ライフサイエンスコーパス: fide

1 city is revealed by a small fraction of bona-fide 14-mers (<4%) that may enable subunit exchange.

2 sorbent assay confirmed the presence of bona fide Abeta oligomers, whereas immunoprecipitation-Wester

3 purification identified N65 and N82 as bona fide acceptors for N-glycans.

4 e installation of acetylation mimics or bona fide acetylation within H3 N-terminal tail alters the co

5 the FDA approved drug hydralazine is a bona fide activator of the NRF2/SKN-1 signaling pathway.

6 rted in Arabidopsis are indicative of a bona fide activity that can be associated with the regulation

7 hese sites, and establish that PSGs are bona fide, acute, and persistent targets of WIN site blockade

8 Finally, as predicted for a bona fide AD, mutation of this newly identified AD reduced th

9 ulin-stimulated phosphorylation of four bona fide Akt substrates (TSC2, PRAS40, FOXO1/3a, and AS160)

10 Thus, sphincter muscle cells are bona fide, albeit unconventional, photoreceptors.

11 Thus, CRAF is a bona fide alternative oncogene for BRAF/NRAS/GNAQ/GNA11 wild

12 e electrochemical communication through bona fide AMPA receptor-dependent neuron-glioma synapses.

13 Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics

14 TEs expressed from their own promoter (bona fide) and TEs that are transcribed from a neighboring ge

15 (++)CD16- monocyte differentiation into bona fide anti-inflammatory Mvarphis in a self-autonomous man

16 mune responses(1,2) and can function as bona fide antigens that facilitate tumour rejection(3).

17 hange in the acceptance of obesity as a bona fide area of academic interest.

18 sembly defect is direct, i.e. New1 is a bona fide assembly factor, or indirect, for instance due to a

19 ell suited for such investigations, but bona fide astrocytes have not been described in this system.

20 s Chaetomium thermophilum captured in a bona fide autoinhibited state, which represents a novel confo

21 UIS3 acts as a bona fide autophagy inhibitor by competing with host LC3-inte

22 Mature B2 cells differentiated into bona fide B1 cells upon acquisition of a B1 cell-typical self

23 In addition, the bona fide bacterial PIMT enzymes may play a different or subt

24 evidence of the other MBLAC2 role as a bona fide beta-lactamase allows for reassessment of beta-lact

25 B associate with STAT5 at sites lacking bona fide binding motifs.

26 3'-5' polymerase activity of TLPs as a bona fide biological activity for the first time since its un

27 that shared variants largely represent bona fide biological occurrences of the same variant in the g

28 kuL), a protein of unknown function, as bona fide c-di-AMP-binding proteins.

29 invasion and for the Tarp effector as a bona fide C. trachomatis virulence factor.

30 ivity, demonstrating the plasticity and bona fide callosal potential of L4 neurons.

31 alignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targe

32 esis studies revealed that Subdued is a bona fide CaPLSase.

33 Here, we identify a bona fide cardiac-specific Prkaa2 enhancer that is synergisti

34 conclude that large COPII vesicles are bona fide carriers of PC1.

35 This allowed for dissecting bona fide caveolar functions from those supported by mere cav

36 hat the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for >1 yr in the graft.

37 arkers to distinguish CD8-MP cells from bona fide CD8(+) memory T cells, the developmental origins an

38 e, this is the first demonstration of a bona fide cell adhesion molecule, NECL4, regulating choline h

39 nnexin, which form gap junctions and/or bona fide cell surface channels.

40 triolar-material antibodies to identify bona fide centrosomes and multiplexed these with cell border

41 ve Sirt2 inhibitors with thalidomide, a bona fide cereblon ligand.

42 Our study correlates bona fide changes in PSP and CBD brains with cellular models,

43 se models and human tumours: functional bona fide chemical synapses between presynaptic neurons and p

44 Among them, some members exhibited bona fide CHI activity, which catalyze stereospecific cycliza

45 However, so far the bona fide CHIs are found only in vascular plants, and their o

46 Expressing those primitive bona fide CHIs in the Arabidopsis chi mutant restores the see

47 edgehog (HH) pathway, for example, is a bona fide ciliary signalling system that regulates cell fate

48 We verified their bona fide circular topology using circular DNA deep-sequencin

49 the PDZ domain of nNOS can behave as a bona fide class III PDZ domain and bind to C-terminal sequenc

50 istinguishing abortive coats (ACs) from bona fide clathrin-coated pits (CCPs) is required but unaccom

51 olobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved

52 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor supp

53 am start codon, likely representing the bona fide CLOCK N-terminus.

54 rt were successfully captured including bona fide clusters of cells consistent with each major compon

55 ow the constant curvature model and the bona fide CME population generates vesicles of a predominantl

56 Recognizing AKI as a bona fide complication of diabetes should open up new avenues

57 ctivity-dependent processes are central bona fide components of neuronal TF-differentiation programs

58 stent time-independent detection of its bona fide components.

59 ghtly than domains in proteins that are bona fide components.

60 entified, but nonetheless can represent bona fide compounds, also considerably complicates biological

61 is is a valuable method for identifying bona fide contributors to follicular lymphoma transformation

62 coA and Rhizobium leguminosarum RibN as bona fide copper and riboflavin importers, respectively.

63 ce yet that visual deprivation produces bona fide cortical change.

64 ome CD11c(hi) cells that may not have a bona fide counterpart in vivo.

65 ing fliX-MS to cells identifies several bona fide crosslinks on DNA binding domains, paving the way f

66 ining ADA and Piccolo NuA4 complexes as bona fide crotonyltransferases that promote crotonylation-dep

67 es in PKC-stimulated DAT trafficking in bona fide DAergic terminals.

68 olster the conclusion that CACNA1C is a bona fide, definite evidence long-QT syndrome susceptibility

69 moted the protein stability of USP28, a bona fide deubiquitinase of LSD1.

70 escue studies revealed that Card10 is a bona fide direct miR-181b target.

71 niversally conserved GTPase (HflX) as a bona fide dissociation factor of the S. aureus 100S ribosome.

72 ntration-dependent polymerization via a bona fide DIX domain allows these to recruit ANGUSTIFOLIA to

73 structure provides a prime exemplar of bona fide domain-swapping.

74 Here we report that crenactin forms bona fide double helical filaments that show exceptional simi

75 icking proteins have been identified as bona fide drivers of tumorigenesis.

76 Our work thus identifies TRPA1 as a bona fide drug target for the amelioration of alpha-DC stress

77 trategy towards eventual acquisition of bona fide drug-resistance mechanisms.

78 We demonstrate TaU4 to be a bona fide E2 enzyme through an E2 charging assay.

79 d binding domains of PPARgamma and is a bona fide E3 ligase for PPARgamma.

80 Here, we identified bona fide ECS signals, likely corresponding to carotenoid ban

81 dentified lipopolysaccharide (LPS) as a bona fide effector caspase inhibitor that directly binds casp

82 ength protein from the first group is a bona fide effector protein injected into host cells during in

83 s, ELL1 (also known as ELL) is the only bona fide elongation factor that directly stimulates transcri

84 sive high grade mammary carcinomas with bona fide EMT, histologically similar to human metaplastic br

85 However, validating such candidates as bona fide enhancers requires functional characterization, typ

86 ase changes confirms that exercise is a bona fide environmental time cue for skeletal muscle.

87 Loktanella ALDH16 is found to be a bona fide enzyme, exhibiting NAD(+)-binding, ALDH activity, a

88 A total of 56 genes encoding bona fide enzymes catalyzing the consecutive ten steps of the

89 Hence, Mfn2 stands as a bona fide ER-mitochondria tether whose ablation decreases int

90 ster regulator of HSC identity(5), as a bona fide ERAD substrate that became aggregated in the endopl

91 ntal approaches required to distinguish bona fide EV cargo from merely co-purifying contaminants.

92 vated T cells precludes it from being a bona fide exhaustion marker.

93 The bona fide F-box AnkB effector protein of L. pneumophila strai

94 ormal hematopoiesis and that Brca1 is a bona fide FA-like gene.

95 Because of the limited set of bona fide fibroblast markers, a proper characterization of fi

96 s, involving either the kleptoplasts or bona fide foraminiferal pathway(s) not yet identified.

97 wever, it is crucial to demonstrate the bona fide formation of G4 structures within an endogenous chr

98 combinant TIE protein was shown to have bona fide GA 2-oxidase activity.

99 ond intron of IncRNA, PVT1, as a unique bona fide gained enhancer that restored MYC transcription ind

100 are able to promote the development of bona fide gammadeltaT17 cells from peripheral CD122(-)IL-23R(

101 e definitive evidence that TRAPPII is a bona fide GEF for the yeast Rab11 homologues Ypt31/32.

102 olerant persister cells, which can seed bona fide genetic mechanisms of resistance to EGFR TKIs.

103 cterized, one enzyme was verified to be bona fide GGDPS and all others were demonstrated to function

104 ion of OSTERIX with OLFM4 and LGR5, two bona fide GI stem cell markers, at the crypt cells.

105 D microarray and confirmed one hit as a bona fide GLUT1 ligand, which we named rapaglutin A (RgA).

106 crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

107 and SDC-2, but not SDC-3 or SDC-4, are bona fide HCV attachment receptors.

108 , this effect was not observed with the bona fide HCV IRES.

109 ated ultrastructural features represent bona fide HIV protein complexes.

110 d AddAB even in the complete absence of bona fide hotspot sequences.

111 pluripotency via multiple mechanisms in bona fide hPSCs and reprogrammed cells.

112 lear implications for the generation of bona fide hPSCs for regenerative medicine.

113 an pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline som

114 alian neural stem cell (NSC) fate and a bona fide human disease gene in congenital hydrocephalus (CH)

115 not well characterized, specifically in bona fide human disease tissue.

116 ack an equivalently vetted inventory of bona fide human enhancers.

117 work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general strateg

118 using insights obtained from the first bona fide human immunoproteasome cocrystal structures.

119 he data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo.

120 n et al. developed a method to identify bona fide IgE(+) MBCs in humans, demonstrated their extreme r

121 We establish ZFP91 as a bona fide IMiD-dependent CRL4(CRBN) substrate and further sho

122 These results reveal that AARS1 is a bona fide in vitro substrate of METTL21C and suggest a role f

123 ctivated later during the transition to bona fide induced pluripotent stem cells (iPSCs).

124 itosans, which can now be recognized as bona fide information-carrying molecules.

125 n of the preinitiation complex (PIC) to bona fide initially transcribing complex (ITC), elongation co

126 ucose from the hemolymph, a hallmark of bona fide insulin action.

127 ays to determine which of these exhibit bona fide interactions.

128 We identify RcsF and OmpA as bone fide interactors of BamA, and we show that MetQ associat

129 170 independent experiments, to filter bona fide interactors.

130 nd epithelial junctional remodeling, as bona fide IRF6 partner proteins.

131 These data confirm that Neto2 is a bona fide KAR auxiliary subunit that is an important constitu

132 and doublecortin-like kinase 1 and 2 as bona fide KLHL15 interactors and mapped KLHL15 interaction re

133 the cydD phenotype, unlike that of the bona fide l-cysteine exporter eamA, parallels that of the l-c

134 uctural, and organizational features of bona fide LBs.

135 eficient mice confirmed that FADS3 is a bona fide LCB desaturase and required for the introduction of

136 emonstrated that those cells behaved as bona fide LCs when inserted in a three-dimensional rebuilt ep

137 These studies establish APOL1 as a bona fide LD-associated protein, and reveal that recruitment

138 e hypothesis that tetrapods inherited a bona fide limb regeneration programme concomitant with the fi

139 over observed cell types encodes their bona fide lineage relationships.

140 lcium imaging to determine how a set of bona fide lineage-related interneurons contribute to sensorim

141 isplay to isolate peptides that possess bona fide LIR (LC3-interacting region) properties and are sel

142 n summary, ALT joins PAN/nut1/T1.1 as a bona fide lncRNA of KSHV with potentially important roles in

143 oietic progenitors not derived from the bona fide long-term hematopoietic stem cells give rise to tis

144 Our findings uncover a key class of bona-fide LRRK2 substrates and a novel regulatory mechanism o

145 transcriptome-wide analysis identifies bona fide MARF1 target mRNAs and indicates that MARF1 predomi

146 protein-coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial ti

147 sts that MCD/C5s, as a class, represent bona fide MB tumors.

148 e structural modifications of MD-222, a bona fide MDM2 PROTAC degrader, converts it into a "molecular

149 r studies present deep insight into the bona fide mechanisms underlying castration resistance and pro

150 ts establish the adhesion receptor as a bona fide mechanosensor that directly senses and responds to

151 IL-12) improved accuracy in detecting bona-fide memory CD8 T-cell responses suggesting this as the

152 1 expression superimposes with Lmx1a, a bona-fide mesDA lineage marker, during the active phase of me

153 ns and hydrogen bonding structures in a bona fide metalloenzyme proton pathway.

154 or the trimeric G protein Galphai and a bona fide metastasis-related gene that serves as a platform f

155 In vitro MGE-like cells resembled bona fide MGE cells but expressed lower levels of Foxg1 and E

156 ble via optical microscopy, making them bona fide microbes.

157 other methods incorrectly classify most bona fide micropeptides as noncoding.

158 stion as to whether RNA viruses produce bona fide microRNAs (miRNAs) during infection has been the fo

159 s (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remains unclear.

160 ositives, but surprisingly lacked >2000 bona fide microRNAs.

161 ified phosphodiesterase 7B (PDE7B) as a bona fide miR-200c target.

162 hase subunit genes ATP5G1 and ATPIF1 as bone fide miR29b-1/a targets.

163 MirCure can be used to revisit previous bona fide miRNAs annotations to improve miRNA databases.

164 rstood features can clearly distinguish bona fide miRNAs from the myriad other small RNAs generated b

165 l dysfunction, which is associated with bona fide mitochondrial disorders.

166 eading up to the discovery of the first bona fide molecular catalyst system and follow with a compreh

167 ng, established that lot 150048 are not bona fide MT-4 cells.

168 at temperatures too low for assembly of bona fide MTs, both tau isoforms promoted the formation of lo

169 While some progenitors are bona fide multipotent and contribute progeny to all major pan

170 d screening of peptides recognized by a bona fide murine Treg cell clone isolated from the visceral a

171 n is well established, the existence of bona fide N(omega)-methylarginine demethylases (RDMs) is cont

172 lase AbyU, an enzyme shown here to be a bona fide natural Diels-Alderase.

173 e physiological features of the desired bona fide neuronal subgroups remains an unanswered question a

174 Thus, ASICs have become bona fide neurotransmitter-gated ion channels, activated by t

175 also provides evidence for thousands of bona fide novel elements of RNA processing-alternative splice

176 FXR activity in vivo, thus providing a bona fide novel therapeutic agent to treat enterohepatic diso

177 We thus propose that PINs are a bona fide NPA target.

178 le in the helicase domain of Rep68 as a bona fide oligomerization domain (OD).

179 zed astrocytes, supporting AVIL being a bona fide oncogene.

180 Only a small number of genes are bona fide oncogenes and tumor suppressors such as Ras, Myc, b

181 ole in cell transformation, making it a bona fide oncometabolite.

182 ate (D-2-HG) have been characterized as bona fide oncometabolites.

183 es, we propose a high confidence set of bona fide palmitoylated proteins in brain and provide a resou

184 urprisingly, T. brucei still contains a bona fide Pam18 orthologue that, while essential for normal g

185 Our approach reliably discerns bona fide PAS from false PAS that arise due to internal poly(

186 dentifies c.620C>T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibility al

187 e many facets of the immune response to bona fide pathogens as well as commensals.

188 press a subset of cellular genes, as do bona fide PEL cells.

189 However, validation of the effect of bona fide phosphorylation in vivo and assessing the therapeut

190 conformational changes are sensitive to bona-fide phosphorylation on S13 and S16 within the N17 domai

191 g support for the notion that WNK4 is a bona fide physiological intracellular Cl(-) sensor and that C

192 ination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal tr

193 e, this is the first demonstration of a bona fide physiological role for a Tad pilus in this bacteria

194 e that both subunits of the complex are bona fide PKC substrates.

195 ls for managing Wnt-driven tumors, is a bona fide PORCN inhibitor whose IC50 for inhibition of Wnt fa

196 orces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequenc

197 Finally, we argue that glucagon is a bona fide postprandial hormone that evolved to concurrently a

198 The bona fide PPARgamma activators we identified induced adipogen

199 from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.

200 However, no bona fide primate pheromones have been identified.

201 In other disorders, the bona fide prion characteristics are still under investigation

202 ted in the absence of any cofactors are bona fide prions provides a strong support for the protein-on

203 ation-prone proteins are now considered bona fide prions.

204 (O2()) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electron re

205 Archaea are bona fide prokaryotes but employ a eukaryote-like transcripti

206 -C also revealed biologically supported bona fide promoter-enhancer interactions and topologically as

207 ction was long-lasting (>8 weeks) and a bona fide property of SA-4-1BBL, as treatment with an agonist

208 structural modifications can convert a bona fide PROTAC degrader into a molecular glue compound, whi

209 and chloroplasts, the identification of bona fide protease substrates has been very challenging.

210 ction that cannot be distinguished from bona fide protein isoforms.

211 M glycosylation, identifying CEACAMs as bona fide protein receptors for Hp.

212 ions in the free form and when bound to bona fide Py-tract RNA ligands.

213 The bona fide quiescent CFs derived from human induced pluripoten

214 Mof deletion or FAO inhibition induces bona fide quiescent ground-state ESCs with an intact core plu

215 R7 and R8 photoreceptors target to the bona fide R7 target layer where they form connections with pr

216 new regulator of body weight and as the bona fide receptor mediating the metabolic effects of GDF15,

217 olved redox events, and (ii) screen for bona fide redox-sensor targets.

218 resented here demonstrate that tRFs are bona-fide regulatory microRNA-like small RNAs involved in the

219 exposure to THC-rich cannabis vapor has bona fide reinforcing properties and collectively support the

220 Here we show that RUNX1 functions as a bona fide repressor of transcription activated by AML1-ETO.

221 ogy, illustrates the configuration of a bona fide resting state voltage sensor, observed without the

222 dence that confirms its membership as a bona fide Rhodococcus.

223 n vitro analyses, we further focused on bona fide ribosome interactors (i.e. SEC61) and ER proteins (

224 7-mer and 16-mer synthetic bRNAs reveal bona fide RNA branchpoints in the Dbr1 active site.

225 The presence of bona fide RNA G4s in cells has long been a matter of debate.

226 ere, we review the distinct features of bona fide RNA sensors, Toll-like receptors and retinoic-acid

227 strate that Hfq CLASH robustly captures bona fide RNA-RNA interactions.

228 mutant flies, indicating that 340R is a bona fide RNAi suppressor, the absence of which uncovers a po

229 We demonstrate that YonO is a bona fide RNAP of the SPbeta bacteriophage that specifically

230 though iRPE displayed features close to bona fide RPE, no or a modest increase of the RPE65 protein l

231 implicate the ompA RNA thermometer as a bona fide S. dysenteriae virulence factor in this bacterial p

232 terion to identify and characterize the bona fide SARS-CoV FP.

233 monstrate that these CpdX compounds are bona fide selective GC receptor agonistic modulators (SEGRAMs

234 Identifying TCRs directed against bona fide self-antigens is made difficult by the extraordinar

235 that zebrafish explants do not undergo bona fide self-organization, but rather display features of g

236 ike protein phosphatase 2 (AtSLP2) is a bona fide Ser/Thr protein phosphatase that is targeted to the

237 s (Nod26-like major intrinsic protein), bona fide silicon transporters, whereas EcLsi2 and EcLsi3, an

238 We propose that NEMURI is a bona fide sleep homeostasis factor that is particularly impor

239 However, to date, only a very few bona fide small molecules have been reported against the HA.

240 target proteins, with orally available, bona fide small molecules remains a significant but immensely

241 We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and sta

242 This work establishes SORB-1 as a bona fide sorbin family protein-one of the late additions to

243 gustatory system, evidence that it is a bona fide sour taste receptor.

244 acinar cells that are not considered a bona fide source for stem cells.

245 cSCs to show that oncogenic McSCs are a bona fide source of melanoma that expand in the niche, and th

246 ive function of PTBP1 and its role as a bona fide splicing activator.

247 e physiology, identify c-MYC as a novel bona fide SPOP substrate, and help explain the frequent inact

248 We verified that this approach captures bona fide sRNA-mRNA interactions.

249 ogeny and adaptive purpose of IL-6 as a bona fide stress hormone coordinating systemic immunometaboli

250 e, we demonstrate that lipin 1beta is a bona fide substrate for casein kinase II (CKII), a protein ki

251 y further defining PPP2R5 proteins as a bona fide substrate of HIV-1 Vif.

252 suggesting that this mutated form is a bona fide substrate of this degradation pathway.

253 proximately 1000 peptides identified 32 bona fide substrates of the plant NatB complex.

254 e it to provide evidence that SMT7 is a bona fide SUMO protease.

255 Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs

256 -VSV-SARS-CoV-2 spike) that served as a bona fide system mimicking SARS-CoV-2 infection.

257 cally shown that psoriasis represents a bona fide T cell-mediated disease primarily driven by pathoge

258 y and loci-specific profiles similar to bona fide T(SCM) isolated from healthy donors, with intermedi

259 patients, and we provide evidence that bona-fide T3 phosphorylation alters Huntingtin exon 1 protein

260 and in vivo designate this protein as a bona fide target for the development of novel anti-TB interve

261 induction of Bcl-xL and IkappaBalpha, 2 bona fide target genes of the canonical NF-kappaB pathway.

262 esearch reveals that mitochondria are a bona fide target of Coxiella effectors and MceA is a complex-

263 MAP4 is a novel bona fide target of HPV16E7 protein which binds and recruits

264 target evaluation in this uncommon yet bona fide target-rich disease.

265 by a process analogous to that used by bona fide TBDT ligands.

266 we report a simple strategy to examine bona fide TE expression, termed BonaFide-TEseq.

267 ryotic genomes have been shaped by both bona fide TE integration preferences in eukaryotic genomes an

268 a simple alternative approach to assess bona fide TE transcription at single-cell resolution and prov

269 ements, which have all the hallmarks of bona fide TEs yet which lack high homology with currently kno

270 s pseudopilins forming shorter Tff than bona fide Tfp-forming major pilins, underlining the evolution

271 cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proin

272 ults support the notion that SPHK1 is a bona fide therapeutic target for the treatment of AML.

273 icability to the in vitro derivation of bona fide tissue progenitors of all germ layers.

274 ung rather than residing in the lung as bona fide tissue-resident CD69(+) NK cells.

275 ertoire employing TCRdeltaVs, NARTCRVs, bona fide trans-rearrangements from shark IgH clusters, and a

276 chanistically, we identified FOXO1 as a bona fide transcriptional repressor of HAS2.

277 ogies for identifying cell lineages and bona fide transcriptional signals, it is necessary to combine

278 affected H3K27 acetylation contained a bona fide TRbeta1-binding site.

279 determine whether these profiles reveal bona fide TREEs, we tested the sufficiency and requirements o

280 Th1/Tregs arise in atherosclerosis from bona fide Tregs, rather than from T-effector cells.

281 Bona fide trophoblast stem cell lines and extra-embryonic end

282 Furthermore, bona fide TS and XEN cell lines can be derived from EPSCs in

283 biochemical analyses uncover CEP83 as a bona fide TTBK2 substrate with four phosphorylation sites cha

284 provide genetic evidence that Bap1 is a bona fide tumor suppressor gene and offer key insights into t

285 Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regula

286 Long understood as a bona fide tumor suppressor that safeguards the integrity of t

287 Merlin/NF2 is a bona fide tumor suppressor whose mutations underlie inherited

288 endogenous GLS2, defying its role as a bona fide tumor suppressor.

289 we provide evidence that both HATs are bona fide tumor suppressors that control MHCII expression and

290 We also establish H1 as a bona fide tumour suppressor and show that mutations in H1 dri

291 tic CHIs, suggest that emergence of the bona fide type II CHIs is an ancient evolution event that occ

292 eum subterraneum' operate together as a bona fide ubiquitin modification system, mediating a sequenti

293 onstrate that the protein Sov1 is an in bona fide VAR1 mRNA translational activator and additionally

294 rmore, GSC also transdifferentiate into bona fide vascular endothelial cells (GEC), which inherit mut

295 er for men than for women, suggesting a bona fide "Vietnam War" effect.

296 zing antibody titers showed evidence of bona fide viral infection or experienced any symptoms during

297 our knowledge, the first characterized, bona fide virulence factor secreted by Acinetobacter species.

298 om primordial selfish genetic elements, bona fide viruses evolved on multiple, independent occasions

299 rt that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP that can trigge

300 tR from S. agalactiae (PDB 3KKC) is the bona fide zinc efflux regulator SczA, and binds two zinc ions