ライフサイエンスコーパス: fibrotic response

1 microvascular rarefaction with an exuberant fibrotic response.

2 astic alveolar epithelial cells regulate the fibrotic response.

3 and the emerging role of lymphocytes in the fibrotic response.

4 during chronic liver injury and mediate the fibrotic response.

5 ce of hematopoietically derived cells to the fibrotic response.

6 he expression of these mRNAs and enhance the fibrotic response.

7 d inflammation was followed by an attenuated fibrotic response.

8 ependent tissue injury eventually leads to a fibrotic response.

9 and SPARC mediate different aspects of this fibrotic response.

10 philia is not necessary for development of a fibrotic response.

11 e mice highlighted the reversibility of this fibrotic response.

12 block Ras/MEK/ERK signaling and abolish the fibrotic response.

13 these mice will have a significantly reduced fibrotic response.

14 key effector cells in the development of the fibrotic response.

15 New Zealand White rabbits failed to elicit a fibrotic response.

16 ollagen, suggesting a possible basis for the fibrotic response.

17 d IPF fibroblasts but had no effect upon the fibrotic response.

18 blast state transitions underlie the heart's fibrotic response.

19 alization and reductions in inflammation and fibrotic response.

20 t recognition and delayed propagation of the fibrotic response.

21 liver fibrosis and the early intervention of fibrotic response.

22 genesis, oxidative stress, polarization, and fibrotic response.

23 ineate a framework for understanding the CNS fibrotic response.

24 tory role for the Gbeta(1)gamma dimer in the fibrotic response.

25 thogenic leukocyte subtypes, which drive the fibrotic response.

26 IPF lung fibroblasts reduced the exacerbated fibrotic response.

27 ac fibroblasts as principal mediators of the fibrotic response.

28 rive myofibroblast formation and the cardiac fibrotic response.

29 k between inflammatory potential and initial fibrotic response.

30 ory response was followed by a subsequent M2 fibrotic response.

31 her large, nor associated with a significant fibrotic response.

32 l heart regeneration, resulting in a default fibrotic response.

33 d in TGF-beta1 or BLM, respectively, induced fibrotic responses.

34 mmation, wound healing, and their subsequent fibrotic responses.

35 events critical for the inflammatory and the fibrotic responses.

36 t at sites of Th2 inflammation and in tissue fibrotic responses.

37 s subpopulations that have distinct roles in fibrotic responses.

38 oxically elevated in murine lungs undergoing fibrotic responses.

39 modulate the heart's innate inflammatory and fibrotic responses.

40 ps of genes involved in the inflammatory and fibrotic responses.

41 es that distinguish transient from sustained fibrotic responses.

42 ways and genes involved in the regulation of fibrotic responses.

43 ith the reduced cholangiocyte senescence and fibrotic responses.

44 ial anti-AF therapeutic strategies targeting fibrotic responses.

45 ole for SPAG17 in the negative regulation of fibrotic responses.

46 f ROCK1 expectedly reduced TGF-beta1 induced fibrotic responses.

47 ted partially to peritoneal inflammatory and fibrotic responses.

48 val, and increased lung inflammatory and pro-fibrotic responses.

49 ontribution of LPA1/2/3 in mediating the pro-fibrotic responses.

50 causes prominent changes in hypertrophic and fibrotic responses accompanied by augmentation of Smad3/

51 of stimulating liver cell proliferation and fibrotic responses, accompanied by signs of oxidative st

52 nical roles for macrophages in mediating the fibrotic response after a heart attack include extracell

53 The fibrotic response after diverse forms of injury is chara

54 hypothesized that it may play a role in the fibrotic response after injury.

55 ay hold promise for favorably modulating the fibrotic response after MI and after other cardiovascula

56 evels under basal conditions and an enhanced fibrotic response after sustained stimulation of the ang

57 armacologic inhibition of MTHFD2 ameliorated fibrotic responses after intratracheal bleomycin instill

58 pporting a role for MC bFGF in the pulmonary fibrotic response and its clinical consequence.

59 e the mechanism(s) whereby GCs influence the fibrotic response and mechanisms underlying these effect

60 kinase within the fibroblast to program the fibrotic response and myofibroblast formation in vivo, s

61 ggest novel methods for the reduction of the fibrotic response and promotion of regeneration.

62 elastin and collagen expression, promoting a fibrotic response and subsequent stabilization of existi

63 ermore, poly(I:C) abrogated TGF-beta-induced fibrotic responses and blocked canonical Smad signaling

64 ells) and/or myofibroblasts to mimic in vivo fibrotic responses and dynamics.

65 ived conditioned medium promoted LPS-induced fibrotic responses and senescence in cholangiocytes, and

66 dothelial SHIP-1 is essential in controlling fibrotic responses and SHIP-1 is a target of miR-155.

67 ng a major role for macrophages in pulmonary fibrotic responses and suggesting a main role for Map3k8

68 -alpha (PGC-1alpha), a metabolic mediator of fibrotic response, and pharmacologic inhibition of PGC-1

69 mune system, the tumor microenvironment, the fibrotic response, and stem cell function.

70 d, and the cell types that contribute to the fibrotic response are incompletely defined.

71 It is not clear how the hypertrophic and fibrotic responses are transcriptionally regulated.

72 clear anchorage in DKO mice coincided with a fibrotic response as indicated by increased collagen and

73 rkedly reduced the pressure overload-induced fibrotic response as well as fibrosis mediated by a hear

74 h to endometrial pathologies which involve a fibrotic response (Asherman's syndrome, endometriosis) a

75 y during fibrosis and the macrophage-derived fibrotic response associated with collagen deposition cu

76 by impaired regeneration, inflammation, and fibrotic response at day 14, increased fat infiltration,

77 etion of Gbeta(1) led to derepression of the fibrotic response at the mRNA and protein levels under b

78 nesis of HP, amplifying the inflammatory and fibrotic response by paracrine signaling inducing the se

79 mportant structural cells can perpetuate the fibrotic response by regulating the differentiation, rec

80 te that loss of REV-ERBalpha exacerbates the fibrotic responses by promoting collagen and lysyl oxida

81 ibroblasts, we investigated the induction of fibrotic responses by the S1P receptor (S1PR) agonists S

82 ding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, wher

83 with scleroderma skin demonstrated multiple fibrotic responses centered around human IL-6 signaling,

84 e persistence of necrotic cells stimulated a fibrotic response characterized by extensive collagen de

85 on of the gland showed an aberrant sustained fibrotic response characterized by increased levels of E

86 30-40 microm showed angiogenesis and reduced fibrotic response, coinciding with a shift in macrophage

87 otubule-localized TRPC3-GEF-H1 axis mediates fibrotic responses commonly in cardiac myocytes and fibr

88 nal deterioration followed by an exaggerated fibrotic response compared with control animals.

89 l mice, however, demonstrated enhanced early fibrotic responses compared with wild-type mice with pan

90 ssion of the involved genes and mitigate the fibrotic response, confirming a key role for p53 in rena

91 growth factor alone produce only a transient fibrotic response, connective tissue growth factor and t

92 The fibrotic response contained increased amounts of types I

93 ts position Egr-1 downstream of c-Abl in the fibrotic response, delineate a novel Egr-1-dependent int

94 n adipocytes is a critical component of the "fibrotic response," directly linked to metabolic dysfunc

95 etwork, which transited to a two-compartment fibrotic response displaying an alphaSMA cold external c

96 l inflammation orchestrates inflammatory and fibrotic responses, driving podocyte damage through down

97 nitric oxide participates in modulating the fibrotic response during the development of pulmonary gr

98 urrounded by a layer of CD3(+) T cells and a fibrotic response encapsulating the lesions were observe

99 sible outcomes to postnatal wound healing: a fibrotic response (EPF-mediated) and a regenerative resp

100 mesenchymal transition (EMT) is important in fibrotic responses, formation of cancer stem cells, and

101 oint at a possible shift in inflammation and fibrotic response from adipose tissue to liver and a pos

102 to dietary induction of the inflammatory and fibrotic response genes.

103 Galectin-3 regulates inflammatory and fibrotic responses; however, its role in cardiac remodel

104 xpression was induced after the onset of the fibrotic response, IL-10, IL-13, and Stat6 dependent, an

105 e increased secretion of IL-1beta, induces a fibrotic response in adjacent airway fibroblasts.

106 is not only protective, but can reverse the fibrotic response in carbon tetrachloride-induced fibros

107 The fibrotic response in Clusterin deficient (CLU-/-) mice p

108 et failed to significantly contribute to the fibrotic response in either acute or chronic infection.

109 We investigated whether the enhanced fibrotic response in GM-CSF-/- animals was due to a defi

110 e hypothesis that MC bFGF contributes to the fibrotic response in human interstitial lung disease, we

111 (+) cells are sufficient to reconstitute the fibrotic response in IL-21R-deficient mice.

112 lates at least 50% of the renal interstitial fibrotic response in obstructive nephropathy, an effect

113 ch in turn may have a profound effect on the fibrotic response in SSc.

114 sed collagen expression, leading to an early fibrotic response in the abdominal aortic wall and resul

115 ngiotensin II infusion revealed a pronounced fibrotic response in the absence of miR145.

116 uninjured CFs initiated a self-perpetuating fibrotic response in the adult heart that was exacerbate

117 MRI allowed the visualization of the primary fibrotic response in the aortic wall.

118 underlying mesenchymal tissue demonstrated a fibrotic response in the dermis of the skin but not the

119 iary dysfunction and aberrant epithelial pro-fibrotic response in the multifactorial disease pathogen

120 pulmonary inflammation and intensifying the fibrotic response in the patients.

121 ing dedifferentiation and contributes to the fibrotic response in the tubulointerstitium (TI) after u

122 oid-specific deletion of Tgfb1 abrogates the fibrotic response in this injury model and reduces fibro

123 The reduced fibrotic response in wounds from IL-1R KO mice could be

124 s an important role in ductular reaction and fibrotic responses in a BDL mouse model of cholestatic l

125 ent and selective UCHL1 inhibitors block pro-fibrotic responses in a cellular model of idiopathic pul

126 ZYZ-168 appeared to inhibit the fibrotic responses in a concentration dependent manner,

127 gnificant insight into the border immune and fibrotic responses in AD.

128 othelial-mesenchymal transition (EndoMT) and fibrotic responses in bleomycin (BLM) induced lung fibro

129 ponectin receptor agonists abrogated ex vivo fibrotic responses in explanted normal and SSc fibroblas

130 genesis after chronic colitis by stimulating fibrotic responses in fibroblasts.

131 In these rats, CRMS induces microvascular fibrotic responses in heart and kidneys, associated with

132 al TRPC3 inhibition significantly suppressed fibrotic responses in human cardiomyocytes and cardiac f

133 ociated with cell-type specific inflammatory-fibrotic responses in ischemic kidney injury, discerns c

134 ug compounds predicted to generate divergent fibrotic responses in male vs. female conditions, which

135 lly, we show that KAT5 inhibition alleviates fibrotic responses in patient-derived human fibroblasts.

136 oth conjunctival inflammatory and subsequent fibrotic responses in patients with OCP.

137 nant Cf48 (rCf48) enhanced TGF-beta1-induced fibrotic responses in renal fibroblasts and epithelial c

138 lial damage of the glands elicits immune and fibrotic responses in SS.

139 dothelial miR-155 plays an important role in fibrotic responses in the lung through EndoMT.

140 od pressure control and for hypertrophic and fibrotic responses in the mouse heart and aorta.

141 elenting and destructive progression of most fibrotic responses in the pulmonary, cardiovascular, int

142 ay an important role in the inflammatory and fibrotic responses in viral and/or nonviral human airway

143 1 expression increases on fibroblasts during fibrotic responses in vivo, and IL-13 increases collagen

144 cin sulfate provoked lethal inflammatory and fibrotic responses in WT (CCR4(+/+)) mice, but such resp

145 ver of unrestrained wound healing (i.e., the fibrotic response) in these and other organ systems.

146 Genes involved in the fibrotic response, including ACTA2, TGFBR1, and TGFBR2 w

147 f48 binding to mRNA of genes involved in the fibrotic response, including Serpine1, Acta2, Ccn2, and

148 ellate cell (HSC) lines in culture activates fibrotic responses, indicating that loss of MPI promotes

149 dence that implicate c-Abl as a mediator for fibrotic responses induced by transforming growth factor

150 ngs also imply that cellular homeostasis and fibrotic response involve the integration of signaling t

151 subpopulations of macrophages in promoting a fibrotic response is an emerging target.

152 st lines into immunodeficient mice, and this fibrotic response is dependent on the interaction betwee

153 ess, but current evidence indicates that the fibrotic response is driven by abnormally activated alve

154 e I increased at 48 hours, suggesting that a fibrotic response is induced after the amniotic sac punc

155 genetically modified mice and show that the fibrotic response is largely independent of B and T lymp

156 This fibrotic response is observed following multiple anti-gl

157 One chemokine that is repeatedly linked to fibrotic responses is monocyte chemoattractant protein-1

158 Activation of fibrotic responses is the main distinguishing feature be

159 13-PE inhibited silica-induced granuloma and fibrotic responses noted at 24 h and 15 d after the last

160 de (CGRP) in denervated kidneys mimicked the fibrotic response observed in innervated obstructed kidn

161 diated CD69 blockade in WT mice mimicked the fibrotic response of cd69(-/-) mice.

162 on and inflammation but no difference in the fibrotic response of IPF fibroblasts.

163 ts a functional role of this molecule in the fibrotic response of keratocytes to wound healing.

164 e alpha8beta1 integrin may contribute to the fibrotic response of organs to injury.

165 extracellular messenger, enhancing specific fibrotic responses of keratocytes to TGFbeta.

166 he liver by determining the inflammatory and fibrotic responses of nfkappab1-null mice in an experime

167 We next investigated the fibrotic responses of tendon-derived cells isolated from

168 and in vivo loss of Sox9 blunted the cardiac fibrotic response on ischemic injury.

169 nd with either an augmented hypertrophic and fibrotic response or a diminished hypertrophy and resist

170 Inflammatory and fibrotic responses persisted for 4 mo in DBA/2J mice, wh

171 tiation of fibroblasts to myofibroblasts and fibrotic responses remain incompletely defined.

172 psulated with CXCL12 evaded the pericapsular fibrotic response, resulting in long-term functional com

173 An unabated fibrotic response results in chronic liver disease and c

174 ranslation at several time points during the fibrotic response, revealing transient and early-respond

175 ssion profiles demonstrated inflammatory and fibrotic responses selectively in females.

176 These mice develop a robust fibrotic response similar to littermate genotype control

177 the S. rectivirgula-induced inflammatory and fibrotic response, suggesting that the CD4(+) T cell rep

178 ury incites an overwhelming inflammatory and fibrotic response that leads to expansive fibrous tissue

179 is a novel transcriptional regulator of the fibrotic response that may act to restrict fibrosis to c

180 mental approaches whose aim is to reduce the fibrotic response that the typical mammal displays in re

181 e the hyaluronan matrix without inducing pro-fibrotic responses that lead to nephropathy and proteinu

182 n and hepatocyte apoptosis, as well as early fibrotic responses; these findings indicate that shifts

183 as a global genomic regulator to direct the fibrotic response through its coordinated regulation of

184 ced by TGF-beta and serves to limit vascular fibrotic responses through negative feedback regulation

185 lin/LRP1 co-complex in tissue remodeling and fibrotic responses through stimulation of anoikis resist

186 d a novel approach to evade the pericapsular fibrotic response to alginate-microencapsulated SC-beta

187 via A2B receptors to counterbalance the pro-fibrotic response to ATP.

188 ) mice showed a significantly increased lung fibrotic response to bleomycin compared with WT mice.

189 n during this fibrotic phase led to enhanced fibrotic response to bleomycin.

190 e to bleomycin, but reconstitutes their lung fibrotic response to bleomycin.

191 a-deficient mice that develop an exaggerated fibrotic response to determine whether changes in type 2

192 tic mediators in this model, we examined the fibrotic response to FITC in mice that were genetically

193 lammatory response to bleomycin, however the fibrotic response to injury was unaltered compared with

194 st that Th cytokine subsets can modulate the fibrotic response to injury.

195 tional macrophages that are required for the fibrotic response to injury.

196 oliferative window and precipitated a robust fibrotic response to left ventricular pressure overload.

197 regard to the capacity of MSCs to influence fibrotic response to liver injury and will explore the p

198 of stellate cells is a central event in the fibrotic response to liver injury, we hypothesized that

199 a macrophage membrane protein regulates the fibrotic response to lung injury and suggest a novel tar

200 , we demonstrate that Thy1(-/-) mice mount a fibrotic response to MAP gels that includes inflammatory

201 of the maladaptive remodeling and myocardial fibrotic response to PO.

202 Estradiol replacement restored the fibrotic response to that of the intact female mice in t

203 cient (Sphk2(-/-)) mice showed an attenuated fibrotic response to UUO compared with wild-type mice, a

204 The lung fibrotic response to V(2)O(5) partially resolves where f

205 TLR4-, and C5aR-mediated proinflammatory and fibrotic responses to bacteria that were consistent with

206 the specific molecular mechanisms underlying fibrotic responses to biomedical implants have yet to be

207 P1(-/-) or EP3(-/-) mice, showed exaggerated fibrotic responses to bleomycin administration in vivo a

208 whether MMP-8 regulates lung inflammatory or fibrotic responses to bleomycin, we delivered bleomycin

209 ling and EndoMT in regulating angiogenic and fibrotic responses to injury.

210 that GRP blockade decreases inflammatory and fibrotic responses to radiation in mice.

211 crophages might be effective in ameliorating fibrotic responses to silica in the lung.

212 temic disease processes, and inflammatory or fibrotic responses to stimuli.

213 , there was no evidence of resolution of the fibrotic response up to 45 days after bleomycin therapy.

214 n of an anti-inflammatory agent) on the host fibrotic response using a previously developed animal mo

215 ect effect on cardiac fibroblasts to inhibit fibrotic responses via extracellular signal-related kina

216 Fibrotic response was assessed by quantitative real time

217 e IL-13 receptor alpha-2-Fc, the exacerbated fibrotic response was completely inhibited.

218 ormally demonstrating that their exacerbated fibrotic response was due to heightened IL-13 activity.

219 established in both genotypes; however, the fibrotic response was profoundly worsened in Egr-1-defic

220 gammadelta T cells are effector cells in the fibrotic response, we performed adoptive transfer experi

221 otential role in modulating inflammatory and fibrotic responses, we examined the expression of the nu

222 nd its availability governs the intensity of fibrotic responses, we investigated p300 expression in S

223 Fibrotic responses were associated with changes in expre

224 eomycin or vehicle, and pulmonary injury and fibrotic responses were compared.

225 In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-d

226 Fibrotic responses were studied using proliferation, mig

227 ng adiponectin mounted an exaggerated dermal fibrotic response, while transgenic mice with constituti

228 limited induction of PGE(2) and an enhanced fibrotic response with increased lung collagen content c

229 pendent effects of methylprednisolone on the fibrotic response, with an emphasis on YAP/TAZ-TEAD sign

230 ne a normal healing response and an aberrant fibrotic response within the same gland to uncover mecha