ライフサイエンスコーパス: firmly

1 ion of anything to which one can attach them firmly.

2 endothelium where it activates leukocytes to firmly adhere engaging integrin clustering, a process of

3 ed as the likelihood for a blood-borne NP to firmly adhere to the vessel walls, is a fundamental para

4 r cells tethered and rolled on BMEC and then firmly adhered to and traversed BMEC via sequential depe

5 are sheet-like, leading edge protrusions in firmly adherent cells that contain Arp2/3-generated dend

6 digestive tract, for example, is lined by a firmly adherent mucus layer that is typically devoid of

7 polarize and start crawling, only few remain firmly adherent over time.

8 Respiratory diphtheria, characterized by a firmly adherent pseudomembrane, is caused by toxin-produ

9 Double-conjugated MSs specifically detected firmly adhering leukocytes (P<0.01), allowing in vivo qu

10 Conjugated MSs specifically interacted with firmly adhering leukocytes, allowing quantification of t

11 tential recorded when an electrode is pushed firmly against cardiac tissue.

12 lays femtomolar binding affinity, placing it firmly alongside the CB[7].Diam(NMe3)2 complex.

13 positioned histidine residue contributes to firmly anchor, via a dative bond, a biotinylated rhodium

14 lled away from their position and that these firmly anchored mitochondria preferentially localize to

15 lymerization with latrunculin A reduces this firmly anchored pool.

16 mily in which flavin mononucleotide (FMN) is firmly anchored to the protein.

17 In the same reaction step, the monoliths are firmly anchored to the surface of the capillary.

18 Yet both groups firmly and equally interpret peace as the termination of

19 lematic Polypodium, a parasite of fish eggs, firmly as sister taxon to Myxozoa within the Cnidaria.

20 Our data firmly assign THEMIS to the TCR-proximal signaling casca

21 We provide evidence to firmly associate KMT2C, ASH1L, and KMT5B haploinsufficie

22 ehyde, is neither molecularly identified nor firmly associated to an encoding gene.

23 on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcino

24 nd the geological provenance of the artifact firmly associates it with a host of Middle Paleolithic s

25 The inability of biofilm to firmly attach to the surface and its effective removal u

26 modulus of both poorly attached (round) and firmly attached (close to flat) cells.

27 ing cells in addition to those that are more firmly attached and migrating in random directions.

28 d to circumvent this problem is to fabricate firmly attached metal species onto the voids of a mesopo

29 to tear or crush its contents, or a tool is firmly attached to a table or free to be lifted.

30 However, many cells cannot be firmly attached to many substrates.

31 ng the other is allowed because one motor is firmly attached to one microtubule while it is stepping

32 hizosphere, which consists of soil particles firmly attached to roots, engage in symbiotic associatio

33 , only a fraction of the cell population was firmly attached to S(0) globules.

34 ompass a series of microenvironments and are firmly attached to teeth.

35 ayer prior to competition and to (ii) remain firmly attached to the bilayer during competition.

36 lop enough adhesion with the substrate to be firmly attached to the substrate.

37 A 'staple-pin' architecture firmly attaches the scaffolding silk to the substrate an

38 mentum by more than half before the mosquito firmly attaches to a surface.

39 oduced is usually so small that it cannot be firmly attributed to electrochemical nitrogen fixation(7

40 A key additional piece of evidence that firmly authenticated the established chronology was the

41 First, they are firmly based in mathematics and its proofs.

42 target fear memories, placing these memories firmly behind the crosshairs of neurobiologically inform

43 We firmly believe that our findings will inspire future res

44 It is, however, firmly believed that this polymerization method will bec

45 find that the nonpolar groups of protein can firmly bind to TMD layers or graphene to expose polar gr

46 Our simulation results reveal that EGCG firmly binds to HMGB1 near Cys106, which supports previo

47 t rather with surface changes induced by the firmly bound Be(2+) and an accompanying Na(+) cation.

48 e assembly factor N7BML (NDUFAF2), was found firmly bound instead.

49 trary to all known competitive technologies, firmly bound part of arsenic preventing its leaching bac

50 ing isotherms indicating that these proteins firmly bound pelargonidin at both pH 7.0 and 3.0 (bindin

51 on the initial concentration of AgNO(3), are firmly bound to Fe NPs, which prevents their release eve

52 Sea stars adhere firmly but temporarily to various substrata as a result

53 volves Glu192 in binding, thus succeeding in firmly capping the S1 pocket.

54 They were firmly cell associated, resisted phosphatidylinositol-sp

55 ng intermonomer interaction, which induces a firmly closed conformation of dimers and crucially invol

56 As firmly closed dimers markedly shorten VWF's effective le

57 ately one-half of the constituent dimers are firmly closed via the strong intermonomer interaction.

58 constrict its movement and as a consequence, firmly closes the steric gate, which in wild-type enzyme

59 g reaction that leaves the 5' end of the DNA firmly complexed with its otherwise intact protein capsi

60 ed a new type of ruthenium catalyst that was firmly confined by ordered mesoporous carbons through th

61 zation high-resolution mass spectrometry, we firmly confirmed six positional isomers of the MW 212 OS

62 Although studies over the last decades have firmly connected a number of genes and molecular pathway

63 Taken together, our results firmly corroborate the concept that CTMP promotes Akt ph

64 The magnetic inclusions are found to be firmly coupled to the cell membrane, enabling a direct t

65 Proton transport by FO is firmly coupled to the rotation of the c-ring relative to

66 These data firmly demonstrate that Lig4(R278H) activity renders NHE

67 Our findings firmly demonstrate that XRCC1 is not a requisite factor

68 Our results firmly demonstrated that this immunization strategy agai

69 er activity assay and DNA binding assays, we firmly demonstrated the key role of this SRE motif in SR

70 , their role in seizure control has not been firmly demonstrated.

71 dergo CSR similarly to Ku-deficient B cells, firmly demonstrating that an A-EJ pathway distinct from

72 nd its location in plant cells remains to be firmly determined.

73 Among The 96 nodules, 88 were firmly diagnosed as low-grade dysplastic nodules (LGDNs;

74 within affected regions of PD brain has been firmly documented, however no treatments exist that are

75 tly penetrates into the underlying stroma to firmly embed in the endometrium.

76 f 200 nm fluorescent polystyrene beads which firmly embed in the extracellular polymeric substance (E

77 n for removing such filters when they become firmly embedded along the vena cava endothelium.

78 re composed of a strong electrophilic center firmly embedded in a negatively charged framework of exc

79 concept has finally been realized and is now firmly embedded in ongoing drug discovery programs, and

80 til this rapidly evolving field becomes more firmly embedded into surgical research and implementatio

81 in Papua New Guinea, where surgical care is firmly embedded within national health plans and receive

82 e packaging, and pre-existing contamination (firmly enclosed into the matrix).

83 a series of stabilization steps before being firmly encoded.

84 How Msp1 selects its substrates and firmly engages them during the energetically unfavorable

85 deed, local schistosome transmission appears firmly engrained for intermediate snail hosts can be fou

86 Cyclophanes have been firmly entrenched as a distinct class of compounds for w

87 nt and ubiquitinated CYP3A species that were firmly ER-tethered.

88 Future studies will be necessary to more firmly establish (or refute) this hypothesis.

89 These findings firmly establish a cell-division-independent role for co

90 Our data firmly establish a previously unrecognized specific role

91 understood, and there has remained a need to firmly establish a requirement for phagosome maturation

92 These data firmly establish an endogenous role for AhR as a regulat

93 Here we firmly establish Ccr4-Not as a positive elongation facto

94 Our results firmly establish DBC1 as a critical positive regulator o

95 ogical, biochemical and pharmacological data firmly establish MCU as an essential component of the mi

96 These findings firmly establish missense mutations in HIF-2alpha as a c

97 Using phylogenomic data, we firmly establish phylogenetic relationships among the ma

98 These results firmly establish TAF4 as a bona fide E-protein coactivat

99 These findings firmly establish that alterations in innate immunity inf

100 that calcium is involved in RCH, and here we firmly establish that calcium signaling mediates cold se

101 Our kinetic data firmly establish that G-triplexes are intermediates to G

102 These results firmly establish that in HIV-1, CA is a strong determina

103 Our results firmly establish that metalenses can have widespread app

104 The data firmly establish that only the extracellular amino termi

105 Our results firmly establish that SAS-6 can impose cartwheel symmetr

106 Our results firmly establish that under a similar experimental condi

107 e and cleavage of the Notch S2 site and thus firmly establish the feasibility of a mechanotransductio

108 We firmly establish the link between Kras-INP1KO pancreatic

109 Further studies are required to firmly establish the link between microvascular alterati

110 Collectively, our in vitro and in vivo data firmly establish the molecular segregation between gamma

111 ies and reaction conditions was performed to firmly establish the optimized reaction conditions requi

112 Together, our results firmly establish the pathophysiologic involvement of end

113 Our results firmly establish the potential for lightweight, ultrathi

114 An X-ray analysis was carried out to firmly establish the stereochemistry of the products.

115 In summary, our results firmly establish the transforming potential of adult OPC

116 igation on a large population is required to firmly establish their effects on breast cancer risks.

117 the structure ( approximately 4 A) does not firmly establish this bonding.

118 In this article, we firmly establish this summer CANA pattern, providing evi

119 ious examination was SFM) and after FFDM was firmly established (when the previous examination was FF

120 fore the benefits and risks of doing so were firmly established appears to have had unintended clinic

121 Still, no biomarker has been firmly established as a clinically useful prognostic too

122 Fractional flow reserve (FFR) is not firmly established as a guide to treatment in patients w

123 vated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral arou

124 Obesity has been firmly established as a major risk factor for common dis

125 distachyon is a weedy grass species that is firmly established as a model for the comparative and fu

126 In rodents, SR-BI has been firmly established as a physiologically relevant HDL rec

127 Allosteric disulfides are firmly established as a sophisticated means by which a p

128 MRI is firmly established as an essential modality in the imagi

129 edical therapy and attention to risk factors firmly established as fundamental aspects of management,

130 Perovskites have been firmly established as one of the most promising material

131 Cadmium telluride, CdTe, is now firmly established as the basis for the market-leading t

132 quitting smoking, is a heritable trait with firmly established associations with sequence variants i

133 nesis of neurological diseases remains to be firmly established because most current research is perf

134 R chemical shift (delta(29)Si = -155) and is firmly established by its experimental molecular structu

135 Although studies have not firmly established causality, onset of regular marijuana

136 ted the interaction of viperin with its most firmly established cellular target, farnesyl pyrophospha

137 A firmly established central intermediate is the purine ba

138 ling of bacteria, work over the last century firmly established complement as a key mediator of the g

139 r, the in vivo role of NK cells has not been firmly established due to the lack of animal models with

140 displayed by the fkbp52-deficient mice have firmly established FKBP52 as a promising target for the

141 environment for optimal activity, it is not firmly established how these enzymes are maintained in t

142 the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials.

143 In contrast to hydrogen bonding, which is firmly established in organocatalysis, there are still v

144 secondary to medical conditions but are not firmly established in primary mood disorders.

145 Screening for colorectal cancer is more firmly established in PSC patients with IBD and includes

146 in adult homoeothermic vertebrates was first firmly established in songbirds.

147 or neuron degeneration, but neither has been firmly established in the pathogenesis of ALS.

148 mportance of genetic predisposition has been firmly established in these illnesses, children (offspri

149 As well as a firmly established increased risk of cardiovascular dise

150 Quantum chemistry has firmly established itself as a reliable method for inves

151 In contrast to these firmly established principles of signal transduction, mu

152 s one of very few RTKs that remain without a firmly established protein ligand.

153 not related to an inability to switch from a firmly established response strategy to an allocentric p

154 in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a high

155 The research of the past two decades has firmly established that hormones modulate numerous aspec

156 Mounting evidence has firmly established that low levels of cardiorespiratory

157 Experiments have firmly established that magnesium is required for effici

158 The Aspreva Lupus Management Study (ALMS) firmly established that MMF is equivalent to intravenous

159 However, it is firmly established that new neurons are generated in the

160 Theoretical and experimental studies have firmly established that protein folding can be described

161 Our data reported herein firmly established that SpnH, SpnI, and SpnK are the res

162 It is also firmly established that their aberrant generation and ac

163 It is now firmly established that this enzyme-catalyzed modificati

164 ysis of genetically engineered mouse models, firmly established the gain-of-function (GOF) properties

165 phenocopy and biochemical evidence, we have firmly established the role of FKF1 in regulation of cel

166 If firmly established this property of Ras would require pr

167 genetic drivers of this cancer have not been firmly established, and the features that contribute to

168 left ventricular (LV) volume and function is firmly established, and the guidelines of the American C

169 and the bacterial flagellar system has been firmly established, based upon both sequence similaritie

170 itiating DNA mutations in melanocytes is now firmly established, but how the microenvironmental effec

171 origins of the actin cytoskeleton have been firmly established, but it has become clear that the bac

172 While its efficacy is firmly established, data on safety are still incomplete.

173 wild-type p53 in tumor suppression has been firmly established, mounting evidence has demonstrated t

174 glutamate receptors in this process has been firmly established, the contribution of metabotropic GAB

175 tone tail acetylation and gene activation is firmly established, the mechanisms by which acetylation

176 tor of apoptotic JNK signaling in neurons is firmly established, the molecular mechanism underlying t

177 whether it was acquired after resistance was firmly established, the strain temporally preceding the

178 xchange of subunits between bilayers thus is firmly established, which becomes a crucial consideratio

179 g interest in these methods and they are now firmly established, with a plethora of different techniq

180 though their mode of regulation has not been firmly established.

181 ty, but its possible roles in cancer are not firmly established.

182 in the pathophysiology of the liver has been firmly established.

183 ated activation within the gut remains to be firmly established.

184 sms for this observed tradeoff have not been firmly established.

185 function and action mechanism are yet to be firmly established.

186 of language-to-music effects have yet to be firmly established.

187 mited and the underlying notions are not yet firmly established.

188 tes and direction of transport have not been firmly established.

189 e during the 2009-2010 pandemic has not been firmly established.

190 ogene possessing tumorigenicity has not been firmly established.

191 tive selection in normal mice has never been firmly established.

192 st and was subsequently lost before becoming firmly established.

193 these changes upon abstinence remains to be firmly established.

194 functionality, and quality of life have been firmly established.

195 t this association is plausible, but not yet firmly established.

196 osis, but its association with gender is not firmly established.

197 f hematopoietic stem/progenitor cells is not firmly established.

198 earer and regulatory guidelines will be more firmly established.

199 d and their function in islets have not been firmly established.

200 ugh a cause-effect relationship has not been firmly established.

201 transition into exponential growth to become firmly established.

202 ukocytes (CLs) in the normal cornea has been firmly established.

203 ound at atomic steps and surface defects, is firmly established.

204 promoting the transformations have not been firmly established.

205 s) through which risk is conferred have been firmly established.

206 -related outcomes in middle-aged patients is firmly established.

207 its role in other tauopathies has yet to be firmly established.

208 ue of integrated team delivery models is not firmly established.

209 and distribution of excitatory neurons were firmly established; glutamatergic neurons in the anterio

210 tin filament severing protein cofilin is now firmly established; however, the contributions of other

211 cancer.Significance: This large cohort study firmly establishes an association between an index of vi

212 Our study firmly establishes ATOH7 as a retinal disease gene and p

213 gh extensive validations, this meta-analysis firmly establishes globally generalizable, predictive ta

214 This study firmly establishes kin discrimination in a bacterial mul

215 usters in these cofactor-deficient proteins, firmly establishes P*-cluster as a catalytically active

216 , where RD is self-reported by participants, firmly establishes six RD risk loci: FAT3, COL22A1, TYR,

217 Detection of HO-:C-OH in the gas phase firmly establishes that it is stable to isomerization, y

218 The new evidence firmly establishes that the Al-Cu-Fe alloys (including q

219 This study firmly establishes the combination of missense, nonsense

220 Our study thus firmly establishes the functions for three of the protei

221 ntained at a median follow-up of 8 years and firmly establishes the role of RT in the treatment of me

222 lls than in buffer, a surprising result that firmly establishes the significance of quinary interacti

223 oundaries of the original idea of Kekule and firmly establishes the usefulness of the sigma-aromatici

224 dermal peels and enlargement of protoplasts, firmly establishing a direct guard cell response to red

225 urately reproduced by our model calculation, firmly establishing Majorana nature of the zero mode.

226 noallelic mutations in 18 affected families, firmly establishing TGFBR1 as the causative gene.

227 edge appear as electrons accumulate, thereby firmly establishing the energy and momentum of the edge.

228 XAFS) spectra and reconstitution activities, firmly establishing the M-cluster-bound NifEN (designate

229 n outgrowth in cultured neurons and in vivo, firmly establishing the role of sliding in axon outgrowt

230 effect of glutaraldehyde, anti-leptin can be firmly fixed.

231 utionary model of early biochemistry that is firmly grounded in phylogenomic information and biochemi

232 firing and hemodynamic response that are not firmly grounded in rigorous theory or experimental evide

233 Bayesian analysis is firmly grounded in the science of probability and has be

234 ten discount evidence that contradicts their firmly held beliefs.

235 While the U6 snRNA catalytic core remains firmly held in the active site cavity of Prp8 by protein

236 them, three isomers of feruloyl-sucrose were firmly identified and another was strongly supposed to b

237 hormone for which the receptor has not been firmly identified.

238 al research followed by clinical studies may firmly identify Nur77 as a pharmacologic target for infl

239 Our results also firmly implicate FNIII domain-mediated interactions in T

240 Bone morphogenetic proteins (BMPs) are firmly implicated as intra-ovarian regulators of follicl

241 Human studies have firmly implicated voltage-gated sodium channels in human

242 mponent, and copy number variants (CNVs) are firmly implicated.

243 Our revised timescale more firmly implicates volcanic eruptions as catalysts in the

244 opulations of large frugivorous vertebrates, firmly in the agenda of reducing emissions from deforest

245 L phylogeny revealed that Simonsenia belongs firmly in the Bacillariaceae, with which it shares a sim

246 Our results firmly indicate that (i) the supergroup Excavata is not

247 In such an orientation, the oleoyl chain is firmly inserted into the membrane.

248 Our study places phenotypic integration firmly into an ecological context.

249 site of B cell development in swine are not firmly known.

250 Our findings are important as they firmly link sleepwalking to the neuroscience of motor co

251 ions with ILK, a signal transduction pathway firmly linked to cell motility and invasion.

252 Zika virus (ZIKV) infection is now firmly linked to congenital Zika syndrome (CZS), includi

253 lution and as FOXP2 is the sole gene to date firmly linked to speech and language development.

254 A lubricant can be firmly locked into the structures and, owing to its flui

255 d to sandwich the layer of biological sample firmly on the electrode surface.

256 , whereas Galphai2-deficient T cells adhered firmly on the sinus, which prevented their retraction, f

257 The sensitizer is anchored firmly on the surface of NiO, and the binding is resista

258 February 2012, the South-East Asia Region is firmly on track for polio-free certification in early 20

259 hesion force, water droplets could either be firmly pinned to the surface, forming various patterns o

260 Phylogenetic analyses firmly place the palmophyllalean Verdigellas peltata alo

261 ovoke many diseases, including autoimmunity, firmly positioning the unfolded protein response as a ma

262 o humans from exposure to pathogens has been firmly put into a risk assessment framework.

263 Proton release from DBA2+ is firmly related to glucose concentrations within the phys

264 inated communication-current theories remain firmly rooted in an individualistic account and have lar

265 Although existing models of allostery are firmly rooted in the current structure-function paradigm

266 tive behavior depends on cortical structures firmly rooted in the emotional brain from which they hav

267 in transforming theory into practice remains firmly rooted in the underlying quantitative principles

268 ys a twisted L-shaped beta-helical structure firmly stabilized by a 3D hydrogen-bonded scaffold.

269 In contrast, the antagonist epimer remained firmly stabilized in the binding pocket.

270 ion on which the field of autophagy research firmly stands.

271 This firmly suggests hydraulic traits as targets for future r

272 Our results firmly support a structural plasticity view of microtubu

273 Collectively, these data firmly support the premise that muscle carnitine availab

274 involvement of Sia in the animal strains is firmly supported by crystallographic studies, it is not

275 usly long-wavelength emission for DMP and is firmly supported by polarity-, viscosity-, and temperatu

276 This is firmly supported by steady-state photon upconversion mea

277 otion is along the minimum energetic pathway firmly supporting the experimental results.

278 autoimmune encephalomyelitis (EAE) research firmly supports this hypothesis.

279 (N- and C-terminal) lipidated proteins that firmly tether to the surface of producing cells.

280 s providing causal evidence have established firmly that face-selective brain areas are central to fa

281 This work establishes firmly the metal-doped B rings as a new class of novel a

282 dern observations--are required to establish firmly the role of the Agulhas system in a warming clima

283 ate for the oxaphosphetane formation step is firmly tied to the stereochemistry of the final alkene.

284 Diffraction revealed that the Abeta anchors firmly to the highly charged DMPG bilayers in the interf

285 integrin-based platforms to move and adhere firmly to the surface of other cells.

286 along its backbone allowed it to attach more firmly to thin filaments than the wild-type isoform, pro

287 ions related to different scenarios, such as firmly trapped or labile guest facing the {Mo9O9} pores.

288 ARAP3-deficient cells adhere more firmly under flow conditions in vitro and to the vessel

289 etween shape and electronic structure is now firmly underpinned by molecular-orbital theory(2-5).

290 However, the maxilla is firmly united with the skull, indicating an akinetic ros

291 excellent agreement with biochemical results firmly validates the MPD analyses, which, we expect, can

292 in SIFSIX materials grasp every atom of SO2 firmly via S(delta+) ...F(delta-) electrostatic interact

293 othelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding to ICAM-1 constitutiv

294 cess termed cell-autonomous immunity-equates firmly with survival of the species.

295 e produced models were assembled, positioned firmly within a 3D printed shell mold simulating the ski

296 With these structures we are now firmly within the "atomic age" of electron cryomicroscop

297 (Capnodiales, Dothideomycetes) and place it firmly within the clade Pseudocercospora s. str., now ac

298 results demonstrate that Fdg neurons operate firmly within the sensorimotor watershed, downstream of

299 hin the plane of the epithelium but are kept firmly within this plane to give a symmetric division.

300 lf-assemble, biomimetic microelectronics can firmly yet gently attach to an inorganic or biological t