally female specific.

3 d in both samples, and the associations were female specific.

4 The effect is female specific.

5 Most drug effects appeared to be female-specific.

6 dorsolaterally in the female AL appear to be female-specific.

7 to CGRP after two distinct stimuli are also female-specific.

8 eases in anxiety-like behavior and IL-6 were female-specific.

9 aggression and confirmed that the effect was female-specific.

10 ntial gonad and subsequently become male- or female-specific.

11 hich recombinant TRA/TRA2 could activate the female-specific 5'-splice site of fru.

12 pheromone 11-cis-vaccenyl acetate (cVA) and female-specific 7,11-dienes influence courtship behavior

13 By using monoclonal antibodies against female-specific A. gambiae salivary gland proteins, two

14 le of these loci, revealing them as the most female-specific accessible regions genome-wide.

15 s but not in the case of males, resulting in female-specific activation of apoptotic genes.

16 tive GC1 (soluble guanylyl cyclase) mediates female-specific, adaptive RV pressure-overload remodelin

17 f which two were male specific and four were female specific; all were ancestry specific.

18 This is because m(6)A is required for female-specific alternative splicing of Sxl, which deter

19 ibility to arthritis) and disease onset were female specific and were identified on chromosomes 3, 7,

20 ether the facts that (1) the ix phenotype is female-specific and (2) functions at the end of the sex

21 Four female-specific and 2 male-specific neuroticism risk loc

22 e ability of hTRA-2 alpha to regulate dsx is female-specific and depends on the presence of the dsx s

23 t vitamin D(3)-mediated protection in EAE is female-specific and E(2)-dependent suggests that declini

24 The three female-specific and five male-specific transcripts are t

25 Acute responses to meningeal CGRP are female-specific and sensitization to CGRP after two dist

26 We validated seven female-specific and two sex-associated markers in a larg

27 This makes the W (female-specific) and the Z chromosomes an excellent mode

28 kcrosses to distinguish among male-specific, female-specific, and zygote-specific sources of transmis

29 tative A. gambiae odorant receptors exhibits female-specific antennal expression and is down-regulate

30 less-expressing neurons and examined whether female-specific apoptosis in these lineages accounts for

31 Seven dimorphic lineages also had female-specific arbors.

32 A new female-specific arthritis-severity recessive locus was i

33 nel Piezo convey the signal of copulation to female-specific ascending neurons, LSANs, in the ventral

34 x-specific effects were only a few, e.g. the female-specific association between VAT and O-methylasco

35 We also identify a Latino female-specific association in RAP1GAP2.

36 otypes and other complex traits, including a female-specific association with frontotemporal dementia

37 cts identified four genomic regions, showing female-specific associations with diastolic BP or pulse

38 Insects carrying a female-specific autocidal genetic system offer an attrac

39 alternative splicing in insects to engineer female-specific autocidal genetic systems in the Mediter

40 The adult UBR3-/- mice had female-specific behavioral anosmia.

41 uces male-typical behaviors while disrupting female-specific behaviors.

42 hat Trpc2-/- female mice show a reduction in female-specific behaviour, including maternal aggression

43 fic sexual behavior to control one module of female-specific blood-feeding behavior in a deadly vecto

44 avioral responses at doses up to 3.8 mug are female-specific both acutely and following central and p

45 mones in organizing and activating male- and female-specific brain circuits and have uncovered new me

46 onstrate that gld-1(null) germ lines express female-specific, but not male-specific, molecular marker

47 ) for fatal cancer; and 0.37 (0.12-0.87) for female-specific cancers.

48 overall) were most commonly associated with female-specific cancers: endometrial cancer in 83 (30%)

49 correspond to either the non-specific or the female-specific carcass and the testis-specific transcri

50 3.0-kb testis-specific transcript, a 4.5-kb female-specific carcass transcript, a 3.5-kb ovary-speci

51 male Swiss Webster mice detected a potential female-specific cDNA, designated Y2.

52 neurons in the ventral nerve cord undergoes female-specific cell death that is DSX(F)-dependent.

53 tive expression of WNT ligands, and profound female-specific changes in mesenchymal and epithelial lu

54 There were female-specific changes in metabotropic glutamate recept

55 and how these inputs are processed to direct female-specific changes that occur in response to mating

56 Female-specific characteristics increasing stroke risk i

57 result of the lack of recombination in this female-specific chromosome.

58 Female-specific chrXi:autosomal translocations result in

59 controls the expression of key factors in a female-specific circuit.

60 pheromone function to a previously described female-specific compound.

61 initially focused on reproductive health and female-specific conditions.

62 controls the rate-limiting step in producing female-specific contact sex pheromone (CSP) that stimula

63 Further, this "female-specific crossover maturation inefficiency" is in

64 ore frequently with other males that secrete female-specific cuticular hydrocarbon pheromones, but no

65 es of male courtship behavior in response to female-specific cuticular hydrocarbons.

66 : male-biased BCL6, which was repressed, and female-specific CUX2, which was induced.

67 deficiency resulted in the repression of the female-specific Cyp2a4 and expression of the male-specif

68 le liver and can strongly trans-activate the female-specific CYP2C12 promoter.

69 s in females), whereas OT knockdown produces female-specific deficits in gregariousness, pair bonding

70 ta-analysis, we identified 439 male- and 297 female-specific DEGs in all cell types, with 32 genes in

71 bedding ELS (1) produces an early emerging, female-specific depressive phenotype that responds to a

72 We show that VPO is controlled by a pair of female-specific descending neurons (vpoDNs).

73 dependent on both DSXF and HER controls the female-specific differentiation of the foreleg bristles

74 ions between cells in mosaic females lead to female-specific disease manifestations.

75 sion molecule, how its mutations bring about female-specific disorders remains elusive.

76 a and tra-2 of both a 5' splice site and the female-specific doublesex (dsx) 3' splice site, suggesti

77 ndantly to direct female differentiation and female-specific doublesex pre-mRNA splicing.

78 athway, which is positively regulated by the female-specific doublesex protein (DSXF).

79 her activate Takeout expression, whereas the female-specific Doublesex protein represses takeout inde

80 first empirical demonstration of the strong female-specific drive predicted by new models of selfish

81 ogether, our studies identify LINC00473 as a female-specific driver of stress resilience that is aber

82 so evident by the up- and down-regulation of female-specific Ds-Yolk protein 1 (Ds-Yp1) gene expressi

83 midline crossing is repressed in females by female-specific Dsx (Dsx(F)).

84 h the male-specific DSX(M) represses and the female-specific DSX(F) activates transcription of yolk p

85 gaster encodes both male-specific (DSXM) and female-specific (DSXF) polypeptides, which are required

86 However, Atp10A(-/-) mice displayed female-specific dyslipidemia characterized by elevated p

87 thought to be mediated by numerous male- and female-specific effector genes whose expression is contr

88 ssion, and structural plasticity, along with female-specific effects on vHIP-dependent behaviours.

89 evealed that GR transcriptional activity has female-specific effects, whereas male mice can compensat

90 x differences in THC metabolism, including a female-specific elevation in the bioactive metabolite 11

91 In addition, we observed female-specific elevation of phosphorylated MARCKS level

92 Pcgf3/5 gene knockout results in female-specific embryo lethality and abrogates Xist-medi

93 by maternal RNAi or CRISPR-Cas9 resulted in female-specific embryonic lethality.

94 ining genes specify execution capability and female-specific enhancement of courtship behavior throug

95 We examined whether estrogen modulates the female-specific EOD and, if so, whether it regulates EOD

96 expression of ERbeta, we observed dramatic, female-specific exacerbation of intestinal inflammation

97 of the Tcdsx pre-mRNA were identified in the female-specific exon and the adjoining intronic sequence

98 lation of nonsynonymous substitutions in the female-specific exon occurred at less than linear rate r

99 id rate than either the common domain or the female-specific exon.

100 ated on the domain common to both sexes, the female-specific exons, and the and male-specific exon.

101 a steroid hydroxylase cytochrome P450 whose female-specific expression in adult rat liver is transcr

102 signal element genes (XSEs) that induce the female-specific expression of Sxl are transcribed extrem

103 Female-specific expression of the fourth gene, fit (fema

104 Unlike the chicken Z chromosome, which has female-specific expression of the noncoding RNA MHM (mal

105 Furthermore, this female-specific expression pattern is dependent on the p

106 utations, which inappropriately activate Sxl female-specific expression.

107 Although several female-specific factors have been shown to be early indi

108 ail and present evidence suggesting that the female-specific fl(2)d(1) allele is antimorphic with res

109 egypti, was engineered to have a repressible female-specific flightless phenotype.

110 It is expressed in male- and female-specific forms and these proteins function as sex

111 that, in the case of the Georgian Jews, the female-specific founder event appears to have resulted i

112 enhancer located immediately upstream of the female-specific fru 5' splice site and are recognized by

113 e-specific pattern through activation of the female-specific fru 5' splice site.

114 Activation of female-specific fru splicing requires cis-acting tra and

115 The TIF pathway may represent an ancestral female-specific function acquired by Sxl in an early evo

116 Here, we uncover a female-specific function of G9a and demonstrate that del

117 Genes involved in female-specific functions moved onto the X chromosome wh

118 ally female specific not because it lost non-female-specific functions, but because those functions a

119 allowed Sxl to lose essential ancestral non-female-specific functions, we determined the CG3056 null

120 efine when Sxl might have lost ancestral non-female-specific functions, we isolated and characterized

121 cestor of melanogaster Sxl ever shed its non-female-specific functions.

122 helial tissue and ALOX15 from blood) and one female-specific gene (HLA-DQA1 from epithelial tissue) t

123 this is the first observation of exclusively female-specific gene activity during preadult developmen

124 ublesex, typically involved in fat body- and female-specific gene activity in Diptera.

125 Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary r

126 response to a male stimulus, is a model for female-specific gene regulation.

127 ism for Lepidoptera that functions without a female-specific gene.

128 he XY(DSD) gonad, and high activation of the female specific genes, including FOXL2, RSPO1, CYP19A1,

129 rentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulate

130 We characterized four novel, male- or female-specific genes and found that all are expressed m

131 genes within 4 days; however, several highly female-specific genes showed weak or no feminization, ev

132 Both genes are physically linked to female-specific genes that encode proteins expressed in

133 rect CUX2 binding was seen at several highly female-specific genes that were positively regulated by

134 a biologically plausible candidate gene for female-specific genetic determination of RV function, sh

135 a biologically plausible candidate gene for female-specific genetic determination of RV function, sh

136 ata imply a major role for XCI in generating female-specific, genetically directed, stochastic divers

137 We performed male- and female-specific genome-wide association studies in 2653

138 5b gene disruption also led to the loss of a female-specific, GH-regulated hepatic CYP2B enzyme.

139 Female-specific gout data are scarce despite perceived d

140 in local tissues act together to specify the female-specific growth of the larval body.

141 patient cohort, model simulations predicted female-specific guidelines for CRT, which were 9-13 ms l

142 A female-specific high density linkage map was built for S

143 n the two sites previously described for the female-specific histamine-binding protein (FS-HBP), the

144 ether this male/female difference was due to female-specific hormones such as estrogen, the hearts of

145 /Ca2+ exchanger can be overcome partially by female-specific hormones such as estrogen.

146 For example, downregulation of the female-specific hub gene Dusp6 in mouse prefrontal corte

147 by intrathecal xestospongin C attenuated the female-specific hypersensitivity induced by MBP(84-104).

148 al CGRP were not specific to rats as similar female-specific hypersensitivity responses were seen in

149 G9a deficiency causes a failure of XCI and female-specific hypersensitivity to drug inhibition of H

150 (protoperithecia) and chemotropic growth of female-specific hyphae (trichogynes) towards a cell of t

151 nd EGCs and identify DUSP9 as a regulator of female-specific hypomethylation.

152 d with higher markers of bone remodeling and female-specific impairments in cortical and trabecular b

153 Furthermore, we observed a female-specific increase in transcriptomic and proteomic

154 These data strongly suggest that the female-specific increasing risk of MS is mediated throug

155 specific expression of the fourth gene, fit (female-specific independent of transformer), is not cont

156 he short integument (sin1) mutation causes a female-specific infertility, and a defect in the control

157 partially permissive in mice and results in female-specific infertility.

158 Consistent with the female-specific inheritance pattern of FDH, Porcn hemizy

159 ally, AcIr76b mutants manifest significantly female-specific insemination deficits, and although AcIr

160 Our study demonstrates that the female-specific isoform of Dsx collaborates with Hox gen

161 Two male-specific and one female-specific isoforms of T. castaneum transformer (Tc

162 Male- and female-specific isoforms of the Doublesex (DSX) transcri

163 ikely to be the molecular transducer for the female-specific KOR component of spinal morphine antinoc

164 A screen for female-specific larvicides that facilitate Aedes aegypti

165 One adult female-specific lectin was identified as mannan-specific

166 ects homozygous for a dominant, repressible, female-specific lethal gene system are used.

167 that loss-of-function mutations in the flex (female-specific lethal on X) gene caused female-specific

168 ex (female-specific lethal on X) gene caused female-specific lethality because flex(+) acts as a posi

169 es are deficiencies that cause lethality and female-specific lethality in a piwi2 mutant background,

170 tion suppression via sex ratio distortion or female-specific lethality is also explored.

171 llow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipu

172 oth MSL1 and MSL2 in females results in 100% female-specific lethality.

173 s but not females pass the pulse, results in female-specific lethality.

174 Repression of female-specific lincRNAs in male liver, but not that of

175 Here we investigated whether CUX2, a highly female-specific liver transcription factor, contributes

176 Candidate female-specific loci were evaluated against invasively m

177 Candidate female-specific loci were evaluated against invasively m

178 This study identified 2 novel female-specific loci, and 1 male-specific locus.

179 former in chromosomal females eliminates the female-specific Lon isoform expression, Lon proteolytic

180 ce, although viable, display fully penetrant female-specific lymphoproliferative disorder.

181 imals, suggesting a possible explanation for female-specific lymphoproliferative disorder.

182 The proarrhythmic effects of BPS were female specific; male rat hearts were not affected by BP

183 o and ovarian tumor (otu) are expressed in a female-specific manner in embryonic germ cells, consiste

184 fic markers and activating the expression of female-specific markers.

185 Our work demonstrates a female-specific mechanism for the promotion of chronic p

186 action for CGRP in migraine and suggest that female-specific mechanisms downstream of CGRP receptor a

187 regions predicted to be most susceptible to female-specific meiotic drive, but we found a significan

188 single decision is used, a male-specific or female-specific meiotic entry would lead necessarily tow

189 l mutant of matrimony, a gene that encodes a female-specific meiotic regulator of Polo kinase,(3)(,)(

190 that the Anopheles gambiae protein AgOr1, a female-specific member of a family of putative odorant r

191 Female-specific molecular changes potentially account fo

192 The expression of a female-specific mouse lacrimal gland mRNA that encoded p

193 The female-specific neo-W chromosome of the African monarch

194 odel can account for both high mean rates of female-specific nondisjunction in Drosophila and humans

195 that Drosophila Sxl may appear functionally female specific not because it lost non-female-specific

196 upted in male splice variants but not in the female-specific one.

197 of neuropathic injury, we observed a robust female-specific onset of mechanical hypersensitivity in

198 sformation of synaptic inputs into male- and female-specific outputs that generate sexually distinct

199 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity.

200 Activation of female-specific oviposition descending neurons (oviDNs)

201 Among associated loci, 412 were female-specific (P(female) <= 5 x 10(-8); P(male) > 5 x

202 ha2 urinary globulin (alpha2u) genes and the female-specific P450 2C12 gene was down-regulated by som

203 epresent a unique pharmacological target for female-specific pain control.

204 y recognized as an important factor in pain, female-specific pain signaling is not well studied.

205 However, a female-specific pathway that is dependent on both DSXF a

206 One is a female-specific pathway, which is positively regulated b

207 der CSD, while another putative QTL showed a female-specific pattern consistent with either a sex-dif

208 The female-specific pattern of CYP2C12 expression is thus pr

209 al males into pseudo-females and confers the female-specific pattern of Lon isoform expression, Lon p

210 licing from the male-specific pattern to the female-specific pattern through activation of the female

211 We unambiguously defined male- and female-specific patterns of gene expression during Arabi

212 minal ganglion neurons directly activate the female-specific pC1 neurons.

213 ted RNA from 800 uL blood was analyzed using female-specific pfs25 and male-specific pfmget or mssp q

214 ly, we show that the production of male- and female-specific piRNAs is conserved in all four species,

215 such as Sxl, snf, ovo and otu which control female-specific processes in the ovary.

216 -function activity in males: it promotes the female-specific processing of tra pre-mRNAs.

217 which our results suggest is related to the female-specific production of the sex pheromones ascr#1

218 ta), alternatively spliced male-specific and female-specific products of the doublesex (dsx) gene pla

219 the bipotential somatic gonad to promote the female-specific program.

220 ific expression systems (e.g., early-acting, female-specific promoters) in insects other than Drosoph

221 mous feminizing signals was known to involve female-specific protein encoded by the master sex-determ

222 d inhibition of translation by Sex-lethal, a female-specific protein operating at the top of the sex

223 ads to the inference that ix may require the female-specific protein product of the doublesex (dsx) g

224 f positional candidate genes showed that the female-specific QTL failed to complement a P-element ins

225 This female-specific QTL, which we name Fsia1, is located on

226 With this data set, we identified 26 female-specific RAD loci, putatively located on the W ch

227 3a13 shares 92% nucleotide identity with the female-specific rat CYP3A9, its expression does not exhi

228 CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose

229 ttribute these observations to high rates of female-specific recombination near the chromosomal ends

230 chronic variable stress model to precipitate female-specific reduction in sucrose preference and perf

231 These results identify female-specific regulation of LXA4-producing tissue PMN

232 We also show that female-specific regulation of Sxl in the germline involv

233 l anatomy and also resulted in abrogation of female-specific regulation of these genes.

234 (vi) CUX2, a female-specific repressor of male-biased genes, also act

235 echanisms of male-specific vulnerability and female-specific resilience impacting intracellular signa

236 ion of LXRalpha in transgenic mice confers a female-specific resistance to lithocholic acid (LCA)-ind

237 before or during birth could be considered a female specific risk factor for stroke, with differences

238 Adding each of the female-specific risk factors did not improve the c-index

239 Adding all female-specific risk factors simultaneously increased th

240 articularly dynamic and are likely to confer female-specific risks for neuropsychiatric disorders.

241 Sxl encodes a female-specific RNA binding protein and in somatic cells

242 ost-transcriptionally by Sex lethal (SXL), a female-specific RNA-binding protein that regulates alter

243 prolactin, which is most well known for its female-specific role in lactation, has a role in the mal

244 Epigenetic editing uncovered a female-specific role of Cdk5 activation in attenuating f

245 sexually dimorphic and therefore may play a female-specific role, such as processing of information

246 an sexual development have either a male- or female-specific role.

247 lly deep framework for the evolution of OT's female-specific roles in pair bonding and maternal funct

248 Our results indicate that female-specific selection has a significant effect on W

249 SC), a tug-of-war between opposing male- and female-specific selection pressures.

250 romosome after >100 generations of different female-specific selection regimens in different breeds o

251 omosome is predicted to be subject to strong female-specific selection stemming from its female-limit

252 n of up-regulation associated with increased female-specific selection.

253 We have created a conditional female-specific self-limiting strain of B. oleae (OX3097

254 target gene hunchback but also the normally female specific Sex-lethal promoter, Sxl-Pe, in the pole

255 susceptibility is caused by the presence of female-specific sex hormones.

256 on caused a delay in production of the major female-specific sex pheromones (the 7,11-C27 and -C29 di

257 The initial expression of the female-specific sex-determining gene Sex-lethal in the b

258 In Drosophila, the female-specific SEX-LETHAL (SXL) protein is required for

259 licing event, yet the mechanism by which the female-specific SEX-LETHAL RNA-binding protein prevents

260 ovide further evidence of the existence of a female-specific SIA mechanism and highlight the importan

261 male-specific sites and induced a subset of female-specific sites in male livers.

262 Here, we report that a group of female-specific small proteins, early nodulin-like prote

263 cell number and type contribute to male- and female-specific songs in frogs and birds.

264 red and sufficient to activate the regulated female-specific splice site.

265 out of miR-1-3p results in the expression of female-specific splice variants of Bdtra and doublesex (

266 osphorylation of one or more proteins in the female-specific splicing enhancer complex.

267 The Drosophila doublesex female-specific splicing enhancer consists of two classe

268 Female-specific splicing is activated through the activi

269 Male- and female-specific splicing isoforms of DSX share a novel D

270 Male- and female-specific splicing isoforms share a novel DNA-bind

271 ons of AsuMf result in a shift from male- to female-specific splicing of doublesex and fruitless, lea

272 le differentiation pathways by directing the female-specific splicing of Sxl and tra pre-mRNAs.

273 suggested a role for snf in establishing the female-specific splicing pattern of the sex determinatio

274 In addition, mRNA levels for ST2A2, a female-specific ST gene, were suppressed 50% in females

275 mpatibilities that produce male-specific vs. female-specific sterility.

276 Female-specific summary-level data from FinnGen (sixth r

277 uirement of m(6)A and its reader YT521-B for female-specific Sxl alternative splicing reveals that th

278 al Sxl as a major intronic m(6)A target, and female-specific Sxl splicing is compromised in multiple

279 ation, and YT521-B overexpression can induce female-specific Sxl splicing.

280 This female-specific system is now known to be estrogen-depen

281 The absence of female-specific Tap gene defects also indicates this can

282 All the three female-specific TcDsx proteins share common OD1 and OD2

283 's zygotic function suggests that one set of female-specific terminal differentiation genes, the yolk

284 and in fat body cells of the spermatheca (a female-specific tissue), through a canonical DSX-binding

285 osomal and X-linked genes with expression in female-specific tissues evolve at similar rates.

286 We found female-specific tra mRNA in eggs as predicted by this tr

287 pattern of variation was found for a cryptic female-specific transcript (H5) but a very different pat

288 These factors regulate male- and female-specific transcription of many genes.

289 For example, female-specific transcription of the yolk protein 1 gene

290 generated, by crossing FL3#2 which carries a female-specific tTA overexpression cassette, with EF1#12

291 er of BNST neuronal identity, we uncovered a female-specific upregulation of the coexpression of Prkc

292 Subsequent to the discovery of a female-specific urinary discriminator by LC-MS, further

293 age across the genus shows that species with female-specific UVRh1 expression lack UVRh1 gDNA in male

294 Our analysis also shows that female-specific viruses generally give better results th

295 male-specific vitelline coat lysin (VCL) and female-specific vitelline envelope receptor for lysin (V

296 Maternal inheritance via the female-specific W chromosome was long ago proposed as a

297 on the Z chromosome and the nonrecombining, female-specific W chromosome.

298 at this transcript comes from a locus on the female-specific W chromosome.

299 regulates the LXA4 circuit to induce delayed female-specific wound healing in the cornea.

300 egulatory regions, which cooperate to ensure female-specific Xist upregulation at the correct develop