1 s chromosome and creating a new tool for QTL
fine mapping.
2 ne and eJunction with SCZ GWAS using SMR and
fine mapping.
3 DNA topology, as a prioritization metric for
fine-mapping.
4 of incorporating additional ancestry in MHC
fine-mapping.
5 ioning posterior probabilities from Bayesian
fine-mapping.
6 false positives and disrupt the accuracy of
fine-mapping.
7 5 of which are further supported by genetic
fine-mapping.
8 The reduced accuracy in
fine-mapping a known causal variant in a low-level biolo
9 After
fine mapping,
a gene encoding a calcium(2+)/hydrogen(+)
10 RASQUAL substantially improves
fine-mapping accuracy and sensitivity relative to existi
11 ll as functional annotation data, to improve
fine-mapping accuracy at pleiotropic risk loci.
12 omputationally scalable framework to improve
fine-mapping accuracy by leveraging functional annotatio
13 functional elements to increase trans-ethnic
fine-mapping accuracy.
14 Fine-mapping across African American cohorts was conduct
15 Imputation-based
fine-mapping across the class II MHC region suggests tha
16 Imputation-based
fine-mapping across the extended MHC region showed that
17 Fine-mapping aims to identify causal variants impacting
18 We used the trans-ethnic
fine-mapping algorithm PAINTOR3 to prioritize risk varia
19 Here we developed a
fine-mapping algorithm to identify candidate causal vari
20 Fine-mapping analyses and functional annotation revealed
21 Genome-wide association studies and
fine-mapping analyses for resistin were performed in 562
22 Association and
fine-mapping analyses identified a protein-coding varian
23 sociations: colocalization, conditional, and
fine-mapping analyses together with TWAS-based pathway i
24 Imputation and
fine-mapping analyses were performed in these two region
25 Fine mapping analysis by integration with genome-wide ex
26 Fine-mapping analysis of bm4 narrowed the candidate regi
27 Fine-mapping analysis of MHC region demonstrates an impo
28 Here, we conducted a large-scale MHC
fine-mapping analysis of rheumatoid arthritis (RA) in a
29 Here, we report a
fine-mapping analysis of the 9q31.2 susceptibility locus
30 We performed genetic
fine-mapping analysis of the CCNE1 region using data fro
31 cancer risk, we performed a high resolution
fine-mapping analysis that involved genotyping 517 SNPs
32 osomes 7, 8, 14, and 19 and 11 SNPs from the
fine-mapping analysis that were associated with high-den
33 Applying
fine-mapping analysis to 233 known and new loci associat
34 We apply
fine-mapping analysis to dissect associations in the hum
35 We performed a novel
fine-mapping analysis to winnow the number of putative c
36 In the
fine-mapping analysis, 52 939 single-nucleotide polymorp
37 may guide the development of new methods for
fine mapping and association mapping of complex traits.
38 We report the
fine mapping and cloning of a tomato (Solanum lycopersic
39 For each COPD eQTL,
fine mapping and colocalization analysis to identify cau
40 in these QTL regions can be used for future
fine mapping and developing SNP chips for marker-assiste
41 opening new potential avenues of research in
fine mapping and gene set enrichment analysis.
42 naringenin chalcone accumulation followed by
fine mapping and genetic transformation, we identified a
43 markers of this QTL can be used for further
fine mapping and marker assisted selection in peanut bre
44 Genetic
fine mapping and Mendelian randomization uncover wide-sp
45 analytical framework that integrates genetic
fine mapping and Mendelian randomization with epigenome-
46 Here, we have identified through
fine mapping and meta-analysis EVI5 as the most plausibl
47 Fine mapping and region-based association testing provid
48 Sequential
fine mapping and transgenic complementation demonstrated
49 Fine mapping and validation of genes causing beta cell f
50 Through additional
fine mapping and whole-genome sequencing, we determined
51 Our boosted scores may improve
fine-mapping and candidate gene discovery for common dis
52 ources developed in this study will underpin
fine-mapping and cloning of agronomically important gene
53 decade has witnessed significant progress in
fine-mapping and cloning of genes controlling QDR.
54 el from the observed data and (2) separating
fine-mapping and colocalization analysis.
55 Integration of WGS-based
fine-mapping and complementary epigenomic datasets provi
56 Fine-mapping and conditional analyses in the METSIM stud
57 By integrating genetic
fine-mapping and epigenomic annotation data and performi
58 Fine-mapping and experimental analyses showed that rs142
59 Here we report
fine-mapping and functional analysis of one such locus r
60 complex traits that have been validated with
fine-mapping and functional analysis.
61 Further
fine-mapping and functional studies are required to iden
62 Fine-mapping and functional studies of new risk loci cou
63 In silico
fine-mapping and functional validation identified a comm
64 improved risk prediction and inform further
fine-mapping and functional work to better understand th
65 In this study, Dw2 was identified by
fine-mapping and further confirmed by sequencing the Dw2
66 technologies provide new ways to accelerate
fine-mapping and gene isolation in crops.
67 endometrial cancer, and now report extensive
fine-mapping and in silico and laboratory analyses of th
68 alleles for bladder cancer risk that require
fine-mapping and laboratory investigation, which could f
69 in an empirical Bayes framework, we perform
fine-mapping and observe that high-posterior SNPs (for b
70 ent to capture causal variants, we performed
fine-mapping and re-genotyping of the three loci using 1
71 proaches to variant prioritization - genetic
fine-mapping and regulatory annotation enrichment.
72 In subsequent
fine-mapping and replication association studies in appr
73 This facilitates the
fine-mapping and subsequent functional characterization
74 Here we conducted
fine-mapping and targeted sequencing of the candidate lo
75 Fine-mapping and trans-Omics analyses with gene expressi
76 causal variants, compared to 2% by QTL-based
fine mapping,
and a 6.9-fold overall reduction in median
77 uld provide targets for genetic improvement,
fine mapping,
and marker-assisted selection in future st
78 4 Latinos, performed targeted sequencing for
fine mapping,
and tested for disease correlations with g
79 s are an essential component in identifying,
fine mapping,
and understanding their trait variability.
80 antitative trait loci (eQTL) colocalization,
fine-mapping,
and human rare-disease, animal-model, and
81 ntification of population-specific variants,
fine-mapping,
and polygenic risk score estimation.
82 e(s) at this locus, we employed an in silico
fine-mapping approach using genotyped and imputed SNP da
83 We review the basic
fine-mapping approach, which is computationally fast and
84 We use 1716 CpG-SNPs to test three
fine-mapping approaches (Bayesian imputation-based assoc
85 er risk variants, identified through genetic
fine-mapping,
are significantly enriched in mencRNA exon
86 This problem of
fine-mapping association signals predates GWAS, but the
87 Through
fine-mapping,
association analysis, expression analysis,
88 er at 50 samples than conventional QTL-based
fine mapping at 500 samples, with more than 17% of loci
89 Fine mapping at the CD4bs indicated that conformational
90 t not for GTF2E2, supporting the statistical
fine-mapping at this locus and demonstrating that RBPMS
91 Statistical
fine-mapping at this locus pointed to RBPMS at this locu
92 We then combined
fine-mapping,
bioinformatics, and bench-based approaches
93 Fine mapping by local association analysis identified RE
94 Fine-mapping by dense regional genotyping in over 15,000
95 We performed
fine-mapping by targeted sequencing at WLS, MEF2C, ARHGA
96 lidifying the foundation for large-scale QTL
fine mapping,
candidate gene validation, and developing
97 timating causal variant probabilities (i.e.,
fine mapping)
cannot produce valid estimates from asQTL
98 high-resolution HLA and MICA imputation for
fine mapping causal variants in the MHC.
99 ns important in biological research, such as
fine mapping causal variants, distinguishing pathogenic
100 ing the ability to use these annotations for
fine mapping causal variation.
101 iction models, imputing untyped variants and
fine-mapping causal variants from summary statistics of
102 the value of high-resolution imputation for
fine-mapping causal variants in the MHC.
103 post-GWAS analyses were performed, including
fine-mapping,
colocalization, phenome-wide association s
104 Using
fine-mapping combined with epigenomic data from induced
105 Fine mapping,
conditional analyses, and exome array geno
106 Crystallography was employed for
fine-mapping conformational epitopes in binary and terna
107 uantitative immune variables, sequence-based
fine mapping,
cross-population and cross-phenotype analy
108 We show that this is because
fine-mapping data sets are not randomly selected from am
109 monstrated that integration of these genetic
fine-mapping data with genomic annotation can highlight
110 By using a combination of genetic
fine mapping,
data on DNase hypersensitivity, and electr
111 om trait-associated variants is essential to
fine mapping disease loci.
112 Fine-mapping edQTLs with schizophrenia risk loci reveale
113 TL and Roadmap Epigenomics data could assist
fine-mapping efforts.
114 idate functional SNPs are first evaluated by
fine mapping,
epigenomic profiling, and epigenome editin
115 ants are non-coding, often requiring genetic
fine-mapping,
epigenomic profiling, and individual repor
116 Risk loci are typically dissected through
fine-mapping experiments in trans-ethnic cohorts for lev
117 Here we perform genetic
fine-mapping for blood cell traits in the UK Biobank to
118 Application of MR-MEGA to
fine-mapping four type 2 diabetes susceptibility loci in
119 TAC-seq can provide powerful information for
fine-mapping gene-regulatory variants and for linking di
120 one of the most racially/ethnically diverse
fine-mapping genetic studies of HDL-C, LDL-C, and trigly
121 Fine-mapping genome-wide association study loci identifi
122 We performed a
fine-mapping genome-wide association study of the geneti
123 Here we establish, through
fine mapping,
genome sequencing, genetic complementation
124 ol subjects, totaling 3,134 subjects using a
fine-mapping genotyping platform was conducted.
125 Fine-mapping highlighted missense driver variants in 11
126 Fine-mapping highlighted multiple association patterns c
127 Further sequence analysis and
fine mapping identified a candidate gene for dw as a non
128 9, P = 0.34); however, in African Americans,
fine mapping identified a top hit in FADS2 associated wi
129 Fine mapping identified putative causal variants with do
130 Functional
fine mapping identified six loci (RREB1, INHBC, HLF, UBE
131 Fine-mapping identified rs1800795 as the most likely cau
132 A recent high-density
fine-mapping (
ImmunoChip) study of genetic associations
133 and liver cells, including at MTNR1B, where
fine mapping implicated rs10830963 as driving T2D associ
134 Through
fine mapping in German and Chilean samples, an approxima
135 tamers, intracellular cytokine staining, and
fine mapping in interferon-gamma enzyme-linked immunospo
136 We used natural variation and
fine mapping in the crop Brassica oleracea to show that
137 s risk variants and illustrates the value of
fine mapping in the resolution of GWAS signals.
138 1) are mediated, we undertook transancestral
fine-mapping in 22 086 cases and 42 539 controls of East
139 This study highlights the importance of
fine-mapping in diverse populations.
140 The goal of
fine-mapping in genomic regions associated with complex
141 s of this study suggest that high-resolution
fine-mapping in large samples can convert many discoveri
142 trait locus (QTL) mapping of F2 hybrids and
fine-mapping in nearly isogenic lines to characterize th
143 egions using genotyping and imputation-based
fine-mapping in populations of European (cases/controls:
144 Through
fine-mapping,
in three regions (1q32, 3p24, 10q25), we i
145 Fine-mapping indicated association closest to the PKP2 g
146 Within the 6p21.1 locus,
fine-mapping indicates that the association is driven by
147 In a previous
fine-mapping investigation of 19 breast cancer loci, we
148 d functional analyses (including statistical
fine-mapping,
investigations into gene expression, and t
149 Fine mapping is a widely used approach for identifying t
150 by detecting lineage-level differences when
fine-mapping is intractable.
151 arental populations are innovative tools for
fine mapping large numbers of loci.
152 Fine-mapping located B1 to a region containing only two
153 e association studies, whole-exome analysis,
fine mapping,
Mendelian randomization, and transcriptomi
154 ASMA (Population Allele-Specific Mapping), a
fine-mapping method that integrates QTL and asQTL inform
155 n causal variants to serve as models to test
fine-mapping methodology.
156 Recent
fine mapping methods using summary-level data require th
157 All of the
fine-mapping methods failed to reach the expected 95% co
158 causal variant(s), a variety of statistical
fine-mapping methods have been proposed to prioritize va
159 cant loci-to specify prior probabilities for
fine-mapping methods such as SuSiE or FINEMAP.
160 Recent
fine-mapping methods using summary data from genome-wide
161 elop a computationally efficient multinomial
fine-mapping (
MFM) approach that borrows information bet
162 Fine mapping of 18q21 in 1978 Latinos identified a signi
163 We performed
fine mapping of 39 established type 2 diabetes (T2D) loc
164 Fine mapping of 6p21.32-p22.1 identified 6 genome-wide s
165 Fine mapping of a rapid-flowering mutant was done using
166 ovel genetic risk loci for CAD and performed
fine mapping of all 161 risk loci to obtain a credible s
167 Fine mapping of AQP4 p201-220 and p135-153 epitopes iden
168 all previously associated loci, and perform
fine mapping of causal variants.
169 Fine mapping of conformational epitopes is a powerful to
170 Fine mapping of epitopes by surface plasmon resonance al
171 ce (TS) consortia focused on gene discovery,
fine mapping of loci, and functional genomics using stat
172 Fine mapping of mQTLs and integration with single-cell g
173 The map constructed will facilitate QTL and
fine mapping of quantitative traits, map-based cloning,
174 prior loci (9p21), as well as advancing the
fine mapping of regions because of shorter average LD (F
175 Genetic
fine mapping of sex-specific asthma association signals
176 s, quantification of oncogenic selection and
fine mapping of sister-chromatid-exchange events.
177 Fine mapping of the 161 CAD loci generated lists of cred
178 s and independent case-control data sets for
fine mapping of the common variant association signal us
179 Fine mapping of the HLA region identified association wi
180 We performed haplotype analyses and
fine mapping of the ORMDL3 locus in a cross-sectional (I
181 Further
fine mapping of the promoter sequence paves the way to b
182 Fine mapping of the region in this study and the EVE Ast
183 In this study, we present a
fine mapping of the structural determinants that allow s
184 It also provides a resource for
fine mapping of the supergene and other major shell phen
185 diffraction analyses, which could complicate
fine mapping of the various intermediate states.
186 Fine mapping of this locus identified a number of polymo
187 Here we report the
fine mapping of this locus using data from 101,943 subje
188 Here, we report the
fine mapping of this locus using data from 104,660 subje
189 gene networks and novel cell subpopulations,
fine mapping of transcription kinetics, and the relation
190 Finally, functional
fine-mapping of 11q13.5 using CRISPR-activation (CRISPRa
191 = 57,292), we performed trans-ethnic (AA+EA)
fine-mapping of 54 established EA FG or FI loci with det
192 Here we report
fine-mapping of 94 inflammatory bowel disease loci using
193 We used SNP genotyping and imputation-based
fine-mapping of a multiethnic ALL case-control populatio
194 fine a lower bound for P-values, which makes
fine-mapping of associated regions difficult because, in
195 e identification of causal variants or rapid
fine-mapping of broad loci to smaller intervals.
196 effects, we combined recent advances in the
fine-mapping of causal T2D risk variants with the increa
197 nes in smaller cohorts and (ii) assisting in
fine-mapping of challenging regions, e.g. major histocom
198 Fine-mapping of chromosome 19 revealed 13 putatively cau
199 neurons contributing to AD by comprehensive
fine-mapping of DNA methylation at enhancers, genome-wid
200 hput, saturating in situ mutagenesis permits
fine-mapping of function across genomic segments.
201 ions have led to improved identification and
fine-mapping of genetic variants associated with adaptat
202 Fine-mapping of genomic regions implicated in genome-wid
203 plotypes in African genomes have facilitated
fine-mapping of loci discovered in other human ancestry
204 Here we report the concurrent nanoscale
fine-mapping of membrane topography, diffusivity, and pa
205 We further review methods for simultaneous
fine-mapping of multiple datasets, either exploiting dif
206 Here, we show that
fine-mapping of pancreatic and testicular cancer GWAS wi
207 We perform
fine-mapping of PCa risk across TET2 using genotypes fro
208 nality of aligned Strand-seq data, to enable
fine-mapping of sister chromatid exchanges, germline inv
209 Functional characterization and
fine-mapping of that locus reveal a putative causal vari
210 We performed
fine-mapping of the 21 risk regions (including 250 kb on
211 Fine-mapping of the association signals identifies speci
212 uely powered design, we investigated whether
fine-mapping of the HLA region could narrow the missing
213 Fine-mapping of the human leukocyte antigen (HLA) region
214 ilibrium between the two populations allowed
fine-mapping of the locus to a 7 kb region overlapping e
215 To perform detailed
fine-mapping of the major-histocompatibility-complex reg
216 Fine-mapping of the promoter activity revealed that two
217 Fine-mapping of these components in southern African pop
218 Fine-mapping of this region identified a single nucleoti
219 Enrichment analysis,
fine-mapping of urate-associated loci and colocalization
220 e need for functional studies and additional
fine-mapping of variants in the 1q12-locus.
221 thnic association analysis for discovery and
fine-mapping offers a framework for further follow-up an
222 f GWAS is that it always requires subsequent
fine-mapping or sequencing to pinpoint causal mutations.
223 ies, such as annotation-based casual variant
fine-mapping,
pathogenic variant discovery as well as ca
224 tory marks) can be integrated for increasing
fine-mapping performance within single-population studie
225 ulks of genetic recombinants screened from a
fine-mapping population to precisely quantify the associ
226 ion analysis also converged significantly in
fine-mapping potentially causative domains within these
227 ations than mixed effects models and achieve
fine-mapping precision, at comparable computational cost
228 Fine-mapping prioritized the lead common missense varian
229 Fine-mapping prioritized variants annotated as functiona
230 Fine mapping proved to be effective to refine the previo
231 Bivariate
fine mapping provided evidence that the individual varia
232 bined three distinct approaches: multiethnic
fine-mapping,
putative functional annotation (based upon
233 Trans-ancestry
fine-mapping reduced the sets of candidate causal varian
234 most relevant tissues and can gain power as
fine-mapping resolution and cell-specific annotations be
235 linkage disequilibrium, we achieve improved
fine-mapping resolution at 22 previously reported and 4
236 We observed improvements in the
fine-mapping resolution at many susceptibility loci.
237 y modeling pleiotropic risk regions improves
fine-mapping resolution compared to standard single trai
238 MFM has the potential to increase
fine-mapping resolution in related diseases enabling the
239 ave demonstrated that our approach increases
fine-mapping resolution over existing methods.
240 Taking advantage of the
fine-mapping resolution power of African genomes, we ide
241 ional annotation data, fastPAINTOR increases
fine-mapping resolution relative to existing methods.
242 We also demonstrate improved
fine-mapping resolution, in loci containing a single cau
243 ver, particularly among signals with greater
fine-mapping resolution.
244 71% of signals reside within genes and
fine mapping resolves 23 signals to one or two likely ca
245 Our
fine-mapping results indicate that in nine of 24 shared
246 However,
fine mapping revealed subtle and strong differences in h
247 Fine mapping reveals that two variants correlated with r
248 Fine-mapping reveals 40 high-confidence variants driving
249 Fine-mapping reveals a single haplotype as a potential c
250 th data from cis-eQTL enrichment, functional
fine-mapping,
RNA co-expression, and patterns of physiol
251 to combine meta-analysis results and aids in
fine-mapping shared variants at these locations.
252 probabilities are over-conservative in most
fine-mapping situations.
253 variants that are causal requires a further '
fine-mapping'
step.
254 red to standard single trait and pleiotropic
fine mapping strategies.
255 Lastly, we described a
fine-mapping strategy for these 42 eQTL target-gene asso
256 eotide polymorphisms (SNPs) used in GWAS and
fine mapping studies have causal effects through their i
257 er prioritized potential loci for downstream
fine mapping studies in the search for CCLE specific sus
258 ssions, and could readily be used for future
fine mapping studies.
259 Bayesian genetic
fine-mapping studies aim to identify the specific causal
260 Fine-mapping studies determined that nonneutralizing mAb
261 Although previous HLA
fine-mapping studies have identified amino acid polymorp
262 sing our method to improve the resolution of
fine-mapping studies will enable more efficient expendit
263 In genomic
fine-mapping studies, some approaches leverage annotatio
264 To illustrate application in
fine-mapping studies, we applied our MGW-prioritization
265 functional score that can be incorporated in
fine-mapping studies.
266 gulatory elements, an important component of
fine-mapping studies.
267 This
fine-mapping study confirmed previous associations and i
268 We performed a
fine-mapping study of 14,551 subjects from multi-ancestr
269 Here, we conducted a large-scale
fine-mapping study of PsV risk in the MHC region in 9,24
270 se our method to improve the resolution of a
fine-mapping study of type 1 diabetes.
271 Our trans-ethnic HLA
fine-mapping study reveals that (i) a common set of amin
272 Here we conduct the first
fine-mapping study, which thoroughly investigates the SL
273 00-fold larger, traditional imputation-based
fine-mapping study.
274 n leucocyte antigen (HLA) and trans-ancestry
fine-mapping substantiate that distinct variants in HLA-
275 ng disease-associated variants in human, but
fine-mapping the causal variants remains a challenge.
276 isk, but linkage disequilibrium (LD) hinders
fine-mapping the causal variants.
277 Fine-mapping the primary MHC association through high-re
278 (1) demonstrates the utility of trans-ethnic
fine mapping through integration of GWASs involving dive
279 able for additional investigations including
fine mapping to elucidate the biological basis of the fi
280 allelic expression analysis and trans-ethnic
fine mapping to identify transcript-specific cis-acting
281 o compute a novel and more refined GRS using
fine mapping to include a large number of genetic varian
282 s (HS) facilitate gene discovery by allowing
fine mapping to only a few megabases, significantly decr
283 genome-wide association analysis (GWAS), and
fine-mapping to examine genetic factors associated with
284 Fine-mapping to identify causal variants in genome-wide
285 The family data were used in the
fine-mapping to identify SNPs that showed novel associat
286 We use
fine-mapping to quantify the probability that each eSTR
287 r locus using a single trait to 12 SNPs when
fine-mapping two traits simultaneously.
288 Fine mapping using sequence and imputed genotype data ha
289 tion analysis Program (HAPRAP), that enables
fine mapping using summary statistics and haplotype info
290 GWAS associations, substantial benefits for
fine-mapping using diverse cohorts and insights into cli
291 ining cell types associated with disease and
fine mapping variants.
292 The panel of SNPs used for
fine mapping was also tested for association with transc
293 For
fine mapping we interrogated SNPs within +/- 250 kb flan
294 Through genetic
fine mapping,
we prioritized rs9349379, a common SNP in
295 Here, through genetic
fine-mapping,
we define a set of tightly linked variants
296 dian credible set size compared to QTL-based
fine mapping when applied to H3K27AC ChIP-seq from just
297 statistical methods have been developed for
fine-mapping with the use of summary statistics from gen
298 ngle non-causal SNP, lead to inaccuracies in
fine-mapping,
with stochastic search more robust than st
299 ture mapping identified 5 significant peaks;
fine mapping within these peaks identified 2 rare varian
300 Fine-mapping yielded a minimum P = 1.13 x 10(-14), but d