ライフサイエンスコーパス: flagellar

1 Sperm flagellar 1 (also called CLAMP) is a microtubule-associa

2 gated the localization and function of sperm flagellar 1, or CLAMP, in human intestinal epithelia cel

3 Our results demonstrate that flagellar abundance correlates with growth rate, where f

4 oteins in Caulobacter crescentus, which tune flagellar activity in response to binding of the second

5 apid and precisely timed modulation of their flagellar activity.

6 s that are coincident with specific gaits of flagellar actuation, suggesting that it is a competition

7 show that C. bombi establishes infections by flagellar anchoring to the ileum epithelium.

8 Pase, FleN, FleQ regulates the expression of flagellar and exopolysaccharide biosynthesis genes in re

9 stators, suggesting that FlcA is crucial for flagellar and stator assemblies.

10 including ubiquitination, transcription, and flagellar and vesicular transport systems.

11 metries of basal body positioning and of the flagellar apparatus that are coincident with specific ga

12 of the type III secretion system (T3SS) and flagellar apparatus.

13 We showed that TbUnc119 binds to a flagellar arginine kinase TbAK3 in a myristoylation-depe

14 The screw-type flagellar arrangement enables a unique mode of propagati

15 , and their localization also changes during flagellar assembly and disassembly.

16 rotist Giardia is an ideal model to evaluate flagellar assembly and length regulation.

17 glycosylation plays an essential role in the flagellar assembly and motility of T. denticola.

18 nt functions to the spirochete's periplasmic flagellar assembly and rotation.

19 d in lower expression of genes encoding many flagellar assembly components, which led to a motility d

20 we investigated the effect of growth rate on flagellar assembly in Escherichia coli using steady-stat

21 Numerous global regulators control flagellar assembly in response to cellular and environme

22 Previous studies have also shown that flagellar assembly is affected by the growth-rate of the

23 enes underlying flagellar body secretion and flagellar assembly overexpressed in low- and high-titer

24 n small deviations from the highly regulated flagellar assembly process can abolish motility and caus

25 ng the outer membrane, a crucial step in the flagellar assembly process.

26 ion of flagellar biogenesis and implies that flagellar assembly transcriptionally regulates the produ

27 Genes involved in flagellar assembly were enriched in the fecal microbiome

28 d that genes involved in bacterial mobility, flagellar assembly, bacterial chemotaxis and LPS synthes

29 Lysinoalanine crosslinks are not needed for flagellar assembly, but they are required for cell motil

30 ations of BB0270 and its profound impacts on flagellar assembly, morphology and motility in B. burgdo

31 show the T. brucei BBSome is dispensable for flagellar assembly, motility, bulk endocytosis, and cell

32 order to maintain the function of the entire flagellar assembly.

33 ing sulfur oxidation, nitrate reduction, and flagellar assembly.

34 etwork involving more than 60 genes controls flagellar assembly.

35 IDA8 encodes flagellar-associated polypeptide (FAP)57/WDR65, a highly

36 free state and in complex with FliD and the flagellar ATPase FliI.

37 Here we carried out functional analyses of a flagellar axonemal inner-arm dynein complex in the blood

38 ity and interdoublet shear stiffness, of the flagellar axoneme in the unicellular alga Chlamydomonas

39 he observation of the maturation of a second flagellar basal body in late G1 phase, DNA replication i

40 lecular phenotypes to trace the evolution of flagellar-based swimming.

41 The CP coordinates the flagellar beat and defects in CP projections are associa

42 ydrodynamic power balance, we infer the mean flagellar beat frequency and conjecture that its diurnal

43 g at an adaptation mechanism controlling the flagellar beat.

44 the chemomechanical energy efficiency of the flagellar beat.

45 ation of digitised kinematic descriptions of flagellar beating from videomicroscopy.

46 ate (AMP) and adenosine diphosphate (ADP) on flagellar beating is not fully understood.

47 y more common model systems, and the complex flagellar beating shapes that power it make its quantita

48 Axonemal dynein ATPases direct ciliary and flagellar beating via adenosine triphosphate (ATP) hydro

49 e that CFAP45 supports mammalian ciliary and flagellar beating via an adenine nucleotide homeostasis

50 on N-DRC assembly and its role in regulating flagellar beating.

51 models confirmed the importance of TTC29 for flagellar beating.

52 critical for TTC29 axonemal localization and flagellar beating.

53 underlying the spationumerical regulation of flagellar biogenesis and implies that flagellar assembly

54 output - precise numerical control of polar flagellar biogenesis required to create species-specific

55 FlhG ATPases numerically regulate polar flagellar biogenesis, yet FlhG orthologs are diverse in

56 otransferase and abundance of genes encoding flagellar biosynthesis protein had good accuracy for ide

57 ic pathways and a suppression of ciliary and flagellar biosynthetic pathways.

58 tipartite mechanism that likely influences a flagellar biosynthetic step to control flagellar number

59 eriocyte environments, with genes underlying flagellar body secretion and flagellar assembly overexpr

60 the mucus structure, the compression on the flagellar bundle causes buckling, disassembly and reorga

61 Scattering data from aligned flagellar bundles confirmed the theoretically predicated

62 he ability to steer these devices and induce flagellar bundling in multi-flagellated nanoswimmers.

63 ens, we show that FlhG links assembly of the flagellar C ring with the action of the master transcrip

64 While FlrA and the flagellar C-ring protein FliM have an overlapping bindin

65 Flagellar Ca(2+) signaling nanodomains, organized by mul

66 teins of known localization such as TcFCaBP (flagellar calcium binding protein) and TcVP1 (vacuolar p

67 be actively overcome and that the parasite's flagellar cAMP signaling pathway facilitates this.

68 Herein, we report that FliD (BB0149), a flagellar cap protein (also named hook-associated protei

69 Collectively, we propose that the flagellar cap protein FliD promotes flagellin polymeriza

70 f these spirochetes depends crucially on the flagellar/cell wall stiffness ratio.

71 FliT is a key flagellar chaperone that binds to several flagellar prot

72 for FliT appear to be shared among the other flagellar chaperones.

73 , leading us to rename BB0326 as periplasmic flagellar collar protein A or FlcA.

74 sis of the travel time of IFT protein in the flagellar compartment.

75 ncy to form multimers independently of other flagellar components.

76 cts the flagellar gene regulatory network to flagellar construction.

77 at ultimately determines the precise form of flagellar coordination in unicellular algae.

78 rnal to the cell, must provide an additional flagellar coupling.

79 valent forms of eukaryotic cell motility are flagellar-dependent swimming and actin-dependent cell mi

80 However, very little is known about flagellar disassembly.

81 , adding to our growing catalog of bacterial flagellar diversity.

82 neural stimulation, drive time-irreversible flagellar dynamics, thereby providing thrust for untethe

83 about the role of protein methylation during flagellar dynamics, we focused on protein arginine methy

84 ximal flagellum inflexible and alters the 3D flagellar envelope, thus preventing sperm from reorienti

85 Two modes of action within the flagellar export apparatus are proposed, in which the mo

86 The membrane-embedded part of the flagellar export apparatus contains five essential prote

87 homolog of the F(1) ATPase motor, within the flagellar export apparatus remains unclear.

88 provided by flagellin subunits entering the flagellar export channel prior to their unfolding.

89 protein 2), controls flagellin stability and flagellar filament assembly in the Lyme disease spiroche

90 r is a molecular machine that can rotate the flagellar filament at high speed.

91 e addressed a significant question whether a flagellar filament can form a new cap and resume growth

92 We can now show that the archaeal flagellar filament contains a beta-sandwich, previously

93 show that, when a cell gets stuck, the polar flagellar filament executes a polymorphic change into a

94 the atomic structure of the C. jejuni G508A flagellar filament from a 3.5- angstrom-resolution cryo-

95 The bacterial flagellar filament has long been studied to understand h

96 A-dependent repression of translation of the flagellar filament protein, flagellin.

97 adjacent subunit compared to other bacterial flagellar filament structures.

98 The bacterial flagellar filament, largely composed of a single protein

99 he chief flagellar protein flagellin and the flagellar filament.

100 otein that forms the anchor for the archaeal flagellar filament.

101 le bacteria are propelled by rigid, helical, flagellar filaments and display distinct swimming patter

102 ile mutant cells that are unable to assemble flagellar filaments and pentagon-shaped caps (10 nm in d

103 Flagellar filaments are assembled from thousands of subu

104 ce has been "tuned" over evolution.Bacterial flagellar filaments are composed almost entirely of a si

105 Flagellar filaments are therefore able to re-grow if bro

106 ds, we investigated the structure of SJW1660 flagellar filaments as well as the intermolecular forces

107 ella putrefaciens with fluorescently labeled flagellar filaments at an agarose-glass interface.

108 l mobility is powered by rotation of helical flagellar filaments driven by rotary motors.

109 ear-atomic resolution cryo-EM structures for flagellar filaments from both Gram-positive Bacillus sub

110 ility, we determined the structure of native flagellar filaments from the spirochete Leptospira by in

111 Seven mutant flagellar filaments in B. subtilis and two in P. aerugin

112 d confinement and the left handedness of the flagellar filaments result in exclusively clockwise circ

113 atomic resolution cryo-EM structures of nine flagellar filaments, and begin to shed light on the mole

114 ated with bundling of straight semi-flexible flagellar filaments.

115 of bacterial T4P, archaeal T4P and archaeal flagellar filaments.

116 in propulsion before and after the change in flagellar form.

117 its positive effect on T3SS gene expression, flagellar formation and amylovoran production.

118 s response by studying the swimming of three flagellar forms.

119 This cyclic nucleotide regulates flagellar function and besides, the master regulator of

120 monstrating the evolutionary conservation of flagellar function related to male fertility across king

121 t-gated ion channels that, via regulation of flagellar function, enable single-celled motile algae to

122 eds, no significant difference was found for flagellar gait kinematics.

123 opose a mathematical model that connects the flagellar gene regulatory network to flagellar construct

124 ation, rather than suppressing activators of flagellar gene transcription as in Vibrio and Pseudomona

125 ational fidelity downregulates expression of flagellar genes and suppresses bacterial motility.

126 erichia coli flagellar synthesis showed that flagellar genes are activated in stochastic pulses witho

127 by regulating the transcription of class-III flagellar genes in sigma(54)-dependent manner.

128 dependent peptide motifs were represented in flagellar genes.

129 r a given body geometry, there is a specific flagellar geometry that minimizes the critical flexibili

130 ibe the structural characterization of novel flagellar glycans from a number of hypervirulent strains

131 tant role in the regulation of energy taxis, flagellar glycosylation, cellular communication via quor

132 We discuss our theory's implication for flagellar growth influenced by beating and provide possi

133 efficient for the return of kinesin-2 affect flagellar growth kinetics.

134 The flagellar helicity remained right-handed with a 1.3 mum

135 eria eject their flagella at the base of the flagellar hook when nutrients are depleted, leaving a re

136 taining 39 (ccdc39) gene that is part of the flagellar hydin network.

137 ImageJ Macros for flagellar identification are provided, and high accuracy

138 In addition, these parasites exhibit non-flagellar intracellular mechanisms of nutrient sensing,

139 using 3D Lagrangian tracking and fluorescent flagellar labelling.

140 ted a stable dual knockdown strain with both flagellar length and disk defects.

141 show that this 'active disassembly' model of flagellar length control explains in quantitative detail

142 Flagellar length control in Chlamydomonas is a tractable

143 negative feedback mechanism that facilitates flagellar length control in Chlamydomonas.

144 his mechanism has been recently proposed for flagellar length control in the single cell organisms Ch

145 n of kinesin-2a and kinesin-13 causes severe flagellar length defects that mirror defects with morpho

146 Maintenance of flagellar length requires an active transport process kn

147 he flagellar tips is inversely correlated to flagellar length.

148 To determine how four different flagellar lengths are maintained, we used live-cell quan

149 dent disassembly mechanism controls multiple flagellar lengths within the same cell.

150 enerate a nearly complete atomic model for a flagellar-like filament of the archaeon Ignicoccus hospi

151 This flagellar-load based mechanism ensures that cells in the

152 f multiple virulence determinants, including flagellar machinery and alterations in type VI secretion

153 We found that ArcZ and OmrAB repress the flagellar master regulator flhD post-transcriptionally.

154 control occurs through the expression of the flagellar master regulator, FlhD4C2.

155 n composition, being enriched in a subset of flagellar membrane proteins, proteases, proteins from th

156 y of disease-causing amastigotes but not for flagellar membrane trafficking.

157 ostained TbHrg indicated localization to the flagellar membrane, and scanning electron microscopy rev

158 ly traffic specific membrane proteins to the flagellar membrane, but the mechanisms for this traffick

159 failure of the calcium channel to enter the flagellar membrane, detachment of the flagellum from the

160 hey can also resort to a radically different flagellar mode, which we discovered here.

161 robust regulatory mechanisms to ensure that flagellar morphogenesis follows a defined path, with eac

162 ament subunits, is critical to the change in flagellar morphology and swimming pattern, and lack of f

163 ced by a reduction in secretory activity and flagellar motility and an increase in adenosine triphosp

164 gen Clostridium difficile, c-di-GMP inhibits flagellar motility and toxin production and promotes pil

165 The role of ArcZ as an activator of flagellar motility appears to be unique to E. amylovora

166 RmaA play an integral role in regulation of flagellar motility by acting primarily on the master reg

167 Our study of dimeric NDK5 in a flagellar motility control complex, the radial spoke (RS

168 of the chemosensory machinery that controls flagellar motility in Escherichia coli.

169 tants have reduced swimming speed when using flagellar motility in liquid.

170 Bacterial flagellar motility is controlled by the binding of CheY

171 To reach these openings, the bacteria use flagellar motility to swim from stigma tips to the hypan

172 rodigiosin antibiotic, and downregulation of flagellar motility.

173 CWDEs), type III secretion system (T3SS) and flagellar motility.

174 entral role in the regulation of ciliary and flagellar motility.

175 in Caenorhabditis elegans, but up-regulating flagellar motility.

176 axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to adaptive im

177 The bacterial flagellar motor (BFM) is the rotary motor that rotates e

178 Unlike the bacterial flagellar motor (BFM), ATP (adenosine-5'-triphosphate) h

179 e show that CheY2 does not interact with the flagellar motor and that the Che2 system does not transf

180 The bacterial flagellar motor can rotate in counterclockwise (CCW) or

181 d by force) drives mechanosensitivity of the flagellar motor complex.

182 a, and Shewanella oneidensis cells, we study flagellar motor disassembly and assembly in situ.

183 amic resistance) and the power output of the flagellar motor for individual cells over extended time

184 The flagellar motor has been known to briefly pause during r

185 Recent experiments on the bacterial flagellar motor have shown that the structure of this na

186 -electron tomography to visualize the intact flagellar motor in the Lyme disease spirochete, Borrelia

187 ts are depleted, leaving a relic of a former flagellar motor in the outer membrane.

188 The bacterial flagellar motor is a molecular machine that can rotate t

189 The flagellar motor is a sophisticated rotary machine facili

190 y to dynamically monitor the activity of the flagellar motor is a valuable indicator of the overall e

191 The stator-complex in the bacterial flagellar motor is responsible for surface-sensing.

192 The bacterial flagellar motor is the most complex structure in the bac

193 Also, the flagellar motor itself mediated a repellent response ind

194 Direction switching in the flagellar motor of Escherichia coli is under the control

195 acromolecular machines such as the bacterial flagellar motor requires the spatio-temporal synchroniza

196 receptor stimulation to a highly cooperative flagellar motor response.

197 assembly mechanism has been proposed for the flagellar motor starting from the inner membrane, with t

198 rotein-protein binding and single cell-based flagellar motor switching analyses.

199 has an additional function of assisting the flagellar motor to shift from counterclockwise to clockw

200 The bacterial flagellar motor, a cell-envelope-embedded macromolecular

201 Recent observations of the bacterial flagellar motor, among others, bring these notions into

202 ral elaborations of the alphaproteobacterial flagellar motor, including two novel periplasmic ring st

203 This has revealed that in the bacterial flagellar motor, protein molecules in both the rotor and

204 ins to the cytoplasmic switch complex of the flagellar motor, resulting in changes in swimming speed

205 many bacteria is powered by a bidirectional flagellar motor.

206 not bind to PG until it is inserted into the flagellar motor.

207 ctionally equivalent bacterial flagellum and flagellar motor.

208 ng switch complex, the control center of the flagellar motor.

209 e is an ancient and conserved feature of the flagellar motor.

210 uch as the F1Fo-ATPase, the ribosome, or the flagellar motor: each one of these structures requires m

211 Although it is known that diverse bacterial flagellar motors produce different torques, the mechanis

212 We propose that higher viscous loads on flagellar motors result in lower DegU-P levels through a

213 measured the dynamic responses of individual flagellar motors to determine the chemotaxis response.

214 look at the response of individual bacterial flagellar motors under stepwise changes in external osmo

215 ad wild type numbers of basal bodies and the flagellar motors were functional.

216 needed to power the spirochete's periplasmic flagellar motors.

217 n a relatively unexplored type of eukaryotic flagellar movement.

218 gnetic actuation of self-assembled bacterial flagellar nanorobotic swimmers.

219 -like GTPase, has been found to regulate the flagellar number and polarity; however, its role in B. b

220 ces a flagellar biosynthetic step to control flagellar number for amphitrichous flagellation, rather

221 G ATPase domain was not required to regulate flagellar number in C. jejuni.

222 kinesin-13-mediated disassembly in different flagellar pairs.

223 lar sterol enrichment results from selective flagellar partitioning of specific sterol species or fro

224 ts into how spirochetes control their unique flagellar patterns.

225 Following the discovery that flagellar phosphodiesterase PDEB1 is required for trypan

226 The flagellar pocket (FP) is the exclusive site of uptake fr

227 vagination of the plasma membrane called the flagellar pocket (FP).

228 YRK1 localisations in logarithmic (mainly in flagellar pocket area and endosomes) and late stationary

229 s cytoplasmic face is a structure called the flagellar pocket collar (FPC), which is essential for FP

230 The flagellar pocket plays a crucial role in parasite pathog

231 surface attachment by the flagellum and the flagellar pocket, a Leishmania-like flagellum attachment

232 One of these is the flagellar pocket, an invagination of the cell membrane a

233 d more intense TbHrg accumulation toward the flagellar pocket.

234 ceptor-mediated endocytosis occurring in the flagellar pocket.

235 e compare the morphology and function of the flagellar pockets between different trypanosomatids, wit

236 rey; contact is always via the piliated, non-flagellar pole of the predator, involving MglA(Bd), but

237 Based on these results, we concluded that a flagellar polymorphism is essential for spreading in str

238 morphology and swimming pattern, and lack of flagellar polymorphism.

239 We determined that each flagellar pore is the site of IFT accumulation and injec

240 a canonical membrane-bound flagellum at the 'flagellar pore'.

241 flagellin glycan chain and demonstrate that flagellar post-translational modification affects motili

242 bilization through the thrust force of their flagellar propulsion.

243 e question of size when applied to the chief flagellar protein flagellin and the flagellar filament.

244 number and position of PF via regulating the flagellar protein stability and the polar localization o

245 ked to phosphorylation of an uncharacterised flagellar protein.

246 Several flagellar proteins are methylated on arginine residues d

247 er, and therefore assist in unfolding of the flagellar proteins before feeding them into the transpor

248 ensing environmental conditions, and various flagellar proteins have been implicated in sensing roles

249 ey flagellar chaperone that binds to several flagellar proteins in the cytoplasm, including its cogna

250 eriments in cells that lack either all other flagellar proteins or just the MS-ring protein FliF.

251 l localization of these PRMTs changes during flagellar regeneration and resorption.

252 osome release increased when cells underwent flagellar resorption.

253 s are methylated on arginine residues during flagellar resorption; however, the function is not under

254 The flagellar rod acts as a driveshaft to transmit torque fr

255 the complex that regulates the direction of flagellar rotation assume either 34 or 25 copies of the

256 It also uses flagellar rotation to swim through liquid and swarm acro

257 ossesses two different stator units to drive flagellar rotation, the Na(+) -dependent PomAB stator an

258 e for the conformational change required for flagellar rotation.

259 ton-driven conformational changes that drive flagellar rotation.

260 or ATP synthesis, transport of nutrients and flagellar rotation.

261 To dissect the mechanism underlying flagellar rotational switching, we use Borrelia burgdorf

262 tors are disengaged and sequestered from the flagellar rotor when bound by MotI.

263 Sequence analysis of T3SS and flagellar ruler proteins shows that this mechanism is pr

264 howed that EB1-FP is highly mobile along the flagellar shaft and displays a markedly reduced mobility

265 onstruction of the swimming trajectories and flagellar shapes of specimens of Euglena gracilis We ach

266 ng protein 1 (EB1) remains at the tip during flagellar shortening and in the absence of intraflagella

267 and VPS4, attenuated ectosome release during flagellar shortening and shortening was slowed.

268 diate ectosome release and thereby influence flagellar shortening in Chlamydomonas.

269 that the PbifA promoter is dependent on the flagellar sigma factor FliA, and positively regulated by

270 We propose a model in which flagellar stators are disengaged and sequestered from th

271 rther, these agents have opposite effects on flagellar sterol enrichment and cell metabolism in the t

272 We tested whether flagellar sterol enrichment results from selective flage

273 is a conserved axonemal protein required for flagellar structure and beating and that TTC29 mutations

274 nfertility of humans and animals in terms of flagellar structure and movement.

275 ia, spirochetes possess a unique periplasmic flagellar structure called the collar.

276 ffect on collar formation, assembly of other flagellar structures, morphology, and motility of the sp

277 To investigate the structural basis of flagellar supercoiling, which is critical for motility,

278 , optimized, and implemented light-sensitive flagellar swimmers actuated by these neuromuscular units

279 The flagellar swimming of euglenids, which are propelled by

280 eA, or the 16-residue "target region" of the flagellar switch protein, FliM, leads to easily measurab

281 conformation Cle proteins interact with the flagellar switch to control motor activity.

282 Mutations impairing flagellar synthesis are inferred to increase DegU-P, whi

283 rained by a large set of single-cell E. coli flagellar synthesis data from different strains and muta

284 single-cell experiments in Escherichia coli flagellar synthesis showed that flagellar genes are acti

285 ion and besides, the master regulator of the flagellar synthesis signaling pathway, FleQ, has been sh

286 containing the switch protein from a Vibrio flagellar system at 3.2 angstrom resolution.

287 eria are capable of switching on and off the flagellar system by altering translational fidelity, whi

288 ied model for C-ring assembly by NF-T3SS and flagellar-T3SS.

289 te that T. brucei senses heme levels via the flagellar TbHrg protein.

290 to directly and noninvasively determine the flagellar thrust force and swimming speed of motile cell

291 longstanding claim that mastigonemes enhance flagellar thrust in C. reinhardtii, and so, their functi

292 res have been widely hypothesized to enhance flagellar thrust; however, detailed hydrodynamic analysi

293 ported with anterograde IFT particles to the flagellar tip, dissociates into smaller particles, and b

294 To investigate how EB1 accumulates at the flagellar tip, we used in vivo imaging of fluorescent pr

295 isplays a markedly reduced mobility near the flagellar tip.

296 onstrate that kinesin-13 localization to the flagellar tips is inversely correlated to flagellar leng

297 l protein KHARON as being important for both flagellar trafficking of the glucose transporter GT1 and

298 tational direction, which causes polymorphic flagellar transformation.

299 fferent filtration mechanism that requires a flagellar vane (sheet), something notoriously difficult

300 A CFD model with a flagellar vane correctly predicts the filtration rate of