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1 nesis screen (phenotype-based mutagenesis or forward genetics).
2 germline mutagenesis and positional cloning (forward genetics).
3 ng epidermal barrier formation identified by forward genetics.
4 sis for functional genome annotation through forward genetics.
5 and behavior will likely continue to rely on forward genetics.
6 hat have resulted from these applications of forward genetics.
7  using mouse reverse genetics and Drosophila forward genetics.
8 gene knockdown, and the advent of RNAi-based forward genetics.
9 lear non-coding RNAs have been refractory to forward genetics.
10 ain were developed by genome engineering and forward genetics.
11  T-DNA insertion collection with traditional forward genetics.
12 s become the rate limiting step in mammalian forward genetics.
13 tional consequences of mutations obtained by forward genetics.
14 e broadly, our approach will enable unbiased forward genetics across mammalian organ systems.
15 reen for complex I defects, we isolated, via forward genetics, amc1-7 nuclear mutants (for assembly o
16                               Independently, forward genetics analysis identified a quantitative trai
17                           Here, we integrate forward genetics and biochemistry to gain insights into
18                                              Forward genetics and cross-resistance profiling determin
19                       Using a combination of forward genetics and cytological screening, we uncover a
20 ide a model system in which a combination of forward genetics and live-cell imaging can allow researc
21                    Maize, with its excellent forward genetics and male sterility screens, was used to
22                                   We applied forward genetics and proteomics in Arabidopsis to identi
23                                        Using forward genetics and quantitative behavioral studies, we
24  one of two distinct lines of investigation: forward genetics and reverse genetics approaches.
25 nas aeruginosa but instead conduct classical forward genetics and select for mutations in a single ge
26 generation of Indel markers will enhance the forward genetics and the overall usage of the Tnt1 mutan
27 de, including the identification of genes by forward genetics and the study of natural ionomic variat
28  throughput model for developmental biology, forward-genetics, and drug discovery.
29                                    We used a forward genetics approach and mapped the locus determini
30                            GCN data-informed forward genetics approach enabled cloning of the gl14 ge
31 ere we develop an alternative to the classic forward genetics approach for dissecting complex disease
32          We conclude with an assessment of a forward genetics approach for identifying genes involved
33 nd milder in C57BL/6 (B6) mice has allowed a forward genetics approach for the identification of gene
34                                      Using a forward genetics approach in cells coinfected with BTV-1
35                             Here, by using a forward genetics approach in mice, we describe the isola
36                                Here, using a forward genetics approach in mice, we identify histone d
37                                          Our forward genetics approach on dark-grown hypocotyls uncov
38                                          The forward genetics approach proceeds from measurable pheno
39                                            A forward genetics approach revealed how an epistatic inte
40                                    Through a forward genetics approach selecting for defective vocali
41  RNA interference (RNAi) presents a powerful forward genetics approach to dissect virus-host cell int
42                     In this study, we used a forward genetics approach to identify a mutant mouse str
43                 We used an ozone-sensitivity forward genetics approach to identify Arabidopsis thalia
44     This study illustrates the power of this forward genetics approach to identify atypical virulence
45                     Here we took an unbiased forward genetics approach to identify genes of large eff
46                                We utilized a forward genetics approach to identify genes required to
47                              Here, we used a forward genetics approach to identify SPA1 and CUL4, com
48                              Here, we used a forward genetics approach to investigate the mechanism o
49 insertional mutagenesis is a high-throughput forward genetics approach to randomly disrupt (trap) hos
50             We developed a JAZ family-based, forward genetics approach to screen randomized jaz polym
51                             Here we employ a forward genetics approach to understand MEP pathway regu
52                                    Using the forward genetics approach, a suppressor line, termed as
53                                      Using a forward genetics approach, one nonsense and four missens
54                                   Using this forward genetics approach, several genes were identified
55                                      Using a forward genetics approach, Souza et al. identify Nfkbid
56                                      Using a forward genetics approach, we identified the lysosomal e
57                                      Using a forward genetics approach, we identify a penicillin-bind
58                                      Using a forward genetics approach, we identify a unique ETI-asso
59                                   By using a forward genetics approach, we isolated a novel mutant al
60  the primary aims of genetic studies using a forward genetics approach.
61        Our results substantiate the use of a forward-genetics approach for studying sleep behaviours
62         Here we present a human genome-scale forward-genetics approach for the identification of lncR
63 ion networks can be disentangled by applying forward genetics approaches simultaneously to the host a
64                                   The use of forward genetics approaches to find sequence variations
65                             Finally, we used forward genetics approaches to identify marker-trait ass
66 t endomembranes, namely optical tweezers and forward genetics approaches, which are based either on t
67 S, a TM mutation recently identified through forward genetics as a cell culture-adaptive mutation.
68 sis WAVE-DAMPENED 2 (WVD2) was identified by forward genetics as an activation-tagged allele that cau
69 al advances have recently opened the door to forward genetics as well as extremely efficient and prec
70                       Using a combination of forward genetics, biochemical reconstitution, and AlphaF
71 es the power with which RNA interference and forward genetics can be used to expose the dependencies
72                           The application of forward genetics can reveal new factors required for the
73    Two complementary approaches, reverse and forward genetics, can be used to achieve this goal.
74                            These examples of forward genetics contrast with reverse genetic approache
75                                    Through a forward-genetics CRISPR-Cas9 screen, we identified an an
76                                      Using a forward genetics ENU mutagenesis screen for recessive mu
77                                    Classical forward genetics first discovered its immune role in 200
78 ay explores how classical approaches such as forward genetics fit into this emerging framework.
79 e results clearly demonstrate the utility of forward genetics for the discovery of novel genes and pa
80 newal, and illustrates the power of RNAi and forward genetics for the systematic study of self-renewa
81  However, their utility for phenotype-driven forward genetics has been hampered by the difficulty of
82 out an active circulation and amenability to forward genetics has led to the identification of numero
83                                              Forward genetics identified regulators of lysosomal traf
84 eferred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with atax
85 n-seq) is a powerful method for genome-scale forward genetics in bacteria.
86           MutChromSeq enables reference-free forward genetics in barley and wheat, thus opening up th
87                                        Using forward genetics in Caenorhabditis elegans, we identifie
88 ith a novel genetic composition generated by forward genetics in combination with topoisomerase inhib
89  the rate-limiting step, inhibiting unbiased forward genetics in even the most tractable model organi
90 indings illustrate the power and efficacy of forward genetics in identifying ASD genes and highlight
91 ighlight the potential for GWA to complement forward genetics in identifying the genetic basis of eco
92 tential to remove a major roadblock to using forward genetics in Leishmania, understanding Leishmania
93                             Both reverse and forward genetics in mice are currently gaining momentum
94             In this article, we focus on how forward genetics in mice can be used to explore dermatol
95 g Beauty (SB), the possibility of performing forward genetics in mice has been reinforced.
96                                        Using forward genetics in mice, we identified an orphan protei
97                                To facilitate forward genetics in Neurospora, we have adapted microarr
98 sults showcase the promise of genome-enabled forward genetics in nonmodel species.
99 ased discovery of causal genetic lesions via forward genetics in patients who have a rare disease elu
100 estigate rosette development, we established forward genetics in S. rosetta.
101 ns that will greatly facilitate the power of forward genetics in vertebrate models.
102                                 The power of forward genetics in yeast is the foundation on which the
103  commonly relied on the classical methods of forward genetics, integration of different genomics data
104                                  Conversely, forward genetics is a phenotype-driven approach that inv
105 ved to be responsible for these disorders, a forward genetics method of gene discovery was used to id
106  the conventional cloning approach and makes forward genetics more feasible and powerful in molecular
107 e to an unbiased, state-of-the-science mouse forward genetics pipeline.
108                                              Forward genetics provides an excellent tool to find, in
109                                 Empowered by forward genetics, research using Caenorhabditis elegans
110                           Here, we perform a forward genetics screen for ARF hypercondensation, ident
111                                       From a forward genetics screen for temperature-sensitive defect
112                  Using a confocal microscopy forward genetics screen for the identification of Arabid
113 of the auditory sense organs, we performed a forward genetics screen in mice.
114 ed a virus-induced gene-silencing-based fast-forward genetics screen in Nicotiana benthamiana.
115                                            A forward genetics screen led to the identification of the
116 isolated through a confocal microscopy-based forward genetics screen of the Golgi in Arabidopsis thal
117 mpensate for PUFA-deficiency, we performed a forward genetics screen to isolate novel fat-2(wa17) sup
118                                     From our forward genetics screen, we determine that ABA biosynthe
119                                         In a forward genetics screen, we identified huskless, which l
120 nce to biotrophic fungal pathogens, we did a forward-genetics screen using Medicago truncatula Tnt1 r
121 date candidate oncogenic drivers of HCC in a forward genetics screening approach.
122                          Transposon-mediated forward genetics screening in mice has emerged as a powe
123 utation cloning will enable broader usage of forward genetics screens and have significant impacts in
124                                              Forward genetics screens in mice have facilitated the id
125  had been identified previously in extensive forward genetics screens using induced mutants, suggesti
126  for mapping new mutations generated through forward genetics screens.
127                           Identified through forward genetics, spe-9 was the first gene to be identif
128 are considered primarily through the lens of forward genetics, starting at the organismal level and p
129 nthesis of alpha-(1,3)-glucan, we employed a forward genetics strategy to isolate physically marked m
130                                      Using a forward genetics strategy, we identified benzamide-resis
131                                     Numerous forward genetics studies have been performed in Chlamydo
132 quired for reverse-genetics studies than for forward-genetics studies, but genetic analysis is suffic
133 abilities such as efficient transposon-based forward-genetics technologies for Anopheles mosquitoes n
134                          Absent are powerful forward-genetics technologies, such as enhancer and gene
135                                    Classical forward genetics, the identification of genes responsibl
136                          For high-resolution forward genetics, this unprecedented access to genomic v
137 etter understand the genetic factors we used forward genetics to discover genes that have not previou
138 a powerful vertebrate model system for using forward genetics to elucidate mechanisms of early develo
139 actors that limit viral replication, we used forward genetics to enrich for a murine norovirus (MNV)
140                                      We used forward genetics to identify duplicate T-DNA insertions
141                                      We used forward genetics to identify the causative gene underlyi
142                   Genetic mapping is used in forward genetics to narrow the list of candidate mutatio
143       Here we use mathematical modelling and forward genetics to reduce an asymmetric cell cycle to i
144                                 Here we used forward genetics to search for mechanisms underlying nat
145 ls of idiopathic autism, serving as a potent forward genetics tool to dissect the complexity of autis
146 ene silencing, is a widely used reverse- and forward-genetics tool in plant functional genomics.
147                                              Forward genetics was used to isolate Chlamydomonas reinh
148 B than type I or type III strains, and using forward genetics we found that this difference is a resu
149                                      Through forward genetics, we have identified a new mutant with e
150                                        Using forward genetics, we identified Arabidopsis SP1, which e
151                                        Using forward genetics, we identify a gene associated with mid
152                                  Here, using forward genetics, we identify lep-5, a lncRNA acting in
153                                  Using mouse forward genetics, we report what is, to our knowledge, t
154  advantages of in vivo imaging, the power of forward genetics, well-established high efficiency for t
155 s, together with both classical and chemical forward genetics, were consistent with flux through the
156 approach combines the strength of Drosophila forward genetics with detailed in vivo imaging of ddaC n
157  study in Drosophila, synthesizing classical forward genetics with DNA microarrays, brings us closer
158 Here, we generated reassortant reoviruses by forward genetics with enhanced infective and cytotoxic p
159                                        Using forward genetics with progeny from a type II x type III

 
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