ライフサイエンスコーパス: formyl peptide receptor

1 onse of these cells to ligands selective for formyl peptide receptor.

2 ned using the open reading frame of murine N-formyl peptide receptor.

3 Fpr-rs7 are 53-74% identical to other mouse formyl peptide receptors.

4 activity through differential activation of formyl peptide receptors.

5 perimental systems to identify an annexin A1-formyl peptide receptor 1 (ANXA1-FPR1) bidirectional ast

6 Our results demonstrate that formyl peptide receptor 1 (FPR1) and neutrophilic NADPH

7 Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 int

8 Binding of formyl peptide receptor 1 (FPR1) by N-formyl peptides ca

9 -37, an antimicrobial peptide, which induced formyl peptide receptor 1 (FPR1) expression by keratinoc

10 th MS, we identified increased expression of formyl peptide receptor 1 (FPR1) in central nervous syst

11 Formyl peptide receptor 1 (FPR1) is a G protein-coupled

12 The formyl peptide receptor 1 (FPR1) is primarily responsibl

13 ceptor to be described on human neutrophils, formyl peptide receptor 1 (FPR1), is one such receptor t

14 osis by CXC chemokine receptor 2 (CXCR2) and formyl peptide receptor 1 (FPR1), respectively.

15 n jejunal cryosections with probes to detect formyl peptide receptor 1 (FPR1).

16 upled leukocyte chemotactic receptor Fpr1 (N-formyl peptide receptor 1) began to develop bilateral po

17 or 4), EGR2 (Early Growth Response 2), FPR1 (Formyl Peptide Receptor 1), IL6 (interleukin-6), RGS2 (r

18 ted from wild-type mice and mice lacking the formyl peptide receptor 1, we demonstrate that LTB(4) ac

19 nds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2).

20 In these studies, we performed formyl peptide receptor-1 (FPR) localization and evaluat

21 out experiments to study the capacity of the formyl peptide receptor-1 (FPR1) to desensitize chemokin

22 tein B1 (HMGB1), respectively, as well as to formyl peptide receptor-1 (FPR1), which interacts with A

23 polymorphonuclear neutrophils (PMNs) through formyl peptide receptor-1 and Toll-like receptor (TLR) 9

24 Activation of the G-protein coupled formyl peptide receptor 2 (ALX/FPR2) by the lipid mediat

25 ponse to O(3) includes altered expression of formyl peptide receptor 2 (ALX/FPR2), a G protein-couple

26 (R)-6 activated the endogenous LX receptor formyl peptide receptor 2 (ALX/FPR2).

27 tive module, an enzyme hydrolysis site and a formyl peptide receptor 2 (FPR2) agonist.

28 Formyl peptide receptor 2 (FPR2) agonists can boost the

29 tide receptor-like 1 and its mouse homologue formyl peptide receptor 2 (FPR2) are G protein-coupled r

30 Formyl peptide receptor 2 (FPR2) emerges as a central re

31 Annexin A1 (AnxA1) mainly acts through Formyl Peptide Receptor 2 (FPR2) inducing the resolution

32 Formyl peptide receptor 2 (FPR2) is a chemoattractant re

33 Formyl peptide receptor 2 (FPR2) is a G protein-coupled

34 a) receptor one knockout (KO), AnxA1 KO, and formyl peptide receptor 2 (FPR2) KO mice were infected w

35 Formyl peptide receptor 2 (FPR2) modulates inflammatory

36 Neutrophils expressing formyl peptide receptor 2 (FPR2) play key roles in host

37 The human formyl peptide receptor 2 (FPR2) plays a crucial role in

38 to decipher the protective role of RvD1 via formyl peptide receptor 2 (FPR2) receptor signaling in a

39 Selective agonists and antagonists of formyl peptide receptor 2 (Fpr2) suggested that Fpr2 med

40 timization of a peptidomimetic antagonist of formyl peptide receptor 2 (FPR2) was explored by an appr

41 Formyl peptide receptor 2 (FPR2), a classical chemoattra

42 igated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as NLRP3 infla

43 oncentrations of PSMalpha2 are recognized by formyl peptide receptor 2 (FPR2), but unlike the prototy

44 nd SAA1 activated the SAA1-binding receptor, formyl peptide receptor 2 (FPR2), which drove the epithe

45 sful in identifying an endogenous ligand for formyl peptide receptor 2 (FPR2)/lipoxin A4 receptor (AL

46 Here we report that formyl peptide receptor 2 (Fpr2/3) null mice display a m

47 ding and activation of the human and mouse N-formyl peptide receptor 2 (huFPR2).

48 hat TNF-alpha up-regulated the expression of formyl peptide receptor 2 (mFPR2) in mouse microglial ce

49 ike 1 (FPRL1) and its mouse homologue murine formyl peptide receptor 2 (mFPR2) mediate the chemotacti

50 n (G-protein-coupled receptor 32 [GPR32] and formyl peptide receptor 2 [ALX/FPR2]), and cytokine expr

51 SAnxA1 bound and activated formyl peptide receptor 2 in a similar way as the parent

52 and lung IRI was evaluated in C57BL/6 (WT), formyl peptide receptor 2 knockout (Fpr2(-/-)) and nucle

53 een phosphatidylserine on the dying cell and formyl peptide receptor 2 on the phagocytosing microglia

54 Formyl peptide receptor 2 regulates monocyte recruitment

55 regulation of ALX/FPR2 (lipoxin A4 receptor/formyl peptide receptor 2) expression.

56 ceptor-2 (FPR2/ALX) and in mFPR2(-/-) (mouse formyl peptide receptor 2) mice lacking the mouse homolo

57 s by airway epithelial cells in an ALX/FPR2 (formyl peptide receptor 2) receptor-dependent manner.

58 roteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2, and annexin 1.

59 We investigated airway levels of formyl peptide receptor 2-lipoxin receptor (FPR2/ALXR),

60 crophage training in vitro was mediated by a formyl peptide receptor 2-TNF-2-HG-PGE(2)/PGE(2) recepto

61 th human FPRL1 or its mouse ortholog, murine formyl peptide receptor 2.

62 as shown by experiments with DCs lacking the formyl peptide receptor 2.

63 ta, and TNF-alpha from human monocytes via a formyl peptide receptor 2/ATP/P2X purinoceptor 7 axis.

64 ayed specific binding to the AnxA1 receptor (formyl peptide receptor 2/Lipoxin A4 receptor [FPR2/ALX]

65 armacology, and identifies biased agonism in formyl peptide receptor 2/lipoxin A4 receptor pharmacolo

66 The formyl-peptide receptor 2 (FPR2) is a G-protein-coupled

67 Endothelial-bound cathelicidin activates formyl-peptide receptor 2 on classical monocytes, result

68 Here we tested whether the formyl-peptide receptor 2/3 (Fpr2/3)--ortholog to human

69 e, we tested whether the lipoxin A4 receptor formyl-peptide receptor 2/3 (Fpr2/3; ortholog to human F

70 LL-37, via formyl peptide receptor-2 (FPR-2), triggered the release

71 ocortin-4 receptor, the Smoothened receptor, formyl peptide receptor-2 (FPR2), the relaxin receptor (

72 ll interfering RNA-induced knockdown of LXA4 formyl peptide receptor-2 (FPR2/ALX) and in mFPR2(-/-) (

73 293 cells, confirming the use of FPRL1/mouse formyl peptide receptor-2 by CRAMP.

74 cells transfected with either FPRL1 or mouse formyl peptide receptor-2, the mouse homologue of FPRL1,

75 Formyl peptide receptor 3 (Fpr3, also known as Fpr-rs1)

76 ey player in allergy to tropomyosins and the formyl peptide receptor 3 in allergy to lipocalins are o

77 c peptide WKYMVm, a selective agonist of the formyl peptide receptor, a 2-fold increase in leukocyte

78 Formyl peptide receptor activation of three mitogen-acti

79 ed gut epithelial cells resulted in specific formyl peptide receptor activation.

80 tor activity and opsonin receptor activity/N-formyl peptide receptor activity in GO Function enrichme

81 an intracellular metabolic wave responds to formyl peptide receptor agonists, but not antagonists, b

82 formulate requirements for these specific N-formyl peptide receptor agonists.

83 the role of the inside-out signaling through formyl peptide receptor and CXCR4 in the regulation of a

84 t for two chemoattractant receptor subtypes, formyl peptide receptor and formyl peptide receptor-like

85 t disrupting the ternary complex between the formyl peptide receptor and G alpha(i2).

86 The solubilized N-formyl peptide receptor and Galpha(i3) protein interacte

87 tin polymerization to prevent exocytosis via formyl peptide receptor and Rho kinase signaling pathway

88 -independent pathways of activation by the N-formyl peptide receptor and the chemokine receptors, and

89 we generated a fusion protein between the N-formyl peptide receptor and the G(alpha)(i2) protein.

90 n of MMP-1 secretion was inhibited by both a formyl peptide receptor antagonist and pertussis toxin,

91 We conclude that formyl peptide receptors are coupled to three MAPK casca

92 Formyl peptide receptors are G-protein-coupled, seven-tr

93 Formyl-peptide receptors are highly expressed on neutrop

94 of the G(i)-protein-coupled high-affinity N-formyl peptide receptor by f-met-leu-phe and HIV-derived

95 Activation of the low-affinity N-formyl peptide receptor by the HIV-derived F-peptide sup

96 N-formyl peptide receptors comprise a group of Gi-coupled

97 Ternary complexes were assembled using three formyl peptide receptor constructs (wild type, formyl pe

98 We found that formyl peptide receptor could use the endogenous Rac1 as

99 togen-activated protein kinase pathway in an formyl peptide receptor-dependent manner, delineating a

100 rophils, but not nonclassical monocytes in a formyl-peptide receptor-dependent manner.

101 iate these effects, whereas recognition by N-formyl peptide receptor family members was dispensable.

102 PR1) is a member of the chemotactic GPCR-7TM formyl peptide receptor family, whose principle function

103 ecognition and selectivity mechanisms of the formyl peptide receptor family.

104 e supernatants and a potent agonist at human formyl peptide receptor (FPR) 1.

105 emotaxis, suggesting that this peptide binds formyl peptide receptor (FPR) 2.

106 tion of microglia and astrocytes through the formyl peptide receptor (FPR) 2.

107 PSMs exert their function by binding to the formyl peptide receptor (FPR) 2.

108 an endogenous anti-inflammatory circuit via formyl peptide receptor (FPR) 2/lipoxin receptor (ALX) (

109 ta3 in lymphocytes, we coexpressed the human formyl peptide receptor (fPR) and alphaIIb beta3, findin

110 encoding two seven-transmembrane receptors, formyl peptide receptor (FPR) and formyl peptide recepto

111 stributions of two separate receptors, the N-formyl peptide receptor (FPR) and the high-affinity IgE

112 o two different G protein-coupled receptors (formyl peptide receptor (FPR) and the low affinity formy

113 In humans and rabbits, the formyl peptide receptor (FPR) binds N-formyl-Met-Leu-Phe

114 The formyl peptide receptor (FPR) couples to pertussis toxin

115 Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vo

116 The formyl peptide receptor (Fpr) family is well known for i

117 G protein-coupled receptor belonging to the formyl peptide receptor (FPR) family, conveys the biolog

118 O receptors comprising 5 of 7 members of the formyl peptide receptor (FPR) family.

119 We asked whether the human neutrophil N-formyl peptide receptor (FPR) forms dimers in Chinese ha

120 rt that following receptor activation, the N-formyl peptide receptor (FPR) forms distinct membrane cl

121 in impaired chemotaxis signaling through the formyl peptide receptor (FPR) in neutrophils, culminatin

122 ulation; and 3) potential involvement of the formyl peptide receptor (FPR) in the protective action d

123 timulation of numerous GPCRs including the N-formyl peptide receptor (FPR) initiates rapid cell round

124 The formyl peptide receptor (FPR) is a chemotactic G protein

125 The human N-formyl peptide receptor (FPR) is a member of the family

126 The formyl peptide receptor (FPR) is a prototypical chemoatt

127 The human formyl peptide receptor (FPR) is a prototypical G(i) pro

128 enth transmembrane domain of the chemotactic formyl peptide receptor (FPR) is highly conserved among

129 The human N-formyl peptide receptor (FPR) is representative of a gro

130 One of the major functions of the N-formyl peptide receptor (FPR) is to mediate leukocyte de

131 Leu-Phe binding site in the human neutrophil formyl peptide receptor (FPR) lies in the predicted tran

132 ulture filtrates appeared to act through the formyl peptide receptor (FPR) of PMNs, since it was foun

133 eptide, cFLFLFK-PEG-(64)Cu, that targets the formyl peptide receptor (FPR) on leukocytes is described

134 The formyl peptide receptor (FPR) on neutrophils, which bind

135 ed to express cloned prototype chemotactic N-formyl peptide receptor (FPR) or its variant, FPR-like 1

136 E neutrophils in a dose-dependent manner via formyl peptide receptor (FPR) stimulation.

137 ibit diminished chemotaxis and low levels of formyl peptide receptor (FPR) surface expression.

138 To understand the role of arrestins in N-formyl peptide receptor (FPR) trafficking, we stably exp

139 Following activation by ligand, the N-formyl peptide receptor (FPR) undergoes processing event

140 The specific role of the high affinity formyl peptide receptor (FPR) was then tested using spec

141 The N-formyl peptide receptor (FPR), a G protein-coupled recep

142 s of members of the arrestin family with the formyl peptide receptor (FPR), a member of the GPCR fami

143 alyses of molecular assemblies involving the formyl peptide receptor (FPR), a well described member o

144 mined this mechanism in the context of the N-formyl peptide receptor (FPR), a well-characterized memb

145 The fMLF binding to its receptor, formyl peptide receptor (FPR), resulted in significant a

146 By contrast, formyl peptide receptor (FPR), the primary fMLP receptor

147 In the case of the N-formyl peptide receptor (FPR), these latter two processi

148 f phosphorylation deficient mutants of the N-formyl peptide receptor (FPR), we have explored the role

149 Human formyl peptide receptor (FPR)-like 1 (FPRL1) and its mou

150 Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveal

151 did not show NF-kappaB activation, whereas N-formyl peptide receptor (FPR)-transfected HL-60 cells we

152 d phosphorylation-deficient mutants of the N-formyl peptide receptor (FPR).

153 nd-dependent signaling by the G(i)-coupled N-formyl peptide receptor (FPR).

154 eceptor phosphorylation in the case of the N-formyl peptide receptor (FPR).

155 eptor for N-formylated chemotactic peptides, formyl peptide receptor (FPR).

156 recombinant human phagocyte chemoattractant formyl peptide receptor (FPR).

157 d activation of a specific G-protein-coupled formyl peptide receptor (FPR).

158 NA, and a synthetic NFP (WKYMVm), agonist of formyl peptide receptor (FPR).

159 The expression of the genes encoding formyl peptide receptor (FPR)1 and FPR2, the high- and l

160 R4-initiated signaling events that couple to formyl peptide receptor (FPR)1 mRNA stabilization, macro

161 -37pA induces calcium and chemotaxis through formyl peptide receptor (FPR)2/ALX, whereas its D-stereo

162 luding one compound previously shown to be a formyl peptide receptor (FPR/FPRL1) agonist.

163 Formyl peptide receptors (FPR), part of the G-protein co

164 the classical chemoattractant C5a (C5aR) or formyl peptide receptors (fPR).

165 he-Leu-Phe-Leu-Phe (Boc-2), an antagonist of formyl peptide receptors (FPR/FPRL1).

166 This suggests that the formyl-peptide receptor (FPR) and its variant FPRL1 (FPR

167 G-protein-coupled receptors, members of the formyl-peptide receptor (FPR) family, appear to mediate

168 peptide Ac2-26 occurred via receptors of the formyl-peptide receptor (FPR) family, most likely FPR-rs

169 s a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil

170 netic or pharmacological inhibition of the N-formyl peptide receptor Fpr1 leads to increased insulin

171 N-formyl peptide receptor (FPR1) and N-formyl peptide rece

172 an G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Sacchar

173 Mouse neutrophils lacking formyl peptide receptors (Fpr1/2(-/-)) are defective in

174 luminal casts depends on the high-affinity N-formyl peptide receptor, Fpr1.

175 The neutrophil formyl peptide receptors, FPR1 and FPR2, play critical r

176 15-epi-LXA4 activated formyl peptide receptor (FPR2) and GPR120 on alternative

177 The N-formyl peptide receptors (FPRs) are a family of G-protei

178 N-formyl peptide receptors (FPRs) are critical regulators

179 N-Formyl peptide receptors (FPRs) are G protein-coupled re

180 Formyl peptide receptors (FPRs) are G-protein-coupled re

181 r current work showed that G-protein-coupled formyl peptide receptors (FPRs) directly mediate neutrop

182 Formyl peptide receptors (FPRs) may contribute to inflam

183 N-formyl peptide receptors (FPRs) serve as phagocyte patte

184 class of such receptor-ligand pairs involves formyl peptide receptors (FPRs) that have been shown to

185 Wild-type and 35 mutant formyl peptide receptors (FPRs) were stably expressed in

186 cular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-c

187 as trace amine-associated receptors (TAARs), formyl peptide receptors (FPRs), and membrane-spanning 4

188 cquisition of neuronal specificity by immune formyl peptide receptors (Fprs).

189 xA1) facilitates inflammation resolution via formyl peptide receptors (FPRs).

190 ed a significant difference in expression of formyl peptide receptors (FPRs).

191 te ERK pathway activity via interaction with formyl peptide receptors (FPRs).

192 Formyl-peptide receptors (FPRs) are important pattern re

193 sion of mRNAs for annexin A1 (AnxA1) and the formyl peptide receptors [(Fprs) 1, 2, and 3], a loss of

194 Wild type formyl peptide receptors (FPRwt) and receptors deleted o

195 The N-formyl peptide receptor-G protein interactions were inhi

196 In addition to formyl peptide receptor, Galpha(16) also enhanced NF-kap

197 rmyl peptide receptor constructs (wild type, formyl peptide receptor-Galpha(i2) fusion, and formyl pe

198 S can markedly enhance the expression of the formyl peptide receptor gene (FPR1) in mouse macrophages

199 The formyl peptide receptor gene family contains three membe

200 rmyl peptide receptor-Galpha(i2) fusion, and formyl peptide receptor-green fluorescent protein fusion

201 ligand-receptor interactions with the murine formyl peptide receptor homologs.

202 These include the human formyl peptide receptor, human trace amine-associated re

203 of various mutants of PI 3-kinase with the N-formyl peptide receptor identified a link to class Ia PI

204 This first report of a functional formyl peptide receptor in cells of fibroblast origin op

205 ecently presented evidence for a role of the formyl peptide receptor in vivo.

206 otaxis was not due to a diminished number of formyl peptide receptors in either murine or human PMNs,

207 AnxA1 and its peptides each activated formyl peptide receptors in goblet cells.

208 we identified the expression of functional N-formyl peptide receptors in model SK-CO15 intestinal epi

209 Stimulation of formyl peptide receptors increases the mitochondrial mem

210 drial ATP production and requires an initial formyl peptide receptor-induced Ca(2+) signal that trigg

211 lso primed neutrophils in vivo, resulting in formyl peptide receptor-induced CD11b expression and CD6

212 7SH cells, activation of the chemoattractant formyl peptide receptor induces cortical actin polymeriz

213 eins were previously reported to function as formyl peptide receptor inhibitors.

214 ressive periodontitis to study Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis f

215 The N-formyl peptide receptor is a G protein-coupled transmemb

216 Human G protein-coupled formyl peptide receptor like 1 (FPRL1) and its mouse hom

217 Human formyl peptide receptor like-1 (FPRL-1) receptor, origin

218 We chose to study formyl peptide receptor like-1 (FPRL1), a chemotactic re

219 The human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse hom

220 ed by an agonistic ligand MMK-1 specific for formyl peptide receptor-like 1 (FPRL1) and vice versa, s

221 Formyl peptide receptor-like 1 (FPRL1) is a G protein-co

222 nctions of cathelicidin are mediated through formyl peptide receptor-like 1 (FPRL1), we hypothesize t

223 receptors, formyl peptide receptor (FPR) and formyl peptide receptor-like 1 (FPRL1), which are with h

224 ough the use of a G protein-coupled receptor formyl peptide receptor-like 1 (FPRL1), which has been r

225 Ca(2+) mobilization in, human monocytes and formyl peptide receptor-like 1 (FPRL1)-transfected human

226 N-formyl peptide receptor (FPR1) and N-formyl peptide receptor-like 1 (FPRL1, now known as FPR2

227 Human formyl peptide receptor-like 1 and its mouse homologue f

228 ways involving a G protein-coupled receptor (formyl peptide receptor-like 1 in migration) and the epi

229 ith WRW4, an antagonist of the transmembrane formyl peptide receptor-like 1 protein attenuated LL-37'

230 ion (P < 0.001, r = 0.55) was found with the formyl peptide receptor-like 1 protein that mediates che

231 xis of human phagocytic cells to a number of formyl peptide receptor-like 1-specific ligands but had

232 ceptor subtypes, formyl peptide receptor and formyl peptide receptor-like 1.

233 peptide receptor (FPR) and the low affinity formyl peptide receptor-like-1 (FPRL1)) to initiate a si

234 d by MMK-1, an agonistic ligand specific for formyl peptide receptor-like-1 (FPRL1), and vice versa,

235 lial cells occurs via recently characterized formyl peptide receptors located in the plasma membrane.

236 This system takes advantage of the lack of formyl peptide receptor-mediated response in COS-phox ce

237 high affinity ligand-binding state in the N-formyl peptide receptor (NFPR).

238 migratory events through interactions with n-formyl peptide receptors (nFPRs), we examined the expres

239 the binding of fluorescent peptide to the N-formyl peptide receptor of neutrophils at 37 degrees C h

240 cyl-phenylalanyl-lysine-fluorescein to the N-formyl peptide receptor on human neutrophils were charac

241 leukemia (RBL) cell lines expressing either formyl peptide receptor or FPRL1, Quin-C1 induced enzyme

242 (2+)-mobilizing G protein-coupled receptors (formyl peptide receptor, P2Y2 purinergic receptor, and c

243 ven luciferase reporter, Galpha(16), and the formyl peptide receptor responded to fMLP with a approxi

244 ytometer, we determined that there are two N-formyl peptide receptor states for human neutrophils at

245 ive oxygen species production in response to formyl peptide receptor stimulation.

246 ed ERK and p38 MAPK signaling in response to formyl peptide receptor stimulation.

247 ulation and cAMP accumulation in response to formyl peptide receptor stimulation.

248 sing events and cellular responses for the N-formyl peptide receptor system on human neutrophils as a

249 rat basophilic leukemia-2H3 cells expressing formyl peptide receptor, the PKG inhibitors KT5823 and R

250 parison of the coupling of the beta(2)AR and formyl peptide receptor to G(ialpha2) revealed receptor-

251 To study the signaling pathway from the N-formyl peptide receptor to the actin cytoskeleton, we de

252 These results demonstrate that Lsc links formyl-peptide receptors to RhoA signaling pathways that

253 Using formyl peptide receptor-transfected U937 cells, we furth

254 Formyl-peptide receptor type 2 (FPR2), also called ALX (

255 Formyl-peptide receptor type 2 (FPR2; also called ALX be

256 n goblet cells was measured to determine the formyl peptide receptors used by the compounds and the a

257 An expression vector coding for the N-formyl peptide receptor was microinjected into porcine a

258 es C by the six different agonists for the N-formyl peptide receptor were measured.

259 centration-dependent reconstitution of the N-formyl peptide receptor with endogenous G proteins.

260 hetic peptide, WKYMVm, a potent activator of formyl peptide receptors with preference for FPRL1 was d

261 icro-opioid, D(1)dopamine, and neutrophil N -formyl peptide receptors with the predictions of our mod