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1 e can be subjected to precise intermolecular fine-tuning.
2 to another in the absence of plant-specific fine-tuning.
3 to creating flat bands that does not involve fine-tuning.
4 rks, trained in stages of initialization and fine-tuning.
9 ial band-pass structures that do not require fine-tuning and are robust against environmental and cel
10 to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryot
11 hly specialized sensory cells conferring the fine-tuning and high sensitivity of the mammalian cochle
13 using only a subset of the INbreast data for fine-tuning and without further reliance on the availabi
14 logical plasticity mechanism for dynamically fine-tuning AP conduction velocity, which potentially ha
16 obably determined by hydrophobicity, but the fine tuning appears to arise from the distribution of ca
19 hange strategy, which is a powerful tool for fine-tuning atomic structure of electrocatalysts via sur
21 sitivity of inflammasome pathways provides a fine-tuning balance between adequate immune response and
23 his dynamic arrest that enables the observed fine-tuning by charge and the resulting calibration betw
24 hosphorylation but also provide evidence for fine-tuning Ca(2+) channel functions in maintaining cell
25 a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45
29 autoinhibition is an important mechanism for fine-tuning cell-ECM adhesion during cell migration in d
31 NTRC and the FDX-FTR-TRXs redox systems for fine tuning chloroplast performance in response to chang
32 stems, NTRC and FDX-FTR-TRXs, participate in fine-tuning chloroplast performance in response to chang
33 discuss how molecular design is pivotal for fine-tuning color and optimizing power efficiencies, hig
34 ng protein, shedding light to understand the fine-tuning control of the different vesicle fusion even
35 s to incorporate spirocycles followed by its fine-tuning, culminating in highly selective compounds 2
37 nal modification of steroid receptors allows fine-tuning different properties of this family of prote
38 l specification, the underlying mechanism of fine-tuning double flower formation remains largely uncl
41 hniques to demonstrate that Mg2+ ions act as fine-tuning elements of the amino acid-sensing lysC apta
43 vides a potential compensatory mechanism for fine-tuning energy expenditure to energy balance in real
44 plants to adapt to changing environments by fine-tuning energy production in leaves and the availabi
46 umber of bioorthogonal chemistries, but also fine-tuning existing reactions for particular applicatio
48 ltiple genes, often within the same pathway, fine-tuning expression of key factors and stabilizing ge
50 ng site, the Tyr-541 residue participates in fine-tuning Gd(3+)-sensitivity, and that the Asn-584 res
51 chromatin accessibility can be harnessed for fine-tuning gene expression to optimal phenotypes in spe
52 highlighted the relevance of this process in fine-tuning GLP-1R responses in pancreatic beta cells to
53 ntrabodies and provide a novel framework for fine-tuning GPCR functions with potential therapeutic im
54 erated in plants provides an opportunity for fine-tuning growth, development, and responses to the en
55 oietic tumor suppressor and is important for fine-tuning hematopoietic stem and progenitor cell homeo
56 hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron loa
57 ntroduces a hybrid approach for creating and fine tuning high-Q nanocavities, involving the local dep
60 udy identifies a novel role for microRNAs in fine-tuning immune homeostasis and thereby maintaining t
61 al communities contribute to human health by fine-tuning immune responses and reducing dietary nitrat
62 ment for numerous optical elements and their fine tuning in conventional design, paving the way for r
63 an immuno-metabolic crosstalk essential for fine-tuning innate immune cell activation and highlights
65 ral responses are vital to durable immunity, fine-tuning is critical to preventing catastrophes such
68 ll behavior during vascular morphogenesis by fine-tuning junctional mechanocoupling between endotheli
70 lation of BMP signal transduction provides a fine-tuning mechanism based on the two major enzymes tha
71 te that O-GlcNAcylation of DELLAs provides a fine-tuning mechanism in coordinating multiple signaling
73 ted Laplacian operator and combine it with a fine-tuning mechanism related to the weighted vertex cov
75 sts is a highly regulated process, requiring fine-tuning mechanisms especially during chloroplast dif
76 amic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize targ
78 in-3 variants as scaffolds for designing and fine-tuning new chemokine-binding agents that suppress i
79 supports host protection during infection by fine-tuning NF-kappaB activity, suggesting that SP110b m
80 d in vivo, and identify a ZNRF4-RIP2 axis of fine-tuning NOD2 signalling to promote protective host i
83 es of novel UAS-Cas9 transgenes, which allow fine tuning of Cas9 expression to achieve high gene edit
84 city of the CBC:HapX:DNA interaction permits fine tuning of CBC:HapX binding specificities that could
88 nominal M n+1AX n compounds enables not only fine tuning of existing properties but also entirely new
91 n underscores the importance of SLC25A46 and fine tuning of mitochondrial fission and fusion in ponto
92 ct with other G(i)-coupled receptors for the fine tuning of neuronal activity.SIGNIFICANCE STATEMENT
93 ranscription factors and coregulators in the fine tuning of organismal metabolism.HDAC3 is a critical
96 unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a gener
99 ays between pump and probe pulses allows for fine tuning of spectral resolution, bandwidth and imagin
100 unctional group of the dipolarophile and the fine tuning of the catalyst plays an important role in p
103 r level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and li
106 of a Nedd8-moiety to Cullin proteins) in the fine tuning of the NF-kappaB response (via Cullin-1).
110 lar body and repair of adult tissues require fine--tuning of cell adhesion, cell mechanics, and inter
111 linkers of the framework allow for chemical fine-tuning of activity and stability and, perhaps most
113 sent select examples of functional molecular fine-tuning of allosterism and discuss consequences rele
114 e for mounting novel responses and decreased fine-tuning of BCR specificities by somatic hypermutatio
116 to damaged chromatin, ZMYM3 facilitates the fine-tuning of BRCA1 interactions with DNA damage sites
117 M is influenced by calcium, allowing further fine-tuning of Ca(V)1.3 channel activity for particular
121 material properties of the cell wall and the fine-tuning of cellular biophysical parameters in the mu
122 TIP isoforms allow the spatial and temporal fine-tuning of cellular water transport, which is critic
123 ation dynamics play an intricate role in the fine-tuning of chromatin states during periodontal devel
124 ase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditi
128 calization and activity, suggesting that the fine-tuning of DA homeostasis involves multiple mechanis
129 btle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites.
130 ge remains to identify guidelines that allow fine-tuning of detergents for individual applications in
131 al stresses that require the involvement and fine-tuning of different stress signaling pathways.
132 ebbian-type learning rules and contribute to fine-tuning of distinct aspects of inhibitory function m
133 ebbian-type learning rules and contribute to fine-tuning of diverse aspects of inhibitory function me
134 e of the nucleocytosolic compartment and the fine-tuning of dNTP levels for chloroplast translation a
137 indings point at resource partitioning and a fine-tuning of enzyme levels in E. coli to respect the c
138 based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis pa
140 our results demonstrate for the first time a fine-tuning of FACT by a ubiquitin proteasome system in
141 vation, "envelope docking" of ACCase permits fine-tuning of fatty acid supply during the plant life c
142 ent advances in the design, preparation, and fine-tuning of fluorophores by means of multicomponent r
145 , in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide ran
146 regulation is an important mechanism for the fine-tuning of gene expression via 3'-untranslated regio
149 nt of two independent H3.3 genes facilitates fine-tuning of H3.3 expression across cellular programs.
154 advances, in particular how pharmacological fine-tuning of innate/adaptive immunity and its combinat
156 rol of thickness thus enables generation and fine-tuning of intrinsic strain to optimize catalytic re
157 ively stimulate abortive termination without fine-tuning of kinetic rate parameters at ribosome stall
159 NHCs and provides a guide to the structural fine-tuning of ligand requirements and stereochemical mo
162 he body of work on the synthesis and optical fine-tuning of meso-aryl-substituted bacteriochlorins.
163 tween its various metastable states, through fine-tuning of molecular packing in a reproducible manne
164 lopments in materials, thin-film processing, fine-tuning of morphology, and optimization of device fa
165 for a variety of processes, ranging from the fine-tuning of motor skill learning to important social
166 s without requiring any form of learning, or fine-tuning of neuronal parameters to replicate these re
167 he involvement of the receptor mGluR5 in the fine-tuning of NMDA receptors, specifically in the conte
168 These data demonstrate miR-644a mediated fine-tuning of oncogenesis, stimulating pathways and res
170 nd alternative platforms that do not require fine-tuning of parameters and can be easily scaled to la
172 ial counterregulatory role of EBV miR in the fine-tuning of PD-L1/L2 expression remains to be establi
173 icity and anisotropy, can further permit the fine-tuning of plasmon behaviors in borophene, potential
174 osine modulation may provide a mechanism for fine-tuning of plasticity and learning according to brai
176 criptome diversification is required for the fine-tuning of protein expression in monocytes, suggesti
177 eceptor-interacting proteins also facilitate fine-tuning of receptor activity and tissue specificity.
178 m memory, which is robust to noise and where fine-tuning of recurrent excitation or inclusion of sub-
179 trograde signaling pathways is essential for fine-tuning of responses to the prevailing environmental
184 ds for RGD-recognizing integrin subtypes; 5) fine-tuning of the affinity and selectivity by additiona
185 in that it enables the flexible control and fine-tuning of the aspect ratio and the plasmonic resona
187 By capitalizing on a more precise genetic fine-tuning of the biotin-binding vestibule, unrivaled l
188 bolites biliverdin IXbeta and IXdelta, allow fine-tuning of the cell-surface signaling system in resp
190 ffinity to the substrate-binding pocket, and fine-tuning of the chemical composition of the polymer t
197 rent solvent systems, as key factors for the fine-tuning of the extraction properties, are discussed.
198 propose a general mechanism that enables the fine-tuning of the Fermi velocity in Dirac materials in
199 tential therapeutic target that could enable fine-tuning of the integrated stress response for benefi
200 l bursting individually allows combinatorial fine-tuning of the level of MHC class I gene expression
201 ystematic study, we show that the structural fine-tuning of the linkers allows access to variations i
204 hes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjus
207 uch polyplex formulation and determined that fine-tuning of the polyplex structure is essential for e
208 arylpalladium insertion was controlled by a fine-tuning of the reaction system, which provided regio
209 this deacetylase proteome could lead to the fine-tuning of the regulation of microtubule dynamics an
210 noncovalent attractive interactions through fine-tuning of the remote substituents of the D(2)-symme
213 lin head domain, as well as protein-specific fine-tuning of the VBS sequence, including sequence inve
214 rsity of their building blocks, which allows fine-tuning of their chemical and physical properties by
215 plication in molecular electronics is in the fine-tuning of their electronic properties through struc
216 ar design of these detergents, we anticipate fine-tuning of their properties for specific application
218 is landscape that allows for both gross- and fine-tuning of tissue oxygen unloading to meet the disti
222 he aortic microenvironment landscape and the fine-tuning of various factors interacting to control he
224 nabled model provides insights into thermal "fine-tuning" of carbohydrate metabolism and a warning th
227 vity, and suggest a hypothalamic circuit for fine-tuning orexin signals to changing ethological prior
228 ricity, and find that any gap closing with 1 fine-tuning parameter between two gapped states changes
233 plicing of Nf1 is an important mechanism for fine-tuning Ras/ERK signaling as well as learning and me
235 results implicate a dynamic actin network in fine-tuning receptor mobility and receptor-ligand intera
240 stem, with modular components that allow for fine-tuning selectivity, should enable the safer and mor
242 henotyping, we propose target haplotypes for fine-tuning starch structure in rice through marker-assi
244 ate channeling for metabolic flux control by fine-tuning substrate-binding affinity for the key enzym
245 ongly correlated regime and does not require fine tuning, suggesting that this state is generic for p
248 f refractive power will lead to a customized fine-tuning that provides patients with the individual v
249 y realize defect-free epitaxial growth while fine tuning the chemical composition, layer thickness an
250 populations of ribosomes are responsible for fine tuning the control of protein synthesis in dynamic
252 ivalent approach may provide a mechanism for fine tuning the efficacy of allosteric compounds in futu
253 ted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical
255 le for the beta-catenin signaling pathway in fine tuning the granulocytic production, opening venues
256 ssion via inhibition of MAPK signaling, thus fine tuning the RAS-MAPK pathway to optimize proliferati
259 abling generation of multineutral layers and fine-tuning the accumulated stresses on specific element
262 ell identity in a largely indirect manner by fine-tuning the activity of other major chromatin remode
265 ate how cellular protein regulation works by fine-tuning the conformational state space of proteins.
266 potential role for a 'housekeeping' gene in fine-tuning the development of an ecologically important
268 surface with dimethoxydimethylsilane allowed fine-tuning the effective pore size and reversing surfac
269 le 2D layered tin iodide perovskites through fine-tuning the electronic property of organic ammonium
270 ycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine si
272 ugh a feedback loop that might contribute to fine-tuning the expression of more than a thousand of MY
273 urther demonstrate the general importance of fine-tuning the integrative properties of neuronal dendr
276 with G1 progression may thus be critical for fine-tuning the orientation of the polarity axis in yeas
278 ong foundation to improve yield potential by fine-tuning the photoperiod-dependent control of inflore
280 ategy allowed us to establish principles for fine-tuning the properties of fluorophores and to develo
283 restricting its association with S2, thereby fine-tuning the spatial organization of miR-122/Ago2 com
284 catalysts, beyond the classical methods like fine-tuning the steric and electronic properties of the
285 s and reveal its crucial role in dynamically fine-tuning the transcriptional cascade of a unicellular
286 the S1 helix also play an important role in fine-tuning the voltage dependence of activation, regula
290 a nexus for sleep and mood regulation while fine-tuning these processes to adapt to seasonal changes
292 er desirable results and would require model fine-tuning to be on a par with those trained with targe
295 ic infection in nonpregnant animals and that fine-tuning Treg activity may provide novel immunotherap
296 that CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 signaling in ECs, sugges
297 nstream of PINK1 and HTRA2 for mitochondrial fine tuning, whereas TRAP1 loss of function leads to red
298 ramerization are physiological mechanisms of fine-tuning, whereas anticytokine and anticytokine recep
299 the possibility for atom-precise structural fine-tuning which makes them remarkable candidates for s