ライフサイエンスコーパス: filamentation

1 ing, invasive growth, cell-cell adhesion, or filamentation).

2 or clpP delays cell division and exacerbates filamentation.

3 t Izh2p and Izh3p negatively regulate fungal filamentation.

4 protein termed Dfi1p and results in invasive filamentation.

5 nd SC5314 and DAY185 demonstrated pH-induced filamentation.

6 l and tightly regulated role in pseudohyphal filamentation.

7 ransduction cascade, thus promoting invasive filamentation.

8 ns under conditions of vegetative growth and filamentation.

9 m-sensing molecule, with exposure inhibiting filamentation.

10 stitutively activates pheromone response and filamentation.

11 to inhibit pathogenesis by repressing fungal filamentation.

12 by implicating these genes in the process of filamentation.

13 istinct developmental programs of mating and filamentation.

14 mutants incapable of inhibiting C. albicans filamentation.

15 suggesting that chloramphenicol induces the filamentation.

16 ignificant to study and understand bacterial filamentation.

17 1 MAPKs to induce mating and Kss1 to promote filamentation.

18 mutants are defective in IAA perception and filamentation.

19 namely, adherence to the agar substrate and filamentation.

20 er Snf1-Gal83 or Snf1-Sip2 is sufficient for filamentation.

21 s ability to promote yeast agar invasion and filamentation.

22 ytometry were used to monitor cell death and filamentation.

23 the Msb2 regulon contains genes that control filamentation.

24 ciple for the power scaling of laser-induced filamentation.

25 At least two signaling pathways regulate filamentation.

26 mplex transcription factor cascade regulates filamentation.

27 otic resistance selection and prevented cell filamentation.

28 ants exhibited medium-conditional defects in filamentation.

29 l morphology, resulting in Ecoli MG1655 cell filamentation.

30 s Ecm22 and Upc2 in Saccharomyces cerevisiae filamentation.

31 provide insight into fundamental aspects of filamentation.

32 ons and high temperatures promote white cell filamentation.

33 the balance of physical mechanisms governing filamentation.

34 llectively constitute the molecular basis of filamentation.

35 ls, as assayed by LDH release, and escape by filamentation.

36 Human enhancer of filamentation 1 (HEF1) has been implicated in signaling

37 strate (CAS) family member human enhancer of filamentation 1 (HEF1), but not p130CAS or Src-interacti

38 easomal degradation of the human enhancer of filamentation 1 (HEF1), which is a member of the Cas fam

39 uding the p130Cas paralog, human enhancer of filamentation 1 (HEF1/Cas-L/Nedd9) was identified.

40 Altered expression of human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) has

41 Human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) is

42 metastatic adapter protein human enhancer of filamentation 1 (HEF1; NEDD9) links PGE(2) to the cell c

43 HEF1 (human enhancer of filamentation 1) is a member of a docking protein family

44 bstrate, and its homologue human enhancer of filamentation 1, thus regulating formation of focal adhe

45 Human enhancer of filamentation-1 (HEF1), a multifunctional docking protei

46 id rate of DNA damage, as indicated by their filamentation, a high rate of mutation among the survivo

47 isms, we observed that A. baumannii inhibits filamentation, a key virulence determinant of C. albican

48 Lactic acid bacteria are known to suppress filamentation, a key virulence feature of C. albicans, t

49 avalanches of low energy electrons via laser filamentation, a phenomenon that results in a spatial en

50 RT subunit genes abolish alkaline pH-induced filamentation, a phenotype previously seen for rim101 an

51 olid matrix such as agar results in invasive filamentation, a process in which cells change their mor

52 entified new genes required for pH-dependent filamentation, a trait previously associated with virule

53 pe known as haploid fruiting, which involves filamentation, agar invasion and sporulation in response

54 Calcine urin regulates filamentation and 37 degrees C growth via distinct pathw

55 xpression of either yqaH or yqaM caused cell filamentation and abnormal chromosome segregation, which

56 ver two to three generations, accompanied by filamentation and accretion (in approximately 2% of cell

57 Filamentation and adherence to host cells are critical v

58 As a cell surface glycoprotein that mediates filamentation and adherence, Als1p has both structural a

59 which functions as a downstream effector of filamentation and also mediates cell-cell adherence (flo

60 factor, Znf2, in XL280 abolished or enhanced filamentation and biofilm formation, consistent with its

61 We propose that filamentation and cell death resulting from thymine depr

62 During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression.

63 eptides cause DNA segregation abnormalities, filamentation and DNA damage.

64 inated process is crucial for correct septin filamentation and efficient growth of polarised cells, s

65 toxin that inhibits cell growth, causes cell filamentation and eventually cell death.

66 Here, we have explored the cause of filamentation and identified a potentially important cli

67 lity of phenanthriplatin to induce bacterial filamentation and initiate lysis in lysogenic bacteria c

68 es including mating, cell wall biosynthesis, filamentation and invasive growth.

69 ding of the transcription factor Tec1 during filamentation and is differentially regulated by the MAP

70 UPC2 expression also increases during filamentation and is inhibited by the transcription fact

71 expression of IF2-2/3 essentially eliminated filamentation and largely restored MMS resistance.

72 nto FtsZ spirals, arcs, and foci, leading to filamentation and lysis.

73 y complement the nitrogen starvation induced filamentation and mating defects of Saccharomyces cerevi

74 wild-type infB allele exhibited significant filamentation and MMS sensitivity in this background whe

75 naling pathways controlling Candida albicans filamentation and pathogenicity.

76 cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypi

77 products were also sufficient for the known filamentation and recombination activities of the respec

78 ved that deletion of clpX or clpP suppresses filamentation and reduces FtsZ84 degradation.

79 amage or of antibiotic treatment also led to filamentation and reduction in viability both in broth a

80 genesis; compromising Hsp90 function induces filamentation and relieves repression of Ras1-protein ki

81 lling by neutrophils and also had defects in filamentation and tissue invasion.

82 s mutant that lacked key genes important for filamentation and virulence also significantly induced e

83 results, Als1p was required for both normal filamentation and virulence in the mouse model of haemat

84 elated MAP kinase and cAMP pathways regulate filamentation and virulence of human and plant fungal pa

85 Highly related signaling processes control filamentation and virulence of many human fungal pathoge

86 alone resulted in stalled replication forks, filamentation, and a decrease in viability.

87 ncludes reduced viability, SOS induction and filamentation, and abnormal nucleoid morphology.

88 Further, disruption of ALS1 inhibited filamentation, and autonomous expression of Als1p restor

89 n in Escherichia coli, and its localization, filamentation, and bundling at the mid-cell are required

90 and Fig2p can function in mating, invasion, filamentation, and flocculation.

91 three distinct MAP kinase pathways: mating, filamentation, and HOG.

92 ad a reduced growth rate in vitro, decreased filamentation, and impaired capacity to damage epithelia

93 divJ results in a reduced growth rate, cell filamentation, and mislocalized stalks.

94 transcription factor that regulates mating, filamentation, and virulence in Saccharomyces cerevisiae

95 transcription factor that regulates mating, filamentation, and virulence in Saccharomyces cerevisiae

96 hows that isolates also varied in adherence, filamentation, and virulence.

97 filastatin based on its strong inhibition of filamentation, and we use chemical genetic experiments t

98 Filamentation appeared to be in response to a Toll-like

99 ation and invasion/cell-cell adhesion during filamentation are separable processes controlled by the

100 estriction-modification system, and identify filamentation as a defining mycobacterial response to hi

101 onset of modulation instability and multiple filamentation as a result of a favourable interplay betw

102 der stress such as DNA damage, which induces filamentation as cell cycle progression is blocked to al

103 e kil gene was shown to cause cell death and filamentation as described previously.

104 is required for nitrogen starvation-induced filamentation as ste12 mutants rarely produce pseudohyph

105 c signalling cascades to regulate mating and filamentation, as well as growth at high temperature whi

106 rization, utilizing an in vitro NaCl-induced filamentation assay.

107 supporting mutational analysis and in vitro filamentation assays.

108 e evaluated in vitro using proliferation and filamentation assays.

109 plexity of the underlying nonlinear physics, filamentation-assisted self-compression of ultrashort la

110 corroborated by expression profiling of five filamentation-associated genes using quantitative real-t

111 ired for expression in alkaline media of two filamentation-associated genes, HWP1 and ECE1, but is no

112 form filaments at 22 degrees C and enhancing filamentation at 37 degrees C in nutrient-rich medium.

113 o high lithium concentrations and to repress filamentation at acidic pH.

114 tone and dodecanol also affected C. albicans filamentation at similar concentrations.

115 ase III holoenzyme, that causes extreme cell filamentation but does not affect either cell growth or

116 the absence of Tec1 and for the induction of filamentation by butanol, a related phenomenon.

117 gh ERG11 levels, whereas GPI2 determines the filamentation by cross-talk with Ras1 signaling.

118 ntents had reduced growth rates and impaired filamentation capacities.

119 farnesol, which inhibits Cyr1 and represses filamentation, caused an increase in the fraction of Ras

120 After filamentation, cellular diameter varied erratically alon

121 n of plasmids, loss of transforming ability, filamentation, changes in the pool sizes of various nucl

122 SOS induction and filamentation commenced after an apparently normal cell

123 Filamentation control pathways seem closely related in C

124 The heterogeneity in EspA filamentation could arise from phase-variable expression

125 at mutant strains did not have a generalized filamentation defect.

126 hich facilitates hyphal maintenance, rescues filamentation defects of hir1Delta/Delta cells, suggesti

127 CASQ2 missense variants evaluated exhibited filamentation defects, but only p.R33Q convincingly fail

128 4 strain, which is temperature sensitive for filamentation due to a mutation in ftsZ, we observed tha

129 acC pathway is involved in regulating fungal filamentation during ex vivo Aspergillus infection of th

130 data suggest a mechanism for bacterial cell filamentation during infection under anaerobic condition

131 as found to inhibit cell-cell fusion but not filamentation during sexual reproduction.

132 While undergoing filamentation, each source wavelength was spectrally bro

133 ich time the available laser sources limited filamentation experiments in the atmosphere to the near-

134 ored in TLR4-deficient mice, suggesting that filamentation facilitates the transition to additional r

135 laser pulse's diffraction, self-focusing and filamentation from phase 'streaks' imprinted onto probe

136 The filamentation function of Kil and recombination activity

137 tes Kss1, but not Fus3, in vivo and promotes filamentation gene expression while suppressing mating g

138 ans, a homozygous mutant of the pH-dependent filamentation gene rim13 or a mutant reference strain co

139 c1 tethers Ste12 to TCS elements upstream of filamentation genes and defines the filamentation genes

140 Filamentation genes are bound by the Tec1/Ste12/Dig1 com

141 pheromone response elements [PREs]), whereas filamentation genes are supposedly regulated by the coop

142 tream of filamentation genes and defines the filamentation genes as a subset of Ste12-regulated genes

143 However, most filamentation genes do not contain an FRE; instead, they

144 and degradation and allows the induction of filamentation genes in response to pheromone.

145 uding genes implicated by expression change, filamentation genes known previously through a phenotype

146 hus permitting speculation about C. albicans filamentation genes not yet discovered.

147 1, a cofactor of Ste12 for the expression of filamentation genes, is rapidly degraded during pheromon

148 mutants are noninvasive, lack surface-spread filamentation, grow slowly, and exhibit impaired cell ad

149 re cell division defect that results in cell filamentation (>50 microm).

150 So far, laser filamentation has been triggered with the use of ultrafa

151 percontinuum generation in femtosecond laser filamentation have enabled applications from stand-off s

152 protein that influences C. albicans growth, filamentation, host cell interactions, and virulence.

153 DprA facilitates RecA filamentation; however, the filaments cannot engage in D

154 , and their expression is upregulated during filamentation in an Ecm22/Upc2-dependent manner.

155 and autonomous expression of Als1p restored filamentation in an efg1 homozygous null mutant.

156 A systematic study of filamentation in atmospheric air was performed using a t

157 , we show the evidence of mid-infrared pulse filamentation in atmospheric air.

158 work offers a fresh new look at the role of filamentation in C. albicans biofilm formation, and desc

159 cell surface protein Als1p is an effector of filamentation in C. albicans.

160 g1p, which is known to be a key regulator of filamentation in C. albicans.

161 diasis and to investigate the role of fungal filamentation in disease progression.

162 Laser filamentation in gases is often carried out in the labor

163 pectral broadening of the supercontinuum for filamentation in molecular gases, which is observed for

164 to be conserved regulators and effectors of filamentation in multiple fungi.

165 Intense femtosecond pulse filamentation in open-air has been utilized for long dis

166 or mutation of the Sok2 repressor, restored filamentation in rapamycin treated cells, supporting mod

167 stance was also shown to inhibit C. albicans filamentation in the context of an in vitro biofilm.

168 t proteins and signaling pathways leading to filamentation in the human fungal pathogen.

169 ant cells were elongated, and some exhibited filamentation in the intracellular environment.

170 explaining the atomic basis of calsequestrin filamentation in the presence of calcium.

171 Filamentation in the recB mutant decreased to 3%, but in

172 Filamentation in three strains of P. aeruginosa depends

173 eports have noted the occurrence of cellular filamentation in V. cholerae, with variable propensity t

174 1p, a transcription factor regulating fungal filamentation, in experimental Candida albicans keratiti

175 logical defects, including cell widening and filamentation, indicating a role in cell shape maintenan

176 ations conferred SDS sensitivity and partial filamentation, indicating that Tat export of authentic s

177 t, causing loss of viability and severe cell filamentation, indicative of SOS induction.

178 Filamentation induced by antibiotics appears to trigger

179 Filamentation induced by cAMP (Fic) domain proteins have

180 f enzymes, defined by the presence of a Fic (filamentation induced by cAMP) domain, catalyzes this ad

181 Specifically, we showed that the human Fic (filamentation induced by cAMP) protein, HYPE/FicD, catal

182 Filamentation induced by cyclic AMP (FIC)-domain enzymes

183 The ubiquitous proteins with FIC (filamentation induced by cyclic AMP) domains use a conse

184 s with the G2 cyclin Clb2p and phenotypes in filamentation induced by S-phase arrest.

185 vph1Delta/Delta cells remained competent for filamentation induced by Spider media and YPD, 10% FCS,

186 e transfer of phosphorylcholine to Rab1 in a filamentation-induced by cAMP(Fic) domain-dependent mann

187 ngtin yeast-interacting protein E (HYPE) and filamentation-induced by cyclic AMP (FIC)-1, respectivel

188 diatomic molecules play an essential role in filamentation-induced supercontinuum generation, which c

189 e defects in three responses to alkaline pH: filamentation, induction of PRA1 and PHR1, and repressio

190 NO causes cell filamentation, induction of the SOS response, and DNA re

191 scription factor Ume6, a master regulator of filamentation, inhibits gut colonization, not by effects

192 ional HOG pathway during osmotic stress in a filamentation/invasion-pathway-dependent manner.

193 new insights into the means by which aerial filamentation is accomplished.

194 pe of regulatory networks that control yeast filamentation is broad and incompletely defined.

195 which acts with AcrEF, suggesting that cell filamentation is caused by the loss of AcrEF function.

196 contain active AdhE monomers, and that AdhE filamentation is essential for its activity in vitro and

197 tructures provides insight showing that AdhE filamentation is essential for substrate channeling with

198 (s) by which Snf1-Gal83 and Snf1-Sip2 affect filamentation is independent of FLO11.

199 We demonstrate that C. albicans filamentation is not required for escape from host immun

200 In high-NA conditions, filamentation is primarily governed by geometrical focus

201 Filamentation is regulated by multiple pathways includin

202 ding human fungal pathogen Candida albicans, filamentation is thought to be required for immune cell

203 oor substrate for Ste7, although the related filamentation MAPK, Kss1, is an excellent substrate.

204 The complex regulation of filamentation may reflect the versatility of C. albicans

205 the adhesion phenotype was controlled by the filamentation mitogen-activated kinase (fMAPK) pathway,

206 urthermore, phenotypic comparison of various filamentation mutants illustrates that cell elongation a

207 The modular abstraction of the filamentation network enables the association of filamen

208 were integrated as the nodes and edges of a filamentation-network graph.

209 In the solute stress treatments, cell filamentation occurred more frequently in the presence o

210 n of a weakly ionized plasma channel through filamentation of an ultraintense femtosecond laser pulse

211 However, NK cells were unable to inhibit filamentation of C. albicans.

212 Filamentation of Candida albicans occurs in response to

213 In particular, the level of filamentation of cells within the biofilms formed in SU

214 XP results in increased FtsZ degradation and filamentation of cells.

215 This regulatory defect did not prevent filamentation of gat1Delta mutants in nitrogen repressin

216 indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae.

217 entous growth, and were largely required for filamentation of sok2/sok2 mutant strains.

218 Filamentation of swarming cells of B728a was not observe

219 ysine-63-linked polyubiquitin chain to cause filamentation of the adaptor protein MAVS and activation

220 i isolate, the msbB mutation also results in filamentation of the cells at 37 degrees C but not at 30

221 The filamentation of the dead cells, and their protection by

222 We measured large-scale filamentation of the hot electron distribution at the ta

223 ps, resulting in a commensurate large-scale filamentation of the magnetic field profile.

224 is accelerated by ATP and inhibited by ADP, filamentation of the mutated proteins is blocked indiscr

225 of non-cognate ParF proteins suggesting that filamentation of the ParF proteins is enhanced by a comm

226 Additionally, filamentation of TOP52 was observed, a process critical

227 Filamentation of ultrashort laser pulses in the atmosphe

228 Here, we demonstrate filamentation of ultrashort mid-infrared pulses in the a

229 In this study, the effect of cellular filamentation on gliding motility of Myxococcus xanthus,

230 s at CDC25; they are viable but defective in filamentation on serum-containing medium.

231 dependent enx3/enx3 mutants are defective in filamentation on Spider medium.

232 geted transcription factor from an ancestral filamentation or biofilm pathway, and the upregulated ge

233 tasmtB strain was not accompanied by reduced filamentation or defects in cell polarity.

234 ucing lexA3 decreased, but did not eliminate filamentation or defects in partitioning.

235 powers up to 30 times the critical power for filamentation P cr .

236 mone pathway signaling erroneously activates filamentation pathway gene expression and invasive growt

237 at these different components operate in the filamentation pathway in vivo.

238 Parallel results were observed for filamentation pathway signaling, suggesting that the req

239 c1, the transcription factor specific to the filamentation pathway.

240 nctions as a downstream effector of the EFG1 filamentation pathway.

241 tly, most of the genes regulated by multiple filamentation pathways encode known virulence factors.

242 alitatively different between the mating and filamentation pathways.

243 Filamentation per se is not the cause of cell death, bec

244 ay to screen for alleles that complement the filamentation phenotype of M. smegmatis 628-53 following

245 NA replication, and their depletion caused a filamentation phenotype that phenocopied defects in this

246 mal in rne null mutant bacteria reverses the filamentation phenotype, it does not restore CFA.

247 ion of each G1 cyclin results in a different filamentation phenotype, varying from a significant defe

248 The growth defect and filamentation phenotypes associated with 2-aminopurine e

249 The cold-sensitivity and filamentation phenotypes were suppressed by all members

250 ers altered cellular morphologies, including filamentation, polar bulging, curving, and, surprisingly

251 ies of sRNA DicF in their genomes, with cell filamentation previously being linked to bacterial patho

252 id medium in which cph1/cph1 is defective in filamentation, previously identified differentially expr

253 ck protein Hsp90, which negatively governs a filamentation program dependent upon the Ras-protein kin

254 is required to prevent the activation of the filamentation program during pheromone response.

255 volved in trehalose metabolism, disrupts the filamentation program in response to heat.

256 Intracellular growth and filamentation provided an advantage to the bacteria in e

257 Filamentation (pseudohyphae) was associated with DB colo

258 zation front expansion and the appearance of filamentation radiating from the laser spot within a sub

259 ranscription start site driven by the master filamentation regulator Znf2.

260 g homozygous null mutations in the following filamentation regulatory genes: CLA4, CPH1, EFG1, and TU

261 Recent virulence studies of filamentation regulatory mutants argue that both yeast a

262 Multiple filamentation regulatory pathways have been discovered i

263 Mutants with defined defects in filamentation regulatory pathways have reduced virulence

264 of FtsZ ring formation and a high degree of filamentation relative to wild-type cells.

265 Filamentation relies on the dynamic balance between self

266 ndent of Rim20p and Rim8p; in these strains, filamentation remains pH dependent.

267 The fusion protein (MEK/ERK) induced a filamentation response element promoter and led to a gro

268 The filamentation results from increased expression of QueE,

269 We identify filamentation self-compression scaling strategies whereb

270 This suggests that distinct filamentation signaling pathways converge to regulate a

271 s to phenocopy Cfl1-expressing cells via the filamentation-signaling pathway.

272 We suggest that during filamentation Ste12 becomes activated and reduces SUT1/S

273 Both mutations disrupt filamentation, suggesting that disease pathology is due

274 The Arabidopsis At filamentation temperature sensitive (FtsH) metalloprotea

275 P-dependent metalloprotease belonging to the FILAMENTATION TEMPERATURE-SENSITIVE H (FTSH) family.

276 FtsZ (filamentation temperature-sensitive Z) is the bacterial

277 iate subsequent morphogenetic events such as filamentation that lead to infection.

278 ity of the NRG1 transcript, thus controlling filamentation through a feedback loop.

279 ble cell types, white and opaque, to undergo filamentation to adapt to diversified environments.

280 Deletion of the 5' UTR increases C. albicans filamentation under a variety of conditions but does not

281 emented mutant M. smegmatis 628-53 undergoes filamentation under nonpermissive conditions.

282 Plasma channel generation (or filamentation) using ultraintense laser pulses in dielec

283 Filamentation was completely inhibited at concentrations

284 were significantly reduced, and M199-induced filamentation was impaired in the vph1Delta/Delta mutant

285 E. coli filamentation was observed by light microscopy when cell

286 f morphology-specific markers confirmed that filamentation was suppressed by 200 microM 3-oxo-C12 hom

287 regulate differential gene expression during filamentation, we have constructed a partial C. albicans

288 tin, required for actin-actin contact during filamentation, were also nonessential for viral transcri

289 that in Escherichia coli, Hsp90 causes cell filamentation when expressed at high levels.

290 SpyA inhibited vimentin filamentation, whereas a catalytic site mutant of SpyA h

291 n of either ECM22 or UPC2 leads to increased filamentation, whereas cells lacking both ECM22 and UPC2

292 tive growth for haploid invasion and diploid filamentation, whereas Fig2p is required for mating.

293 sources such as starches can also stimulate filamentation, whereas haploid cells undergo a similar i

294 ess-free, starvation-independent inducers of filamentation, which we use to describe the properties o

295 LAB and low temperatures support opaque cell filamentation, while neutral pH conditions and high temp

296 ion has a bacteriostatic effect and leads to filamentation, while the degP::Tn10 surA::kan combinatio

297 By inducing femtosecond filamentation with the modulated pulse, we can concentra

298 Depletion of ObgE also results in cell filamentation, with polyploid DNA content.

299 Filamentation within the region persists for several pic

300 inosa, was sufficient to inhibit C. albicans filamentation without affecting fungal growth rates.