ライフサイエンスコーパス: five-membered ring

1 e even mild activation sufficed to close the five membered ring.

2 ng a new stereogenic center on the C2 of the five-membered ring.

3 ives with fixed envelope conformation of the five-membered ring.

4 be a(5)-PhobPH in which the H lies over the five-membered ring.

5 t the level of oxidation in the newly formed five-membered ring.

6 e option of closing to a three-membered or a five-membered ring.

7 o a carbamate 9 by opening and reclosing the five-membered ring.

8 erred increased RARbeta specificity over the five-membered ring.

9 imes less active than its counterpart with a five-membered ring.

10 gen is incorporated into a six- instead of a five-membered ring.

11 ) in common that are connected via a central five-membered ring.

12 p by two naphthoquinone units connected by a five-membered ring.

13 ng a fully substituted and highly oxygenated five-membered ring.

14 with an imino-to-sulfur substitution in the five-membered ring.

15 and cyano functionalities to annulate a new five-membered ring.

16 oligoenes that contain both six-membered and five-membered rings.

17 th SO(2) gave 1:1 copolymers with cis-linked five-membered rings.

18 aromatic hydrocarbons (PAHs) augmented with five-membered rings.

19 indicates C-C bond length alternation in the five-membered rings.

20 he diastereotopic methylene hydrogens on the five-membered rings.

21 compared to the limited reactivity of other five-membered rings.

22 onal (1D) chain of [3]triangulenes linked by five-membered rings.

23 ficient simultaneous construction of the two five-membered rings.

24 th the metal centre shared by five identical five-membered rings.

25 ation of anthanthrene derivatives with fused five-membered rings.

26 5]-radialene-like structures at the proximal five-membered rings.

27 [3 + 2] manner to give rise to seven- and/or five-membered rings.

28 dition to a strong pi-conjugation within the five-membered rings.

29 F(4)](8), given the inherent angle strain in five-membered rings.

30 difunctional compounds and oxygen-containing five-membered rings.

31 resents an oxygen at the apex of three fused five-membered rings.

32 owest vertically excited states, but regular five-membered ring (5-MR) heteroaromatics with one or tw

33 cyclic aromatic hydrocarbon (PAH) carrying a five-membered ring-9H-fluorene (C(13) H(10) )-is produce

34 oquinolines or benzazepines containing fused five-membered rings, a feature found in the cephalotaxus

35 catalysts are effective for the formation of five-membered rings, a ruthenium-based system that affor

36 nzo[k]tetraphene, which "unexpectedly" forms five-membered rings accompanying highly selective 1,2-sh

37 The reactions with the five-membered-ring acetal were interpreted as requiring

38 Reactions of the corresponding five-membered-ring acetals are also 1,2-cis selective in

39 induced radical-mediated ring contraction of five-membered-ring alkenyl boronate complexes into cyclo

40 1- au charge is located in the central fused five-membered rings) allows the formation of a maximum o

41 allenging due to the high flexibility of the five-membered ring (also called furanose).

42 Multinuclear NMR studies of five-membered-ring amine chelated aryllithium reagents 2

43 nase to give phosphates 1-P, 2-P, and 3-P as five-membered ring analogues of shikimate-3-phosphate.

44 nation sequence that constructs both a fused five-membered ring and a 1,4-bridged 7-membered ring; c)

45 a result of improved orbital overlap of the five-membered ring and a reduced steric environment of t

46 eaction channel involves the cleavage of the five-membered ring and concomitant shift of the H-atom f

47 matic heterocyclic carboxylates containing a five-membered ring and various heteroatoms (X = NH, O, S

48 onsisting of 40 uranyl polyhedra linked into five-membered rings and 16 nitrate groups surrounds this

49 es a formal pentalene subunit at the central five-membered rings and [5]-radialene-like structures at

50 metalation of unactivated alkenes to produce five-membered rings and in one case a four-membered ring

51 pyrrolidone-1''-yl)doxorubicin (containing a five-membered ring) and 3'-deamino-3'-(3''-piperidone-1'

52 wed by oxygenation at C-11, formation of the five-membered ring, and a second oxygenation at C-15 to

53 dipolar cycloaddition necessarily creates a five-membered ring, and we have investigated the formati

54 ) of naphthalene is negative (-0.19 eV), the five-membered ring appendage contributes to the stabilit

55 orphyrin derivatives possessing an isocyclic five-membered ring appended with an amidinium functional

56 lso examined, and hydrogen shifts around the five-membered ring are competitive with the mechanisms l

57 lder reactions, cycloadditions that generate five-membered rings are comparatively limited in scope.

58 mation of the tricyclic product in which all five-membered rings are formed.

59 The steric effects of substituents on five-membered rings are less pronounced than those on si

60 pentacene derivatives with externally fused five-membered rings are prepared by means of a key palla

61 hthylenes, which contain four linearly fused five-membered rings, are benchtop stable and behave as h

62 Optimization studies identified a five-membered ring as the preferred conformational lock

63 In both CHCl3 and H2O, the presence of the five-membered ring attenuates the ability of PGB2-EA to

64 Suitable substitution of the five-membered ring backbone exemplarily allowed the Co-c

65 the presence of rhodium catalysts to afford five-membered rings bearing a (Z)-alkylidenylbenzylsilyl

66 enic PARP-1 inhibitors possess an additional five-membered ring between the B and C rings of 6(5H)-ph

67 linked the ketone and dipolarophile to give five-membered rings but mixtures resulted with four atom

68 d by making the three-carbon chain part of a five-membered ring, but with retention of the methylene

69 -C sigma bonds and the destruction of stable five-membered rings, but we have used it here to produce

70 eses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction

71 cular competition between the formation of a five-membered ring by ortho-attack at the armchair edge

72 ., the seven-membered ring hydrogen bond and five-membered ring C(4-5-10-13-14) cyclization, from whi

73 AH) chromophores that are linked between two five-membered rings can access planarized structures wit

74 The five-membered ring carbodiimide is a stable structure, p

75 group was tethered to the acetal group by a five-membered ring compared to one where it was tethered

76 d and studied, all efforts to synthesize the five-membered ring compound have thus far met with failu

77 reviously proposed that beta-residues with a five-membered ring constraint promote two different type

78 n bonds and promoted by beta-residues with a five-membered ring constraint.

79 The beta-residues in our systems have a five-membered-ring constraint (trans-2-aminocyclopentane

80 ene 2p-pi orbital by incorporating it into a five-membered ring, containing two double bonds, or into

81 an efficient strategy for furnishing diverse five-membered ring-containing molecular architectures.

82 Indoles with a deactivated five-membered ring could also take part in the reaction

83 nzylisoserine was readily transformed into a five-membered ring cyclic sulfamidate, which was ring op

84 Even though there are two five-membered ring cyclizations and several triple bond

85 c C-H activation processes proceed through a five-membered-ring cyclometallated intermediate.

86 wire contains one of three different cyclic five-membered rings: cyclopentadiene, furan, or thiophen

87 of atoms that are linked together by double five-membered rings (D5R), or 5(2)4(5) subunits, that ha

88 The five-membered ring derivative AMCPy emerged as a potent

89 of guanine is completely blocked, all of the five-membered ring derivatives incorporate the normal ba

90 acyl myo-inositol products via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observ

91 ogen migration processes are observed in the five-membered ring due to the high barrier to 1,3-hydrog

92 contained amide, amine, and hetero-aromatic five-membered rings, each of which had a hetero-atom and

93 These pathways result in five-membered ring expansion-a critical mechanism crucia

94 omatic ring system and cyclization to form a five-membered ring, followed by hydride loss to yield a

95 s involve the creation of dimers and bridged five-membered rings, followed by the formation of additi

96 sites, five benzene rings fused to a central five-membered ring, for binding of six alkali-metal ions

97 Galactofuranose (Galf) is the five-membered ring form of galactose.

98 nditions, we found that the formation of the five-membered-ring form of ribose is thermodynamically m

99 of ribose is more stable than the furanose (five-membered ring) form at ambient conditions, we found

100 Five-membered ring formation proceeds less readily, but

101 n pathway proceeds via the initial step of a five-membered ring formation upon attack of the hydrazin

102 ism is proposed to account for the selective five-membered-ring formation with the rearrangement of t

103 t binding orientations of the inhibitor core five-membered rings from one series to another.

104 cluding molecules with substructures such as five-membered rings from training spaces nevertheless pr

105 differentiating among these isomers in their five-membered ring furanose structure and smaller energe

106 a butenolide to produce stereoselectively a five-membered ring fused bicyclic lactone, the core stru

107 Introduction of ring strain through five-membered ring fusion at the NC bond slightly increa

108 The open-chloronium ions (E) rearrange to a five-membered-ring halonium ion during ionic chlorinatio

109 Quantum chemical calculations show that five-membered-ring halonium ion intermediates are 11 to

110 eochemistry at the 2- and 5-positions of the five-membered ring has been confirmed by single-crystal

111 tabilized free radical carrying a six- and a five-membered ring, has emerged as a fundamental molecul

112 HC exploration indicates that NHCs with over five-membered rings have a significantly negative influe

113 We report that the silylation of five-membered-ring heteroarenes occurs with high sterica

114 ucture optimization with the introduction of five-membered ring heterocycles at R6 resulted in compou

115 novinyl groups as acceptor and benzannulated five-membered ring heterocycles with alkyl chains of var

116 A study of ortho-substituted five-membered-ring heterocycles was undertaken and subse

117 genetic alphabet may be expanded to include five-membered-ring heterocycles.

118 s, none have shown reliable selectivity with five-membered-ring heterocycles.

119 was utilized for the synthesis of unnatural five-membered ring heterocyclic carbocyclic nucleosides.

120 t features 1,3-dipolar cycloaddition to give five-membered ring (Huisgen) intermediates, followed by

121 ond to nitrogen and the anti isomer favors a five-membered ring hydrogen bond to oxygen.

122 ring-closing metathesis to form the pendant five-membered ring; (iii) making recourse to a monothio

123 red ring in 2c than through the bonds of the five-membered ring in 15 or the six-membered ring in 12b

124 positioning the double bond internal to the five-membered ring in advance of transient ring expansio

125 epresent a facile synthesis of a substituted five-membered ring in flames and stellar outflows.

126 ns-3,4-disubstituted carbo- and heterocyclic five-membered rings in high yields and with good to exce

127 ridine moieties with differently substituted five-membered rings in the backbone of the newly formed

128 ortho-substituted benzene units to construct five-membered rings in this work provides a unique entry

129 m metabolite, comprises a linear array of 10 five-membered rings in two pentacyclic regions that deri

130 nes bearing quaternary carbon centers on the five-membered ring, in good to excellent yields.

131 s, intramolecular hydroacylation has favored five-membered rings, in preference to four membered ring

132 bling the 6,6-ring system before forming the five-membered ring including the quaternary carbon.

133 A five-membered ring indene skeleton is also prepared via

134 n promoted by two copper ions, the resulting five-membered ring intermediate can undergo a fast and i

135 e for sp(3) C-H bonds of methyl groups via a five-membered ring intermediate over the sp(2) C-H bonds

136 sp(3) C-H bonds of beta-methyl groups, via a five-membered ring intermediate, over the aromatic sp(2)

137 cycloaddition with the nitrone, generating a five-membered ring intermediate.

138 ed by N-N bond formation, producing unstable five-membered ring intermediates that spontaneously dehy

139 The five-membered-ring intermediates lead to rearranged prod

140 Incorporation of a five-membered ring into a helicene framework disrupts ar

141 ethodologies which convert readily available five-membered rings into strained four-membered rings.

142 active derivative revealed the presence of a five-membered ring intramolecular hydrogen-bonding netwo

143 emical shift (NICS) values indicate that the five-membered ring is more aromatic than the six-membere

144 A highly diastereoselective synthesis of five-membered rings is achieved from the reaction of the

145 The formation of five-membered rings is against the Baldwin's rule.

146 of the resulting bistetracene analogue with five-membered rings is comprehensively investigated by s

147 formation of the bistetracene analogue with five-membered rings is kinetically controlled while an "

148 of substrates, whereas the formation of the five-membered rings is promoted by the copper species.

149 bene, which has dimethyl substituents in the five-membered rings, is functionalized with amidopyrrole

150 Several five-membered-ring isoindol-1-ones displayed very high i

151 The five-membered ring lactam intermediates in these synthet

152 late directing groups may be used to furnish five-membered ring lactone products.

153 th these results, the order of importance of five-membered ring lactones as competent templates for t

154 diacylglycerol (DAG) analogues embedded into five-membered ring lactones as templates III and IV are

155 The modified FAD contains a fused five-membered ring, linking the C(4a) and N(5) atoms of

156 to an N-C8 cation via the intermediacy of a five-membered ring may be operative in nitrenium ions wi

157 the carbon backbone, the incorporation of a five-membered ring may eventually lead to three-dimensio

158 various combinations of heteroatoms in their five-membered ring moiety, replacing pyrazole with eithe

159 hose alkylidene is derived from an identical five-membered ring monomeric unit.

160 ed chemical structures around the ubiquitous five-membered ring motif, such as potentially therapeuti

161 nucleophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) alp

162 y (rate constants <10(-3) M(-1) s(-1)) while five-membered rings, namely pyrrole and imidazole, were

163 Similarly, the five-membered ring naphthylethyl analogue, phosphorodiam

164 ring core, Ni(mu-E(PhX))(mu-S'(N2))Fe, to a five-membered ring Ni-O-E-Fe-S', where an O atom inserts

165 six-membered ring nitroxides and substituted five-membered ring nitroxides were efficient protectors.

166 ulations and NMR studies have shown that the five-membered ring of mannostatin A is rather flexible o

167 reveals electron density concentrated at the five-membered ring of the readily formed indenyl fragmen

168 lated to compare the aromaticity in both the five-membered rings of 33, 34, 36 and 1,6-dioxa-6a-chalc

169 de chains carried by the beta-lactam and the five-membered rings of the carbapenem core.

170 Here the bent configurations of four- and five-membered rings of uranyl peroxide hexagonal bipyram

171 tion in which one new quaternary carbon, two five-membered rings, one C-N bond, two C-O bonds, and on

172 y reactions directed toward the syntheses of five-membered rings, other carbocycles and, finally, het

173 application of the "inside attack" model for five-membered ring oxocarbenium ions developed previousl

174 nucleophile attack for 2,3-trans-substituted five-membered ring oxocarbenium ions is strongly influen

175 ence is provided that nucleophilic attack on five-membered ring oxocarbenium ions occurs from the ins

176 f Ip/Py and Hz/Py pairs were compared to the five-membered ring pairs Im/Py and Hp/Py on a DNA restri

177 been introduced at the N(1) position of the five-membered ring, potentially mimicking any residues.

178 strategy provides a straightforward entry to five-membered ring products from simple, stable pi-syste

179 mplex is the first structure of PRODH with a five-membered ring proline analogue bound in the active

180 ized in the multiatom SOMOs of the three- to five-membered ring radical anions.

181 bitals participate in conjugation with these five-membered rings, rendering all of them aromatic.

182 The existence of five-membered rings results in a bowl-shaped geometry, a

183 ydroxylation of the C(sp(2))-H bond enabling five-membered ring ruthenacycle intermediates, the cycli

184 opentenes, which can be converted into other five-membered-ring scaffolds with up to five contiguous

185 polyoxafluoronorbornene (m-POFNB) with fused five-membered rings separated by alkenes and flexible si

186 slightly thermodynamically disfavored in the five-membered ring series.

187 double bonds that are identical to the "all five-membered ring" species formed through cyclopolymeri

188 t is absent in all the inactive compounds: a five-membered ring structure, one of whose carbon atoms

189 O leads to the formation of a three-nitrogen five-membered ring structure, which opens up phosphoresc

190 strate and CO, leading to the formation of a five-membered ring structure.

191 All chlorophylls have similar five-membered ring structures, with variations in the si

192 he seven-membered ring cation to contract to five-membered ring structures.

193 In the five-membered-ring substrate series, the k(H) values wer

194 (l-[(18)F]FAla), using a serine-derivatized, five-membered-ring sulfamidate as the radiofluorination

195 which are rare examples in the class of such five-membered-ring sulfur species.

196 , the structure of 1 has parallel and planar five-membered rings symmetrically positioned about the c

197 aving the sugar residue attached to the same five-membered ring system.

198 Five-membered ring systems are ubiquitous throughout nat

199 The reaction produces substituted five-membered ring systems stereoselectively and on prep

200 esulting in the formation of three different five-membered ring systems.

201 contain a 2-amino-3-hydroxycyclopent-2-enone five membered ring, termed C(5)N, which is condensed via

202 iers of 19.1 and 23.0 kcal/mol, leading to a five-membered ring tetroxolane intermediate.

203 of the acyl hydrogen and addition to form a five-membered ring tetroxolane.

204 rturb much more the pi-electron structure of five-membered rings than that of the six-membered ones.

205 of a new stereogenic center on the C2 of the five-membered ring, the reaction proceeds with formation

206 des are capped by diverse amino acid-derived five-membered rings, the tetramic acids and related pyrr

207 the formation of aromatic molecules carrying five-membered rings-the essential building block of nonp

208 negatively with the resonance energy of the five-membered ring; the nonaromatic cyclopentadiene deri

209 e carbon-carbon bond joining the two central five-membered rings then gave the trans isomer 26.

210 resting process for cascade formation of two five-membered rings through spiroannulation followed by

211 The four- and five-membered rings trans-fused to cyclooctene reduce th

212 erted 1,2-acyloxy rearrangement via a cyclic five-membered-ring transition state followed by nickel-c

213 alogues have been elaborated from a panel of five-membered ring trifluoromethylated amino acids (Tfm-

214 d instead of the thermodynamically favorable five-membered rings under appropriate conditions.

215 hat the tert-butyl and p-xylyl groups in the five-membered-ring upper half may be introduced simultan

216 motor comprises a fluorene lower half and a five-membered-ring upper half; the upper-half ring is fu

217 hod is presented for pucker determination of five-membered rings using only residual dipolar coupling

218 substrate to Fe(2+)versus Ni(2+): forming a five-membered ring versus a six-membered ring, respectiv

219 H(8))-the prototype aromatic molecule with a five-membered ring-via a barrierless bimolecular reactio

220 ntiospecific synthesis of the functionalized five-membered ring vinyl stannane from the monoterpene R

221 otope labeling at different positions of the five-membered ring was developed.

222 ommon electrochemical oxidation, whereas the five-membered ring was formed through ring-closing metat

223 The five-membered ring was generated in a stereocontrolled f

224 onic overlapping plus the ring strain of the five-membered ring, whereas steric effects seem to be un

225 localization of 6pi-electrons over the BC2N2 five-membered ring, which thus indicates the aromatic pr

226 yl(crotyl)enolsilanes, when constrained in a five-membered ring with a 1,2-diol, react with aldehydes

227 closing metathesis strategy to construct the five-membered ring with control of both the relative and

228 bearing a terminal alkyne led to the desired five-membered ring with high enantioselectivities (up to

229 180 degrees variation in orientation of the five-membered ring within the active site.

230 It is the second C(7)H(7) isomer with a five-membered ring yet to be detected, the other being v