ライフサイエンスコーパス: final step

1 yield of ~96%, with no side products in the final step.

2 uction of sugar units (here, glucose) in the final step.

3 e 1, converting it to an RNA ligase, for the final step.

4 ghly fluorescent Nile red derivatives in the final step.

5 ent for the formation of the oxindole in the final step.

6 C and a global deprotection strategy as the final step.

7 form, and is the rate-limiting event of the final step.

8 formation of the linking benzodioxane in the final step.

9 in delivering a crucial hydroxy group in the final step.

10 maturation involves heme incorporation as a final step.

11 ned by oxidative cyclodehydrogenation in the final step.

12 rdinated to the nanoparticle surface, in the final step.

13 In the final step, a quick and almost barrierless sulfoxidation

14 However, the final step, acyl migration (am), that takes place throug

15 ncorporate non-biological reactions into the final steps allows determination of pathways to producti

16 ime constant that is thought to describe the final step, as supported by ultra-high resolution mass s

17 ely on evaporative cooling, a time-consuming final step associated with substantial atom loss.

18 the distal convoluted tubule represents the final step before Mg(2+) is excreted into the urine, thu

19 fication process, and that is removed in the final step by a protease.

20 The final step, called maturation, involves a concerted effo

21 psid protein subunits to a nucleus, with the final step completing the icosahedron.

22 A final step consists of partial replacement of aragonite

23 nd negative selection must still undergo one final step, generally termed T cell maturation, before t

24 e P450 11B1 (CYP11B1) is responsible for the final step generating the steroid hormone cortisol, whic

25 As a final step, human radiation doses were extrapolated from

26 in 1 (XRCC1), which completes the fourth and final step in (short-patch) BER.

27 espectively, in a process that serves as the final step in a nutrient-driven "hexosamine-signaling pa

28 eochemistry of the aldol reaction and as the final step in a short synthesis of members of the phaseo

29 >3)-galactosyltransferase (GTB) catalyze the final step in ABO(H) blood group A and B antigen synthes

30 f the YUCCA (YUC) family, which catalyze the final step in auxin biosynthesis.

31 The final step in bile acid synthesis involves conjugation w

32 The inhibition of the final step in blood coagulation, the factor XIIIa (FXIII

33 ylation of 7-methylxanthine to xanthine, the final step in caffeine N-demethylation.

34 The final step in cardiolipin biosynthesis is catalyzed by c

35 nery from biological membranes is a critical final step in cellular processes that require the ESCRT

36 e and phytyl pyrophosphate, required for the final step in chlorophyll a synthesis.

37 downstream from the Plo1 kinase to control a final step in contractile ring assembly.

38 dings identify mechanistic principles of the final step in cut-and-paste transposition and the molecu

39 ent methionine synthase (MetE) catalyzes the final step in Escherichia coli methionine biosynthesis b

40 Caulobacter crescentus, which catalyzes the final step in GDP-perosamine synthesis, the conversion o

41 Pyruvate kinase catalyzes the final step in glycolysis and is allosterically regulated

42 t phosphorylation for the execution of a pre-final step in human NK-cell cytotoxicity.

43 KDO8PP and KDN9PP catalyze the final step in KDO and KDN synthesis, respectively, prior

44 (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethano

45 ction-like behavior in animals, an essential final step in linking animal and human studies of addict

46 yl alcohol dehydrogenase (CAD) catalyzes the final step in monolignol biosynthesis, reducing sinapald

47 The final step in mycolic acid biosynthesis in Mycobacterium

48 The final step in Na(+) channel biosynthesis in central neur

49 uminal site of an inflammatory stimulus, the final step in neutrophil recruitment.

50 Follicle rupture, the final step in ovulation, utilizes conserved molecular me

51 ibit D,D-transpeptidases, which catalyze the final step in peptidoglycan biosynthesis.

52 tial positioning of MurG which catalyses the final step in peptidoglycan precursor synthesis.

53 ol carrier protein SCPx, which catalyzes the final step in peroxisomal fatty acid beta-oxidation.

54 dehydratase (ADT1-6) gene family encodes the final step in Phe biosynthesis in Arabidopsis thaliana r

55 atic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine synthesis.

56 The final step in polyketide synthase-mediated biosynthesis

57 The final step in Q biosynthesis is the reduction of the epo

58 he beta-integrin cytoplasmic domain is a key final step in regulating the affinity of integrins for e

59 The final step in releasing iron is the oxidative cleavage o

60 e miRNA* strand from pre-RISC and may be the final step in RISC assembly, ultimately enhancing target

61 drobenzophenanthridine oxidase (DBOX) is the final step in sanguinarine biosynthesis.

62 rmation of SatPC via LPCAT1 reacylation is a final step in SatPC synthesis prior to transport.

63 ctivation coincides with spermiogenesis, the final step in spermatogenesis, when the spherical sperma

64 The enzyme catalyzes the final step in the arginine dihydrolase pathway convertin

65 DNA/dNTP complex is thought to represent the final step in the assembly of the catalytic complex and

66 The final step in the assembly of the ubiquinol-cytochrome c

67 ransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a p

68 The final step in the biosynthesis of fosfomycin in Streptom

69 pase D (NAPE-PLD) (EC 3.1.4.4) catalyzes the final step in the biosynthesis of N-acyl-ethanolamides.

70 Escherichia coli and have identified the key final step in the biosynthesis of Q.

71 of ( S)-3-chloro-beta-tyrosyl-S-SgcC2 as the final step in the biosynthesis of the ( S)-3-chloro-5-hy

72 The final step in the biosynthesis of the antibiotic chloram

73 em-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful

74 Lipoyl synthase (LipA) catalyzes the final step in the biosynthesis of the lipoyl cofactor, t

75 The final step in the biosynthesis of the sesquiterpenoid an

76 hoxy-3beta-tropine) with benzoic acid is the final step in the biosynthetic pathway leading to the pr

77 ves pGpG, which is necessary to complete the final step in the c-di-GMP degradation pathway.

78 The final step in the cascade involves reduction of the Cys(

79 oxidation of toxic sulfite to sulfate as the final step in the catabolism of the sulfur-containing am

80 indings illuminate an important role for the final step in the CD74-MHC II pathway and a new target f

81 b(I)alamin adenosyltransferase catalyzes the final step in the conversion of vitamin B 12 into the ac

82 te (PLP)-dependent enzyme that catalyzes the final step in the cysteine biosynthetic pathway in enter

83 The final step in the degradation of heparin sulfate involve

84 pimelate decarboxylase (DAPDC) catalyzes the final step in the diaminopimelate biosynthesis pathway o

85 The final step in the egress of herpes simplex virus (HSV) v

86 Enoyl-ACP reductases catalyze the final step in the elongation cycle of the bacterial fatt

87 ced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway.

88 findings suggest that uropod elongation is a final step in the leukocyte extravasation cascade, which

89 noyl-CoA, thus forming the substrate for the final step in the pathway.

90 ls upstream of Aurora B to regulate when the final step in the physical separation of daughter cells

91 eine carboxylmethyltransferase (Icmt) is the final step in the prenylation pathway.

92 act in concert to catalyze folding, with the final step in the process involving closure of the ends

93 lex that spans the periplasm carries out the final step in the process of host lysis.

94 membrane receptors by gamma-secretase is the final step in the process of regulated intramembrane pro

95 minal fragment (APP-betaCTF) constitutes the final step in the production of Abeta peptides.

96 on of signaling precursors and catalyzes the final step in the production of the amyloid beta-peptide

97 chain nuFeHis dropped sharply at 20 mus, the final step in the R-T transition.

98 The final step in the referencing makes use of spacing diffe

99 Distal sodium transport is a final step in the regulation of blood pressure.

100 The final step in the retinoid visual cycle is catalyzed by

101 g as transcriptional activators, mediate the final step in the signaling cascade.

102 nimmobilized GlmU and provides a more facile final step in the synthesis of an unnatural UDP-donor.

103 Gibberellin 3-oxidase (GA3ox) catalyzes the final step in the synthesis of bioactive gibberellins (G

104 kotriene A(4) hydrolase, which catalyzes the final step in the synthesis of leukotriene B(4) (LTB(4))

105 beta, and PIP5KIgamma) can each catalyze the final step in the synthesis of phosphatidylinositol-4,5-

106 l transferase MsbB (LpxM) that catalyzes the final step in the synthesis of the lipid A moiety of lip

107 PAM, an essential enzyme, catalyzes the final step in the synthesis of the majority of neuropept

108 The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in

109 sterone is synthesized by the testis and the final step in this canonical pathway is controlled by th

110 nt thymidylate synthase (FDTS) catalyzes the final step in this de novo production of thymidylate in

111 The final step in this pathway is methylation of the carboxy

112 acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the ester

113 yltransferase, the enzyme that catalyzes the final step in triglyceride synthesis, results in improve

114 of two known DGAT enzymes that catalyze the final step in triglyceride synthesis.

115 wo isoforms (Dgat1 and Dgat2), catalyzes the final step in triglyceride synthesis.

116 LEF/TCFs direct the final step in Wnt/beta-catenin signalling by recruiting

117 mprised of the two enzymes that catalyze the final steps in cysteine biosynthesis: serine O-acetyltra

118 In opium poppy, the antepenultimate and final steps in morphine biosynthesis are catalyzed by th

119 nment plays a critical role in promoting the final steps in neuronal development during the early pos

120 ne group that leads to a different series of final steps in one Rh-based catalytic cycle, thereby ena

121 eductase (XOR), an enzyme that catalyzes the final steps in purine degradation.

122 One of the final steps in the biosynthesis of many neuropeptides re

123 is a bifunctional protein that catalyzes the final steps in the biosynthesis of the purine IMP.

124 s during turnover under H2 suggests that the final steps in the catalytic cycle of H2 oxidation by Hy

125 the free substrate premalbrancheamide as the final steps in the malbrancheamide biosynthetic pathway.

126 One of the final steps in the morphogenetic pathway of phage lambda

127 The final steps in the Renin-Angiotensin-Aldosterone signali

128 cid (DHAA) provided strong evidence that the final steps in the synthesis of artemisinin are nonenzym

129 The final steps in this pathway involve the secondary acylat

130 n (pp150; encoded by UL32) that supports the final steps in virion maturation at cytoplasmic assembly

131 The final step involved a highly unusual Heck cyclization wh

132 The final step involved an SN1-type ring closure catalyzed b

133 The observed KIE (3.3) indicates that the final step involves cleavage of at least one C-H bond.

134 The final step is an iron-catalyzed C-H oxidation.

135 ociation of the U1A-SL2 RNA complex, and the final step is assigned to a reorganization of the U1A pr

136 rstanding of Rab11-regulated mechanisms, the final steps mediating docking and fusion of Rab11-positi

137 imary 3' --> 5' exonucleases involved in the final step of 3'-end maturation, compete with poly(A) po

138 ne synthase (CYP11B2) is responsible for the final step of aldosterone synthesis.

139 ma-lactone oxidase, which is involved in the final step of ascorbate biosynthesis, in many vertebrate

140 eenhouse gas N(2)O to uncritical N(2) as the final step of bacterial denitrification.

141 us oxide (N(2)O) to dinitrogen (N(2)) as the final step of bacterial denitrification.

142 The final step of biogenesis is a concerted reaction involvi

143 Together, our findings indicate that the final step of C-type inactivation of hERG1 channels invo

144 oxyl methyltransferase (ICMT), catalyzes the final step of CAAX processing after prenylation of the c

145 x with affinity-based rapid filtration and a final step of capillary-based enrichment.

146 ughout T cell differentiation, including the final step of CD8 SP selection.

147 d function, mediating OM constriction at the final step of cell division as well as the positioning o

148 onserved role in cytokinetic abscission, the final step of cell division where daughter cells are phy

149 Cytokinesis, the final step of cell division, usually ends with the absci

150 gs of the CYP4G1/2 enzymes that catalyze the final step of CHC biosynthesis in Drosophila and Musca d

151 on of a latent aldehyde tag, unmasked in the final step of chemical synthesis, providing a generic en

152 it dehydrates the stool by facilitating the final step of chloride and fluid absorption.

153 duce sterol double bonds at carbon 24 in the final step of cholesterol or ergosterol biosynthesis.

154 the cilium assembly pathway, controlling the final step of cilia initiation.

155 eukaryotic genomes is now possible, but the final step of circularizing sequences remains unsolved.

156 biosynthesis of nitrogenase, catalyzing the final step of cofactor maturation prior to delivering th

157 ase (CYP11B1), an enzyme responsible for the final step of cortisol biosynthesis, and the two electro

158 Abscission is the final step of cytokinesis and results in the physical se

159 The final step of cytokinesis in animal cells is abscission,

160 Before the final step of cytokinesis, termed abscission, dividing c

161 tor, is required during mitosis exit for the final step of cytokinesis.

162 n of two direct target genes involved in the final step of cytokinin (CK) biosynthesis, LONELY GUY3 (

163 hway, particularly the enzyme catalyzing the final step of erythritol synthesis (reduction of erythro

164 cid oxidase (ACO), the enzyme catalysing the final step of ethylene formation.

165 We propose that the final step of GFP folding is a "locking" mechanism leadi

166 greater decrease in lung function during the final step of glucocorticoid withdrawal.

167 6-phosphatase, an enzyme which catalyses the final step of gluconeogenesis and glycogenolysis.

168 f glucose-6-phosphatase, which catalyzes the final step of glucose production, were significantly hig

169 Pyruvate, which is produced in the final step of glycolysis, participates in anabolic metab

170 , ferrochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these pati

171 of conformational change is provided by the final step of hinge-region expulsion and subsequent clos

172 At the final step of homologous recombination, Holliday junctio

173 acts with the ESCRT-III complex to drive the final step of ILV formation.

174 on of the gene for the enzyme catalysing the final step of InsP6 biosynthesis (InsP5 2-kinase) also d

175 A final step of integrin activation is talin binding to 2

176 The final step of iron-sulfur protein assembly involves tran

177 mmed cell death process that constitutes the final step of leaf development, and it can be regulated

178 The final step of locking has been proposed to involve confo

179 (waaL) at PG1051, which is required for the final step of LPS biosynthesis, abolished the linkage of

180 Alveologenesis, the final step of lung development, is characterized by the

181 The final step of lysis in phage lambda infections of Escher

182 ces to an inward-facing conformation and the final step of maltose translocation into the cell.

183 MCR) from methanogenic archaea catalyzes the final step of methane formation, in which methyl-coenzym

184 In methanogenic Archaea, the final step of methanogenesis generates methane and a het

185 on of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis

186 ntrinsic membrane fission properties, at the final step of mitochondrial division.

187 Cytokinesis is the final step of mitosis when a mother cell is separated in

188 matic depletion of enzymes that catalyze the final step of NAD(+) biosynthesis revealed cell-specific

189 yltransferase (DGAT1-2), which catalyzes the final step of oil synthesis.

190 The final step of peptidoglycan (PG) biosynthesis in bacteri

191 that Pex11p also plays a crucial role in the final step of peroxisomal fission: dynamin-like protein

192 t intermediates and that Tdrkh promotes this final step of piRNA biogenesis but not the ping-pong cyc

193 ssembles and is loaded onto chromatin in the final step of prereplicative complex (pre-RC) formation.

194 tate a novel sialidase reaction in which the final step of product formation is direct abstraction of

195 on mechanism with other sialidases up to the final step of product formation.

196 mate semialdehyde to glutamate, which is the final step of proline catabolism.

197 esses diacylglycerol to triglycerides in the final step of resynthesis for the absorption of fat acro

198 teinyl-tRNA synthase (SepSecS) catalyzes the final step of selenocysteine formation by a poorly under

199 nd acts as an iron-specific chelatase in the final step of siroheme synthesis.

200 cleaves sphingosine 1-phosphate (S1P) in the final step of sphingolipid catabolism.

201 erase (PfCEPT), a key enzyme involved in the final step of synthesis of phosphatidylcholine (PC).

202 ay, but which more generally may exclude the final step of synthesizing acetyl-CoA.

203 ed fatty acid synthesis)-and-pull (increased final step of TAG biosynthesis) engineering strategy.

204 ybenzoate (4-HB) and coenzyme A (CoA) in the final step of the 4-chlorobenzoate dehalogenation pathwa

205 During dispersion, the final step of the biofilm life cycle, single cells egres

206 glycosyltransferases are responsible for the final step of the biosynthesis of ABO(H) human blood gro

207 f N(6)-(isopentenyl)adenosine (i(6)A) in the final step of the biosynthesis of the hypermodified tRNA

208 of TCA was most effective when added in the final step of the clean-up procedure instead of during e

209 The final step of the four-step dTDP-L-rhamnose biosynthesis

210 holine phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for p

211 by a water-catalyzed proton transfer in the final step of the hydroarylation.

212 ds and processes uridylated pre-let-7 in the final step of the Lin28-let-7 pathway.

213 The final step of the marineosin pathway is thus a MarA cata

214 ferrous enzyme (and formation of NFK) in the final step of the mechanism, which formally requires red

215 s been originally identified to catalyse the final step of the methanogenesis pathway.

216 The final step of the methylerythritol phosphate isoprenoid

217 iphosphate decarboxylase (MDD) catalyzes the final step of the mevalonate pathway, the Mg(2+)-ATP dep

218 3 phosphorylation may play a key role in the final step of the PAK1 activation process.

219 hat acts to reduce enoyl-ACP substrates in a final step of the pathway.

220 rms the six-membered carbocyclic ring in the final step of the pathway.

221 utenyl diphosphate reductase (HDR/IspH), the final step of the plastidic isoprenoid production pathwa

222 The final step of the protocol involves colabeling by immuno

223 late intermediates formed in the initial and final step of the reaction supported the first mechanism

224 eogenic center in each product is set at the final step of the synthesis by enantioselective (er = 61

225 ion to give tetracyanobuta-1,3-dienes in the final step of the synthesis, undergoes four reversible 3

226 aryotic thiazole synthase and identifies the final step of the thiamin-thiazole biosynthesis.

227 iallelic mutations in arginase 1 (ARG1), the final step of the urea cycle, and results biochemically

228 It has long been hypothesized that the final step of thiazolyl peptide biosynthesis involves a

229 the midhypocotyl, whose expansion drives the final step of this developmental transition under optima

230 hiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-loadin

231 The final step of this process involves severing the SP1 pep

232 we report that SNAREs are essential for the final step of this process, with KRAS localization to th

233 The final step of this route demonstrates the chemical feasi

234 The final step of this route exemplifies a novel synthesis o

235 LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked p

236 f the tags is predicted to change during the final step of transposition, this recognition strategy s

237 major 3' --> 5' exonucleases involved in the final step of tRNA 3'-end maturation, confirming their r

238 E3 ubiquitin ligases catalyze the final step of ubiquitin conjugation and regulate numerou

239 el mechanism of APC/C inhibition wherein the final step of ubiquitin transfer is targeted and raise t

240 At the final step of VEPART, robustness is assessed by identify

241 A final step of wastewater treatment with lime was perform

242 al RNA metabolism, most likely acting in the final steps of 23S rRNA maturation.

243 decades ago, the enzymes responsible for the final steps of 5S and 23S rRNA 5'-end maturation have re

244 These data suggest that M2 mediates the final steps of budding for influenza viruses, bypassing

245 The final steps of cell division are tightly coordinated in

246 a peptide from another peptidoglycan in the final steps of cell wall assembly.

247 The biosynthetic enzymes for the final steps of chloroplast lipid assembly are associated

248 ich were previously believed to occur as the final steps of chromomycin A(3) biosynthesis, indeed tak

249 hase is a bifunctional enzyme catalyzing the final steps of CoA biosynthesis by coupling phosphopante

250 nsendothelial migration, indicating that the final steps of extravasation, where actin polymerization

251 erts pyruvate into the mitochondrion for the final steps of glucose oxidation.

252 pI of Clostridium pasteurianum to reveal the final steps of H-cluster maturation occurring within apo

253 Thus, ESCRT machinery is involved in the final steps of HCMV replication.

254 The final steps of lacticin 481 biosynthesis are proteolytic

255 earliest moments of tumor development to the final steps of metastasis.

256 The mechanisms driving the final steps of mitochondrial division are still unclear.

257 s, are opening the gates to study one of the final steps of mitosis--silencing the spindle checkpoint

258 recting the cytokinesis machinery during the final steps of mitosis.

259 he hybrid state of binding that precedes the final steps of mRNA and tRNA translocation.

260 h then, in turn, provides cues to permit the final steps of neuronal differentiation.

261 NafY participates in the final steps of nitrogenase maturation, having a dual rol

262 rocess associated with DSB formation and the final steps of oocyte selection.

263 omologue Chp2 (Rv1184c) is essential for the final steps of PAT biosynthesis.

264 re bacterial DD-peptidases that catalyze the final steps of peptidoglycan biosynthesis.

265 , is an essential enzyme responsible for the final steps of peptidoglycan synthesis and is covalently

266 To better characterize the final steps of pluripotency induction, we optimized an e

267 While the initial and final steps of PQQ biosynthesis, involving PqqD/E and Pq

268 This sequence models the final steps of proposed Fe-mediated nitrogen fixation pa

269 s a Rab11-binding partner that regulates the final steps of Rab11-positive vesicle docking at the pla

270 of initiation complex formation licenses the final steps of ribosome maturation by signaling RNases t

271 A gamma-glutamyl ligase catalyzes the final steps of the F420biosynthesis pathway by successiv

272 C, 14), a triketone that failed to reach the final steps of the herbicidal design and development pro

273 educed degradative capacity that impairs the final steps of the intimately connected autophagic and p

274 and opposite dependencies of the initial and final steps of the mechanism on the heme reduction poten

275 Deletion of the final steps of this pathway revealed that quinone molecu

276 and Vamp7 with Stx3, which cooperate in the final steps of this selective apical traffic pathway.

277 l changes occurring during maturation, whose final step often requires the specific binding of 'decor

278 As a final step, phosphorylated ATP7B was transferred from th

279 eport thermodynamically distinct initial and final steps, respectively, in the Hv1 activation pathway

280 gatorily occur on cell surfaces, whereas the final step(s) is endosomal.

281 This modification is usually performed as a final step, since sulfonated molecules are poorly solubl

282 functionalization, and a surprisingly simple final step that intersects a presumed biosynthetic inter

283 In the final step, the 3-ketone intermediate undergoes a beta-e

284 ntenyl phosphate kinase (IPK) catalyzing the final step, the formation of IPP.

285 The final step, the formation of the thioether linkage with

286 In the final step, the holder is set on top of the microfluidic

287 In its final step, the procedure reconstitutes the original dat

288 [2 + 2 + 2] alkyne cyclotrimerization as the final step, the short and efficient synthesis of cyclopr

289 ol is significantly more efficient than the "final-step-threading" method employed previously and ena

290 precursor that can be fully aromatized in a final step through a DDQ-mediated dehydrogenation reacti

291 aniline derivative, and an annulation in the final step to close the quinoline ring, leading to a dih

292 drazine, instead forming the N-N bond in the final step via oxidation-induced coupling on Ti.

293 C-2 arylation as a final step was also possible by Liebeskind-Srogl cross-c

294 The final step was thwarted by a pinacol-like rearrangement

295 At the final step, we introduce a method to automatically seed

296 In the final step, we show that the experimentally observed app

297 As a final step, we then demonstrate that the feedback system

298 of the epidithiodiketopiperazine core in the final step, were developed to address this highly sensit

299 In particular, we have focused on the final step wherein the neural folds approach one another

300 resulting in an overall yield of 74% with a final step yield of 91%.