ライフサイエンスコーパス: foamy virus

1 mia virus, avian sarcoma leukosis virus, and foamy virus.

2 ity, proviral DNA detection and isolation of foamy virus.

3 recombination between genetically divergent foamy viruses.

4 ed novel vectors, including lentiviruses and foamy viruses.

5 es of integrase-DNA complexes from prototype foamy virus, a member of the Spumavirus genus of Retrovi

6 Vectors derived from foamy virus, a nonpathogenic retrovirus, show higher pre

7 s have no effect on the infectivity of human foamy virus, a spumaretrovirus lacking zinc fingers in i

8 ls followed by viral titration with the FAB (foamy virus-activated beta-galactosidase expression) ass

9 creased when this insulator was removed from foamy virus and significantly reduced when the insulator

10 y viruses, suggesting an association between foamy viruses and primates since the haplorrhine-strepsi

11 ly mimic the integrase tetramer of prototype foamy virus, and two flanking integrase dimers that enga

12 e Class I and Class II retroviral sequences, foamy viruses, and deltaretroviruses, as well as filovir

13 Foamy viruses are a member of the spumavirus subfamily o

14 Foamy viruses are a ubiquitous family of nonpathogenic r

15 Foamy viruses are complex retroviruses that lead to eith

16 Foamy viruses are complex retroviruses whose replication

17 Foamy viruses are nonpathogenic retroviruses that offer

18 Foamy viruses are retroviruses of the spumavirus family

19 Foamy viruses are retroviruses whose Pol protein is synt

20 Spumaviruses, commonly called foamy viruses, are complex retroviruses that establish l

21 fy a novel insulator, and support the use of foamy virus as a vector for gene therapy, especially whe

22 a unique insulator, and supports the use of foamy virus as a vector for gene therapy.

23 Thus, foamy virus assembly is distinct from that of other reve

24 e of a replication-competent clone of bovine foamy virus (BFV) and have quantitated the amount of spl

25 Here we demonstrate that bovine foamy virus (BFV) expresses high levels of three viral m

26 we describe three miRNAs expressed by bovine foamy virus (BFV), a member of the spumavirus subfamily

27 Human foamy virus can establish persistent infections in human

28 in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)] RT w

29 aposi sarcoma herpesvirus LANA and prototype foamy virus chromatin-binding sequences that blocked nuc

30 3), human papillomavirus 8 E2, and prototype foamy virus chromatin-binding sequences.

31 Foamy viruses, complex retroviruses that infect mammals,

32 icant level of transduction, indicating that foamy viruses could not be pseudotyped with VSV-G to gen

33 In arrested cells no foamy virus DNA band was detected in cells harvested at

34 iter infectious pseudotypes, while the human foamy virus Env protein did not.

35 fied the 18-kDa leader peptide (LP18) of the foamy virus envelope protein (FVenv) as a new substrate

36 Foamy virus evolution closely parallels that of the host

37 as the Tas transactivator encoded by primate foamy virus, fail to inhibit RNA interference in human c

38 e been reported for integrase from prototype foamy virus featuring an additional DNA-binding domain a

39 Feline foamy virus (FFV) is a contact-dependent retrovirus form

40 The foamy virus (FV) genome contains two promoters, the cano

41 The cellular factors that mediate foamy virus (FV) latency are poorly understood.

42 Foamy virus (FV) replication is resistant to most nucleo

43 Foamy virus (FV) replication, while related to that of o

44 METHODOLOGY/PRINCIPAL FINDINGS: We used a foamy virus (FV) vector expressing the P140K mutant of m

45 Foamy virus (FV) vectors are particularly attractive gen

46 etroviral vectors based on the nonpathogenic foamy viruses (FV) are an alternative gene-transfer syst

47 Foamy viruses (FV) are complex retroviruses that natural

48 Foamy viruses (FV) are complex retroviruses that possess

49 Retroviral vectors based on foamy viruses (FV) are efficient gene delivery vehicles

50 Foamy viruses (FV) are retroviruses that naturally infec

51 Foamy viruses (FV) are the oldest known genus of retrovi

52 Foamy viruses (FV) comprise a subfamily of retroviruses.

53 Foamy viruses (FV) differ from orthoretroviruses in many

54 iruses but similar to the hepatitis B virus, foamy viruses (FV) require expression of the envelope pr

55 Foamy viruses (FV) synthesize Pol from a spliced pol mRN

56 Spumaviruses, commonly called foamy viruses (FV), are complex retroviruses that establ

57 Foamy viruses (FVs) are an ancient lineage of retrovirus

58 Foamy viruses (FVs) are ancient retroviruses that are ub

59 Foamy viruses (FVs) are classified in the family Retrovi

60 Although foamy viruses (FVs) are endemic among nonhuman primates,

61 Among all retroviruses, foamy viruses (FVs) are unique in that they regularly ma

62 Foamy viruses (FVs) assemble using pathways distinct fro

63 ysine motif-in the glycoproteins of all five foamy viruses (FVs) for which sequences were available.

64 Foamy viruses (FVs) or spumaviruses are retroviruses tha

65 Foamy viruses (FVs), or spumaviruses, are integrating re

66 ation signal sequence in Gag, we observed no foamy virus Gag importation into the nucleus in the abse

67 blished evidence for the first time that the foamy virus genome and Gag translocation into the nucleu

68 The foamy virus genome is detected by confocal microscopy in

69 ken together, these results suggest that the foamy virus genome persists in nondividing cells without

70 This report shows that the foamy virus genome remains unintegrated in G(1)/S phase-

71 Although the tas and ORF-2 regions of foamy viruses have significantly diverged, the results p

72 Foamy viruses have the largest genomes among mammalian r

73 coded, respectively, by the human and simian foamy viruses, have been mutationally defined, they show

74 domain, whereas similar chimeras with human foamy virus (HFV) (containing no zinc fingers) Gag had a

75 As with the human foamy virus (HFV) and feline foamy virus, we have detect

76 reviously constructed vectors based on human foamy virus (HFV) and found that they were able to trans

77 tional transactivator, termed Bel-1 in human foamy virus (HFV) and Tas or Taf in the related simian f

78 nscriptional transactivator encoded by human foamy virus (HFV) can efficiently activate gene expressi

79 A putative cleavage site of the human foamy virus (HFV) envelope glycoprotein (Env) was altere

80 n investigating the characteristics of human foamy virus (HFV) integration.

81 Human foamy virus (HFV) is a retrovirus of the spumavirus fami

82 Human foamy virus (HFV) is the prototype member of the spumavi

83 Human foamy virus (HFV) is the prototype of the Spumavirus gen

84 Human foamy virus (HFV) is the prototype of the Spumavirus gen

85 genomes of the spumaviruses, of which human foamy virus (HFV) is the prototype, are very similar to

86 The Gag protein of human foamy virus (HFV) lacks Cys-His boxes present in the nuc

87 vectors derived from the nonpathogenic human foamy virus (HFV) to transduce human CD34(+) cells and m

88 The infectivity of human foamy virus (HFV) was examined in primary and cultured h

89 howed marked cytopathology characteristic of foamy virus, HFV-infected monocyte-derived macrophages f

90 little sequence similarity with its primate foamy virus homologs, but the putative nucleocapsid (NC)

91 hanism behind the low genotoxic potential of foamy virus, identifies a unique insulator, and supports

92 mechanism underlying the low genotoxicity of foamy virus, identify a novel insulator, and support the

93 y to a recent crystal structure of prototype foamy virus IN bound to DNA.

94 , we report a crystal structure of prototype foamy virus IN bound to viral DNA prior to 3'-processing

95 of full-length integrase from the prototype foamy virus in complex with its cognate DNA.

96 al structures of the intasome from prototype foamy virus in complex with target DNA, elucidating the

97 the X-ray crystal structure of the prototype foamy virus IN target capture complex together with our

98 we demonstrate a sequence-specific effect of foamy virus, independent of insertional bias, contributi

99 gstrom resolution structure of the prototype foamy virus intasome engaged with a nucleosome core part

100 Co-crystal structures of the prototype foamy virus intasome have shown that all three FDA-appro

101 transpososomes with structures of Prototype Foamy Virus intasomes suggests a binding mode for target

102 d contrast with earlier studies on prototype foamy virus intasomes.

103 conserved DD35E catalytic core motif of the foamy virus integrase sequence.

104 nc finger of Spt10p is homologous to that of foamy virus integrase, perhaps suggesting that this inte

105 s compared with those observed for prototype foamy virus integrase.

106 Foamy virus is an attractive vector for gene therapy.

107 he transcription of genes carried by primate foamy viruses is dependent on two distinct promoter elem

108 The observation that BFV, a foamy virus, is able to express viral miRNAs in infected

109 Thirteen (56%) were coinfected with a simian foamy virus known to be acquired through severe bites.

110 tly earlier than the LTR promoter during the foamy virus life cycle.

111 mediated by a 36-bp insulator located in the foamy virus long terminal repeat (LTR) that has high-aff

112 We demonstrate that the foamy virus long terminal repeats contain an insulator e

113 discovery of PSFVaye indicates that primate foamy virus might be more broadly distributed than previ

114 promoters, an effect not explained solely by foamy virus' modest insertional site preference for nong

115 Here we generated nonintegrating foamy virus (NIFV) vectors by introducing point mutation

116 sented in our manuscript show that oncolytic Foamy Virus (oFV) vectors are capable of persisting unin

117 V) from the genomes of two chimpanzee Simian Foamy Viruses (PAN1 and PAN2) and inserted a GFP transge

118 microscopy of the transfected cells revealed foamy virus particles.

119 p12-M63-PM15 nonviable mutant with prototype foamy virus (PFV) and Kaposi's sarcoma herpesvirus (KSHV

120 Vector systems based on Prototype Foamy Virus (PFV) are promising candidates for gene and

121 ntegrase (IN) enzyme of retrovirus prototype foamy virus (PFV) consists of four domains: amino termin

122 uncovered critical interactions of prototype foamy virus (PFV) Gag with nucleosomes via a highly cons

123 rized the in vitro activity of the prototype foamy virus (PFV) IN from the Spumavirus genus and deter

124 termined crystal structures of the prototype foamy virus (PFV) IN tetramer, in complexes with viral D

125 Here we show that the prototype foamy virus (PFV) intasome is proficient at stable captu

126 energy transfer (smFRET), we show prototype foamy virus (PFV) intasomes specifically bind to DNA str

127 Prototype foamy virus (PFV) integrase (IN) forms a tetramer bound

128 l structures revealed a network of prototype foamy virus (PFV) integrase residues that distort tDNA:

129 he recent crystal structure of the prototype foamy virus (PFV) integrase-viral DNA complex revealed n

130 maging tools to determine that the prototype foamy virus (PFV) retroviral intasome searches for an in

131 ate (dNTP) incorporation kinetics of primate foamy virus (PFV) reverse transcriptase (RT) in comparis

132 The prototype foamy virus (PFV) structural protein GAG associates with

133 a retroviral Gag protein from the prototypic foamy virus (PFV) that is almost devoid of ubiquitin acc

134 sarcoma leucosis virus (ASLV) and prototype foamy virus (PFV).

135 When prototype foamy virus Pol is expressed as an orthoretroviral-like

136 Foamy virus Pol precursor protein processing by the vira

137 These data suggest that foamy viruses possess a replication pathway containing f

138 the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (

139 However, foamy virus replication also resembles that of hepadnavi

140 Foamy virus replication is cell cycle dependent; however

141 d simian foamy viruses, that is critical for foamy virus replication.

142 Thus vectors based on foamy viruses represent a promising approach for HSC gen

143 or intasomes, from the spumavirus prototype foamy virus revealed a functional integrase tetramer, an

144 elements in spleen necrosis virus and human foamy virus RNA and support the model that divergent ret

145 The full-length sequence of simian foamy virus serotype 2 (SFVmcy-2), isolated from a Taiwa

146 position 50 to alanine (R50A) of the simian foamy virus SFV cpz(hu) inhibits proper capsid assembly

147 -cell lymphotrophic virus (STLV), and simian foamy virus (SFV) and for nucleic acids of these same vi

148 Simian Foamy Virus (SFV) can be transmitted from non-human prim

149 Simian foamy virus (SFV) infection and the subsequent immune re

150 Recently, simian foamy virus (SFV) infection was reported in 4 of 231 ind

151 Zoonotic infections with simian foamy virus (SFV), a retrovirus endemic in most Old Worl

152 , simian type D retrovirus (SRV), and simian foamy virus (SFV).

153 Simian and human foamy viruses (SFV and HFV) encode a transcriptional tra

154 lence (4/231, 1.8%) of infection with simian foamy viruses (SFV) among humans occupationally exposed

155 Simian foamy viruses (SFV) are complex retroviruses that are ub

156 oonotic transmission of Old World NHP simian foamy viruses (SFV) has been documented, leading to nonp

157 bal redistribution of PFV and macaque simian foamy virus (SFVmac) integration sites toward centromere

158 Simian foamy viruses (SFVs) are highly prevalent in a variety o

159 Simian foamy viruses (SFVs) are ubiquitous, non-pathogenic retr

160 Zoonotic simian foamy viruses (SFVs) establish persistent infections in

161 We studied simian foamy viruses (SFVs) from common marmosets, spider monke

162 organization to other complex retroviruses, foamy viruses share several features with their more dis

163 Alu PCR revealed foamy virus-specific DNA amplification from genomic DNA

164 ys they were allowed to cycle, at which time foamy virus-specific DNA amplification was readily obser

165 t PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy v

166 The resistance of foamy virus supports the hypothesis that the zinc finger

167 Simian foamy viruses (SVF) are ubiquitous in nonhuman primates

168 s (HFV) and Tas or Taf in the related simian foamy viruses, that is critical for foamy virus replicat

169 ns were introduced into human NK-92 cells by foamy virus transduction.

170 reviously demonstrated the utility of simian foamy virus type 1 (SFV-1) as a vector system by transie

171 We have cloned proviral DNA of simian foamy virus type 1 (SFV-1) from linear unintegrated DNA

172 Tas DNA binding site derived from the simian foamy virus type 1 (SFV-1) internal promoter.

173 structed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-act

174 se a model for transactivation of the simian foamy virus type 1 internal promoter in which Tas intera

175 anscriptional transactivator (Tas) of simian foamy virus type 1 strongly augments gene expression dir

176 erapy we constructed a replication competent Foamy Virus vector (oFV) from the genomes of two chimpan

177 hs of the dystrophin open reading frame in a foamy virus vector and quantified packaged vector RNA an

178 These results demonstrate that a foamy virus vector can be administered with therapeutic

179 34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete r

180 In newborn SCID-X1 dogs, injection of a foamy virus vector expressing the human IL2RG gene resul

181 and efficacy of in vivo gene therapy using a foamy virus vector for the correction of canine X-linked

182 2-11 and miR-155 function in vivo, we used a foamy virus vector to express the miRNAs in human hemato

183 ults represent the first successful use of a foamy virus vector to treat a genetic disease, to our kn

184 Foamy virus vectors are well-suited for stable delivery

185 be the first stable packaging cell lines for foamy virus vectors based on SFV-1.

186 This potential was applied by optimising foamy virus vectors carrying the full-length dystrophin

187 ing bone marrow cells marked with integrated foamy virus vectors that express green fluorescent prote

188 We found foamy virus vectors to be remarkably less genotoxic, wel

189 Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion d

190 disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human

191 with the human foamy virus (HFV) and feline foamy virus, we have detected a spliced pol mRNA by PCR.

192 HIV, simian immunodeficiency virus, MLV, and foamy virus, we show that global and local integration s

193 s within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 milli

194 man immunodeficiency virus type 2, and human foamy virus, which were produced by cell lines expressin

195 FV-1 which is distantly related to the human foamy virus will provide a means to understand the biolo

196 We have found an endogenous foamy virus within the genomes of sloths and show that f