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1 nd minimizing the parameters that need to be fine-tuned.
2 to another in the absence of plant-specific fine-tuning.
3 to creating flat bands that does not involve fine-tuning.
4 rks, trained in stages of initialization and fine-tuning.
5 e can be subjected to precise intermolecular fine-tuning.
7 ting that electrophysiological responses are fine-tuned across species to produce optimal cardiac fig
8 examine how long-range GABAergic projections fine-tune activity in distinct distant networks and how
9 based receptor usage, entailing a concerted, fine-tuned activity of two envelope protein species, is
10 reveals a paradigm whereby tissue mechanics fine-tune adaptive immune responses in health and diseas
11 uct triptycene-based electron acceptors with fine-tuned adjustment of electronic properties, such as
12 nt of a myriad of macrocyclic receptors with fine-tuned affinities and selectivities, has enormously
13 files of the coumarin-IPP derivatives can be fine-tuned: an electron-donating group at PPh(3) enhance
14 ermining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr.
16 ffector molecules that arrange and achieve a fine-tuned and advanced response to diverse bacteria.
17 s the steric and electronic properties to be fine-tuned and hence the application profile of the cata
22 hange strategy, which is a powerful tool for fine-tuning atomic structure of electrocatalysts via sur
23 ) delve into posttranscriptional events that fine-tune ATXN1 expression and uncover a key role for 5'
24 sitivity of inflammasome pathways provides a fine-tuning balance between adequate immune response and
25 Here, we show experimentally that higher, fine-tuned barrier profiles result in significantly enha
26 tion of cytidine is a molecular mechanism to fine tune base pairing specificity and affect the coding
27 complex proteins as mechanotransducers that fine-tune beta-catenin signaling in a manner dependent o
30 ionts, the level of symbiosis development is fine-tuned by a range of local and mobile signals that a
33 f the EBFC-based sensor can be independently fine-tuned by changing the surface density of enzymes an
34 signals(2); however, how these pathways are fine-tuned by diverse cues from commensal bacteria is no
37 DLK-1, and likely other Hsp90 substrates, is fine-tuned by the antagonism between MEC-15 and the chap
38 h and dynamics can be properly modulated and fine-tuned by the choice of metal, redox state, and liga
39 Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hor
43 a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45
45 3 additional clusters of EBV-regulated genes fine-tune cell signaling, migration, and immune response
47 autoinhibition is an important mechanism for fine-tuning cell-ECM adhesion during cell migration in d
51 NTRC and the FDX-FTR-TRXs redox systems for fine tuning chloroplast performance in response to chang
52 stems, NTRC and FDX-FTR-TRXs, participate in fine-tuning chloroplast performance in response to chang
54 n genes, adds another layer of regulation to fine-tune condition-specific gene expression in animals
56 ul therapeutic targets aimed at preserving a fine-tuned crosstalk between the different cardiac cells
61 icate that cyclin C destruction pathways are fine tuned depending on the stress and that its terminal
62 ed, paving the way toward the realization of fine-tuned deterministic control of excited-state decay.
65 hniques to demonstrate that Mg2+ ions act as fine-tuning elements of the amino acid-sensing lysC apta
67 vides a potential compensatory mechanism for fine-tuning energy expenditure to energy balance in real
69 umber of bioorthogonal chemistries, but also fine-tuning existing reactions for particular applicatio
70 dependent FAAP20 degradation is modulated to fine-tune FA pathway activation remains largely un-known
71 ctivities of viral PRO/DUBs may generally be fine-tuned features of interaction with host factors.
76 Moreover, we discover that UBQLN2 UBL is fine-tuned for the hRpn10 UIM-1 site over the UIM-2 site
78 g with mutations that potentially change and fine-tune functions of the proteins coded in its genome.
80 chromatin accessibility can be harnessed for fine-tuning gene expression to optimal phenotypes in spe
81 highlighted the relevance of this process in fine-tuning GLP-1R responses in pancreatic beta cells to
82 oietic tumor suppressor and is important for fine-tuning hematopoietic stem and progenitor cell homeo
83 ts into how IL-10 receptor complex stability fine-tunes IL-10 biology and opens new opportunities to
85 al communities contribute to human health by fine-tuning immune responses and reducing dietary nitrat
87 thracene and the hemicyanine moiety could be fine-tuned in order to maximize the sensitivity of the o
88 eby virulence gene expression can be rapidly fine-tuned in response to the highly dynamic spatiotempo
89 p-dependent regulation of myc mRNA stability fine-tunes individual neural stem cell proliferation rat
91 ings identify a NIK-SIX signalling axis that fine-tunes inflammatory gene expression programs under b
92 ilability of >40%, offers the possibility to fine tune insulin acting profiles and provides long-term
93 he daf-2 locus generates a truncated IR that fine-tunes insulin signaling in response to the environm
94 g of two divergent species can disrupt these fine-tuned interactions, as newly formed allopolyploid s
96 isms that orchestrate the (de)acylation that fine-tunes ion channel function in physiology and diseas
98 recruited via scaffold-client interactions) fine-tunes it by transforming the scaffold-scaffold bond
99 te effects in the regulation of Osx level to fine-tune its activity during osteoblast differentiation
101 les of phosphorylation and dephosphorylation fine-tune Katanin level and activity to deliver the appr
103 ected to different stress responses, it also fine-tunes light signalling by reducing the biological a
104 eus signaling pathways; in turn, the nucleus fine-tunes lysosomal biogenesis and functions through tr
105 drug treatment could reflect a mechanism to fine-tune M. tuberculosis membrane properties to its adv
108 ron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxifica
109 ates ICP0 substrate recognition via multiple fine-tuned mechanisms in HSV-1 infection.IMPORTANCE HSV-
110 protease-based dynamic regulation circuit to fine-tune metabolic flow, we achieve 12.63 g L(-1) shiki
112 amic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize targ
115 The osmosensory behavior of Cnu involves a fine-tuned modulation of disorder in the fourth helix an
116 directly, by recruiting essential factors to fine-tune MTs for their many essential roles in cells.
118 in-3 variants as scaffolds for designing and fine-tuning new chemokine-binding agents that suppress i
120 es of novel UAS-Cas9 transgenes, which allow fine tuning of Cas9 expression to achieve high gene edit
121 city of the CBC:HapX:DNA interaction permits fine tuning of CBC:HapX binding specificities that could
125 ct with other G(i)-coupled receptors for the fine tuning of neuronal activity.SIGNIFICANCE STATEMENT
129 unctional group of the dipolarophile and the fine tuning of the catalyst plays an important role in p
131 r level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and li
133 linkers of the framework allow for chemical fine-tuning of activity and stability and, perhaps most
135 ation dynamics play an intricate role in the fine-tuning of chromatin states during periodontal devel
137 btle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites.
138 ge remains to identify guidelines that allow fine-tuning of detergents for individual applications in
139 ebbian-type learning rules and contribute to fine-tuning of distinct aspects of inhibitory function m
140 e of the nucleocytosolic compartment and the fine-tuning of dNTP levels for chloroplast translation a
141 indings point at resource partitioning and a fine-tuning of enzyme levels in E. coli to respect the c
142 vation, "envelope docking" of ACCase permits fine-tuning of fatty acid supply during the plant life c
146 advances, in particular how pharmacological fine-tuning of innate/adaptive immunity and its combinat
148 lopments in materials, thin-film processing, fine-tuning of morphology, and optimization of device fa
149 These data demonstrate miR-644a mediated fine-tuning of oncogenesis, stimulating pathways and res
150 nd alternative platforms that do not require fine-tuning of parameters and can be easily scaled to la
153 trograde signaling pathways is essential for fine-tuning of responses to the prevailing environmental
156 By capitalizing on a more precise genetic fine-tuning of the biotin-binding vestibule, unrivaled l
157 ffinity to the substrate-binding pocket, and fine-tuning of the chemical composition of the polymer t
160 tential therapeutic target that could enable fine-tuning of the integrated stress response for benefi
161 arylpalladium insertion was controlled by a fine-tuning of the reaction system, which provided regio
162 noncovalent attractive interactions through fine-tuning of the remote substituents of the D(2)-symme
163 lin head domain, as well as protein-specific fine-tuning of the VBS sequence, including sequence inve
164 plication in molecular electronics is in the fine-tuning of their electronic properties through struc
165 ar design of these detergents, we anticipate fine-tuning of their properties for specific application
166 is landscape that allows for both gross- and fine-tuning of tissue oxygen unloading to meet the disti
169 he aortic microenvironment landscape and the fine-tuning of various factors interacting to control he
171 or one of 600 human action classes, and then fine-tuned on a small dataset of 438 CT scans annotated
172 lgorithms and conditional probabilities were fine-tuned on a training set of 86 patients (mean age, 4
176 vity, and suggest a hypothalamic circuit for fine-tuning orexin signals to changing ethological prior
178 evolutionarily diversified large family that fine-tunes osmoregulation but is likely to fulfill addit
179 ristics, such as pK(a), we have been able to fine-tune our methodology to facilitate identification o
180 ricity, and find that any gap closing with 1 fine-tuning parameter between two gapped states changes
188 g with potential isomerization activity that fine-tunes product profiling and affects the production
190 results implicate a dynamic actin network in fine-tuning receptor mobility and receptor-ligand intera
191 Liver regeneration after injury requires fine-tune regulation of connective tissue growth factor
192 scape, representing an evolved mechanism for fine-tuned regulation of an effective but balanced neutr
193 hese findings provided a new mechanism about fine-tuned regulation of Ctgf through Hnf4alpha antagoni
194 ve maintenance of beta-cell identity through fine-tuned regulation of key transcription factors ensur
196 ey catabolic recycling pathway that requires fine-tuned regulation to prevent pathologies and preserv
197 hanism provide a platform for polymerases to fine-tune replication rates and fidelity to optimize vir
200 oduction regulates the redox environment and fine tunes Rho activity across the spermatheca through o
203 1) regulates the biosynthesis of ethylene to fine-tune root and root hair development, which are impo
204 stem, with modular components that allow for fine-tuning selectivity, should enable the safer and mor
208 ngs suggest that NEMO serves as a toolkit to fine-tune specific signals in physiologic and pathologic
209 t chemical modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating
210 ng that ERF12 functions heterochronically to fine-tune stochastic variation in wild type floral numbe
212 strate the ability of CD28 co-stimulation to fine tune subset-specific responses by thymic resident N
213 ate channeling for metabolic flux control by fine-tuning substrate-binding affinity for the key enzym
216 ts as a critical nonmetabolic regulator that fine-tunes Th17 cell differentiation and function in aut
217 f refractive power will lead to a customized fine-tuning that provides patients with the individual v
219 sses of mechanosensory receptors and neurons fine tune the physical assessment of an oviposition site
220 We argue that such approaches are needed to fine tune the relevant features necessary for improving
221 It was concluded that it may be possible to fine tune the rheological properties of the final chymos
222 te that this reciprocal regulation serves to fine tune the splicing patterns of many downstream targe
223 st immune system restricts translocation and fine tunes the composition and distribution of the micro
224 populations of ribosomes are responsible for fine tuning the control of protein synthesis in dynamic
226 le for the beta-catenin signaling pathway in fine tuning the granulocytic production, opening venues
227 ssion via inhibition of MAPK signaling, thus fine tuning the RAS-MAPK pathway to optimize proliferati
231 alization procedure allowing us to precisely fine-tune the amount of azobenzene on the functionalized
232 cost, which, in turn, serve as a platform to fine-tune the balance between stability and flexibility
233 wed that physiological concentration of BBSs fine-tune the color of the animals, providing the physio
234 while fine-grained edge dropout can further fine-tune the dropout at the interaction (edge) level.
235 probes within the cage are useful handles to fine-tune the electron transfer rates, paving the way fo
236 pithelial identity TF HNF1B, and it acted to fine-tune the expression of genes encoding highly glycos
238 veal how dynamic, charge-charge interactions fine-tune the interactions mediated by specific motifs,
241 plied as a multifunctional solid additive to fine-tune the morphology and improve device efficiency a
242 be adaptive if it allows past generations to fine-tune the phenotypes of future generations in respon
243 anisms in play is essential to being able to fine-tune the selectivity and achieve efficiency in the
245 x steps that is inherent to ferritins and to fine-tune the structure-function relationship of each re
246 e studies, we conclude that KSHV uses PPD to fine-tune the temporal expression of its genes by preven
247 ts show that E1A and E4orf3 work together to fine-tune the viral replication program during the cours
250 ne system critically acts as a rheostat that fine-tunes the balance between dormancy and disease prog
251 recognition domain and homodimeric interface fine-tunes the distinct target selection between the two
252 ggest that New1 is a translation factor that fine-tunes the efficiency of translation termination or
253 g transcriptomic analyses, we show that CHD7 fine-tunes the expression of a gene network that is crit
256 omeric composition of the Kv1.3 channelosome fine-tunes the precise balance between anterograde and i
258 abling generation of multineutral layers and fine-tuning the accumulated stresses on specific element
260 ell identity in a largely indirect manner by fine-tuning the activity of other major chromatin remode
261 ate how cellular protein regulation works by fine-tuning the conformational state space of proteins.
263 ong foundation to improve yield potential by fine-tuning the photoperiod-dependent control of inflore
266 restricting its association with S2, thereby fine-tuning the spatial organization of miR-122/Ago2 com
267 catalysts, beyond the classical methods like fine-tuning the steric and electronic properties of the
269 However, it remains a mystery how animals fine-tune their photophore luminescence to match the int
273 ion of the two pathways may allow neurons to fine-tune their response to injury and other stresses.
274 lic peptides, it is frequently necessary to "fine-tune" their conformations, e.g., by imposing greate
275 us, to improve the grain filling, we need to fine tune these crucial enzymes and their regulation, wh
277 and exudation and, consequently, how plants fine tune this complex belowground web of interactions.
278 ral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regul
281 nal coumarin-based COUPY fluorophores can be fine-tuned through replacement of the para-pyridinium mo
282 ll wall needs to be constantly monitored and fine-tuned to allow for growth while preventing mechanic
283 ation, energy, and nutrient requirements-are fine-tuned to an organism's growth and trophic strategy.
285 e latter, we expect idiobionts-as being less fine-tuned to host development-to be generally less tole
286 aling transduction are tightly regulated and fine-tuned to keep the signaling output "just right." Hy
289 tic antibodies with broad specificity can be fine-tuned to navigate in vivo exposure and tolerability
290 ty of kinetochore-microtubule attachments is fine-tuned to prevent or correct erroneous attachments w
295 ic infection in nonpregnant animals and that fine-tuning Treg activity may provide novel immunotherap
296 slational regulatory mechanism by which Sov1 fine-tunes Var1 synthesis with its assembly into the mit
297 ramerization are physiological mechanisms of fine-tuning, whereas anticytokine and anticytokine recep
298 the possibility for atom-precise structural fine-tuning which makes them remarkable candidates for s
299 rode material of supercapacitors needs to be fine-tuned with an inexpensive, high conducting source.