ライフサイエンスコーパス: foldamer

1 , detectable by (13)C NMR, is induced in the foldamer.

2 even in solvents that normally denature the foldamer.

3 ked geometry characteristic of this class of foldamer.

4 al-centered reduction of a Cu(II)-containing foldamer.

5 ntimicrobial helical sulfono-gamma-AApeptide foldamers.

6 mers in the synthesis of aromatic oligoamide foldamers.

7 abilize the folding in a variety of peptidic foldamers.

8 us allowing the rational design of new short foldamers.

9 formations and expands the repertoire of the foldamers.

10 gen- and halogen-bonding triple-strand anion foldamers.

11 secondary structures formed by beta-peptide foldamers.

12 , the released SWCNTs appeared to be free of foldamers.

13 ve a strong interfacial interaction with the foldamers.

14 omposed of either alpha-peptides or peptidic foldamers.

15 udy the secondary structures of these hybrid foldamers.

16 /beta-peptides") are intriguing as potential foldamers.

17 atic conformational studies of gamma-peptide foldamers.

18 zation of short o-phenylene ethynylene (oPE) foldamers.

19 irector of absolute helicity in nickel-salen foldamers.

20 nd oligomers and synthetic biological hybrid foldamers.

21 ly described, solvent-driven folding of m-PE foldamers.

22 reated based on the folding of these helical foldamers.

23 ons, including the synthesis of beta-peptide foldamers.

24 as a design element in the field of dynamic foldamers.

25 onformational flexibility available to these foldamers.

26 nstrumentalize the future directed design of foldamers.

27 lecular systems such as self-replicators and foldamers.

28 rminus of alpha-amino-iso-butyric acid (Aib) foldamers.

29 s prompting the design of new peptidomimetic foldamers.

30 n the foldamer-from single- to triple-strand foldamers.

31 rocesses ("effect") in these oligoazobenzene foldamers.

32 on mechanism across nanosized, rigid helical foldamers.

33 conformational transition of the pentameric foldamer 105 is reflected in distinct spectral character

34 Helical foldamer 2 was synthesized and bound to human carbonic a

35 rption bands compared to the monomer M (tau4,foldamer = 20 ps, tau4,monomer = 9 ps).

36 o unique structures, which we call colloidal foldamers(8).

37 etic details of donor-acceptor oligorotaxane foldamers, a class of molecular switches.

38 l polymers (covalent and supramolecular) and foldamers acting on the conformational composition or mo

39 Crystallography confirmed that the foldamers adopted 3(10) helical conformations.

40 Peptidomimetic foldamers adopting well-defined three-dimensional struct

41 The alpha/beta-peptide foldamer adopts a helical conformation that displays a c

42 In water, this foldamer adopts a right-handed helical conformation with

43 vibrational features of the monomer and the foldamer after photoexcitation, with an additional time

44 ral role, on the basis of comparisons with a foldamer analogue that shows much-reduced binding.

45 sed in various shape persistent macrocycles, foldamers and "molecular machines".

46 munications exist in secondary structures of foldamers and copolymers via a network of noncovalent in

47 m for the self-assembly of synthetic peptide foldamers and gives new insights into molecular recognit

48 poly(quinoxaline-2,3-diyl)s), well known as foldamers and helical polymers, respectively, exhibit di

49 rous organic cages, supramolecular capsules, foldamers and mechanically interlocked molecules.

50 The conformations of three cholate foldamers and one molecular basket were studied by fluor

51 e important building blocks for designing of foldamers and other biomimetic structures.

52 a series of structurally related amphiphilic foldamers and present a more refined model of their conf

53 inhibitors, including constrained peptides, foldamers and proteomimetic-derived ligands.

54 c chemical system where structurally complex foldamers and self-replicating assemblies emerge spontan

55 It demonstrates that foldamers and self-replicators, formed from the same bui

56 to photoinduced charge transfer between the foldamers and SWCNTs.

57 ffold for novel stereodefined peptidomimetic foldamers and topologically biased libraries necessary f

58 The review then inspects multianion foldamers, and this section is organized by the number o

59 rther advance this strategy by combining the foldamer approach with side chain cross-linking to creat

60 Here we report such a foldamer architecture based on alternating pyridine-dike

61 Foldamer architectures dictate the unfolding and refoldi

62 mulations revealed that both the peptide and foldamer are helical in an intriguing reciprocal staplin

63 Foldamers are an intriguing family of biomimetic oligome

64 Anion foldamers are defined as single- or multistrand complexe

65 The designed foldamers are highly active against S. aureus in an anim

66 Synthetic foldamers are particularly attractive systems for develo

67 In this respect, peptidic foldamers are perhaps the best-characterized systems, as

68 le helices formed from synthetic peptides or foldamers are promising building blocks for the creation

69 Foldamers are synthetic and designable oligomers that ad

70 Mixed quinoline-pyridine foldamers are thus a promising class of selective G4 lig

71 thus far formed by the folding of unnatural foldamers, are generated.

72 The studies revealed that a QPY foldamer as a stator can reversibly control the intermes

73 Overall, using aromatic oligoamide foldamers as a chiral model, we demonstrate the capabili

74 d NMR confirm left-handedness of the helical foldamers as well as HCA dimerization.

75 Forty-eight copies of the foldamer assemble into a 5-nm cage-like structure, an om

76 d to the backbone of a quinquepyridine (QPY) foldamer at the second and fourth pyridine rings, respec

77 ization of azobenzene moieties embedded in a foldamer backbone and the resulting conformational helix

78 A number of foldamer backbones have been described as useful mimics

79 t among several alpha/beta- and beta-peptide foldamer backbones only alpha/beta-peptides intended to

80 nstructing rotamer libraries for non-natural foldamer backbones.

81 ical secondary structures available to these foldamer backbones.

82 ped a series of MLL-mimicking peptidomimetic foldamers based on a sulfonyl-gamma-AApeptide backbone.

83 A novel class of peptidomimetic foldamers based on diaza-peptide units are reported.

84 Thus, foldamer-based approaches to catalyst development repres

85 Our work developed a novel peptide foldamer-based strategy for inducing protein aggregation

86 alysis of the EPR spectra shows that the L,D foldamers bear two types of complexation sites that are

87 The trans-dominated helical foldamer becomes less stable upon photoisomerization to

88 hanges in intramolecular organization as the foldamer becomes more compact.

89 d the 14-helicity of a well-studied class of foldamers, beta(3)-peptides, in water.

90 d conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biol

91 Glutamate-functionalized oligocholate foldamers bound Zn(OAc)(2), guanidine, and even amine co

92 re comprised of a central helical oligoamide foldamer bridge with 9, 14, 18, 19, or 34 8-amino-2-quin

93 re has revealed several key requirements for foldamer bundle formation in aqueous conditions, and pro

94 Finally, dimethyl sulfoxide denatures the foldamer by putative solvent binding, which then lowers

95 ng block, from which a self-replicator and a foldamer can emerge along two distinct and competing pat

96 Foldamers can also selectively target sequence variants

97 helical diastereomers of nickel-salen-based foldamers can be observed on a NMR time scale.

98 mational studies of the basic units of these foldamers can be of invaluable assistance in designing n

99 Numerical simulations show that foldamers can further interact to make complex supracoll

100 f bioinspired unnatural backbones leading to foldamers can provide effective peptide mimics with impr

101 These helical foldamers can serve as novel platforms for the systemati

102 oligomers with well-defined conformations ("foldamers") can mimic protein secondary structural eleme

103 lene ethynylene)s, which are single-stranded foldamers, can be made to reversibly disperse and releas

104 uted glycine, represent a versatile class of foldamers capable of folding into defined secondary and

105 gress has been reported within this context, foldamer capsules reported thus far are largely restrict

106 An achiral but helical foldamer carrying a basic binding site interacts selecti

107 Such foldamer catalysts are shown to form an autocatalytic se

108 centers, promising a generation of synthetic foldamer catalysts for enantioselective transformations

109 he binding site, and reversibly switches the foldamer chain between its left and right-handed conform

110 tatistical mechanical partition functions of foldamer chain molecules.

111 Two epimeric series of foldamers characterized by the presence of a repeating a

112 series of oligomers forms ordered beta-turn foldamers, characterized by a 311 pattern.

113 development of a new class of antimicrobial foldamers combating emerging antibiotic-resistant pathog

114 ies of aromatic helix-sheet-helix oligoamide foldamers composed of several different photosensitive d

115 mational ordering of this important class of foldamer compounds.

116 studied as important examples of biomimetic "foldamer" compounds, as they exhibit a capacity to popul

117 creasingly important class of peptidomimetic foldamers comprised of N-alkylglycine units that have be

118 Foldamers consisting of at least 13 droplets exhibit ope

119 Synthetic foldamers consisting of beta-amino acids offer excellent

120 Peptidic foldamers, consisting of various amino acid based backbo

121 between molecules, as the three amphiphilic foldamer constitutional isomers that formed hydrogels up

122 Nanosized butterfly-coil foldamers containing alternating phenazine-1,6-dicarboxa

123 alpha/gamma-Peptide foldamers containing either gamma(4)-amino acid residues

124 characterization of new alpha/gamma-peptide foldamers containing the cyclically constrained gamma-am

125 Our aramid foldamers create artificial water channels with hydropho

126 ructure formed from an amphiphilic arylamide foldamer crystallized from aqueous solution.

127 It is not yet evident if foldamer design can be extended to reliably create terti

128 We thus present a unique foldamer design comprising a robustly folded core with f

129 elated to diverse building blocks and modern foldamer design principles, such as the stereochemical p

130 s expand the scope of heterogeneous-backbone foldamer design to a new tertiary structure class and sh

131 Previously we described a foldamer (designated 1 here) that was generated from GCN

132 The first step in foldamer development is to identify synthetic oligomers

133 lectrical measurements, we observed that the foldamer-dispersed SWCNTs are individually well-disperse

134 Under illumination, transistors based on the foldamer-dispersed SWCNTs demonstrated significant photo

135 Non-natural folded polymers (foldamers) display considerable versatility, and the des

136 The potential of foldamer drug candidates reaching the clinic is still a

137 r, we describe that rational designed hybrid foldamers exhibit potential in the detection of polynucl

138 uctures that have been identified in several foldamer families can serve as scaffolds for the predict

139 Presented herein is a foldamer for strand mimicry in which dipolar repulsion i

140 toids, have emerged as an important class of foldamers for the study of biomolecular interactions and

141 g interaction-mediated anion recognition and foldamer formation were further confirmed from geometry

142 ense of an otherwise achiral helical peptide foldamer formed from the achiral quaternary amino acids

143 ay during which the hole migrates across the foldamer from the acceptor to the donor.

144 rganized by the number of strands within the foldamer-from single- to triple-strand foldamers.

145 These facially amphiphilic foldamers have a relatively rigid intramolecular hydroge

146 therapeutic perspective, while polyaromatic foldamers have barely evolved from their nascency and re

147 ion to regulate chloride, aryltriazole-based foldamers have been created to "catch and release" chlor

148 based on self-organized aromatic oligoamide foldamers have been designed and prepared in their two e

149 Nonnatural foldamers have been developed to emulate these protein s

150 Novel unprecedented helical foldamers have been effectively designed and synthesized

151 Over the past decade, foldamers have progressively emerged as useful architect

152 Peptides and foldamers have recently gained increasing attention as c

153 ctures comparable to those found in nature ("foldamers") have considerable potential for use in a ran

154 adopt well-defined compact conformations, or foldamers, have been attained utilizing hydrogen bonding

155 Nonnatural folded polymers, or foldamers, have the potential for similar versatility, a

156 Using foldamers having controlled sequences, structures, and w

157 Starting from the crystal structure of the foldamer-hDM2 complex, we identified specific sites suit

158 the H-bonding pattern and the handedness of foldamer helices are rare so far.

159 Several foldamer helices featuring topologically distinct H-bond

160 cently reported water-soluble self-assembled foldamer helix bundle to encapsulate simple guest molecu

161 ping mechanism of hole transport through the foldamer helix, with individual hops occurring on the su

162 Foldamers, however, have not been explored as platforms

163 lation of guests by a complex self-assembled foldamer in aqueous conditions is possible.

164 The middle foldamer in the stack can be replaced by alternate seque

165 ies for achieving stable folding among short foldamers in aqueous solution.

166 s expected to prove useful for this class of foldamers in general.

167 emphasis of this review is on helical anion foldamers in solution, and many of the beautiful complex

168 e conformational analysis of ortho-phenylene foldamers in solution.

169 The behavior of the foldamers in the membrane phase is similar to that of an

170 ort o-phenylenes, a simple class of aromatic foldamers, into twisted macrocycles.

171 Foldamers involving mechanically entangled components wi

172 However, the charge density of the foldamer is one-half that of the natural polymer.

173 Screw-sense inversion in these helical foldamers is coupled with cyclohexane ring-flipping, and

174 his study, a new set of chirality controlled foldamers is provided to probe as biocompatible biopolym

175 n this perspective, the current knowledge of foldamers is reviewed in a drug discovery context.

176 was used to probe the inter-relationship of foldamer length, self-association strength, and ionophor

177 charge transfer is very fast considering the foldamer length.

178 injection rate is largely invariant for all foldamer lengths (ca. 60 ps), the subsequent hole transf

179 As a result, the foldamer-ligand mixture behaves as a biomimetic chemical

180 tetracarboxylic diimide (PTDI) units: linear foldamers lin2 and lin4, monocyclic complement cyc2, and

181 s in the main chain of N,N'-linked oligourea foldamers locally impairs the characteristic three cente

182 In contrast, neutral acetylated peptide-foldamer macrocycles demonstrated activity in a p53-depe

183 Small changes in the structure of a foldamer may lead to gross changes in conformational pre

184 Based on these findings, chain-centered foldamers might find use as models to investigate the fu

185 fined and predictable folding propensities ('foldamers') might lead to molecules with useful function

186 ong these are synthetic oligomeric peptide ("foldamer") mimics, which can display conformational orde

187 dy, we explored a kind of beta-sheet peptide foldamer, named beta(4)-TAT, to influence FUS aggregatio

188 lecularly H-bonded helically folded aromatic foldamers of 3.6 angstrom in hollow cavity diameter coul

189 Prior to heating, all foldamers of the series exhibited spectral characteristi

190 Many foldamers, oligomers that adopt well-defined secondary s

191 s between n = 1 on one side and longer chain foldamers on the other side.

192 The conformational selectivity of foldamers originates from the bulkiness of oligomers wit

193 future biomedical development of urea-based foldamer peptide mimics.

194 orm an mRNA display selection of macrocyclic foldamer-peptide hybrids.

195 and generated a small library of macrocyclic foldamer-peptide hybrids.

196 Analysis of the biological activity of the foldamer peptides showed that four anginex derivatives d

197 Foldamers present a particularly difficult challenge for

198 Foldamers provide an attractive medium to test the mecha

199 deciphering the dynamics of photoswitchable foldamers provides a detailed understanding of their pho

200 s valuable insight toward the development of foldamer quaternary assemblies with improved (bio)physic

201 A synthetic helical aromatic oligoamide foldamer receptor with high affinity and selectivity for

202 tly, the secondary structure of this minimal foldamer regulates its ability to dimerize dihydrofolate

203 he design of novel and functional biomimetic foldamers remains a major challenge in creating mimics o

204 ordinate the zinc ion is not affected by the foldamer replacement.

205 Higher-order foldamers represent a unique class of supramolecules at

206 opt well-defined secondary structures (i.e., foldamers) represent appealing components for the fabric

207 The foldamers retained the beta-sheet tendency, though with

208 Linear, cyclic, and concatenated foldamers reveal that photoabsorption and excitation ind

209 olecule fluorescence studies on chromophoric foldamers reveal that the maximum domain length is deloc

210 ative solvent binding, which then lowers the foldamer's Cl(-) affinity to normal levels.

211 lease using light-dependent control over the foldamer's degree of helix stabilization.

212 s, which highlights the critical role of the foldamer scaffold.

213 saccharides has the potential to afford more foldamer scaffolds with programmable properties and func

214 is an important challenge in peptidomimetic foldamer science.

215 The predictability of the foldamer secondary structure coupled to the high level o

216 permit both rational and modular control of foldamer secondary structure, while maintaining the capa

217 Although foldamer self-association in nonpolar chloroform increas

218 arginine and glutamic acid residues into the foldamer sequence.

219 ign approach that exploits the modularity of foldamer sequences and, in the case of aromatic amide fo

220 l polymers (supramolecular and covalent) and foldamers share the helix as a structural motif.

221 ntaining the same family of (R)-TFEA-labeled foldamers showed broadened but resolvable (19)F resonanc

222 mains challenging to design these so-called 'foldamers' so that they are capable of inducing or contr

223 ce of photoinduced structural changes in the foldamer, starting from the initial ultrafast isomerizat

224 B[n] family, it is possible to fold a single foldamer strand (3) into the CB[8].(a,a,a,s)-3 conformer

225 chalcogen bond donor atoms integrated into a foldamer structural molecular framework containing hydro

226 The review begins by discussing foldamer structure and nomenclature and follows with dis

227 e linkage may be introduced into Aib peptide foldamer structures by standard coupling methods and pho

228 the way for its use in the design of future foldamer structures.

229 However, examples of foldamer subunits within larger architectures remain rar

230 Non-hydrogen bonded foldamers such as those generated from 2,2-disubstituted

231 quid crystals, molecular switches, polymers, foldamers, supramolecular materials, molecular recogniti

232 The dynamic properties of foldamers, synthetic molecules that mimic folded biomole

233 ptoids", are a prototypical example of these foldamer systems and are known to form a helix resemblin

234 opology is seen in few natural and unnatural foldamer systems.

235 Along with other "foldamer" systems, peptoid oligomer sequences can be pre

236 r magnetic resonance (NMR) confirms that the foldamer targets the 3' and 5' ends of this G4.

237 on, with an additional time constant for the foldamer (tau = 150 ps), indicating the initial steps of

238 These results demonstrate the application of foldamer templates as therapeutics.

239 e crystal structure of an alpha/beta-peptide foldamer that adopts a tetrameric helix-bundle quaternar

240 synthesis, and structural analysis of a new foldamer that mimics an extended beta-sheet are presente

241 mulations of the first dynamic water-soluble foldamer that, in response to a stimulus, exploits relie

242 eviously, we reported an abiotic amphiphilic foldamer that, upon heating, undergoes an irreversible c

243 ve been exploited in the design of aedamers--foldamers that adopt a novel, pleated secondary structur

244 ilding blocks to prepare alpha/gamma-peptide foldamers that adopt a specific helical conformation in

245 ic N,N'-linked oligoureas are peptidomimetic foldamers that adopt a well-defined helical secondary st

246 Recent advances in functional foldamers that bind a single anion are examined, includi

247 cation and analysis of helical peptide-based foldamers that bind to a specific cleft on the anti-apop

248 We describe efforts to develop peptidic foldamers that bind to the irregular receptor-recognitio

249 ovel family of helically folded hybrid amide foldamers that can serve as powerful artificial proton c

250 tal structures of six new alpha/beta-peptide foldamers that have a regular alpha-residue/alpha-residu

251 lected stereoisomers, most of them being new foldamers that have been synthesized and characterized f

252 Two photoswitchable foldamers that incorporate azobenzene moieties as the en

253 n the achiral domain of the maleamide-linked foldamers that is absent from the fumaramides.

254 d small (molecular mass <1,000 Da) arylamide foldamers that mimic antimicrobial peptides.

255 The ability to design foldamers that mimic the defined structural motifs of na

256 Here we report heterogeneous-backbone foldamers that mimic the zinc finger domain, a ubiquitou

257 are helical alpha-aminoisobutyric acid (Aib) foldamers that replicate key parts of this information r

258 is to design unnatural backbone oligomers ("foldamers") that fold like natural peptides.

259 sequences and, in the case of aromatic amide foldamers, their amenability to structural elucidation,

260 Termed "foldamers," these agents have diverse potential applicat

261 e rise in predictable designs of abiological foldamers, this water-assisted strategy can, in principl

262 e we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant pept

263 to both ends of an mPE dodecamer induce the foldamer to collapse into a presumed helical conformatio

264 organizing and stabilizing an aryl-triazole foldamer to help extract hydrophilic chloride ions from

265 mbling guests exemplifies the amenability of foldamers to outstanding achievements in molecular recog

266 The ability of these foldamers to resist proteolysis, to mimic the small heli

267 ray to cooperatively interlock the ends of a foldamer together with its helical core.

268 eaction cycle is then set up to generate the foldamer transiently, in the presence of the self-replic

269 tinct folding patterns are identified in two foldamer-type urea-thiourea catalysts bearing a basic di

270 isioned to form the basis for butterfly coil foldamers undergoing reversible extension and contractio

271 ransitions of a donor-acceptor oligorotaxane foldamer using electrospray mass spectrometry interfaced

272 micking the properties of biomacromolecules, foldamers using solvophobic driving forces must be tempe

273 The most stable foldamer was composed of a total of 6 residues beginning

274 bis-hexameric oligo(m-phenylene ethynylene) foldamer was examined in 30 solvents to correlate the un

275 A foldamer was first identified that undergoes flexizyme-m

276 tion relations of beta-amino-acid-containing foldamers, we followed a top-down approach to study a se

277 e mechanism of action of these antimicrobial foldamers, we have investigated the lipid interaction, d

278 All of these foldamers were crystallized from aqueous solution, and a

279 The conformations of these foldamers were studied by fluorescence spectroscopy in h

280 The conformations of the foldamers were studied by UV, fluorescence, fluorescence

281 es, we studied oligo(m-phenylene ethynylene) foldamers, where the introduction of an endo-methyl grou

282 d, conformationally constrained, benzanilide foldamers which selectively bind the catalytic tunnel of

283 nce in a helical oligo(aminoisobutyric acid) foldamer, which is relayed to a reporter group at the re

284 Foldamers, which are oligomers with a strong tendency to

285 library of homologous rigid-rod 310-helical foldamers, which have incrementally increasing lengths a

286 add to the growing evidence that nonnatural foldamers will emerge as an important class of therapeut

287 e identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented secondary and

288 A chiral aryl-triazole foldamer with two azobenzene end groups has been synthes

289 rongest ionophoric activity was observed for foldamers with >10 Aib residues, which have end-to-end d

290 aves the way for development of beta-peptoid foldamers with a desired function, such as catalytic pro

291 he design and construction of nanostructured foldamers with actuator and sensory properties, which ma

292 Combining helical foldamers with alpha-peptides can produce alpha-helix mi

293 In contrast, foldamers with aryl rings in their main chains possess d

294 o folded nanostructures and hence are hybrid foldamers with biological sequences and synthetic proper

295 Oligocholate foldamers with different numbers and locations of guanid

296 ultraviolet spectra of three model synthetic foldamers with heterogeneous backbones, alpha/beta-pepti

297 as are the first examples of hydrogen-bonded foldamers with reversible hydrogen-bond directionality.

298 The development of foldamers with the ability to bind and encapsulate "gues

299 The ortho-phenylenes are a simple class of foldamers, with the formation of helices driven by offse

300 two such principles in the design of peptoid foldamers yields a new and unique secondary structure th