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1 ately 80% of the insulin is extracted during first pass.
2 d glucose metabolism as evaluated by dynamic first-pass (18)F-FDG PET and by proliferation and endoth
4 prostate cancer confirms the utility of the first-pass 18F-FDG blood flow analysis in tumor diagnosi
5 was that patients treated with aspiration as first pass achieve inferior outcomes compared with those
6 fast, low-sensitivity weighted keyword-based first pass algorithm to cast a wide net to gather an ini
7 nterface was successfully used to complete a first-pass alignment on a large-scale GCxGC metabolomics
8 sentative and highly-annotated sequences for first-pass analyses will be essential to deal with the i
10 re made with only 2 volume scans using a new first-pass analysis (FPA) technique and with 20 volume s
14 obutamine followed by contrast-enhanced MRI (first pass and delayed imaging) after a bolus infusion o
17 icrovascular obstruction and infarct size by first-pass and delayed contrast-enhanced magnetic resona
18 aging to arterial access, arterial access to first pass, and the composite door to first pass time.
21 a genomic context; (3) perform customizable first-pass annotation of the data; and (4) present the d
23 d, there is an increasing need for automated first-pass annotation which allows timely access to impo
24 onsidered that an EC was present if: (1) the first pass around the PV antrum did not produce PV isola
25 =6) of MSCs arrest and interrupt flow during first pass at the precapillary level, resulting in decre
28 ypically >85%) so that they could be used in first-pass biological assays without further purificatio
31 odopa equivalent daily dose (LEDD), deriving first-pass candidate protein biomarkers based on p-value
32 CT (11% +/- 6) correlated well with those at first-pass cardiac MR imaging (7% +/- 4, R(2) = 0.72).
40 rior mesenteric artery, indicating increased first-pass clearance of [14C]lactate by the splanchnic o
41 in LTRvc was determined from the splanchnic first-pass clearance of [14C]lactate infused into the su
43 de first an accessible technical overview of first-pass CMR perfusion imaging and contrast it with ot
44 as of method development, include developing first-pass coarse-grained models guided by experimental
45 on is the most effective way to achieve fast first-pass complete reperfusion and should thus be used.
47 ing the left ventricular myocardium during a first-pass contrast bolus in the presence and absence of
50 uantitative cardiac magnetic resonance (CMR) first-pass contrast-enhanced perfusion imaging to qualit
55 of a typical batch of 240 samples (including first-pass data analysis) can be accomplished within 48
58 , we show that physiological PK modelling of first-pass drug absorption, metabolism and excretion in
60 nt-echo sequences can be used to monitor the first-pass dynamics of contrast media, thus defining sel
62 Low solubility, poor permeability, and high first-pass effect of furosemide may also have produced t
63 studied IDN6556, a caspase inhibitor with a first-pass effect, in a large animal (pig) intraportal m
64 e-dependent changes in tacrolimus intestinal first-pass effect, metabolism, or distribution play a ro
68 (2.7 ejection fraction units, p < 0.01), and first-pass ejection fractions were much lower (8.0 eject
70 (ie., hepatic extraction, fraction escaping first-pass elimination in the liver, and hepatic clearan
73 mages (HYPER), or (3) both absence of normal first-pass enhancement and delayed hyperenhancement (COM
74 tively after calculating the up-slope of the first-pass enhancement curve and dividing the value obta
75 Purified progenitors were used to provide a first-pass expression profile of various haematopoiesis-
76 ing advantage of the early kinetics and high first-pass extraction by the myocardium of this radiotra
77 The goals of this study were to measure the first-pass extraction fraction (EF) of 99mTc-tetrofosmin
78 beled myocardial perfusion agent with a high first-pass extraction fraction and delayed redistributio
80 unction and several models for the nonlinear first-pass extraction of (82)Rb by myocardium have been
85 tion of gadolinium chelate and evaluation of first-pass gadolinium chelate perfusion by using highly
86 ging was performed in 29 patients by using a first-pass gadopentetate dimeglumine T2*-weighted echo-p
87 e sequence length polymorphism markers for a first-pass genome scan in crosses involving C32 and SJD
88 BPA was absorbed and underwent an extensive first-pass glucuronidation either in the gut (44%) or in
89 ccurred in 48 (36%) of 134 in the aspiration first pass group, and 46 (34%) of 135 in the stent retri
90 whether patients treated with aspiration as first pass have non-inferior functional outcomes to thos
93 [1,3,2]-dioxaphosphonane (MB07811) undergoes first-pass hepatic extraction and that cleavage of the p
94 t female mice lacking GLUT8 exhibit impaired first-pass hepatic fructose metabolism, suggesting that
95 To address the second question, we measured first-pass hepatic insulin clearance in two recipients o
96 lin into the peripheral circulation bypasses first-pass hepatic insulin clearance, which leads to the
98 desonide, a corticosteroid with an extensive first-pass hepatic metabolism appeared promising for the
102 ntrast-enhanced images were defined as COMB (first pass hypoenhancement) or HYPER (normal first pass
106 ionuclide therapy dosimetry imaging, cardiac first-pass imaging, and positron coincidence imaging and
109 ake (0.04 vs 0.02, respectively; P = .03) at first pass in mCA IX-positive versus mCA IX-negative tum
111 The proportion of patients with successful first-pass intubation did not differ significantly betwe
114 longitudinally assessed in mice by means of first-pass kinetics of nontargeted microbubbles (BR1, BR
116 s study evaluated the suitability of current first-pass magnetic resonance approaches for evaluating
119 measurements of myocardial perfusion during first-pass MDCT imaging in a canine model of LAD stenosi
120 n sequencing and culture-based techniques of first-pass meconium, which forms in the intestine prior
121 ted chemical that escapes from presystemic ("first-pass") metabolic processes and eventually enters s
122 azole, 8.0% of the tacrolimus dose underwent first pass metabolism (E(H)), whereas in the presence of
123 okinetics are remarkable for almost complete first pass metabolism after oral administration, resulti
124 dation in gastrointestinal tract and hepatic first pass metabolism and also limits off-target adverse
127 aempferol to cultured hepatocytes, mimicking first pass metabolism, greatly diminished the inhibitory
129 and extensive distal binding in all tissues, first-pass metabolism and activation of NNK in the airwa
132 rful new tool for preclinical predictions of first-pass metabolism for new drugs in development.
135 aining monooxygenase enzymes involved in the first-pass metabolism of drugs and foreign chemicals in
138 tients with TIPS, there was a marked loss in first-pass metabolism of midazolam as a result of dimini
140 en et al. show in this issue of the JCI that first-pass metabolism of the anticancer agent docetaxel
144 henols undergo extensive modification during first-pass metabolism so that the forms reaching the blo
145 their poor absorption, poor solubility, high first-pass metabolism, and efficient efflux by P-glycopr
147 ug delivery systems as films not only avoids first-pass metabolism, but also provides pain-free admin
156 pectrometry (FIE-MS) is finding utility as a first-pass metabolite fingerprinting tool in many resear
157 pharmacokinetic profile of THC and its main first-pass metabolites (11-hydroxy-THC and 11-nor-9-carb
158 correlation with those obtained by using the first-pass method (Pearson r = 0.80) and gamma variate a
162 as a percentage of left ventricular mass) at first-pass multidetector CT (11% +/- 6) correlated well
163 ed and normal myocardium were comparable for first-pass multidetector CT and cardiac MR imaging, card
166 netic resonance (cine, T2* iron, vasodilator first pass myocardial perfusion, and late gadolinium enh
167 racer uptake, K1 (K1 (mL/g/min) = MBF.E; E = first-pass myocardial extraction of 1-11C-acetate) and w
168 values were converted to MBF values using a first-pass myocardial extraction/flow relationship measu
169 ronary MR angiography performed as part of a first-pass myocardial perfusion and viability assessment
171 imaging for assessment of cardiac function, first-pass myocardial perfusion imaging at rest and duri
172 a "notched" section profile for T1-weighted first-pass myocardial perfusion magnetic resonance (MR)
176 ortical layers and thus are extracted in the first pass of activity through the anteroventral tempora
177 Multidetector CT was performed during the first pass of contrast material to assess myocardial per
178 e diversity of the sequences detected in the first pass of database screening and the ability of a gi
180 s was observed in images acquired during the first pass of gadopentetate dimeglumine in coronary arte
181 lood (18)F-FDG activity, consistent with the first pass of labeled cells in the systemic circulation.
183 t stratification to either direct aspiration first pass or stent retriever first line thrombectomy.
184 oscopy increases the frequency of successful first-pass orotracheal intubation compared with direct l
185 red with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associat
186 29), time to peak (P = .008), upslope of the first-pass peak (P = .011), and late-phase washout slope
188 k-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement.
189 cardiac volumes, function, oxygenation, and first-pass perfusion (0.03 mmol/kg Gd-DTPA bolus) at str
190 mural extent of microvascular obstruction at first-pass perfusion (intraclass correlation coefficient
191 hypothesis that transcatheter intraarterial first-pass perfusion (TRIP) magnetic resonance (MR) imag
192 n = 7) and subacute (1 week, n = 6) resting first-pass perfusion and late gadolinium-enhanced cardio
197 atial resolution of 1.5 x 1.2 x 5.0 mm3, and first-pass perfusion images were acquired for visual com
198 ased maximum signal intensity and upslope at first-pass perfusion imaging and reduced infarct size at
201 es before and after intravenous contrast and first-pass perfusion imaging were acquired, and assessed
204 d-enhancement magnetic resonance imaging and first-pass perfusion magnetic resonance imaging at rest
207 oxide, producing remote vasodilation during first-pass perfusion of the opposite limb; (3) nitrite i
210 MR imaging were used to assess LV function, first-pass perfusion, and delayed contrast enhancement i
211 Cardiac MR imaging consisted of cine, rest first-pass perfusion, and late gadolinium enhancement im
212 R protocol consisted of T2-weighted imaging, first-pass perfusion, cine function, delayed-enhancement
214 I (r = 0.88, slope = 0.79, s.e.e. = 6.0) and first-pass planar scintigraphy (r = 0.86, slope = 1.2, s
215 ed tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which
217 %; P=0.75), the study group displayed higher first-pass PVI (92% versus 73%; P<0.001), lower acute pu
218 vestigation examined the prognostic power of first-pass radionuclide angiocardiography (RNA) ejection
219 ombosis was discovered accidentally from the first-pass radionuclide angiogram that is routinely perf
222 including 45 biplane and 9 single plane) and first-pass radionuclide angiography (n = 38) in patients
223 Good correlation was also observed between first-pass radionuclide angiography and both contrast ve
224 roducible and correlate well with results of first-pass radionuclide angiography but are closer in va
225 sion computed tomography (SPECT) imaging and first-pass radionuclide angiography during a single exer
228 asive tests--the Duke treadmill score (DTS), first-pass radionuclide angiography with calculation of
229 ew demonstrates the importance of performing first-pass radionuclide cardioangiography routinely befo
230 right heart hemodynamics, gas exchange, and first-pass radionuclide ventriculography at rest and wit
233 ing (primary sensory receiving areas) mature first, passing relatively stable outputs about sensorimo
235 consisting of an early 2-min uptake scan-or first-pass scan-and 3 sequential 15-min late 18F-FDG upt
236 tabolite fingerprinting is widely used as a 'first pass' screen for compositional differences, where
237 h for post-hoc normalization of quantitative first-pass screening data in the absence of explicit in-
238 rchaeological and geological field work as a first-pass screening device which obviates the necessity
239 Although the ABCA4 array remains a good first-pass screening option, the NGS platform is a time-
242 in organizing sequencing data and to provide first-pass sequence analysis in an automated fashion.
244 protein data base searching, and (4) limited first-pass sequence annotation, making it difficult to d
245 5.9% in nondiabetic patients, P < 0.001) and first-pass SGU (4.7+/-1.7 vs. 26.5+/-5.1% in nondiabetic
246 0.94, P < 0.01 for nondiabetic patients) and first-pass SGU (r = 0.87, P < 0.05 for NIDDM patients; r
249 LAMP technique in NIDDM by comparing SGU and first-pass SGU during HVC with SGU during the OG-CLAMP e
252 t-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenhanced signal on de
253 rdial infarction (MI): (1) absence of normal first-pass signal enhancement (HYPO), (2) normal first p
256 om an adenoma had already been detected with first-pass standard forward-viewing colonoscopy; none of
257 pid manner and also were able to provide the first-pass structure evidence of a newly discovered natu
261 ent retriever (SR) or a direct aspiration at first pass technique at 7 U.S. centers between June 2013
263 ategies, particularly a direct aspiration as first pass technique, while promising, have not been rig
264 myocytes, and blood cell progenitors without first passing the cells through a pluripotent state.
266 ell-dependent, humoral immune responses must first pass through germinal centers (GCs) within the cor
268 ed insertion alleles for 1976 genes during a first pass through the genome including, unexpectedly, a
270 ompatible with consciousness, the brain must first pass through these hubs in an orderly fashion.
271 in cells treated with aqueous humor that was first passed through a 3-kDa or a 30-kDa, but not a 100-
272 leading to the 1 T benchtop NMR spectrometer first passes through a fixed bed with a radical matrix p
274 ng through a double-gated "check-in" system, first passing through a pore on the hexamer surface and
277 cant linear time trend was noted for door to first pass time (quarter 4 year 2014 median time, 134.5
278 ion number, 16 [IQR, 10-27]), median door to first pass time was 130 minutes (IQR, 101-170 minutes),
279 R, 68-126 minutes), and arterial puncture to first pass time was 18 minutes (IQR, 4-31 minutes).
280 ume was associated with a 3% shorter door to first pass time, up to a case volume of 40 per year ( P<
285 for information extraction can form a useful first-pass tool for assisting human annotation and maint
287 rrival in the emergency department (door) to first pass (treatment initiation) in patients receiving
291 ia Screening Studies project, men provided a first-pass urine specimen, which they returned by post f
292 s, 55 SNPs were successfully analyzed in the first pass using this assay format and all 181 genotypes
293 monstrated better agreement with independent first-pass values (r = 0.90) than did manual measurement
294 ion fraction from tomography correlated with first-pass values with r = 0.82, and end diastolic and e
295 olic volumes from tomography correlated with first-pass values with r = 0.85 and r = 0.91, respective
296 resonance (CMR) included gadobutrol-enhanced first-pass vasodilator stress and rest perfusion followe
298 k yet informative comparative analyses and a first pass visualization of both annotation and analysis
299 retriever group, showing that aspiration as first pass was non-inferior to stent retriever first lin