ライフサイエンスコーパス: firing rate

1 ry balance and an increased action potential firing rate.

2 s and include many genes that could regulate firing rate.

3 d acts as a gain control on the magnitude of firing rate.

4 actor accounting for spontaneous variance in firing rate.

5 carry useful information beyond the average firing rate.

6 he two SPN phenotypes exhibits a higher mean firing rate.

7 nd of neural activity as compared to average firing rate.

8 increase of both spontaneous and NMDA-evoked firing rate.

9 ulators such as monoamines signal changes in firing rate.

10 ing constraints on real-time speed coding by firing rate.

11 d Shal underlie the daily oscillation in LNv firing rate.

12 ot find evidence for speed modulation of the firing rate.

13 re characterized by spike waveform shape and firing rate.

14 ute expression levels increased with maximal firing rate.

15 caused an increase in the spontaneous neuron firing rate.

16 ifferent timescales to maintain network mean firing rate.

17 ufficient to provide homeostasis of the mean firing rate.

18 or motor information with graded changes in firing rate.

19 ges in excitatory input and maintain a lower firing rate.

20 other neural signals, such as single-neuron firing rates.

21 otentiation or depression driven by neuronal firing rates.

22 insic plasticity that downregulates neuronal firing rates.

23 st neurons do not simply convert inputs into firing rates.

24 of neural activity across a range of average firing rates.

25 pre-ictal period, albeit with slightly lower firing rates.

26 erating nerve fiber spike trains at variable firing rates.

27 duced gamma synchronization while increasing firing rates.

28 images from each other using this pattern of firing rates.

29 ristically shifted to later phases at higher firing rates.

30 ly reflected in correlations than individual firing rates.

31 the running speed-dependent gain in neuronal firing rates.

32 d makes it less dependent on the presynaptic firing rates.

33 intrinsic excitability and action potential firing rates.

34 ed with frequency up to the afferent resting firing rate (~100-150 Hz) and at higher frequencies affe

35 mage, bushy cells show increased spontaneous firing rates across a wide-frequency range, suggesting t

36 An analysis of firing rates across time windows revealed the presence o

37 ch that place cells return to their baseline firing rate after exploration.

38 animal shifted tasks the first time, the LC firing rate after visual cue onset increased significant

39 xceeds information that can be obtained from firing rates alone and is evident for inter-areal connec

40 harmonics are represented by local maxima in firing rates along the tonotopic axis, has been characte

41 Firing rate also increased prior to crossing photodetect

42 diction errors, and outcome history in their firing rates also carry significant information in their

43 d CA3-CA1 synaptic transmission and CA1 mean firing rate and attenuated susceptibility to seizures, e

44 (< 100 ms) as well as through variations in firing rate and burstiness at longer time scales.

45 The link between firing rate and CCD was most prevalent in the anterior m

46 je cells uncovered an increased simple spike firing rate and decreased modulation of firing during li

47 ) in the mHb exhibited increased spontaneous firing rate and enhanced firing regularity in brain slic

48 LDH patients have increased BL firing rate and insufficient motor unit recruitment in s

49 neurons encode information by varying their firing rate and patterns precisely fine-tuned through GA

50 s, mimicked the SF effects by increasing the firing rate and regularity, as well as depolarizing the

51 have been characterized by their spontaneous firing rate and responses to sound and those physiologic

52 asal dopamine neuron population activity and firing rate and reverses the restraint stress-induced in

53 indow that maximizes the correlation between firing rate and running speed.

54 gered by the optogenetic modification of the firing rate and spike synchrony of cells.

55 haracterized by a symmetric coupling between firing rate and spike theta-phase.

56 l currents drive changes in action potential firing rate and that these rhythms are abolished when th

57 Within a cell's place field, both the firing rate and the phase of spiking in the local theta

58 ded by a theoretical algorithm restored mean firing rates and basic function such as orientation sele

59 ntained in adaptive conductances that reduce firing rates and can be accessed directly without cued r

60 ifically, sparsely bursting cells have lower firing rates and carry more spatial information than dom

61 ure the initial drop and delayed recovery of firing rates and correlations observed experimentally.

62 single-neuron level, these included ramping firing rates and cycle-specific responses.

63 Comparing Purkinje firing rates and eurydendroid IPSC rates indicated that

64 turn on when neurons are above their target firing rates and include many genes that could regulate

65 rom differences in response strength or mean firing rates and indicates fundamental differences in va

66 When we correlated firing rates and information values, we found that avera

67 how behavioral activity states may modulate firing rates and likely information processing in the ME

68 Firing rates and magnitudes of responses in relation to

69 activates the cortex by restoring deep-layer firing rates and modulating feedforward and feedback con

70 hms of activity with higher action potential firing rates and more positive resting membrane potentia

71 al and proximal apical dendrites, as well as firing rates and ocular dominance, were normal.

72 We found differences in mean firing rates and pause durations among ventral tegmental

73 eshold method, and was more tolerant to high firing rates and simulated recording noise.

74 nses manifested themselves as higher maximum firing rates and/or improved temporal resolution of puls

75 one structure to the other could affect the firing rates and/or the spike patterns.

76 with the modulation of the stimulus-induced firing rate, and importantly, a higher phase coherence i

77 was associated with neuronal energetics and firing rate, and overlapped with changes identified in p

78 the importance of homeostatic maintenance of firing rates, and the functional consequences of feedfor

79 occurred independent of changes in mean STN firing rates, and the relative timing of STN spikes was

80 effect of the axonal and somatic load on the firing rate; and the role that the trigger position on t

81 neuron recordings, we show that hippocampal firing rates are elevated from ~ 500-1500 ms after cue o

82 Analytical forms for neuronal firing rates are important theoretical tools for the ana

83 Together, our findings show that V1 firing rates are rapidly and actively stabilized during

84 gh-gamma power, thought to index the average firing rate around the electrode, was highest for the sm

85 found that neurons bidirectionally regulate firing rates around an individual set point.

86 based largely on models those consider only firing rate as the mechanism of information transfer.

87 ucleus output neurons, bushy cells show high firing rates as well as lower and less variable first-sp

88 The age trajectory of MU firing rate assessed at a single contraction level diffe

89 Firing rates, burstiness, and other electrophysiological

90 average information correlates with average firing rate but that higher-rates found at the onset res

91 hronization were not underlain by changes in firing rate but, rather, by the timing of action potenti

92 These models use a linear speed code by firing rate, but do not consider temporal constraints of

93 er footshock caused smaller increases in BLA firing rate, but this could be augmented by chemogenetic

94 ke-encoded information is evident in average firing rates, but finer temporal coding might allow mult

95 determined whether the "noise" introduced in firing rate by the regulation of CCD is detrimental or b

96 dynamics preceded homeostatic plasticity of firing rates by >30 h.

97 band of Broca does not affect modulation of firing rates by running speed at each time scale tested.

98 ing optogenetics, we show that modulation of firing rates by running speed is independent of MSDB inp

99 that part of the spontaneous fluctuations in firing rate can be attributed to the cortical control of

100 to differential changes in high- versus low-firing rate cells in parallel with increased interneuron

101 information is represented through reliable firing rate changes during unconstrained navigation.

102 rent (0.7-8.8 m/s) directions, and monitored firing rate changes in breathing and blood glucose modul

103 and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal ce

104 -poor environments and preferentially used a firing rate code driven by intra-hippocampal inputs.

105 captures the simultaneous expression of the firing-rate code and theta-phase code in place cell spik

106 Here, we have probed the firing rate coding properties of neurons in medial entor

107 MIF motoneurons presented an overall reduced firing rate compared with SIF motoneurons, and had signi

108 perturbations under DHODH blockade triggered firing rate compensation, while stabilizing firing to th

109 Here we demonstrate that the firing rate, contrast sensitivity, and dynamic range of

110 with smaller proportions of MEC cells having firing rates correlated with locomotion in rTg4510 mice.

111 sequential experience and increased neuronal firing rate correlations can explain the difference betw

112 m to characterize sleep cycles, and examined firing rates, correlations, and sequential firing of neu

113 the learning form also including changes to firing rate couplings between neurons.

114 ta obtained in humans at rest, and show that firing rate covaries with CCD in 16.7% of the sample (25

115 During non-rapid eye movement sleep, MD firing rate decreased around spindle-uncoupled ripples,

116 chanisms may contribute to RS in IT, such as firing rate-dependent fatigue and transsynaptic mechanis

117 mats despite considerable rescaling of their firing rate depending on the visual specificities of eac

118 In contrast, firing rate depression associated with Hebbian plasticit

119 Average firing rate determined the ATP cost across firing patter

120 int models perform similarly at the level of firing rate distributions for the questions we investiga

121 In contrast, upon non-REM (NREM) sleep, firing rate distributions narrowed while interneuron fir

122 ncreased neocortical firing, in both regions firing rate distributions widened during REM due to diff

123 d to exhibit longer latencies and lower mean firing rates due to lower signal amplitudes at their pre

124 dently sufficient for increasing GnRH neuron firing rate during positive feedback or whether both are

125 Moreover, the firing rate during sinusoidal vibration stimuli at low a

126 ing of CA1 place cells, with a ramping-up of firing rate during the waiting period, but no general ov

127 In addition, we observed neurons whose firing rates during navigation were tuned to specific he

128 t-synaptic and intrinsic changes to increase firing rates during positive feedback.SIGNIFICANCE STATE

129 t-synaptic and intrinsic changes to increase firing rates during the preovulatory GnRH surge.

130 synthesize these questions, we analyzed the firing rate dynamics of populations of neurons in both h

131 e we observe typical modest conflict-related firing rate effects, we find a widespread effect of conf

132 firing behavior including switching between firing rates, entering silent periods, or firing several

133 his approach often misses spikes during high firing rate epochs or noisy conditions.

134 whose responses are determined by a dynamic firing-rate equation.

135 We show that firing-rate estimation for speed cells requires integrat

136 ined the optimal integration time window for firing-rate estimation using a general likelihood framew

137 ral constraints of integration over time for firing-rate estimation.

138 Neuronal circuits maintain relatively stable firing rates even in the face of dynamic circuit inputs.

139 carry 5 times more information than the mean firing rates even in the first 100 ms.

140 The increase of the NMDA-evoked firing rate exerted by NS-1738 was superadditive over th

141 en (1) there was a temporal sequence in peak firing rates exhibited by individual neurons, and (2) th

142 Provided that such a temporal order of peak firing rates existed, rotational patterns could be easil

143 The variance in firing rate explained by CCD ranged from 0.5 to 11%.

144 We examined the role of firing rate fatigue and transsynaptic mechanisms by stim

145 responses were postulated to be decreased by firing rate fatigue, to RS in IT.

146 with little or no contribution of intrinsic firing rate fatigue.

147 in encoding by selectively modulating their firing rate for a subset of all possible stimuli.

148 n stripe neurons continued to increase their firing rate for stimulus contrasts above 50%, while thic

149 that relative spike timing is as relevant as firing rate for understanding cortico-basal ganglia info

150 neurons regulate firing around a stable mean firing rate (FR) that can differ by orders of magnitude

151 cells showed an increasing gradient in mean firing rate from proximal to distal CA3.

152 S as a function of the deviation of neuronal firing rates from a locally defined set-point, independe

153 that immediately elevated their spontaneous firing rates (FRs) and developed firing responses to a n

154 that deep layer neurons show higher baseline firing rates (FRs) in GC with deep-layer inhibitory neur

155 neurons from EV-treated monkeys showed lower firing rates, greater spike frequency adaptation, and ex

156 -related plasticity, but to date only upward firing rate homeostasis (FRH) has been demonstrated in v

157 Firing rate homeostasis (FRH) stabilizes neural activity

158 Firing rate homeostasis also occurred normally during ac

159 ivity-regulated transcription could underlie firing rate homeostasis because activity-regulated genes

160 ity-regulated transcription, indicating that firing rate homeostasis can be controlled by non-transcr

161 ng the molecular mechanisms that enable this firing rate homeostasis could potentially provide insigh

162 utilized model investigations to manipulate firing rate homeostasis in a cell-type-specific manner a

163 Thus, firing rate homeostasis in response to increased neurona

164 , we found that cortical neurons can undergo firing rate homeostasis in the absence of activity-regul

165 This maintenance of firing rate, or firing rate homeostasis, is likely mediated by homeostat

166 egulated transcription would be required for firing rate homeostasis.

167 ow-strength oscillatory inputs induce higher firing rate in D2 SPNs but higher coherence between D1 S

168 We also show that preparatory modulation of firing rate in FEF(SEM) predicts movement, providing evi

169 or BDNF, prevented the increase in RA neuron firing rate in LD+T birds.

170 HCN2 modulates action potential firing rate in nociceptive neurons and plays a critical

171 ry responses ex vivo and a decrease in their firing rate in vivo, suggesting a feedforward mechanism

172 rsts increased with clustering, whereas peak firing rates in bursts increased in highly interconnecte

173 were both necessary to explain the elevated firing rates in experienced ferrets.

174 ensory responsive, without affecting overall firing rates in L6 or L2/3.

175 hat high concentrations of lithium increased firing rates in mPFC-, but not NAc-, projecting VTA DA n

176 eatment was insufficient to change the basal firing rates in NAc-projecting VTA DA neurons.

177 Abnormal firing rates in PFC of G(PFC)E mice relate to sparser de

178 Firing rates in the BLA were sustained throughout the tr

179 ic Purkinje neurons (PNs) resulted in low PN firing rates in the cerebellum.

180 In contrast, firing rates in the OFC were phasic and maximal shortly

181 x that is recruited to the seizure, neuronal firing rates increase and waveforms become longer in dur

182 s were predicted from spatial context, while firing rates increased when stimuli were unpredicted fro

183 followed the waxing and waning of spindles; firing rates increased, spikes were more phase-locked to

184 ng membrane potential, decreased spontaneous firing rate, increased current-induced firing threshold,

185 Place cell firing rate increases in early stages of exploration of

186 Trigeminal neuron firing rate increases with airspeed, is modulated by the

187 ty of an increased K(Na) current to increase firing rates independent of any compensatory changes was

188 confidence of a retrieval trial, with higher firing rates indicative of reduced confidence.

189 ponse window that still contains presynaptic firing rate information before the synapse is depressed.

190 Finally, spontaneous firing rate, interspike interval variance, and contrast

191 re tested whether the proposed speed code by firing rate is accurate at short time scales using data

192 parallel, attentional modulation of neuronal firing rate is not uniform but depends upon the match be

193 he alpha-MSH induced increase in MC3R neuron firing rate is probably activity-dependent, and was inde

194 that the effect of alpha-MSH on MC3R neuron firing rate is probably activity-dependent.

195 We find that, although basal neuronal firing rate is unaffected, there is a dose-dependent eff

196 ynaptic strength, membrane excitability, and firing rates, its role at the neural circuit and network

197 erent parameters through minor variations in firing rates, LA cells coded fewer task features with st

198 onding to any haltere motion and others with firing rates linearly related to the haltere frequency.

199 slow homeostatic renormalization of the mean firing rate (MFR), concomitantly accompanied by a slow s

200 without obvious task-related, trial-averaged firing rate modulation - to be assessed for behavioral r

201 on about visual perception in the absence of firing rate modulation.

202 l input fluctuations that cause commensurate firing rate modulations at the single-cell level result

203 revealed statistically significant neuronal firing rate modulations during all task phases (anticipa

204 absence of swimming, olig2(+) ENs had basal firing rates near 8 spikes/s, and EPSCs and IPSCs were e

205 recent evidence suggests that low- and high-firing rate neurons display different plasticity and dyn

206 Firing rates nevertheless increase, providing evidence t

207 tal cellular-level property: the thresholded firing rate nonlinearity of simple cells in the primary

208 the increased synaptic density and decreased firing rate observed in germ-free mice.

209 HCN ion channels govern the firing rate of action potentials in the pacemaker region

210 Here, we show that the tonic firing rate of ChIs in NAc shell is reduced in chronic s

211 at dopamine lesion decreases the spontaneous firing rate of ChIs, whereas chronic treatment with L-DO

212 ed astrocytes in wild-type mice enhanced the firing rate of cortical neurons and gamma oscillations,

213 und that, in dopamine-depleted mice, (1) the firing rate of D2-SPNs was elevated, especially during c

214 FC-DRN neural circuit, in vivo recordings of firing rate of DRN 5-HT neurons, cerebral 5-HT depletion

215 alpha-MSH increased the firing rate of MC3R VTA neurons in acute brain slices fr

216 HCN3 deletion increased the firing rate of medium but not small, sensory neurons.

217 In addition, the mean firing rate of neurons was lower in juveniles.

218 es a general framework for approximating the firing rate of neurons with spatial structure.

219 es from mice, although it did not affect the firing rate of non-MC3R VTA neurons.

220 neurons only respond to the mean population firing rate of Purkinje cells at high frequencies.

221 mice consistently induced an increase in the firing rate of putative cholinergic interneurons and fas

222 nd N-methyl-D-aspartate-evoked (NMDA-evoked) firing rate of rat CA1 hippocampal pyramidal cells, in v

223 rhythmic potentials increase the background firing rate of retinal ganglion cells (RGCs) and overlay

224 to reductions in intrinsic excitability and firing rate of SF1 neurons.

225 mechanistic explanation: variability in the firing rate of single grid cells across firing fields, a

226 The firing rate of speed cells, a dedicated subpopulation of

227 d NAFLD was associated with a nearly doubled firing rate of the hepatic sympathetic nerves, which was

228 y increased both spontaneous and NMDA-evoked firing rate of the neurons, application of PHA-543613 re

229 on about memory content not available in the firing rate of the neurons.

230 The pattern and firing rate of these cells are crucial for the correct m

231 f HFHS diet hyperpolarized and decreased the firing rate of VP neurons without a major change in syna

232 alpha-MSH significantly increased the firing rate of VTA MC3R neurons without altering the act

233 Moreover, the firing rate of ~24% of V1 neurons was modulated by the p

234 We examined the firing rates of CA3 neurons from young and aged, male, L

235 most of which invoke changes in spontaneous firing rates of central auditory neurons resulting from

236 Opiates increase the firing rates of dopaminergic neurons in the VTA by actin

237 Firing rates of ENs nevertheless increased, suggesting t

238 The model describes average firing rates of excitatory and inhibitory interneuron po

239 Sun et al. discover that neuronal firing rates of hippocampal place cells code for periodi

240 d we fit computational models to predict the firing rates of individual neurons at the time of reward

241 and that the SBP correlates better with the firing rates of lower signal-to-noise-ratio units than t

242 behavior in Treasure Hunt, we found that the firing rates of many MTL neurons during navigation signi

243 t this connection, and action potential (AP) firing rates of PV-INs were unchanged.

244 BS generated both increases and decreases in firing rates of single neurons in STN, globus pallidus e

245 ire model; a non-monotonic dependence of the firing rate on the number of dendrites receiving synapti

246 es, but spontaneous fluctuations in cortical firing rate, or "noise," have seldom been related to hea

247 This maintenance of firing rate, or firing rate homeostasis, is likely media

248 tributions and of the index of dispersion of firing rate over different binwidths.

249 neuronal circuits maintain relatively stable firing rates over long periods.

250 iant, GluA3 extends the range of presynaptic firing rates over which rate information in bushy cells

251 In the OFC, firing rates peaked shortly after offer presentation; in

252 s more subtle than expected, with changes in firing rates possibly being dominated by a common extern

253 r interspike intervals and higher repetitive firing rates, possibly by relieving Na(+) channel inacti

254 r extent in both sexes (P < 0.05), whilst MU firing rate progressively decreased with age in females

255 which are comprised of enhanced sound-driven firing rates, reduced first-spike latencies and wideband

256 Instead, moment-to-moment firing rates reflect interactions between synaptic input

257 -restricted ghrelin-induced increases in VAN firing rate require intact VAN GHSR expression.

258 changes to support the high action-potential firing rates required for auditory information encoding.

259 ion developmentally increase to support high firing rates required in the initial stages of auditory

260 However, estimation of firing rates requires integration of spiking events over

261 ensity of VGLUT2(+) puncta and Purkinje cell firing rate respectively, in contrast to the increased s

262 the lower level, indicating a change in the firing rate set point.

263 ifferent timescales to maintain network mean firing rate.SIGNIFICANCE STATEMENT Persistent alteration

264 For a small subset of place fields, we find firing rates significantly increase or decrease with spe

265 ed signals, there was a relative increase in firing rates, similar to that seen in aged rats.

266 linear "ramping" component of each neuron's firing rate strongly contributes to the slow timescale v

267 he externally referenced spatial frames, but firing rates, sub-second cell-pair action potential disc

268 n of STN neurons, there was no net effect on firing rate, suggesting that reduced beta synchrony was

269 unbalanced responses favoring increased SNr firing rates, suggesting a potential locus for cannabine

270 c plasticity is essential for the rebound of firing rates, suggesting that synaptic scaling and intri

271 f amplitude modulation rate in their overall firing rate, thalamostriatal neurons convey information

272 ls with multisensory responses showed higher firing rates than the sum of the unisensory responses at

273 nputs from co-aligned conjunctive cells with firing rates that differ between their fields.

274 e a necessary adjustment to the motor neuron firing rates that increase around the time of birth.

275 ks of spontaneously active neurons, the mean firing rate, the occurrence of rapid bursts of action po

276 Despite their fluctuating firing rates, the preferred firing phase of LRNs during

277 These models consider firing rate to be linearly tuned by running speed in rea

278 sing richness including: independence of the firing rate to the electrotonic length for certain model

279 DOPA of lesioned mice increases baseline ChI firing rates to levels beyond normal activity.

280 electrode arrays homeostatically adapt their firing rates to persistent pharmacological stimulation e

281 ndary visual cortex (V2) respond with higher firing rates to synthetic texture images containing "nat

282 s shown how neurons in the motor cortex have firing rates tuned to movement direction.

283 e report that optogenetic stimulation raises firing rates uniformly across conditions, but improves t

284 ndrial volumes are increased to support high firing rates upon maturity.

285 Our results show that part of spontaneous firing rate variability in regions best known for their

286 used to determine discharge characteristics (firing rate, variability) and biomarkers of peripheral M

287 general observation that increasing the mean firing rate via external stimuli or modulating drives te

288 ngle-spike pacemaking by phasic increases in firing rate via two qualitatively distinct biophysical m

289 hibitor teriflunomide stably suppressed mean firing rates via synaptic and intrinsic excitability mec

290 of iDC stimulation on vestibular nerve fiber firing rate was investigated using loose-patch nerve fib

291 Overall, the MD firing rate was transiently (0.76 +/- 0.06 s) decreased

292 HD cell peak firing rates were generally equivalent along each surfac

293 by depolarizing currents as well as maximal firing rates were increased in neurons expressing the mu

294 hortly after offer presentation; in the BLA, firing rates were sustained and peaked after juice deliv

295 However, higher firing rates were sustained during the lever interaction

296 e field (RF) center size and whole-field RGC firing rates were unaffected by IOP elevation.

297 Many neurons showed peaks in firing rate when a low-numbered harmonic aligned with th

298 In area V1, neurons may reduce their firing rates when their receptive field input can be pre

299 First, 40% of neurons changed their firing rate whenever a fixation landed on the search tar

300 e groups (MU-modes) with parallel scaling of firing rates with changes in the muscle force, and (ii)