ライフサイエンスコーパス: force production

1 scle histology and restored muscle function (force production).

2 vidual sarcomeres within a myofibril affects force production.

3 ngles, a configuration that favors increased force production.

4 ng proper filament polarity and facilitating force production.

5 sin interactions and overall lowers myofibre force production.

6 in kinase (MLCK), a primary regulator of VSM force production.

7 s the thermodynamic driving force underlying force production.

8 rk, entanglement, mechanical interaction and force production.

9 ckground of inhibition, the greater the peak force production.

10 dergo large structural changes important for force production.

11 , mediating free energy changes that lead to force production.

12 f network cohesion and the lack of effective force production.

13 prepositioning the cross-bridge for optimal force production.

14 g actin nucleation and bending for increased force production.

15 d prevent both kinesins from contributing to force production.

16 tion at higher frequency for optimal tetanic force production.

17 n the MU-mode space during accurate cyclical force production.

18 modulate stiffness along the axis of muscle force production.

19 contractile dynamics toward more economical force production.

20 p abruptly transitions from motion to static force production.

21 affinity and affect dynein processivity and force production.

22 s important for efficient actin assembly and force production.

23 malian cochlea include the size and speed of force production.

24 a2+] and/or agents that inhibit cross-bridge force production.

25 against a simple-lever arm model for dynein force production.

26 ared outcome of prenatal defects in myofiber force production.

27 le) contraction, which influences economy of force production.

28 ein's enzymatic properties to its mechanical force production.

29 the pathway of coupling of ATP hydrolysis to force production.

30 leton and adhesions, that decreases traction force production.

31 and the substratum, which increases traction force production.

32 (96-148)) and (b) the calcium sensitivity of force production.

33 bility or to store energy in the polymer for force production.

34 d accuracy, faster reaction times and faster force production.

35 tabilizing microtubules and counterbalancing force production.

36 arcomere structure, as well as a decrease in force production.

37 ergo an ordered-to-ordered transition during force production.

38 ed thin filament sliding speed and isometric force production.

39 ord unified control of posture, movement and force production.

40 and suggest revising quantitative models of force production.

41 e compact, and only those substrates support force production.

42 Ca2+, thus altering the Ca2+ sensitivity of force production.

43 unction, and particularly movement time, and force production.

44 slated into a significant increase in muscle force production.

45 r repolarization of the action potential and force production.

46 Mice with stable SRX exhibited reduced force production.

47 reduced electrically evoked Ca2+ release and force production.

48 d, thus, myosin cross-bridge recruitment and force production.

49 ansport (NCOT) are not explained by rates of force production.

50 tant for contractile functions by increasing force production.

51 ed muscle and body mass, and impaired muscle force production.

52 site of myosin and its lever arm that drives force production.

53 te chemical and mechanical signals to direct force production.

54 responsible for the variability in traction force production.

55 aments in one sarcomere unexpectedly reduced force production.

56 Cs) presumably by their somatic motility and force production.

57 to decreased muscle mechanical stability and force production.

58 ring walking, reaching, flying, or isometric force production.

59 p with a remarkable enhancement in sustained force production.

60 le degeneration is dependent on exercise and force production.

61 al activity compared to observed or imagined force production.

62 agm muscle fiber size and diaphragm-specific force production.

63 weakness by decreasing Ca(2+)-induced muscle force production.

64 the tissues showed an additional increase in force production (1.34+/-0.19 mN/mm(2)), with no change

65 microtubule-binding activities required for force production [1].

66 esulted in the restoration of maximal-effort force production (266 +/- 19 N; P < 0.001) to levels not

67 llows for fast, processive movement and high force production (7 piconewtons).

68 exhibit an increase in muscle mass and total force production, a reduction in specific force, an accu

69 We further introduce two models of active force production: a cytoskeletal swelling force and a po

70 The task involved trading handgrip force production against monetary benefits.

71 rs exhibited a high correlation between mean force production and active workspace (R = 0.90).

72 ctomyosin bundles-are important for cellular force production and adaptation to physical stress and h

73 MV) results in reduced diaphragmatic maximal force production and diaphragmatic atrophy.

74 ithic processing technologies affect chewing force production and efficacy in humans consuming meat a

75 would, however, have facilitated aerodynamic force production and enhanced muscle power output for an

76 Mice with CKD displayed lower muscle force production and greater ischemic lesions in the tib

77 have elucidated the mechanism of ATP-driven force production and have helped unravel the conformatio

78 The mutant muscle displays decreased force production and increased mitochondrial lipid perox

79 eries, together with measurement of arterial force production and intracellular [Ca(2+)].

80 , our results suggest that cardiac myofibril force production and kinetics of activation and relaxati

81 that genetic factors that coordinately alter force production and mechanical resistance are common du

82 (1) Force production and mechanical resistance can be couple

83 ents within living cells accounting for both force production and mechanical stiffness.

84 uality, identifiable by reductions in muscle force production and mitochondrial respiratory capacity.

85 tin, resulting in increased velocity, higher force production and more effective competition against

86 ial to determining an atomic-level model for force production and motion by the motors.

87 However, its mechanism of force production and movement is not understood.

88 tical in vivo for the coordination of dynein force production and movement when the motor is heavily

89 into account the state dependence of muscle-force production and multijoint mechanics, I show that c

90 gmented nitric oxide (NO) on skeletal muscle force production and oxygen consumption ( VO2 ).

91 This limits force production and promotes muscle relaxation.

92 , like motor domain lesions, would influence force production and propagation.

93 coupled to tissue architecture, which change force production and pumping function in the diseased he

94 Heart rate, blood pressure, force production and ratings of perceived exertion were

95 , normalized whole body force, and increased force production and resistance to repeated contractions

96 Whereas all NTPs studied support force production and stiffness that vary by a factor 2 o

97 Dependence of force production and stress resistance on cross-sectiona

98 F-actin organization and by measuring tissue force production and structural stiffness of the blastop

99 mutants decreased the calcium sensitivity of force production and that the two missense mutations (Il

100 inal and transverse directions during active force production and that transverse strains are on aver

101 Force production and the propagation of stress and strai

102 old age and has implications for contractile force production and the rapid execution of motor tasks.

103 surface can work collectively for increased force production and travel distance.

104 ancement of displacement and 41% increase in force production, and a 36% increase in power output for

105 ression of NMJ-related genes, in situ muscle force production, and clearance of glycogen in conjuncti

106 or activities such as cell-shape regulation, force production, and cytokinesis.

107 by increasing the duration and magnitude of force production, and found LIS1 and NudEL to be essenti

108 The size, force production, and pathology of isolated gastrocnemiu

109 regarding the possibility of maximal muscle force production, and suggest that only 97% of the true

110 -terminal portion of troponin I in enhancing force production, and the severe impairment associated w

111 Both innervation and in vivo force production are enhanced when implantation of bioco

112 Muscle size and force production are thought to influence growth of the

113 developed a novel gel-based sensor to report force production as a tissue changes shape; we find that

114 s instead of the hindlimbs are recruited for force production as the wings are much more powerful tha

115 all the flat-plate wings in terms of usable force production as well as the ratio of lift to power b

116 te by slowing ATP-binding, resulting in high-force production at both homotetramer ends.

117 in skinned muscle fibers, thereby increasing force production at longer sarcomere lengths.

118 nvolvement of different muscle groups during force production at the distal (DT) and proximal (PR) ph

119 Two fatiguing exercises were used, involving force production at the distal phalanxes and at the prox

120 During force production at the other site, MVC dropped by 23 %.

121 the fatiguing exercise, but increased during force production at the other site.

122 the rates of mass and heat exchange and the force production between an organism and its environment

123 NL docking thus enhances force production but at a cost to speed and processivity

124 es with the rate, level, and coordination of force production but has little effect on preparatory pr

125 nificant decrement in diaphragmatic specific force production, but to a lesser degree than 12CMV and

126 MgATP, but all the data are consistent with force production by a lever arm mechanism for both subst

127 ere, we used computer simulations to analyze force production by an ensemble of myosin motors against

128 e of outer doublet microtubules, the site of force production by ciliary dynein.

129 Force production by Cin8p was directed toward the plus e

130 ling and common upper limit of mass-specific force production by cyclical motion motors has not been

131 been made on understanding the mechanism of force production by kinesins and myosins.

132 Force production by kinesins has been linked to structur

133 However, isolated reports of yeast-like force production by mammalian dynein have called intersp

134 investigated the energetics associated with force production by measuring the force generated by ski

135 Results for ATP and CTP, which do support force production by muscle fibers, are compared to those

136 response is distinct from a loss in specific force production by muscle, and that sarcolemma-localize

137 veral current hypotheses of the mechanism of force production by muscle, the primary mechanical featu

138 Force production by one finger was accompanied by involu

139 ers of a hand was accompanied by involuntary force production by other fingers (enslaving).

140 by one finger was accompanied by involuntary force production by other fingers (enslaving).

141 Force production by some fingers of a hand was accompani

142 Peritonitis decreased maximal force production by the diaphragm (23.6+/-0.6 versus 21.

143 During heart failure, force production by the heart decreases.

144 in several fields, such as the following: i) force production by the myofibroblast and mechanisms of

145 grel dogs (n= 6) K(+) infusion did not alter force production by the skeletal muscle.

146 ng transport, there was little evidence that force production by the two opposing motors was competit

147 Force production by type IV pilus retraction is critical

148 The biophysics of force production by various kinesins is known in detail.

149 Membrane electromechanical force production can occur at speeds exceeding those of

150 to be the result of a basic deficit in their force production capacity or to be a compensatory mechan

151 s with widely divergent demands in regard to force production, capacity to move processively, and spe

152 lted in a significantly greater reduction in force production compared to CON (65.7 +/- 35.6%; P < 0.

153 e at day 2 to 3 showed a marked reduction in force production compared to that of control littermates

154 ce have an increase in muscle blood flow and force production, compared with the mdx mice.

155 lationship between cardiac morphogenesis and force production (contractility).

156 gate the effects of [OM] on Ca(2+)-activated force production, cross-bridge kinetics, and myocardial

157 mechanism by which muscle function shifts as force production declines, from motor to spring.

158 The PNB attenuated force production despite encouragement to attain the sam

159 , and suggests that the mechanism for dynein force production differs substantially from that of othe

160 e conclude that biaxial strain during active force production distinguishes aponeuroses from free ten

161 reased SR Ca(2+) leak at rest, and depressed force production due to impaired SR Ca(2+) release upon

162 nts that contribute to reduced smooth muscle force production during altered metabolism.

163 s the ability of skeletal muscle to maintain force production during and after exercise.

164 properties of muscle limit maximal voluntary force production during anisometric tasks, i.e., when mu

165 t illustrate the basic processes involved in force production during ATP binding.

166 ymerizing actin to membranes and so mediates force production during compensatory endocytosis.

167 cortex in structural units called nodes for force production during cytokinesis.

168 reduces skeletal muscle mass, strength, and force production during isometric contractions.

169 ertebrate morphogenesis, is not required for force production during late gastrulation and early neur

170 To test whether depolymerization can explain force production during nematode sperm crawling, we cons

171 , peak Ca(2+) transient amplitude and muscle force production during repetitive stimulation are incre

172 performance, which was indicated by reduced force production, fatigue resistance, and sarcoplasmic r

173 there are two possible mechanisms underlying force production for cell motility: the focal adhesion m

174 tubule binding by Ska, rather than acting in force production for chromosome movement, may instead se

175 In contrast, OM does not increase myocardial force production for maximal Ca(2+)-activated conditions

176 due to slower muscle kinetics and decreased force production; force production was reduced because f

177 via alpha(5)beta(1) integrin, depresses the force production from papillary muscle bundles, partly a

178 To distinguish contributions to force production from the mechanotransducer (MET) channe

179 ity greatly reduced the impact that impaired force production had on absolute peak power.

180 esults in a decreased calcium sensitivity of force production (half-maximum at 2.5 vs. 1.3 microM cal

181 This 'reverse transduction' force production has never been demonstrated experimenta

182 ts of OM on cross-bridge kinetics and muscle force production have been conducted at subphysiological

183 because the cross-bridge states involved in force production have yet to be elucidated, the effects

184 ults suggest a novel mechanism for enhancing force production in a muscle, and may be relevant to und

185 the efficient coupling of ATP hydrolysis to force production in a processive reaction whereby force

186 heral nerve reinnervates muscle and restores force production in adult cats, the muscle does not resp

187 However, the role of OHC force production in cochlear amplification and frequency

188 cal effects facilitate increases in traction force production in domains exhibiting decreased actin n

189 conditions would have augmented aerodynamic force production in early forms of flying insects.

190 hysiological functions is the enhancement of force production in fast twitch skeletal muscle fibres.

191 production in a processive reaction whereby force production in forming a tight microtubule complex

192 and to what extent 4AP could enhance muscle force production in HCSMA.

193 lting in a small but significant increase in force production in isolated single fibres and indicatin

194 te (BDP) and prednisolone acetate (PDNA), on force production in isolated, intact, mouse skeletal mus

195 In addition, muscle force production in isometric contraction was increased

196 ion area, levels of contractile proteins and force production in isometric contractions.

197 , leads to pronounced muscle hypertrophy and force production in mice and monkeys.

198 own to increase myofibre calcium release and force production in mouse skeletal muscle during contrac

199 sponding nucleotide triphosphates to support force production in muscle fibers.

200 eparations to develop the hypotheses that 1) force production in myofibrils is largely altered and re

201 We conclude that force production in myofibrils is largely regulated by i

202 , which demonstrated a dramatic reduction in force production in nebulin-deficient skeletal muscle.

203 echanism, regulating structural assembly and force production in relation to cell migration and mecha

204 ials caused a 25-40 % reduction in diaphragm force production in response to bilateral phrenic nerve

205 l sites for interaction with myosin, enhance force production in response to pressure.

206 Direct measurements of isometric force production in single cardiac myocytes demonstrated

207 expression increased the Ca2+ sensitivity of force production in single cardiac myocytes in a transge

208 nemius aponeurosis during active and passive force production in situ.

209 t amino acid residues 110-121 that inhibited force production in skinned carotid artery.

210 ADP dose-dependently increased force production in the absence of Ca(2+) in membrane-pe

211 mol/L, the N-terminal C0C2 peptide activated force production in the absence of calcium (pCa 9).

212 ast, there is no decrease in maximal tetanic force production in the mutant diaphragm or soleus muscl

213 for geometrical and mechanical patterning of force production in tissues.

214 ortening velocity at the time of peak muscle force production increased with walking speed, impairing

215 ative capacity and a significant decrease in force production indicative of lack of efficient myoblas

216 With no effect on muscle force production, inhibiting alphaARs (phentolamine; 10(

217 With no effect on muscle force production, inhibiting alphaARs improved ROV in ol

218 ate of relaxation (lusitropy), and increased force production (inotropy) in response to epinephrine.

219 There is significant interest in quantifying force production inside cells, but since conditions in v

220 smooth muscle that a significant portion of force production is associated with ADP release.

221 In support of this model, mechanical force production is compromised and cell proliferation i

222 This correlation between step size and force production is consistent with a molecular gear mec

223 behaviour of the aponeurosis during passive force production is consistent with uniaxial loading, as

224 voltage-gated Ca2+ release, maximal tetanic force production is decreased and the force frequency cu

225 (3) Force production is distributed between neural and mesod

226 ss; muscle core pO2 approximately 400 mmHg), force production is enhanced but control of contractilit

227 d (approximately 11 microm/h), yet the total force production is five times higher on FN than RGD (ap

228 ations of purified LDs, where duration of LD force production is more than doubled.

229 the two heads of myosin II during motion and force production is poorly understood.

230 How myosin II force production is shaped by isoform-specific motor pro

231 uncertain, and the mechanism of MT-dependent force production is unknown.

232 Foot contact time, a proxy for rate of force production, is a strong predictor of locomotor ene

233 n Ca(2+) dependence of myofilament isometric force production, isometric ATPase rate, and thin filame

234 in order to spatially and temporally control force production-issues that touch on fundamental aspect

235 MLC levels, which is critical for mechanical force production, likely through the direct induction of

236 Actomyosin networks, the cell's major force production machineries, remodel cellular membranes

237 ormed during single- and multifinger maximal force production (maximal voluntary contraction, MVC) fo

238 In analogy to the actomyosin-based force production mechanism in striated muscle, it was or

239 lyte slime ejected from these nozzles as the force production mechanism, and our experiment found a l

240 ssue and modify AChR mRNA expression, muscle force production, motor endplate area, and innervation s

241 investigations and models of skeletal muscle force production must incorporate Tmods.

242 imately 20 nm/mV for 50-microm-long cell and force production of 0.1 nN/mV by the cell.

243 The force production of a bidirectional kinesin-5 has not ye

244 We evaluate five models for isometric force production of a well-studied model system: the loc

245 eins and insulin-like growth factor 1 on the force production of engineered skeletal muscle was chara

246 is1 does not directly alter the stepping and force production of individual dynein motors assembled w

247 To investigate the force production of mouse motor units, we simultaneously

248 In this study we examined the force production of sperm reactivated with 0.1 mM ATP wi

249 its activation of myosin ATPase activity and force production of striated muscles at low free Ca(2+)

250 th heads contributing equally to the maximal force production of the dimer.

251 Absolute force production of the extensor digitorum longus muscle

252 contribution from an increase in the maximum force production of the myofibrils.

253 stroglycan and integrin alpha7 contribute to force-production of muscles, but that only disruption of

254 Conversely, forced production of ALDH2 sharply diminished the N(2)-e

255 anism dictates the pattern of transcription--forcing production of monocistronic mRNAs--and the patte

256 ere arise physical limits to the accuracy of force production on contact.

257 nonsignificant decrease in diaphragm tetanic force production over the experiment in the ventilated-p

258 g the stimulation frequency causes increased force production per unit calcium concentration and decr

259 te directly to kinetochore-MT attachment and force production, perhaps by forming a sliding ring enci

260 For each group, diaphragm force production, posttranslational modification of ryan

261 associated with mitochondrial proton-motive force production preferentially in the cell periphery an

262 hese observations, we present a theory where force production, rather than displacement, was selected

263 tional arm movements; namely, that attempted force production recruits more neural activity compared

264 How birds coordinate aerodynamic force production relative to changes in body orientation

265 apoptosis proteins were down-regulated, but force production remained normal.

266 Aberrant regulation of myocardial force production represents an early biomechanical defec

267 However, force production required in the polymerization model is

268 lecular-mechanical model of MT structure and force production shows that a single depolymerizing MT c

269 gen that contain the RGD motif, also reduced force production significantly.

270 ing myocardium is characterized by decreased force production, slowed relaxation, and depressed respo

271 hen regenerated myofibres matured and active force production stabilized.

272 ditions to be met for models of cytoskeletal force production, such as the dynamic network contractio

273 s elements (sub-synergies) of a multi-finger force production synergy, while only inhibitory projecti

274 Despite the force production task consisting of uncommon digit force

275 , high-fidelity enzymatic reaction cycle for force production that does not require elongating filame

276 ave shown that mavacamten inhibits sarcomere force production, thereby reducing cardiac contractility

277 Motors that use force production to accomplish steady translational moti

278 ations to alter the direction of aerodynamic force production to change their flight trajectory.

279 uture: first, characterizing the coupling of force production to chemical and mechanical changes in m

280 l microfilaments at the edge are involved in force production to drive the cell margin forward while

281 del system for analyzing mechanisms coupling force production to microtubule plus-end polymerization/

282 used fascicle shortening at the time of peak force production to shift to much slower velocities.

283 Whole-muscle force drops from peak force production to zero with just a few micrometers of

284 ically adaptive; dorsal tissues can increase force production up to threefold to overcome a stiffer m

285 d ATPase and in vitro motility but increased force production using an optical trap.

286 nity cross-links, but they can transition to force production via the positive-feedback mechanism des

287 6 hours of mechanical ventilation, diaphragm force production was decreased by 25-30%, restored to th

288 Force production was largely independent of the directio

289 vidence for agonist-induced Ca2+-independent force production was observed.

290 cle kinetics and decreased force production; force production was reduced because fewer mutant myosin

291 At the cellular level, single muscle fibre force production was reduced in OA patients in myosin he

292 After 24 hrs, diaphragm force production was significantly lower in mechanically

293 For measuring axial stiffness and force production, we used an experimental configuration

294 n SOCE, constitutive Ca(2+) entry and muscle force production were lost in mice with muscle-specific

295 When symmetrical sites of force production were used in the two hands, BD was lowe

296 NudE abrogates dynein force production, whereas LIS1 alone or with NudE induce

297 Anticipatory force production with both familiar and novel objects wa

298 d the same steep Ca(2+) dependence as active force production, with a Hill coefficient (n(H)) close t

299 This enables subsequent force production, with cross-bridge targeting further en

300 ongly-bound cross-bridges and rate of myosin force production, with the larger parameter reductions i