ライフサイエンスコーパス: fibroblast growth factor-23

1 f 25(OH) vitamin D, parathyroid hormone, and fibroblast growth factor 23.

2 roid hormone, 1,25-dihydroxyvitamin D(3), or fibroblast growth factor 23.

3 of reduced parathyroid hormone and increased fibroblast growth factor 23.

4 l power to identify novel genetic traits for fibroblast growth factor 23.

5 pression of the phosphate-regulating hormone fibroblast growth factor 23.

6 calcemia, changes in parathyroid hormone, or fibroblast growth factor 23.

7 creases in alkaline phosphatase activity and fibroblast growth factor-23.

8 phosphate excretion, parathyroid hormone, or fibroblast growth factor-23.

9 Fibroblast growth factor-23, 1,25-(OH)2-vitamin D3, and

10 ed osteomalacia involves tumor expression of fibroblast growth factor 23, a hormone that inhibits pro

11 ), and recent findings suggest that blocking fibroblast growth factor 23 actions may be the most effe

12 aline phosphatase, higher circulating intact fibroblast growth factor 23 and decreased bone formation

13 nd Ip6k2 reduced the plasma concentration of fibroblast growth factor 23 and increased bone resorptio

14 te, specifically the secretion and action of fibroblast growth factor 23 and parathyroid hormone.

15 e blood of cKO mice had an elevated level of fibroblast growth factor 23 and reduced level of phospho

16 Serum levels of fibroblast growth factor 23 and sclerostin decreased in

17 ors of osteocytic secreted proteins, such as fibroblast growth factor 23 and sclerostin, have been us

18 thelial cells blocked the effects of PTH and fibroblast growth factor 23 and stabilized the NPT2A-NHE

19 baseline (1990-1992) serum levels of intact fibroblast growth factor-23 and incident ESRD in 13,448

20 related to mineral metabolism/calcification (fibroblast growth factor-23 and OPG [osteoprotegerin]),

21 ke protein 1), CTSL1 (cathepsin L1), FGF-23 (fibroblast growth factor 23), and MMP-12 (matrix metallo

22 d 24,25-dihydroxyvitamin D, decreased intact fibroblast growth factor 23, and elevated inorganic phos

23 tubular reabsorption of phosphate (TRP (%)), fibroblast growth factor 23, and intact parathyroid horm

24 otif chemokine ligand, CD5, interleukin 12B, fibroblast growth factor-23, and monocyte chemoattractan

25 Animal models implicate FGF-23 (fibroblast growth factor-23) as a direct contributor to

26 ect the elevated plasma levels of osteocytic fibroblast growth factor 23 but decreased the elevated l

27 st growth factor 23 (iFGF23) into C-terminal fibroblast growth factor 23 (cFGF23), elevated levels of

28 Plasma fibroblast growth factor-23 concentration increased afte

29 High-fibroblast growth factor-23 concentration positively cor

30 artery disease, diabetes, dialysis vintage, fibroblast growth factor-23 concentration, and age, wher

31 Levels of intact fibroblast growth factor 23 decreased rapidly during the

32 Serum fibroblast growth factor-23 enhanced (P < 0.01), whereas

33 Both fibroblast growth factor 23 (FGF-23) and asymmetric dime

34 Fibroblast growth factor 23 (FGF-23) and Klotho are secr

35 vel circulating phosphaturic factors such as fibroblast growth factor 23 (FGF-23) and PHEX are respon

36 Mutations in fibroblast growth factor 23 (FGF-23) cause autosomal dom

37 Plasma fibroblast growth factor 23 (FGF-23) concentration, plas

38 Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) enhance phosphate e

39 conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial r

40 Fibroblast growth factor 23 (FGF-23) is a hormone that i

41 Fibroblast growth factor 23 (FGF-23) is a phosphorus-reg

42 Fibroblast growth factor 23 (FGF-23) is an endocrine reg

43 gh level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with

44 roid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral h

45 hate, calcium, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) were studied up to

46 Serum phosphate, calcium, and fibroblast growth factor 23 (FGF-23) were up-regulated a

47 bulin and mucin domain containing 4 (TIMD4), fibroblast growth factor 23 (FGF-23), growth differentia

48 The bone-derived hormone fibroblast growth factor-23 (FGF-23) activates complexes

49 kidney disease (CKD) by increased levels of fibroblast growth factor-23 (FGF-23) and parathyroid hor

50 ge-dependent phenotype correlated with serum fibroblast growth factor-23 (FGF-23) and phosphorus leve

51 trations of the phosphate-regulating hormone fibroblast growth factor-23 (FGF-23) are elevated in pat

52 Fibroblast growth factor-23 (FGF-23) inhibits sodium-dep

53 Fibroblast growth factor-23 (FGF-23) is a hormone that p

54 Fibroblast growth factor-23 (FGF-23) is a novel phosphat

55 Fibroblast growth factor-23 (FGF-23) is a phosphate regu

56 Fibroblast growth factor-23 (FGF-23) is one of the circu

57 An elevated level of fibroblast growth factor-23 (FGF-23) is the earliest abn

58 ently, several phosphaturic peptides such as fibroblast growth factor-23 (FGF-23), secreted frizzled

59 hrough cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways.

60 ntially mediated by the phosphaturic hormone fibroblast growth factor-23 (FGF-23).

61 by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvi

62 ip between repeated measures of vitamin D or fibroblast growth factor 23 (FGF23) and infectious and c

63 Klotho acts as transmembrane co-receptor for fibroblast growth factor 23 (FGF23) and is a key regulat

64 morphological, and biochemical phenotypes of fibroblast growth factor 23 (Fgf23) and klotho ablated m

65 There is growing evidence that fibroblast growth factor 23 (FGF23) and Klotho factor pl

66 e demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which no

67 mone (PTH), the vitamin D system, vitamin K, fibroblast growth factor 23 (FGF23) and phosphatase enzy

68 Fibroblast growth factor 23 (FGF23) and phosphate (P i )

69 (3) elicited the expected increase of plasma fibroblast growth factor 23 (FGF23) and reduction of par

70 sphatemic states arising from high levels of fibroblast growth factor 23 (FGF23) are also associated

71 Levels of fibroblast growth factor 23 (FGF23) are elevated in chro

72 The discovery of fibroblast growth factor 23 (FGF23) as a key regulator o

73 The discovery of fibroblast growth factor 23 (FGF23) as the causal factor

74 The rapid rise in circulating fibroblast growth factor 23 (FGF23) associated with kidn

75 The Klotho-fibroblast growth factor 23 (FGF23) axis is associated w

76 s of the parathyroid hormone (PTH)-vitamin D-fibroblast growth factor 23 (FGF23) axis, creatinine, an

77 DHR) is unique among the disorders involving Fibroblast growth factor 23 (FGF23) because individuals

78 genetic analysis or measurement of levels of fibroblast growth factor 23 (FGF23) before treatment.

79 c inflammation and elevations in the hormone fibroblast growth factor 23 (FGF23) contribute to cardia

80 Fibroblast growth factor 23 (FGF23) decreases 1,25(OH)2D

81 etabolic regulators, including elevations of fibroblast growth factor 23 (FGF23) directly contribute

82 We assessed: Fibroblast Growth Factor 23 (FGF23) expression and FGFR1

83 The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert

84 The discovery of fibroblast growth factor 23 (FGF23) has provided a more

85 asma levels of the osteocyte-derived hormone fibroblast growth factor 23 (FGF23) have emerged as a po

86 tency, which antagonize excessive actions of fibroblast growth factor 23 (FGF23) in hereditary hypoph

87 Circulating levels of fibroblast growth factor 23 (FGF23) increase during the

88 Circulating levels of bone-derived fibroblast growth factor 23 (FGF23) increase early durin

89 fibroblast growth factor receptor (FGFR) and fibroblast growth factor 23 (FGF23) indicates that its b

90 f adults with the phosphaturic human hormone fibroblast growth factor 23 (FGF23) induces tubule expre

91 Fibroblast growth factor 23 (FGF23) is a bone-derived en

92 Fibroblast growth factor 23 (FGF23) is a bone-derived ho

93 Fibroblast Growth Factor 23 (FGF23) is a bone-derived ho

94 Fibroblast growth factor 23 (FGF23) is a hormone that re

95 Fibroblast growth factor 23 (FGF23) is a phosphaturic fa

96 An increased circulating level of fibroblast growth factor 23 (FGF23) is an independent ri

97 Fibroblast Growth Factor 23 (FGF23) is increased in seru

98 The regulation of the phosphaturic factor fibroblast growth factor 23 (FGF23) is not well understo

99 Fibroblast growth factor 23 (FGF23) is often elevated in

100 Fibroblast growth factor 23 (FGF23) is part of a previou

101 l phosphate-wasting associated with elevated fibroblast growth factor 23 (FGF23) levels and normocalc

102 iations between elevated serum phosphate and fibroblast growth factor 23 (FGF23) levels and risks of

103 Elevated fibroblast growth factor 23 (FGF23) levels, measured at

104 The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phospha

105 Inflammation also stimulates fibroblast growth factor 23 (FGF23) production by increa

106 Lastly, vadadustat affected fibroblast growth factor 23 (FGF23) profiles: in non-CKD

107 Fibroblast growth factor 23 (FGF23) regulates mineral ho

108 Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) signaling, whereas i

109 Fibroblast growth factor 23 (FGF23) via its coreceptor a

110 Fibroblast growth factor 23 (FGF23) was initially charac

111 assay, B-type natriuretic peptide (BNP) and fibroblast growth factor 23 (FGF23) were recently identi

112 signaling complexes of the endocrine hormone fibroblast growth factor 23 (FGF23) with fibroblast grow

113 sylation of the phosphate-regulating hormone fibroblast growth factor 23 (FGF23) within osteocytes of

114 lcium, phosphate, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D

115 The recognition of fibroblast growth factor 23 (FGF23), a phosphaturic horm

116 Here, we show that fibroblast growth factor 23 (FGF23), a regulator of phos

117 eocyte-derived, phosphate-regulating hormone fibroblast growth factor 23 (FGF23), a risk factor for p

118 cation: elevated circulating 1,25D, 25D, and fibroblast growth factor 23 (FGF23), activation of vitam

119 iprocal manner by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1,25(OH)(2)D(3)

120 e is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1,25(OH)(2)D(3)

121 ,25(OH)2D3 (1,25D), parathyroid hormone, and fibroblast growth factor 23 (FGF23), and their interacti

122 perphosphatemia is associated with increased fibroblast growth factor 23 (FGF23), arterial calcificat

123 egulator of the phosphate-regulating hormone fibroblast growth factor 23 (FGF23), because humans with

124 Membrane-bound Klotho binds fibroblast growth factor 23 (FGF23), but a soluble form

125 a, and osteopenia, with elevated circulating fibroblast growth factor 23 (FGF23), calcitriol (1,25-D(

126 atus, and tested for mediation by C-terminal fibroblast growth factor 23 (FGF23), hemoglobin and para

127 cterised by elevated serum concentrations of fibroblast growth factor 23 (FGF23), hypophosphataemia,

128 on evolving concepts regarding the roles of fibroblast growth factor 23 (FGF23), inflammation and sy

129 ar bone osteocytes in Hyp mice overexpressed fibroblast growth factor 23 (Fgf23), its expression in m

130 nd related hormones, parathyroid hormone and fibroblast growth factor 23 (FGF23), on cardiac remodeli

131 1), the calcium-sensing receptor (CASR), and fibroblast growth factor 23 (FGF23), proteins that contr

132 form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydr

133 Fibroblast growth factor 23 (FGF23), uncarboxylated matr

134 h concentrations of circulating phosphatonin fibroblast growth factor 23 (FGF23), which causes renal

135 sis of the bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23), which results in re

136 The discovery of fibroblast growth factor 23 (FGF23), which revolutionize

137 unique basal and parathyroid hormone (PTH)-, fibroblast growth factor 23 (FGF23)-, and 1,25(OH)2D3-me

138 vels of the bone-derived hormones klotho and fibroblast growth factor 23 (FGF23).

139 s to identify novel genetic associations for fibroblast growth factor 23 (FGF23).

140 mones, such as parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23).

141 with high levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23).

142 n (mKL) and recognized as the coreceptor for fibroblast growth factor-23 (FGF23) and a circulating so

143 ercent tubular reabsorption of phosphate and fibroblast growth factor-23 (FGF23) at all CKD stages, a

144 Fibroblast growth factor-23 (FGF23) induces phosphaturia

145 Higher serum phosphate and fibroblast growth factor-23 (FGF23) levels may be modifi

146 itions, resulting in low serum phosphate and fibroblast growth factor-23 (FGF23) levels.

147 Fibroblast growth factor-23 (FGF23) regulates body phosp

148 Fibroblast growth factor-23 (FGF23), a hormone central t

149 low serum vitamin D levels, increased serum fibroblast growth factor-23 (Fgf23), and osteomalacia.

150 ated longitudinal changes in serum levels of fibroblast growth factor-23 (FGF23), parathyroid hormone

151 ny of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice.

152 hosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23).

153 , including elevated serum concentrations of fibroblast growth factor-23 (FGF23).

154 cholecalciferol on blood pressure and serum fibroblast growth factor-23 (FGF23).

155 sm (including abnormalities in phosphate and fibroblast growth factor 23 [FGF23]) contribute to adver

156 ading triggers physiologic release of FGF23 (fibroblast growth factor-23) from the bone to maintain p

157 other bone health markers, including intact fibroblast growth factor-23 (iFGF-23), intact parathyroi

158 D promotes production and cleavage of intact fibroblast growth factor 23 (iFGF23) into C-terminal fib

159 reted proteins parathyroid hormone (PTH) and fibroblast growth factor 23 inhibited Pi uptake by induc

160 Fibroblast growth factor-23 is a bone-derived hormone th

161 Although FGF23 (fibroblast growth factor 23) is associated with heart fa

162 imed to assess the effect of paricalcitol on fibroblast growth factor-23/KLOTHO axis in renal transpl

163 rminal pro-B-type natriuretic peptide level, fibroblast growth factor 23 level, estimated glomerular

164 Phosphate binder therapy restored plasma fibroblast growth factor 23 levels but had no effect on

165 d not significantly affect plasma C-terminal fibroblast growth factor 23 levels.

166 , ferric citrate greatly reduced circulating fibroblast growth factor 23 levels.

167 ad range of kidney function, higher baseline fibroblast growth factor-23 levels were associated with

168 rus levels, circulating phosphaturic hormone fibroblast growth factor-23 levels, and heart mass.

169 Recent studies suggest that fibroblast growth factor-23 may be an early biomarker of

170 diator of pathologic cardiac remodeling, and fibroblast growth factor-23 may contribute to cardiac re

171 ency anemia, but certain formulations induce fibroblast growth factor 23-mediated hypophosphatemia.

172 Fibroblast growth factor 23 null mice (Fgf-23-/-) have a

173 ion did not affect serum calcium, phosphate, fibroblast growth factor-23, or alkaline phosphatase lev

174 r KTx: the aortic calcification index (ACI), fibroblast growth factor 23, osteoprotegerin (OPG), fetu

175 ns of certain molecules, such as phosphates, fibroblast growth factor 23, parathyroid hormone, sclero

176 d markers of mineral metabolism, the highest fibroblast growth factor-23 quintile (>54.6 pg/ml) compa

177 s, acts as an essential co-receptor with the fibroblast growth factor 23 receptor complex to regulate

178 rathyroid hormone and phosphatonins, such as fibroblast growth factor 23, regulate the activity of th

179 Bone-derived FGF-23 (fibroblast growth factor-23) regulates phosphate homeost

180 ake stimulates parathyroid hormone (PTH) and fibroblast growth factor-23 secretion, increasing phosph

181 ighted the effect of phosphate depletion and fibroblast growth factor-23 suppression on the developme

182 Fibroblast growth factor 23, ucMGP, and fetuin-A concent

183 pass renal clearance of parathyroid hormone, fibroblast growth factor 23, vitamin D metabolites, and

184 Intact fibroblast growth factor 23 was higher and total alkalin

185 Elevated fibroblast growth factor 23 was independently associated

186 The renal extraction of fibroblast growth factor 23 was, on average, lower than

187 sphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associ

188 s regulated by parathyroid hormone (PTH) and fibroblast growth factor 23, which requires Na(+)/H(+) e

189 ced intact parathyroid hormone and increased fibroblast growth factor-23, with a trend to increase in