ライフサイエンスコーパス: foregut

1 ed ability to localize to and block the flea foregut.

2 es the NCC population that migrates into the foregut.

3 netic protein (BMP) signaling in the Xenopus foregut.

4 n, in which the stomodeal ectoderm joins the foregut.

5 Lkr neurons innervate the foregut.

6 specify lung endoderm progenitors within the foregut.

7 lung endoderm progenitors in the developing foregut.

8 ung endoderm progenitors within the anterior foregut.

9 ion of mammalian HCC, a lethal cancer of the foregut.

10 ea midgut but does not form a biofilm in the foregut.

11 of Y. pestis to produce biofilm in the flea foregut.

12 host embryos are restricted to the proximal foregut.

13 develop from endoderm cells in the embryonic foregut.

14 oliferative response of the anterior ventral foregut.

15 eby influencing patterning and growth of the foregut.

16 Fgf10) in the prospective lung region of the foregut.

17 ocated at the dorsal-ventral boundary of the foregut.

18 oused in specialized organs connected to the foregut.

19 e determination from pre-specified embryonic foregut.

20 ively regulates BMP ligand expression in the foregut.

21 the definitive ventral endoderm forming the foregut.

22 lution cell state map of the embryonic mouse foregut.

23 ancreatic gene regulatory network within the foregut.

24 nts sampled along transects and from gosling foreguts.

25 induction of both lung buds in RA-deficient foreguts.

26 regulation of Tgfbeta targets in Raldh2-null foreguts.

27 field of both Raldh2-null and BMS493-treated foreguts.

28 %) were autologous reconstructions; 88 (44%) foregut, 100 (51%) midgut, and 10 (5%) hindgut.

29 e kiwifruit fibre was highly digested in the foregut (80%), and the insoluble fibre in the hindgut (9

30 that most microspheres were retained in the foregut after dietary exposure due to adherence to the h

31 result, neuroendoderm precursors form in the foregut aided by retention of a SoxB1-dependent pluripot

32 or extent of the embryo and initiates heart, foregut and brain development.

33 A subpopulation of vagal NCCs invades the foregut and colonises the entire gastrointestinal tract

34 which form an epithelial bridge between the foregut and epidermis, but little is known about how dev

35 major morphological events in the developing foregut and eye from Carnegie Stages 12 and 13 human emb

36 Amylase is elevated in the foregut and has been used to confirm anastomotic integri

37 ctomyosin contraction drive formation of the foregut and heart tube in the early chick embryo.

38 As early foregut and heart tube morphogenesis are intimately rela

39 nal portal generates tension to elongate the foregut and heart tube.

40 s establish a role for Notch activity in the foregut and highlight the importance of cellular context

41 e expression of genes involved in bilaterian foregut and hindgut patterning during the development of

42 we identified the transcriptomes of Xenopus foregut and hindgut progenitors, which are conserved wit

43 catenin acts as a genome-wide toggle between foregut and hindgut programs.

44 rom neural crest cells (NCCs) that enter the foregut and hindgut to become enteric neural-crest-deriv

45 Firmicutes and Melainabacteria in the murine foregut and hindgut.

46 have disrupted global Notch signaling in the foregut and in the lung during the initial stages of mur

47 ial role in the embryonic development of the foregut and is orthologous to genes encoding the mammali

48 eveal that lncRNAs play an important role in foregut and lung endoderm development by regulating mult

49 organization of the head as well as neural, foregut and mesoderm tissue formation.

50 an be established by the juxtapositioning of foregut and midgut tissues, and potentially serves as a

51 shaped intestinal segment, derived from both foregut and midgut, are often overlooked in clinical pra

52 es, OnTry-G2, was highly expressed in larval foregut and midgut, whereas another group, OnTry-G3, was

53 ng netrin-1 were expressed in the developing foregut and midgut; netrin-1 immunoreactivity was detect

54 elopment, vagal neural crest cells enter the foregut and migrate in a rostro-to-caudal direction, col

55 The foregut and oral tissues converge at the primary mouth,

56 analysis at later stages revealed a loss of foregut and pancreatic endoderm.

57 se embryonic mesenchyme during the time when foregut and pancreatic progenitors are specified and tes

58 emerge from the caudal hindbrain, invade the foregut and populate the gastrointestinal tract.

59 vagal neural crest cells that migrate to the foregut and subsequently colonize and innervate the enti

60 sically altered by their passage through the foregut and were excreted with a smaller overall size an

61 so observed differences between regurgitant (foregut) and midgut bacterial communities of the same in

62 ation in Capitella, which include the brain, foregut, and terminal growth zone.

63 us mammals, which are generally grouped into foregut- and hindgut-fermenters.

64 e products of microbial fermentation in both foregut- and hindgut-fermenting folivorous primates.

65 the differentiation and morphogenesis of the foregut are controlled by several transcriptional regula

66 minal short-chain fatty acids (SCFAs) in the foregut are unknown.

67 rive from migration of ectoderm cells to the foregut, as shown by lineage tracing with the photoactiv

68 ation of the various organs of the posterior foregut, as well as in pancreas and gut endocrine cell d

69 Cells of the posterior foregut assume a pancreatic identity, cells within the e

70 senchyme promotes medial constriction of the foregut at the boundary between the presumptive Sox2+ es

71 Foregut bariatric surgery can be quite effective in impr

72 important in delaying tumor initiation from foregut basal progenitor cells expressing pre-existing t

73 nating from tumor-competent Krt5(+)/Krt15(+) foregut basal progenitor cells.

74 report that the ability to produce a normal foregut-blocking infection depends on induction of the Y

75 human pancreatic specification in the distal foregut, bud formation, and early development.

76 expressed dynamically within the developing foregut, but how its expression characteristics are link

77 , and liver arise from the posterior ventral foregut, but the cell-intrinsic pathway by which these o

78 iciency could be reproduced in RA-sufficient foreguts by hyperactivating Tgfbeta signaling with exoge

79 t it occurs via repulsion of Robo-expressing foregut cells away from the Slit ligand source.

80 In addition, the ventral foregut cells lose adhesion and fail to form a polarized

81 ted decreased proliferation; in addition the foregut cells were enlarged with a randomized orientatio

82 -free media to induce formation of posterior foregut cells, which were differentiated in 3 dimensions

83 tury, scientists have hypothesized that this foregut chamber houses a microbial community, yet this h

84 nts also exhibit stomach segmentation with a foregut chamber proximal to the stomach.

85 ic day (E) 8.5 because of failure of ventral foregut closure and cardiac bifida, whereas GATA6 is ess

86 e movement of tissue progenitor cells during foregut closure.

87 hs possess a highly conserved, low-diversity foregut community with a highly abundant Neisseria speci

88 dorsal (oesophageal) from ventral (tracheal) foregut components-is a crucial event in gastro-respirat

89 A prospectively maintained multidisciplinary foregut database was reviewed for consecutively enrolled

90 Development of more posterior foregut derivatives (stomach and duodenum), as well as l

91 Development of foregut derivatives can be partly restored in mutants by

92 Among distal foregut derivatives, the gastric corpus, antrum, pylorus

93 mous epithelium from definitive and anterior foregut derived cultures.

94 k is a central process in the development of foregut-derived organs.

95 ption factors in the development of anterior foregut-derived tissues and demonstrating functional coo

96 rs Foxp2 and Foxp1 are expressed in multiple foregut-derived tissues including the lung and intestine

97 tracheal organoid units (TOUs) as a model of foregut development and differentiation in vitro, NOG de

98 l stages of ventral morphogenesis, including foregut development and positioning of head and heart.

99 lear factor 3beta (HNF3beta) is essential in foregut development and the regulation of lung-specific

100 In early Caenorhabditis elegans foregut development, the pioneer factor PHA-4/FoxA binds

101 these progenitor cells are specified during foregut development.

102 e cell fate and morphogenesis during Xenopus foregut development.

103 Foregut division-the separation of dorsal (oesophageal)

104 ancreas from a small cluster of cells in the foregut domain of the mouse embryo.

105 rotein complex, is co-expressed with SOX9 by foregut ductal progenitors in the developing human liver

106 In the foregut, ENCC migrated through areas devoid of establish

107 ifferentiate pluripotent cells into anterior foregut endoderm (AFE) derivatives would expand their ut

108 Subsequently, lung-biased anterior foregut endoderm (AFE) is specified by sequential inhibi

109 However, the foregut endoderm also expresses the Wnt-receptor Frizzle

110 ctive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesod

111 on factor Islet1 (Isl1) is expressed in both foregut endoderm and cardiogenic mesoderm and is require

112 blishing the developmental competence of the foregut endoderm and in initiating liver specification.

113 d for robust osr1 and osr2 expression in the foregut endoderm and surrounding lateral plate mesoderm

114 r the establishment of competence within the foregut endoderm and the onset of hepatogenesis.

115 ung epithelial primordial progenitors of the foregut endoderm are thought to be the developmental pre

116 N family protein Cerberus within presumptive foregut endoderm as essential for differentiation of car

117 Although the PI3K pathway is activated in foregut endoderm cells, its inhibition does not block he

118 e notochordal plate, prechordal mesoderm and foregut endoderm during gastrulation.

119 The notochord was adjacent to the dorsal foregut endoderm during the fourth week of development b

120 ely, RA receptor function is required in the foregut endoderm for insulin expression, but not in meso

121 h the establishment of competence within the foregut endoderm for responding to organ-specific signal

122 , we propose that the S1P-dependent anterior foregut endoderm functions primarily through Shh to regu

123 s of Nkx2-1(+) progenitors in the developing foregut endoderm give rise to the entire postnatal lung

124 During organogenesis, the foregut endoderm gives rise to the many different cell t

125 ng early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cel

126 marker for developing liver and pancreas in foregut endoderm has recently been shown to interact wit

127 egulating thyroid lineage specification from foregut endoderm in mouse and Xenopus.

128 loss of hdac1 results in an expansion of the foregut endoderm in the domain from which the liver and

129 The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox

130 tion of beta-Catenin (also termed Ctnnb1) in foregut endoderm leads to absence of both the trachea an

131 Loss of Sin3a in mouse early foregut endoderm led to a specific and profound defect i

132 ding indicates that Pdx-1 is required in the foregut endoderm prior to Ptf1a for pancreatic MPC speci

133 However, the molecular pathways specifying foregut endoderm progenitors are poorly understood.

134 ion of the expression domains of several key foregut endoderm regulators.

135 lls are derived from cell progenitors in the foregut endoderm that subsequently differentiate into th

136 he liver and pancreas are specified from the foregut endoderm through an interaction with the adjacen

137 light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopa

138 yngeal pouches, which form by budding of the foregut endoderm, are essential for segmentation of the

139 alian pulmonary progenitors from the ventral foregut endoderm, but their epistatic relationship and d

140 tissues are both derived from the posterior foregut endoderm, however, the interdependence of these

141 In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression

142 The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and plays a

143 blished that the fetal liver originates from foregut endoderm, the identity of the mechanisms that ma

144 bryonic stem cells (ESCs) was converted into foregut endoderm, then into replicating Nkx2.1+ lung end

145 with differentiation of cells into anterior foregut endoderm, which is followed by their lineage spe

146 re regulated by hedgehog expression from the foregut endoderm, which is required for connection of th

147 Sox2 is expressed in developing foregut endoderm, with highest levels in the future esop

148 In contrast, other foregut endoderm-derived organs, including the thyroid,

149 helial lineages that arise from the anterior foregut endoderm.

150 rise in close proximity from the multipotent foregut endoderm.

151 swim bladder development from a multipotent foregut endoderm.

152 lishment of respiratory progenitors in mouse foregut endoderm.

153 of both trachea and lung, initiates from the foregut endoderm.

154 ce, Sonic hedgehog (Shh) is downregulated in foregut endoderm.

155 ding appropriate pancreas formation from the foregut endoderm.

156 vates a transcriptional program of embryonic foregut endoderm.

157 id-lineage specification, respectively, from foregut endoderm.

158 s, we identified 363 lncRNAs in the lung and foregut endoderm.

159 ive domain for Wnt signaling activity in the foregut endoderm.

160 maintaining pancreas identity by regulating foregut endodermal fates.

161 xclusively in the cytoplasm of epidermal and foregut epithelia, where it forms belt-like filaments ar

162 human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons.

163 Dying cells localise to the fusing foregut epithelial ridges, with disturbance of this apop

164 e that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function

165 rp5 is expressed in the surface cells of the foregut epithelium, whereas wnt11 is expressed in the un

166 nversion caused by ectopic activation of the foregut/esophageal differentiation program.

167 provide potential mechanistic insights into foregut exclusion in RYGB and identify SGLT3 as a possib

168 rew selectively toward cocultured E14 distal foregut explants (P < 0.01).

169 activity in the posterior endoderm inhibits foregut fate while promoting intestinal development.

170 ch Hdac1 may directly or indirectly restrict foregut fates while promoting hepatic and exocrine pancr

171 related with the plant-feeding adaptation of foregut-fermenting herbivores.

172 In foregut-fermenting mammals (e.g., colobine monkeys, arti

173 or the physical mechanisms of heart tube and foregut formation.

174 questions concerning the traditional view of foregut formation.

175 del in which RA signaling is absent from the foregut from its earliest developmental stages.

176 Our findings suggest that separation of the foregut from the body wall is genetically controlled and

177 ragm malformation is a delayed separation of foregut from the dorsal body wall.

178 bal gene expression analysis of RA-deficient foreguts from a genetic [retinaldehyde dehydrogenase 2 (

179 We show that in the foregut Fzd7 signals via both the Wnt/beta-catenin and W

180 Depletion of Sfrp5 results in reduced foregut gene expression and hypoplastic liver and ventra

181 tain robust pSmad1 levels, causing a loss of foregut gene expression and organ agenesis.

182 rare, should be considered in patients with foregut GISTs; (2) GISTs associated with Carney's syndro

183 The mammalian foregut gives rise to the dorsally located esophagus and

184 Migration of the AIP to form foregut has been descriptively characterized(8,9), but t

185 type (eg, laparoscopic vs open, intestinal, foregut, hepatopancreaticobiliary vs abdominal wall proc

186 rp5 locally inhibits Wnt11 to maintain early foregut identity and to allow an epithelium to form over

187 pressed in the anterior endoderm to maintain foregut identity and to allow liver and pancreas develop

188 ion factor that is required to establish the foregut in embryos and to control growth and longevity a

189 SOX2 is expressed in the developing foregut in mouse and zebrafish embryos and an apparently

190 reas and lung originate from the presumptive foregut in temporal and spatial proximity.

191 Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activit

192 ion and adherence of the biofilm to the flea foregut is essential for transmission.

193 e anterior paraxial mesoderm adjacent to the foregut is necessary for the development of insulin-expr

194 y abundant Neisseria species associated with foregut lactate.

195 future segments as well as in the brain and foregut; later, CapI-Notch, CapI-Delta, and CapI-hes2 tr

196 We found normal foregut lengthening despite failure of tracheo-oesophage

197 lls (cDE cells) are specified into posterior foregut-like progenitor cells (cPF cells).

198 ndodermal stem/progenitor cells committed to foregut lineage, possesses potent antioncogenic activity

199 on Six3, both of which are expressed in the foregut lineage.

200 trin from stem/progenitor cells committed to foregut lineage.

201 ndodermal stem/progenitor cells committed to foregut lineage.

202 ing and morphogenetic segregation of ventral foregut lineages.

203 restored proper transgene expression in the foregut, liver, and lung mesenchyme and prevented ectopi

204 The foregut lpm of Osr1/Osr2-depleted embryos fails to expre

205 obox gene hhex, which is one of the earliest foregut markers and is essential for liver and pancreas

206 in human PanIN prompted assessment of other foregut markers by both semiquantitative and real-time r

207 These data show frequent up-regulation of foregut markers in early PanIN lesions and suggest that

208 resulted in up-regulation of the majority of foregut markers seen in early PanIN lesions.

209 this analysis, a cluster of extrapancreatic foregut markers, including pepsinogen C, MUC6, KLF4, and

210 orts the hypothesis that luminal SCFA in the foregut may contribute towards the generation of functio

211 t2 and wnt2b are regulated in the developing foregut mesenchyme is unknown.

212 Ablation of COUP-TFII in the foregut mesenchyme, including the posthepatic mesenchyma

213 We found that woodrats house foregut microbial communities with similar density and v

214 toed sloths have a more variable and diverse foregut microbiota correlated with a variety of SCOAs.

215 The foregut microbiota may provide a number of physiological

216 We hypothesise that adaptation of the foregut microbiota to creosote PSCs in experienced woodr

217 rmite Cornitermes cumulans gut compartments (foregut, midgut, mixed segment and hindgut p1, p3, p4, a

218 ry-pancreatic organ domains specified at the foregut-midgut boundary organoids in the absence of extr

219 cent of tissues derived from mouse explanted foregut-midgut culture.

220 e transcription factor Sox2 is necessary for foregut morphogenesis and esophagus development.

221 ISL1 is a critical player in the process of foregut morphogenesis, acting in a small progenitor popu

222 active septation was observed only in normal foregut morphogenesis, indicating a primary role for sep

223 often resulted in cardia bifida and abnormal foregut morphogenesis.

224 , we examined three outstanding questions of foregut morphogenesis.

225 rphogenesis, particularly implicating Shh in foregut morphogenesis.

226 s infects and replicates as a biofilm in the foregut of cat fleas in a manner requiring hmsFR, two de

227 highly expressed in neuronal tissues and the foregut of embryonic day 8.5 (E8.5) embryos and the head

228 gent of plague, replicates as biofilm in the foregut of fleas that feed on plague-infected animals or

229 rial agent of plague, forms a biofilm in the foregut of its flea vector to produce a transmissible in

230 By contrast, the abnormal foregut of Nkx2.1-null embryos expresses elevated Sox2 a

231 ed after it forms a bacterial biofilm in the foregut of the flea vector that interferes with normal b

232 an-fate commitment from within the posterior foregut of the mammalian endoderm is largely unexplored.

233 ntion site of CCYV virons was located in the foregut of virion-fed vectors.

234 ing force exerted by the elongating pharynx (foregut) on the anterior epidermis during C. elegans emb

235 n of virions, were localized in the anterior foregut or cibarium of a whitefly vector biotype but not

236 d virion retention mechanism in the anterior foregut or cibarium of whitefly vectors.

237 verticulated crop is a unique and overlooked foregut organ in the Diptera that affects many physiolog

238 oderm-mesoderm interactions that orchestrate foregut organogenesis.

239 f the anterior endoderm, which gives rise to foregut organs such as the liver, ventral pancreas, thyr

240 ve attempted to rearrange the anatomy of the foregut organs to stop reflux with minimal success.

241 d specifying the anteroposterior location of foregut organs.

242 specification in a molecular pathway linking foregut pattering by FGFs to Wnt-mediated lung specifica

243 Sox2 and Nkx2.1 during early dorsal/ventral foregut patterning.

244 yonic blastomeres in C. elegans develop into foregut (pharynx) cells in response to the selector gene

245 stablished within the Caenorhabditis elegans foregut (pharynx).

246 inal portal which rolls caudally to form the foregut pocket.

247 lier molecular mechanisms that establish the foregut precursors are largely unknown.

248 of hPSCs into endoderm and subsequently into foregut progenitor (FP) cells, followed by the generatio

249 Fzd7-depleted embryos failed to maintain the foregut progenitor marker hhex and exhibited decreased p

250 w that BMP signaling is required to maintain foregut progenitors and induce expression of the secrete

251 two cell types each originate from Nkx2-1(+) foregut progenitors and the minimal pathways claimed to

252 erentiation in vitro, NOG determines whether foregut progenitors differentiate toward esophageal or t

253 that beta-catenin activation in hPSC-derived foregut progenitors promoted the development of human fu

254 Wnt signaling that is essential to maintain foregut progenitors.

255 n the anterior to allow the specification of foregut progenitors.

256 Patterning of the primitive foregut promotes appropriate organ specification along i

257 ieve transmission by biofilm blockage of the foregut proventriculus of its flea vector.

258 .5 and E8.5, lack active RA signaling in the foregut region.

259 We found that insect foreguts release prophenoloxidases into the lumen, and t

260 on of the lung primordium from the primitive foregut remain unclear.

261 e dorsal and ventral aspects of the anterior foregut, respectively.

262 gut-specific Fzd7-depletion from the Xenopus foregut resulted in liver and pancreas agenesis.

263 as ectopic Notch activation in the embryonic foregut results in reversible defects in villus morphoge

264 ytic activities observed in each gut region (foregut+salivary gland, midgut and hindgut).

265 d transcription factors involved in anterior foregut separation continue to play important roles in t

266 Foregut separation is a rarely considered morphogenetic

267 poptosis in the Apaf1 mutant did not prevent foregut separation, indicating that apoptosis is not req

268 in Adriamycin-treated embryos with defective foregut separation.

269 signaling is identified in tracheoesophageal foregut septation, as animals lacking the cytoplasmic do

270 Explant culture of RALDH2-deficient foreguts show a capacity to undergo lung budding and ear

271 Similar analysis of wild type foregut shows that endogenous RAR alpha activity is requ

272 Foregut-specific Fzd7-depletion from the Xenopus foregut

273 Foregut-specific Szl depletion results in a loss of the

274 ent stem cells (hPSCs) into ventral-anterior foregut spheroids and further into two distinct types of

275 the generation of free-floating 3D posterior foregut spheroids using FGF4, Wnt pathway agonist CHIR99

276 ing pathways hPSCs generate ventral-anterior foregut spheroids, which are then expanded into human lu

277 acid-mediated regional microscopic injury in foregut squamous epithelia.

278 ulated kinase (Erk) in the Bmp4(cko) ventral foregut, suggesting that Bmp signaling promotes Erk phos

279 pression domain of Pdx1 within the posterior foregut suggests that investigating its transcriptional

280 Data on all patients undergoing foregut surgery are collected prospectively.

281 The combination of obesity and foregut surgery puts patients undergoing bariatric surge

282 f sclerotized elements, and a differentiated foregut that is lined with acicular teeth.

283 out the RA-dependent pathways present in the foregut that may be crucial for lung formation.

284 chea and the lungs--arises from the anterior foregut through a sequence of morphogenetic events invol

285 tomach and liver, are derived from the fetal foregut through a series of inductive interactions betwe

286 al precursor state, is also expressed in the foregut throughout gastrulation, suggesting that this re

287 diverse contexts and the differentiation of foregut tissue from stem cells.

288 tages that are prior to, or coincident with, foregut tissue patterning (1-3 somites, 4-6 somites, and

289 that plays a key role in these processes in foregut tissues.

290 the pancreas, and a milder decrease in other foregut tissues.

291 r patterning and morphogenesis of the common foregut tube and its derived organs is essential for via

292 phagus arise from the separation of a common foregut tube during early fetal development.

293 Separation of the single anterior foregut tube into the esophagus and trachea involves cel

294 ry outgrowth or progressive septation of the foregut tube.

295 t Tgfbeta signaling was hyperactive in these foreguts when lung agenesis was observed.

296 aling is prominently present in the anterior foregut where the tracheal primordium originates and tar

297 expressed exclusively in the salivary gland/foregut, whereas symbiotic Cell-2, -3, and -4 are highly

298 tral epithelial domain of the early anterior foregut, which gives rise to the future trachea and lung

299 ated bacterial biofilm formation in the flea foregut, which greatly increased transmissibility.

300 trachea and lung develop from the embryonic foregut, yet acquire and maintain distinct tissue phenot