ライフサイエンスコーパス: fibrillar

1 of the system from soluble Abeta (sAbeta) to fibrillar Abeta (fAbeta) domination upon surpassing a th

2 antaneous increase in photoluminescence with fibrillar Abeta (primary light-switching), and an unprec

3 t attenuated accumulation of or clearance of fibrillar Abeta accumulation in randomized clinical tria

4 PSEN1(Deltaexon9) in neurons and accumulates fibrillar Abeta amyloid and amyloid plaques accompanied

5 Evidence suggests that these non-fibrillar Abeta assemblies are implicated in synaptic dy

6 ology consisted of extracellular diffuse and fibrillar Abeta deposits, hyperphosphorylated/pathologic

7 riability; their power to track longitudinal fibrillar Abeta increases in Abeta+ and Abeta- subgroups

8 al trials; and their ability to relate 24-mo fibrillar Abeta increases to clinical declines.

9 The amount of soluble, fibrillar Abeta oligomers also increased in PS2APP;Trem2

10 Abeta42:Abeta40 ratio and amount of soluble, fibrillar Abeta oligomers were elevated in Trem2-deficie

11 This suggests that non-fibrillar Abeta or early stage plaque depostion might in

12 compared with wild-type mice despite robust fibrillar Abeta plaque deposition.

13 magnetite nanostructures directly bound into fibrillar Abeta showed characteristic superparamagnetic

14 cterize in postmortem human brain tissue non-fibrillar Abeta structures in amyloid plaques of cases w

15 d cores, resembling the cores of full-length fibrillar Abeta structures, and both self-associate thro

16 sion tomography was performed to investigate fibrillar Abeta, astrocytosis and cerebral glucose metab

17 Furthermore, this peptide bound fibrillar Abeta42 and also stained plaques ex vivo in br

18 ded oligoclonal bands, serum levels of glial fibrillar acidic and neurofilament proteins and S100B.

19 letion favors NSC differentiation into glial fibrillar acidic protein (GFAP)-immunoreactive cells ove

20 We observed no fibrillar ADAMTS9 staining after blockade of fibroblast

21 The fibrillar adhesin CshA is an important determinant of S.

22 The multifunctional fibrillar adhesin CshA, which mediates binding to both h

23 duction to regulate alpha5beta1-integrin and fibrillar adhesion assembly and thus reveal an important

24 ins, supporting their activity and promoting fibrillar adhesion formation and integrin-dependent proc

25 ctive beta1-integrin- and tensin-rich mature fibrillar adhesions, and cell spreading.

26 tin increased the localisation of tensin1 to fibrillar adhesions.

27 a5beta1 integrin translocation into proximal fibrillar adhesions.

28 s mimicked by integration of film-terminated fibrillar adhesives to hybrid nematic liquid crystal net

29 , and curcumin, redirect Abeta(17-36) from a fibrillar aggregate to an unstructured oligomer.

30 is an intrinsically disordered protein whose fibrillar aggregates are the major constituents of Lewy

31 , mechanical and morphological properties of fibrillar aggregates at the single molecule and nanomete

32 ta suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation.

33 to reshaping and being incorporated into the fibrillar aggregates is a key determinant of its ability

34 ta2m and their subsequent progression toward fibrillar aggregates is of great importance.

35 Fibrillar aggregates of Abeta and Tau in the brain are t

36 s invariably contains deposits of insoluble, fibrillar aggregates of peptide fragments of the amyloid

37 Fibrillar aggregates possessing distinct structures that

38 nct events, culminating in rapid assembly of fibrillar aggregates that emanate from within mature liq

39 es, however, greatly accelerate formation of fibrillar aggregates, and this effect is especially dram

40 e monomer and the hairpin assembles into non-fibrillar aggregates, demonstrating that the hairpin fol

41 s misfold and self assemble into soluble pre-fibrillar aggregates, i.e., protofibrils, which elongate

42 However, besides the fact that it forms fibrillar aggregates, structural information of Orb2 is

43 beta self-assembles into parallel cross-beta fibrillar aggregates, which is associated with Alzheimer

44 ls, which elongate and mature into insoluble fibrillar aggregates.

45 nsitions of monomers-paranuclei-protofibrils-fibrillar aggregates.

46 amino acid known to self-assemble into toxic fibrillar aggregates.

47 Amyloids are insoluble protein fibrillar aggregates.

48 ase in fluorescence emission upon binding to fibrillar aggregates.

49 s a disease that affects vital organs by the fibrillar aggregation of monoclonal light chains.

50 e the arrest of aggregation in an early, non-fibrillar aggregation stage.

51 also rescues proteins from irreversible non-fibrillar aggregation.

52 We hypothesized that injection of fibrillar alpha-syn into the OB of wild-type mice would

53 We show that distinct fibrillar alpha-Syn polymorphs bind to and cluster diffe

54 e recently showed that structurally distinct fibrillar alpha-Syn polymorphs trigger either Parkinson'

55 resence of Lewy body inclusions comprised of fibrillar alpha-syn within affected regions of PD brain

56 gle-chain variable fragments (scFvs) against fibrillar alpha-syn, a putative disease-relevant form of

57 ta42 (the 42-residue form of Abeta) fibrils, fibrillar alpha-synuclein catalyses the heterogeneous nu

58 emonstrated that intrastriatal injections of fibrillar alpha-synuclein in rodent brain induced a Park

59 suggest a key role for autophagy in clearing fibrillar alpha-synuclein pathologies in human neuronal

60 between the concentrations of monomeric and fibrillar alpha-synuclein that determines the outcome of

61 stigate this further, we have used exogenous fibrillar alpha-synuclein to seed endogenous alpha-synuc

62 yloid-sheet oligomers compared with those of fibrillar alpha-synuclein.

63 Fibrillar alphaS is taken up by pMac by actin-rearrangem

64 the receptor regulated tightly clearance of fibrillar alphaSN by human monocytes.

65 The selectivity of CR4 toward binding fibrillar alphaSN consequently adds an important alphaSN

66 hesize that the parallel monomer stacking in fibrillar alphaSN creates a known danger-associated mole

67 complement receptor (CR) 4 selectively bound fibrillar alphaSN, but not monomeric species.

68 of extracellular amyloid plaques composed of fibrillar amyloid beta (Abeta) peptides and intracellula

69 Although fibrillar amyloid beta (Abeta)-stimulated cytokine secre

70 aggregates, including soluble oligomers and fibrillar amyloid deposits, which are linked with neurod

71 l impairment, but never develops parenchymal fibrillar amyloid deposits.

72 lial activation and its relationship between fibrillar amyloid load at baseline and follow-up in subj

73 hich was associated with a mild elevation in fibrillar amyloid load.

74 midlife BMI was also associated with greater fibrillar amyloid measured by global mean cortical distr

75 ogenic rodent IAPP and thioflavin-T-positive fibrillar amyloid produced by human IAPP aggregation fai

76 iated with Alzheimer's disease (AD) comprise fibrillar amyloid-beta (Abeta) peptides as well as non-p

77 tron Emission Tomography (PiB-PET) to assess fibrillar amyloid-beta burden in cortical and subcortica

78 inflammasome and intracerebral injection of fibrillar amyloid-beta-containing brain homogenates indu

79 lity of macrophages to phagocytose preformed fibrillar amyloid-beta1-42 (P < 0.0001).

80 py data show that the intermediates are more fibrillar and deprotonated than the monomers, whereas th

81 ing on both structural ECM proteins (such as fibrillar and nonfibrillar collagens), and specialized i

82 roED and in it, note characteristics of both fibrillar and oligomeric structure.

83 During contact guidance, the fibrillar architecture of the ECM promotes an elongated

84 ns of 3 form floret-shaped constructs, while fibrillar architectures are formed in water.

85 tural changes that result in the assembly of fibrillar architectures inside cells.

86 e biomechanical characteristics and regional fibrillar arrangement of porcine RDT.

87 We propose the fibrillar arrangement of the NSs core domain in crystals

88 Finally, we show that fibrillar aS loses almost 80% of its scavenging activity

89 the C-terminus in the complete maturation of fibrillar aS.

90 KS6 depend on INVS for localization to these fibrillar assemblies and that ANKS6-NEK8 density within

91 suggesting that it promotes the formation of fibrillar assemblies.

92 Amyloids, fibrillar assembly of (poly)peptide chains, are associat

93 Taking a fibrillar assembly of amyloid beta (Abeta) peptide as th

94 A associates with other A molecules to form fibrillar beta-sheet structures, is common in nature and

95 verity of Alzheimer's neuropathology and (3) fibrillar brain amyloid deposition during aging.

96 the different mature insulins formed larger fibrillar bundles compared to those formed by their B-ch

97 the microtubule associated tau protein into fibrillar cell inclusions is linked to a number of devas

98 ms that govern the formation and assembly of fibrillar cellulosic structures and cell wall composites

99 cells (6/14 [43%] vs 0/14 [0%]; P = .05) and fibrillar collagen (13/14 [93%] vs 2/14 [14%]; P < .0001

100 hesis by SoxE and SoxD regulation of clade A fibrillar collagen (ColA) genes--suggesting that the cho

101 OM) and texture analysis algorithms to image fibrillar collagen (second harmonic generation) and elas

102 aft model and highlight the critical role of fibrillar collagen and DDRs in supporting the growth of

103 High levels of perivascular fibrillar collagen and pulmonary interleukin-6 overexpre

104 al in vivo degradation of the self-assembled fibrillar collagen and the majority of implants experien

105 ontaneous Ca(2+) oscillations in MSCs during fibrillar collagen assembly, and hypothesized that the t

106 the progressive accumulation of disorganized fibrillar collagen by airway fibroblasts.

107 ined more collagen with greater alignment of fibrillar collagen compared with wild-type fibroblast-de

108 50 Pa and increased to 1-6 kPa in areas near fibrillar collagen deposition in fibrotic livers.

109 Microarchitectural cues drive aligned fibrillar collagen deposition in vivo and in biomaterial

110 , organ atrophy was accompanied by increased fibrillar collagen deposition, suggesting a compensatory

111 ls mediate M migration and mechanosensing in fibrillar collagen ECM.

112 The mesothelial niche was enriched with fibrillar collagen in human and murine omental metastase

113 o experiments.Measurements and Main Results: Fibrillar collagen is not only increased but also highly

114 s in mouse (termed SMKO) resulted in altered fibrillar collagen localization with larger, poorly orga

115 sence of a gap of transparency in scattering fibrillar collagen matrices within a narrow range of con

116 g fibroblasts generate deformation fields in fibrillar collagen matrix that provide far-reaching phys

117 the hypothesis that the microarchitecture of fibrillar collagen networks mechanically regulates myofi

118 high-density breast contains more oriented, fibrillar collagen that is stiffer and correlates with h

119 Exposure of the aortic rings embedded in 3D fibrillar collagen to recombinant endorepellin for 2-4 h

120 MIF arises mainly because of alterations in fibrillar collagen turnover leading to collagen fiber ac

121 -) fibroblasts lost their ability to process fibrillar collagen type I and to activate proMMP-2.

122 entric thickening of the perivascular space (fibrillar collagen type I deposition) and affected almos

123 rent genes, the majority of which encode the fibrillar collagen types I, III and V, modifying or proc

124 usceptibility to CatK-mediated hydrolysis of fibrillar collagen was observed following mineralization

125 Mineralization of fibrillar collagen with biomimetic process-directing age

126 Fibrillar collagen, an essential structural component of

127 iological stimulus for MT1-MMP expression is fibrillar collagen, and it has been shown that it up-reg

128 igitation of rete ridges, abundant organized fibrillar collagen, and plentiful arrays of elastic fibe

129 Cre tumors was enriched with stromal-derived fibrillar collagen, compared with wild-type or Hras-driv

130 t while DDR1b clusters co-localized with non-fibrillar collagen, DDR1b/DDR2 filamentous structures as

131 on-chip platelet thrombosis assay on type 1 fibrillar collagen, using whole blood.

132 roblasts are deficient in their packaging of fibrillar collagen-I and express less decorin, important

133 anism for tension-dependent stabilization of fibrillar collagen.

134 mary epithelial cells on stiff matrices like fibrillar collagen.

135 le blood over a 250-mum long patch of type I fibrillar collagen/lipidated tissue factor (TF; approxim

136 An increase in fibrillar collagens 1 and 5 was detected.

137 Cardiac extracellular matrix (ECM) contains fibrillar collagens and proteoglycans, important for mai

138 Fibrillar collagens are present in a wide variety of ani

139 atrix (ECM) is a complex mixture composed of fibrillar collagens as well as additional protein and ca

140 The mechanical strength of fibrillar collagens is highly dependent on the formation

141 exhibited higher stiffness and expression of fibrillar collagens than control fibroblasts, concomitan

142 ts and enhanced expression and deposition of fibrillar collagens) increased progressively.

143 oid potential immunogenicity associated with fibrillar collagens, were fabricated with and without ch

144 on of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of sta

145 educed deposition of both elastic fibers and fibrillar collagens.

146 s and marked depletion of elastic fibers and fibrillar collagens.

147 expression of EMT/myofibroblast markers and fibrillar collagens.

148 ed to the formation and further expansion of fibrillar collagens.

149 he cross-striated banding pattern typical of fibrillar collagens.

150 assembly of plasmonic nanoparticles onto the fibrillar constructs.

151 duced by the variant only after its complete fibrillar conversion.

152 recently solved molecular structures of the fibrillar core of the FUS low-complexity (FUS-LC) domain

153 ctions can optimize packing densities in the fibrillar core structure, in contrast to those forming w

154 eptide and protonated Glu8 is located in the fibrillar core.

155 with a protonated glutamate residue in their fibrillar core.

156 In light chain amyloidosis (AL), fibrillar deposition of monoclonal immunoglobulin light

157 hypothesis of Alzheimer's disease holds that fibrillar deposits of amyloid are an early, driving forc

158 Plaques from sporadic AD patients contain fibrillar deposits of various amyloid proteins/peptides,

159 ima exist, often associated with pathogenic, fibrillar deposits, when the concentration of proteins r

160 aining and analyses of birefringent collagen fibrillar deposits.

161 ions exposed in the oligomers but not in the fibrillar deposits.

162 We propose the characteristic fibrillar dimension (CFD) at which effective sliding is

163 lerated almost threefold to 0.68 mum/min and fibrillar dimensions were increased, underlining the imp

164 pattern linear fibronectin features to mimic fibrillar ECM and elucidate the mechanisms of contact gu

165 mosomes via the engagement of integrins with fibrillar ECM proteins.

166 n catalyzing the formation of cross-links in fibrillar elastin and collagens leading to extracellular

167 Some ECM molecules provide a fibrillar environment around cells, while others provide

168 tic hits interact to change cell behavior in fibrillar environments.

169 Magic-angle-spinning NMR reveals that fibrillar exon1 has a partly mobile alpha-helix in its a

170 membrane retractions, indicating a stepwise fibrillar extension mechanism.

171 t is directly linked to strong deposition of fibrillar extracellular matrix (ECM) components and high

172 gation and maturation into tensin-containing fibrillar FAs in the cell center.

173 he formin INF2 in specifying the function of fibrillar FAs through its ability to generate dorsal SFs

174 ly robust three-dimensional (3D) networks of fibrillar fibronectin (fFn) supported by tessellated pol

175 ro by investigating LTBP-1 organisation with fibrillar fibronectin and show that all trans-retinoic a

176 ine can undergo stable, covalent linkages in fibrillar fibronectin under inflammatory conditions and

177 RPK sequence in the first type III repeat of fibrillar fibronectin.

178 We found that cellular (fibrillar) fibronectin on the surface of transforming gr

179 stingly, in vitro Tau can be induced to form fibrillar filaments by oxidation of its two cysteine res

180 to amyloid structures while MHP1 forms a non-fibrillar film.

181 nding region of the first type III repeat of fibrillar FN (FNIII1H) mediates vasodilatation, and (ii)

182 w that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through alphavbet

183 The amyloid fibrillar form of the protein Tau is involved in a numbe

184 d by a soluble form rather than an insoluble fibrillar form.

185 ly disordered monomeric form to a cross-beta fibrillar form.

186 -1) when compared to the amide-I band of the fibrillar form.

187 40 surface, potentially related to a role in fibrillar formation.

188 bind the toxic oligomers over monomeric and fibrillar forms of Abeta, leading to inhibition of aggre

189 chiometry of each antibody for monomeric and fibrillar forms of Abeta.

190 odent and primate models have indicated that fibrillar forms of alpha-synuclein can initiate the prop

191 oretic behavior of monomeric, oligomeric and fibrillar forms of alpha-synuclein.

192 entified that bind monomeric, oligomeric, or fibrillar forms of amyloid-beta (Abeta).

193 orming ability of monomeric, oligomeric, and fibrillar forms of both Abeta(1-40) and Abeta(1-42).

194 he cellular uptake of soluble oligomeric and fibrillar forms of dGAE and examined the downstream cons

195 for interconversion between prefibrillar and fibrillar forms to identify a conversion pathway between

196 cularly when they are in their oligomeric or fibrillar forms.

197 me toxicity, the potent effects of the short fibrillar fragments can be attributed to their ability t

198 B(4) /Li composite featuring a 3D Li(5) B(4) fibrillar framework filled with metallic Li, which maint

199 ed by the porous structure of the Li(4) B(5) fibrillar framework, together with its lithiophilic surf

200 e kinetics of oligomerization and subsequent fibrillar growth by allowing the conformational changes

201 dimensions greatly exceeding those of their fibrillar homochiral counterparts.

202 Inhibiting formation of these fibrillar hydrogel assemblies mitigates neurotoxicity an

203 further phase transition into poorly soluble fibrillar hydrogels distinct from conventional amyloids.

204 BMDMs treated with soluble but not fibrillar IAPP provided a TLR2-dependent priming stimulu

205 ation of these bigenic mice, the severity of fibrillar inclusion pathology was diminished and unreact

206 einopathy-diseases that are characterized by fibrillar inclusions of RBPs.

207 quantified by d-AQuA was similar to that of fibrillar insulin aggregates detected by atomic-force mi

208 a = 10 mm(2) +/- 6 mm(2)) corresponding to a fibrillar layer burying the guttae of DM in 84% (42/50)

209 CEC density overlying the fibrillar layer compared with the periphery was signific

210 Subgroup analysis revealed that the fibrillar layer may be imaged by slit-lamp biomicroscopy

211 A fibrillar layer with a clear geographic pattern marks ar

212 expression does not trigger the formation of fibrillar LB-like inclusions in mice.

213 of adhesions, which are also more mature and fibrillar-like.

214 ining has a distinct effect on the growth of fibrillar mass density (which can be measured experiment

215 Interestingly, the hybrid wild-type/variant fibrillar material acquired a thermodynamic stability si

216 PEX was defined as typical fibrillar material at the pupil margin and/or on the len

217 hich cells probe and respond to mechanics in fibrillar matrices.

218 with deposition and remodeling of an aligned fibrillar matrix.

219 into how genetic perturbations conspire with fibrillar maturation in the TMEN to drive the invasive b

220 oximately 26% of the maximum adhesion of the fibrillar membrane, which is 14x higher than the adherin

221 esults will enable experimentalists to infer fibrillar morphologies from an appropriate analysis of s

222 le into long fibrils with sequence-dependent fibrillar morphologies.

223 form of 3D texture analysis to delineate the fibrillar morphology observed in 3D Second Harmonic Gene

224 Ammonium-functionalized fibrillar nanocarbon is found to preferentially localize

225 core-shell morphology such as spherical and fibrillar nanostructures could be controlled by adjustin

226 atively studying the relation between the 3D fibrillar network and the optical and mechanical propert

227 r series on the mechanical properties of wet fibrillar networks, and link this to the differences in

228 tors; and is assembled by cells into complex fibrillar networks.

229 molecular gelators into their self-assembled fibrillar networks.

230 neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregated alp

231 The fibrillar oligomer only becomes favored over its prefibr

232 nsist of mainly antiparallel beta-sheets and fibrillar oligomers with only parallel beta-sheets.

233 LLPS) as the precursor phase to form various fibrillar or crustaceous materials that are essential fo

234 Gremlin-1 but a pronounced effect on matrix fibrillar organisation was revealed.

235 anogold affinity tags in the context of wall fibrillar organization.

236 We show that the striped fibrillar pattern cannot be easily predicted from the in

237 on of cellulose in the open state and a more fibrillar pattern in the closed state, indicating that c

238 This striped fibrillar pattern is preserved across the animal kingdom

239 results were grade 1, normal, with parallel fibrillar pattern; grade 2, mild tendinopathy, with cell

240 d as grade 1, normal tendon with homogeneous fibrillar pattern; grade 2, tendon thickening or hypoech

241 ween the pre-fibrillar tetramer form and the fibrillar pentamer in the Abeta40 aggregation landscape

242 s are the solution phase and the macroscopic fibrillar phase, and that there also exists a hierarchy

243 We characterized fibrillar plaque deposition in 6, 12, and 18-22 months o

244 Conclusion: Asymmetry of fibrillar plaque neuropathology occurs frequently in Abe

245 the replication of GPI-anchored prions, with fibrillar plaques forming from poorly glycosylated, GPI-

246 rlier manifestation of neuritic plaques) and fibrillar plaques in Alzheimer's disease (AD) brain sect

247 g high-aspect ratio micropatterns as a model fibrillar platform, we show that metastatic cells overco

248 ly expressed pre-melanosomal markers OA1 and fibrillar PMEL, following early endosomal sorting by the

249 ecedence over surface catalysis and leads to fibrillar polymorphism.

250 Accumulation of fibrillar protein aggregates is a hallmark of many disea

251 metry, which are efficient inhibitors of non-fibrillar protein aggregation.

252 ctionally distinct from the ECM-constituting fibrillar protein networks naturally deposited by cells.

253 link between persistent stress granules and fibrillar protein pathology in disease.

254 and compared to native protein, early-stage-fibrillar protein, and sonicated fibrils in two immortal

255 The extracellular matrix (ECM) is a fibrillar protein-based network, the physical and chemic

256 eins and globular were more susceptible than fibrillar proteins.

257 erved positions, and is reminiscent of other fibrillar proteins.

258 A model of stiffness modulation via enhanced fibrillar recruitment is developed to explain the biophy

259 he extracellular matrix (ECM)-a complex, 3D, fibrillar scaffold of cells in physiological environment

260 The matrix consists of well-separated fibrillar sheets on which the pigment melanin is deposit

261 ganized into complex filament aggregates and fibrillar sheets.

262 Non-fibrillar soluble oligomeric forms of amyloid-beta pepti

263 the formation and propagation of beta-sheet fibrillar species could be an important route for therap

264 rs generated through the catalytic action of fibrillar species during the protein aggregation process

265 cting oligomeric, prefibrillar structures or fibrillar species of amyloidogenic proteins, respectivel

266 racterise the structural ensemble of the pre-fibrillar state of CsgA within the bacterial periplasm,

267 n which Abeta converts from a monomeric to a fibrillar state via a series of kinetically defined step

268 In the fibrillar state, use of circular dichroism, atomic-force

269 l changes from random coil to its beta-sheet fibrillar states.

270 peptides in their monomeric, oligomeric, and fibrillar states.

271 yrrole monomers along with the silk internal fibrillar structure and hence, yielding a more linear PP

272 n very small changes in the assumed material fibrillar structure can produce large changes in the wav

273 ffraction to probe time-dependent changes in fibrillar structure during in situ tensile testing of se

274 in individual plaques there is a gradient of fibrillar structure from core to margins.

275 y manipulating this pathway, we show that BM fibrillar structure influences egg chamber morphogenesis

276 The fibrillar structure of the scaffolds mimics the morpholo

277 whereas they are less ordered than the final fibrillar structure that is slowly formed from the inter

278 y the process of self-assembly nor the final fibrillar structure.

279 minal residues 138-144 prevents formation of fibrillar structures in agreement with the experiment.

280 Self-assembly of proteins into ordered, fibrillar structures is a commonly observed theme in bio

281 es and proteins from the solution phase into fibrillar structures is a general phenomenon encountered

282 Hierarchical assemblies of proteins into fibrillar structures occur in both physiologic and patho

283 FPs do not bind other nonamyloid fibrillar structures such as microtubules or actin filam

284 from disordered monomers to beta-sheet-rich fibrillar structures.

285 em to aggregate and assemble into insoluble, fibrillar structures.

286 rders is the aggregation of tau protein into fibrillar structures.

287 ts potential to polymerize into higher-order fibrillar structures.

288 Only a minority of oligomers converts into fibrillar structures.

289 histories may contain different ensembles of fibrillar structures; (ii) plaques harboring distinct am

290 stabilization, and enhances the formation of fibrillar tau aggregates, highlighting both loss and gai

291 INTERPRETATION: Biomarkers of fibrillar tau deposition can be included with those of b

292 However, fibrillar tau has been dissociated from neuron death and

293 In this work, six different fibrillar Tau isoforms were assembled in vitro.

294 he clear free energy barrier between the pre-fibrillar tetramer form and the fibrillar pentamer in th

295 the conversion from pre-fibrillar trimers to fibrillar tetramers.

296 tact response of migrating cancer cells in a fibrillar TMEN is poorly understood.

297 d greatly facilitate the conversion from pre-fibrillar trimers to fibrillar tetramers.

298 Fibrillar type I collagen-based hydrogels are commonly u

299 , and thioflavin-S binding established their fibrillar ultrastructure, and fluorescence recovery afte

300 n notably for the tripeptide, which produced fibrillar xerogels.