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1 ceptor gamma coactivator 1-alpha) and FGF21 (fibroblast growth factor 21).
2 the energy balance regulating hormone FGF21 (fibroblast growth factor 21).
3 nzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).
4 higher relative abundance in early HCM (eg, fibroblast growth factor-21).
5 es the expression of batokine genes, such as fibroblast growth factor 21.
6 expression of oncogenes, including c-Jun and fibroblast growth factor 21.
7 rent metabolic regulators such as 4E-BP1 and fibroblast growth factor 21.
9 a target gene expression and serum levels of fibroblast growth factor 21, a neuroprotective molecule
11 of DB-LNP encapsulating mRNA encoding human fibroblast growth factor 21 alleviates obesity and fatty
14 n-like protein 3, 3/8, and 4 inhibitors, and fibroblast growth factor-21 analogues have pronounced tr
15 and are approved for this indication, while fibroblast growth factor-21 analogues reduce hepatic ste
16 authors provide a corresponding overview of fibroblast growth factor-21 analogues that share many ch
17 KO mice had increased circulating levels of fibroblast growth factor 21 and adiponectin and were res
18 e had elevated circulating concentrations of fibroblast growth factor 21 and changes in BAT gene expr
19 ng hyperglycemia and include augmentation of fibroblast growth factor 21 and glucagon-like peptide 1.
20 ression of genes involved in beta-oxidation: fibroblast growth factor 21 and peroxisome proliferator-
21 A low BCAA diet transiently induces FGF21 (fibroblast growth factor 21) and increases energy expend
22 nd upregulation of proteins including Bcl-2, fibroblast growth factor 21, and activated protein C can
23 iglycerides and production of the hepatokine fibroblast growth factor 21, another ISR gene target, we
24 glucocorticoid inhibitors, and analogues of fibroblast growth factor 21 are being considered as pote
25 nse to metabolic fluctuations; and 4) FGF21 (fibroblast growth factor 21) as an emerging hormone-like
26 iver weight with fasting and increased liver fibroblast growth factor 21 expression and intact ketoge
27 n1 and decreased p62 protein levels, induced fibroblast growth factor-21 expression, and corrected HF
29 t of 263 proteins analyzed at baseline, only fibroblast growth factor 21 (FGF-21) predicted weight lo
30 ants, HMF infants had higher levels of serum fibroblast growth factor 21 (FGF-21, adjusted standardiz
35 e use of site-specific glycosyltransferases) fibroblast growth factor 21 (FGF21) analogue in developm
36 Pegbelfermin (BMS-986036), a PEGylated human fibroblast growth factor 21 (FGF21) analogue, has previo
37 tohepatitis (MASH), efruxifermin, a bivalent fibroblast growth factor 21 (FGF21) analogue, reduced fi
39 h c-Jun NH2-terminal kinase (JNK) inhibiting fibroblast growth factor 21 (FGF21) and activating Bmal1
40 metabolism and insulin resistance, including fibroblast growth factor 21 (FGF21) and adiponectin, as
41 s, we identified that halofuginone increases fibroblast growth factor 21 (FGF21) and growth different
43 a) and its transcriptional target hepatokine fibroblast growth factor 21 (FGF21) are primary regulato
46 Here, we identified beta-Klotho (KLB), a fibroblast growth factor 21 (FGF21) co-receptor, as a no
48 twork hyaluronic acid/black phosphorus (BP)/ fibroblast growth factor 21 (FGF21) composite hydrogel (
52 ) activity and reduced hepatic PPARalpha and fibroblast growth factor 21 (FGF21) expression and lower
53 ma coactivator-1alpha (PGC-1alpha)-dependent fibroblast growth factor 21 (FGF21) expression in the li
54 lve activation of ER stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle
55 drate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor 21 (FGF21) gene expression in p
62 1), but required expression of liver-derived fibroblast growth factor 21 (FGF21) in both lean and obe
64 of the lipid- and glucose-modulating hormone fibroblast growth factor 21 (FGF21) in the molecular mec
65 ein dilution increases expression of hepatic fibroblast growth factor 21 (FGF21) independent of calor
74 n that transcriptional activation of hepatic fibroblast growth factor 21 (FGF21) is a key event linki
85 Preclinical and clinical data suggest that fibroblast growth factor 21 (FGF21) is anti-fibrotic, im
87 and secretion of the weight-reducing hormone fibroblast growth factor 21 (FGF21) is regulated by diet
88 reported an association between circulating fibroblast growth factor 21 (FGF21) levels and pericardi
95 ss is driven by aberrant mTORC1 activity and fibroblast growth factor 21 (FGF21) production in the li
98 ranscription factor 4 (ATF4), which promotes fibroblast growth factor 21 (FGF21) secretion as a batok
100 circulating concentration of the hepatokine fibroblast growth factor 21 (FGF21) that regulates syste
101 epatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21) was blunted by TCS.
106 virus expressing short hairpin RNA targeting fibroblast growth factor 21 (FGF21) were used to determi
108 Here we show that exposure of female mice to fibroblast growth factor 21 (FGF21), a fasting-induced h
109 ver expression and elevated plasma levels of fibroblast growth factor 21 (FGF21), a hepatokine known
111 show that the prolongevity ketogenic hormone fibroblast growth factor 21 (FGF21), a member of the end
113 ine metabolite 3-hydroxyisobutyrate (3-HIB), fibroblast growth factor 21 (FGF21), adiponectin, and no
114 es, markers of inflammation, serum levels of fibroblast growth factor 21 (FGF21), and activation of s
115 aptive fasting metabolic pathways, including fibroblast growth factor 21 (FGF21), and decreases survi
116 bset of adipocyte genes (group 2), including fibroblast growth factor 21 (FGF21), and that the FGF21
117 ls of methylmalonate, and the MMA biomarker, fibroblast growth factor 21 (Fgf21), as well as integrat
118 ses a series of secreted proteins, including fibroblast growth factor 21 (FGF21), bone morphogenetic
119 ctome leads to elevations in adiponectin and fibroblast growth factor 21 (FGF21), causing WAT beiging
120 stem co-loaded with cobalt sulfide (CoS) and fibroblast growth factor 21 (FGF21), designed for on-dem
121 nsulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA
123 epair after MI through regulation on hepatic fibroblast growth factor 21 (FGF21), illustrating an MR/
124 expressed increased levels of E-cadherin and fibroblast growth factor 21 (FGF21), targets of sirtuin-
125 duced expression and secretion of a myokine, fibroblast growth factor 21 (FGF21), that stimulates ene
126 tly induces one of the key hepatic hormones, fibroblast growth factor 21 (FGF21), to promote lipolysi
127 nd various hormone concentrations, including fibroblast growth factor 21 (FGF21), were assessed at ba
128 +)), AMP-activated protein kinase (AMPK) and fibroblast growth factor 21 (FGF21), which are key compo
129 imulates the liver to synthesize the hormone fibroblast growth factor 21 (FGF21), which then acts on
146 growth/differentiation factor 15 [GDF15] and fibroblast growth factor 21 [FGF21] expression and decre
147 apies based on 3 longevity associated genes (fibroblast growth factor 21 [FGF21], alphaKlotho, solubl
151 a long-acting glycopegylated analog of human fibroblast growth factor 21, is in development for the t
153 tokines and chemokines, lipogenic genes, and fibroblast growth factor 21 levels, a predictive biomark
155 netically modified to produce high levels of fibroblast growth factor-21 live longer than mice with n
156 iting efficiency; LNPs with C-a16 delivering fibroblast growth factor 21 mRNA increased the expressio
157 ncrease hepatic transcription and release of fibroblast growth factor 21, or improve insulin sensitiv
158 adipokines such as leptin, adiponectin, and fibroblast growth factor 21 that potently eliminate exce
159 ity index was 24% (P < 0.01) and circulating fibroblast-growth factor 21 was 21% higher (P < 0.05), w
160 moting the expression of hepatokines such as fibroblast growth factor 21, which may exert systemic me