ライフサイエンスコーパス: frame shift

1 the base next to Tb to unpair, mimicking a "frame-shift".

2 -short) in which 345 bp is deleted without a frame shift.

3 ptide sequences created by the translational frame shift.

4 to prematurely terminate translation and -1 frame shift.

5 terminus, as would be predicted based on the frame shift.

6 ion, of which none was missense, nonsense or frame shift.

7 lone that include the region of the proposed frame-shift.

8 nal deletions, nucleotide substitutions, and frame shifts.

9 ted a single amino acid substitution and two frame shifts.

10 pseudoknots that stimulate -1 translational frame shifting.

11 Ma3 is important for promoting efficient -1 frame-shifting.

12 e codon recognition and negate translational frame-shifting.

13 eletion (c.1148delC) in CNGB3 that induces a frame shift after Thr383, whereas the carriers were hete

14 ion of specific mutations in the genes mucA (frame-shift), algT (substitution), rpoN (substitution),

15 s that attenuate expression and a T424GfsX48 frame-shift allele identified in MCSZ individuals, we de

16 mino acid 382, part of NLSIII, resulted in a frame shift and a 420 amino acid protein (p53(420)).

17 yptic splice site in intron 4 resulting in a frame shift and a premature stop (p.S66Nfs * 15).

18 Two mutations, 485delT and 513insTT, cause a frame shift and a premature stop codon and the third mut

19 p G deletion in the coding region, causing a frame shift and a premature stop codon, led to a nonfunc

20 ontains a single base deletion that causes a frame shift and a premature stop of translation within t

21 use of the nature of the mutation, causing a frame shift and a premature termination of translation,

22 This results in a frame shift and a stop codon after 46 nucleotides.

23 This deletion, which leads to a frame shift and a truncation of the Alx-4 protein, could

24 ediction of the protein sequences, including frame shift and amino acid insertions.

25 -splice site in its pre-mRNA that leads to a frame shift and degradation by NMD.

26 alternative exon (exon 15) that results in a frame shift and early termination.

27 tains a single base insertion that creates a frame shift and leads to premature termination of the Sc

28 ination has previously been used to genotype frame shift and point mutations, and small insertions or

29 deletion of Ash1l exon 4, which results in a frame shift and premature stop codon (p.V1693Afs*2).

30 This mutation is predicted to cause a frame shift and premature stop codon which truncates the

31 ing of exon 5, which creates a translational frame shift and premature stop codon.

32 Recently, frame shift and premature termination mutations in the p

33 ha chain genes (4904delG) that resulted in a frame shift and premature termination of the protein at

34 The mutation causes a frame shift and premature termination which are predicte

35 egion of the rd7 mPNR message that creates a frame shift and produces a premature stop codon.

36 receptor-related protein 5 (LRP5), causing a frame shift and resulting in the replacement of the C-te

37 In addition to numerous frame shift and splice-site mutations, 36 missense mutat

38 hSRBC-coding region mutations including frame shift and truncation mutations were detected in a

39 ide repeats in the 5' region, resulting in a frame shift and truncation.

40 association defect and a modest increase in frame shifting and stop codon read-through.

41 codons, the pseudogene contains a number of frame shifts and a 103-bp deletion.

42 iple-of-3 edited nucleotide cell clones have frame shifts and early truncation of BLG protein, while

43 Alternative splicing results in frame shifts and leads to novel larger translation produ

44 thal doses, AZT has no significant effect on frame shifts and most base-substitution mutations.

45 tations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine recept

46 sequences indicates a pseudogene containing frame shifts and premature stop codons.

47 rete insertion/deletion mutations leading to frame shifts and premature termination implicate haploin

48 portantly, fourth, fully half of spontaneous frame-shift and base-substitution mutation during starva

49 9del), while the latter variant results in a frame-shift and extension at the carboxy terminus (p.Asp

50 more, a subset of previously uncharacterized frame-shift and missense mutations at the N terminus of

51 one base deletion in rat GADD34 results in a frame-shift and premature appearance of a stop-codon res

52 44delGG and ORF15+694_708del15) leading to a frame-shift and premature termination of translation in

53 t nucleotide 342/343, predicted to produce a frame-shift and premature termination.

54 ed a null mutation resulting from a nonsense frame-shift and the emergence of a stop codon.

55 he presumed wild-type normal allele causes a frame-shifted and truncated coding sequence.

56 tion tool that highlights SJ details such as frame-shifts and annotation support for individual sampl

57 ew make it possible to interactively correct frame-shifts and otherwise edit cluster assemblies.

58 n which deletions and insertions (leading to frame shifts) and stop codons were introduced.

59 n our cohort, 7 were missense, 3 nonsense, 2 frame shifting, and 1 splice site.

60 ably occur, and those that result in reading frame shifts are particularly consequential because the

61 Escherichia coli, however, mostly -1 and +1 frame-shifts are observed, which occur predominantly in

62 es not require SOS functions, whereas the +1 frame-shifts are SOS-dependent.

63 upting mutations (nonsense, splice site, and frame shifts) are twice as frequent, 59 to 28.

64 events adapt and get fixed more rapidly than frame-shifting AS events; selection for smaller exon siz

65 The point deletion causes a frame shift at the C-terminal border of the transactivat

66 One mutation causes a frame shift at the sixth codon and is thus likely to def

67 esis first using human cell lines carrying a frame-shift at NADH dehydrogenase (respiratory complex I

68 A frame-shift ATM mutation was found in one peripheral T c

69 H, yet one of these had a homozygous somatic frame-shift BRCA2 mutation, suggesting that some carcino

70 In contrast, as a result of the frame shift caused by the 93 nucleotide deletion, the C-

71 of cryptic nuclear localization signals by a frame shift caused by the mutation.

72 rection or hypothetical reconstruction of 61 frame-shifts caused by either sequence error or mutation

73 sults in a deletion of exon 4 of Vps34 and a frame shift causing a deletion of 755 of the 887 amino a

74 spliced exon that creates a transcriptional frame shift, changing 38 amino acid codons before introd

75 Here, we show that frame-shifted CMPs, which share POG repeat units but ter

76 Other mutations include frame-shift deletion and chromosomal inversion.

77 where affected individuals had a homozygous frame-shift deletion in CCDC88A (c.2313delT, p.Leu772*te

78 , a neurogenetic disease typically caused by frame-shifting deletions or nonsense mutations in the ge

79 undocumented nonsynonymous substitution and frame shift discrepancies between the two resources.

80 line single-base deletion (di) that causes a frame shift downstream from the VP sequences and a loss

81 nd, and further explains why these reference frames shift during movement.

82 We also identified missense and frame-shift ECRG2 mutations in various human malignancie

83 switch from Bacillus anthracis(48 nt), and a frame-shifting element from a human corona virus (59 nt)

84 esis together with syndromes (i.e. ribosomal frame-shifting, embryonic lethality, neurodegeneration a

85 ted in microsatellite sequences, relative to frame-shift error frequencies in coding sequences, from

86 results demonstrate that an increase in both frame shift errors in homonucleotide repeat sequences an

87 The bp deletion results in a frame-shift followed by a stop-codon.

88 These nucleotide deletions cause frame shifts for codon usage, producing proteins which c

89 tes), the anteromedial PFC governs reference frame shifts for social predictions (Agents), and the do

90 more coding indels with higher than expected frame-shift (FS) indels in cancer genomes.

91 ife cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.

92 In light of these results, we reevaluate the frame shift hypothesis of avian wing evolution and concl

93 P1 carried a heterozygous frame-shift IFNGR2 mutation inherited from her father.

94 Gene editing introduced a frame shift in exon 2 of PRTN3.

95 phenotype in the two Lewis(a+b-) animals; a frame shift in futC, regulating conversion of Lewis(x) t

96 boundary of the 5-HT(2A)-R, which produces a frame shift in the coding sequence and a premature stop

97 equent anatomical differentiation reflects a frame shift in the developmental identities of the avian

98 This mutation generates a frame shift in the transcript, introducing a premature s

99 mutation that disrupts splicing, leading to frame shifts in the coding region that predict the gener

100 The decamer duplication mutation produces a frame-shift in the BRI sequence generating a larger-than

101 encodes only one complete Ig domain before a frame-shift in the second Ig domain occurs, leading to e

102 We conclude that dGAP induces both -2 and +1 frame-shifts in a CpG repetitive sequence and that these

103 dGAP-induced frame-shifts in the (CG)3 sequence, therefore, varied fr

104 -Fraumeni-like family; and 14058delG (exon 7 frame-shift) in a 39-year-old with a family cancer histo

105 e presence of mutations-missense, indels and frame shifts-in MCF7 and SKBR3 breast cancer, and non-tu

106 ent variants alter the same codon, or when a frame-shifting indel is followed by a frame-restoring in

107 y consisted of truncating mutations or small frame-shifting indels.

108 nction (LoFs) variants defined as stop-gain, frame shift, initiation codon (INIT) and splice site mut

109 small molecule that inhibits HDR can enhance frame shift insertion and deletion (indel) mutations med

110 hole genome sequencing was used to uncover a frame-shift insertion affecting the alpha-L-iduronidase

111 This study examines the role of a novel frame-shift insertion discovered in a conserved region o

112 fied a deficient CYP97A3 allele containing a frame-shift insertion in orange carrots.

113 n replicating eukaryotic cells, resulting in frame-shifting insertion/deletion (indel) mutations and

114 rrying a specific amino acid substitution or frame shift insertions in the partial NSP1 coding sequen

115 Frame-shifting insertions and deletions (indels) may als

116 This 22 bp duplication causes a frame shift leading to a premature stop codon.

117 eotide at codon 43 of the C-chain, causing a frame shift, leading to a premature stop codon at codon

118 cid PTEN protein at amino acid 68 by the Y68 frame shift, leading to the loss of PTEN protein phospha

119 equence changes are predicted to result in a frame-shift, leading to premature truncation of the lyso

120 The mechanism of frame shift mutagenesis induced by N-(deoxyguanosin-8-yl

121 'exonuclease activity of DNA polymerase III, frame-shift mutagenesis increased 5-7-fold.

122 When these strains were SOS induced, frame-shift mutagenesis increased by approximately 100%.

123 ) except that E1A is deleted, a liposome-E1A frame-shift mutant DNA complex, or just PBS.

124 s of the wild type, and insertion and double-frame shift mutants of Bat that this transcriptional reg

125 on and cleavage site, and JH-associated RGMc frame-shift mutants undergo COOH-terminal cleavage only

126 pendent families, we identified a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33) in

127 A frame shift mutation in MEU1 abolished its ability to ac

128 unremarkable, but genetic testing revealed a frame shift mutation in SCN1A, consistent with severe my

129 3-kinase p110delta (PIK3CD) and a homozygous frame shift mutation in SKAP (KNSTRN), both ablating pro

130 By genetic mapping, we identified a frame shift mutation in the pericentrin (Pcnt) gene.

131 tations in endometrial cancer cells, the Y68 frame shift mutation of PTEN constitutes a major mechani

132 the AnkB homologue of the Paris strain has a frame shift mutation that led to a loss of the CaaX moti

133 A second frame shift mutation was identified in urbs1-2 and is ne

134 ine with the Fas rendered nonfunctional by a frame shift mutation was resistant to H. pylori-induced

135 A novel frame shift mutation, p.

136 the first report of amyloidosis caused by a frame shift mutation.

137 A frame-shift mutation (121ins2) is the predominant but no

138 he recessive red flesh allele resulting in a frame-shift mutation and a premature stop codon.

139 4 after the initiation codon) that creates a frame-shift mutation and an abnormal sequence for the la

140 equence for codon 522 in exon 13, leading to frame-shift mutation and premature termination.

141 ly conserved with mouse Lyst, and contains a frame-shift mutation at nucleotides 117-118 of the codin

142 apaya accessions showed the presence of this frame-shift mutation in all red flesh accessions examine

143 ng and complete PAI-1 deficiency caused by a frame-shift mutation in exon 4 of the PAI-1 gene.

144 uction in maize (Zea mays) is triggered by a frame-shift mutation in MATRILINEAL (MTL), a pollen-spec

145 We characterized a frame-shift mutation in ssfA1, which encodes an alpha su

146 d level, excluding the amino-terminal end, a frame-shift mutation in the 5' region of the gene in T.

147 e generated a stable line of hamsters with a frame-shift mutation in the Avpr1a gene resulting in the

148 ndicate that the Mc phenotype results from a frame-shift mutation in the gene encoding the 16-kDa gam

149 ensitive allele has a disrupted PRD due to a frame-shift mutation in the open reading frame of the do

150 of resistance to thyroid hormone carrying a frame-shift mutation in the THRA gene (THRA-PV) is assoc

151 elevated fat mass and, in both, a homozygous frame-shift mutation involving the deletion of a single

152 In a second family, we identified a frame-shift mutation of GATA4 (E359del) that was transcr

153 ant tubulointerstitial kidney disease due to frame-shift mutation of MUC1 (ADTKD-MUC1) exhibit reduce

154 Megencephaly, or mceph, is a spontaneous frame-shift mutation of the mouse Kv1.1 gene.

155 are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN a

156 A frame-shift mutation that causes a form of syndromic epi

157 ssed in flowers, but its IGS gene contains a frame-shift mutation that renders it inactive.

158 In the mutant allele, a frame-shift mutation truncates the protein N terminal of

159 4 cells were subsequently found to possess a frame-shift mutation within the TLR2 gene which resulted

160 By a frame-shift mutation, we have engineered a human IGF-I r

161 rminus different from that of IIp45 due to a frame-shift mutation.

162 s) intact, whereas the other exhibited an E1 frame-shift mutation.

163 tions (p.Q51X, p.Y149X, p.C156X), three were frame shift mutations (c.28delG, c.105C>A+106_124dup, c.

164 tions, seven are missense mutations, two are frame shift mutations and one is intronic mutation.

165 kn1 alleles carrying nonsense, splicing and frame shift mutations cause severe inflorescence and flo

166 In addition, repair-dependent frame shift mutations in a GCGCGC region of Salmonella t

167 mutation at nt 2018, could be suppressed by frame shift mutations in either exon of NS2 which reopen

168 generated three mutant alleles with reading frame shift mutations in the zebrafish smyhc1 gene using

169 All frame-shift mutations (19/19) were associated with the S

170 We conclude that both TGF-beta RII frame-shift mutations and microsatellite instability occ

171 se gene structure rearrangements resulted in frame-shift mutations and premature termination codons.

172 A10 frame-shift mutations appear to be restricted to sporadi

173 Frame-shift mutations at microsatellites occur as a time

174 Frame-shift mutations in a run of 10 adenines (A10) of t

175 Jurkat T cell line lacks PTEN protein due to frame-shift mutations in both PTEN alleles and therefore

176 There were frame-shift mutations in consecutive Ts in open reading

177 Two frame-shift mutations in GJB2, 167delT and 30delG, were

178 We identified two frame-shift mutations in the gene encoding Ras-related p

179 With SOS, the frequency of frame-shift mutations increased to 2.6%, even though the

180 Frame-shift mutations introduced into just this suppress

181 After frame-shift mutations occurred that restored the EGFP re

182 These two frame-shift mutations segregated with the disease phenot

183 ignificance of variants such as nonsense and frame-shift mutations that are assumed to be clearly pat

184 A majority of ELF3 alterations are frame-shift mutations that result in several cancer-spec

185 nse mutations, but also include nonsense and frame-shift mutations that result in truncated DP-1 deri

186 Within JAK1 the K142, P430, and K860 frame-shift mutations were identified as hot spot mutati

187 MYO1A frame-shift mutations were observed in 32% (37 of 116) o

188 nger nucleases (ZFNs) can introduce targeted frame-shift mutations with high efficiency, thereby enab

189 trast to the digital ON-OFF switches through frame-shift mutations within coding sequences, such modu

190 single-nucleotide variants (1 nonsense and 4 frame-shift mutations).

191 ntified (12 missense, four nonsense and five frame-shift mutations); 14 of these were novel.

192 Frame-shift mutations, generated by nucleotide insertion

193 m non-deletion AGS patients, revealing three frame-shift mutations, two splice donor mutations and on

194 regions and gave rise to common D310 C-tract frame-shift mutations.

195 mature SP-B was associated with nonsense and frame-shift mutations.

196 rying Rcr3 and Pip1 alleles with deleterious frame-shift mutations.

197 erase chain reaction primer sets and for A10 frame-shift mutations.

198 had a higher odds of containing nonsense or frame-shift mutations.

199 erases and induce both base substitution and frame-shift mutations.

200 Nonsense, splice-site, or frame-shifting mutations in RS1 consistently caused elec

201 f MCPH after finding homozygous missense and frame-shifting mutations in seven MCPH families.

202 nd 14 patients had nonsense, splice-site, or frame-shifting mutations in the RS1 gene (group B).

203 Furthermore, we identified novel frame-shifts mutations in the CCR5 gene in HIV seronegat

204 -nucleotide variations and indels leading to frame shifts, nonsense, missense or splice-site alterati

205 elta 3-5), which is predicted to result in a frame-shifted, nonsense mutation in the NH(2) terminus o

206 cient strains, it appears that both types of frame-shifts occurred as a result of misalignment, which

207 '-end of the coding sequence, resulting in a frame shift, occurred in a patient with ASMD and catarac

208 We showed earlier that RluF induced a frame-shift of the RNA, moving A2602 into the stem and t

209 deletion from the coding region and causing frame-shift of translation.

210 alternative splicing (AS) events, especially frame-shifting ones, has been controversial.

211 s stronger in frame-preserving exons than in frame-shifting ones.

212 nd here we demonstrate it perfectly corrects frame-shifts only 60% of the time.

213 latter identified by mutations resulting in frame shift or premature truncation.

214 quire readthrough of a translational reading frame shift or stop codon, common mechanisms used by ret

215 entified FMO splice variants either caused a frame-shift or lacked essential functional sites.

216 ere reduction in VLCAD mRNA in patients with frame-shift or splice-site mutations and absent or sever

217 codons caused by nucleotide substitutions, a frame shift, or altered splicing.

218 for clpX can be relieved by point mutations, frame shifts, or deletion of the gene spr1630, which is

219 to elucidating a mode of co-evolution of the frame-shifted overlapping ORFs in the adeno-associated v

220 The resulting frame-shifted peptide precursor does not enter the secre

221 des 1414 to 1433 in exon 8 that introduced a frame shift predicting the loss of a normal stop codon a

222 erates a defective transcript variant with a frame-shifted premature termination codon which is subje

223 8-aa hydrophilic C terminus resulting from a frame shift produced by deletion of exon 6.

224 marily nucleotide insertions, that produce a frame-shifted protein product with an extended C terminu

225 The resulting mRNA species encodes a frame-shifted protein with a premature termination codon

226 e and activates inclusion of a 109-base pair frame-shifting pseudoexon.

227 Molecular dynamics simulations of the frame-shifting pseudoknot from beet western yellows viru

228 he junction is the most labile region of the frame-shifting pseudoknot.

229 In addition, a frame shift resulted in a stop codon terminating the ded

230 rp2/3 complex component ARPC1B that causes a frame shift resulting in premature termination.

231 The remaining three mutations included two frame shifts resulting from deletion of one or two bases

232 The 97-nt deletion causes a frame shift, resulting in a ATF2-like polypeptide of app

233 The predicted frame shift results in a truncation of the 32-kD major C

234 Using ScarTrek, we detect 74 unique frame-shift scars in 48 genes, with a 3.74% population-l

235 d restore a gene's reading frame, producing "frame-shift scars" suggestive of reversible gene inactiv

236 etion of the SKSR1 gene or expression of the frame-shifted sequence reduces the pathogenicity of the

237 protein-coding regions and correct erroneous frame-shifts, suitable for subsequent phylogenetic analy

238 This mutation (GPIb alpha deltaAT) causes a frame shift that alters the amino acid sequence of GPIb

239 This mutation causes a translational frame shift that encodes for 86 altered amino acids and

240 xa13(Hd) deletion results in a translational frame shift that leads to the loss of wild-type HOXA13 p

241 e enhancement in mutagenesis was due to a +1 frame-shift that occurred at a high frequency.

242 vents have been identified causing a partial frame-shift that results in an altered amino acid sequen

243 applicability of the two similarly protected frame-shifted thiodisaccharide donors, Glc-GlcA and GlcA

244 the second examination, analyses of multiple frame shifts, truncations, and point mutations within th

245 e footprinting results and the analysis of a frame-shifted uORF, in which the repression capability w

246 The predicted exon 10 skipping and resultant frame shift were confirmed with RNA derived from PLL-aff

247 In addition, -1 and -2 base frame shifts were detected with both 1,N2-epsilon-Gua an

248 Three short protein sequence frame shifts were detected with respect to the non-refin

249 tation that produces a translational reading-frame shift with the consequent formation of a stop codo

250 The PKCzetaII coding region is frame-shifted with respect to the PKCzeta open reading f

251 F per transcript and identifies and corrects frame-shifts with high accuracy.

252 Thus, the pol eta products yielded frame-shifts with the N 2 but not the C8 IQ adducts.

253 new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and co

254 is more accurate than Genewise at correcting frame-shifts within an order.

255 ber of tools capable of correcting erroneous frame-shifts within assembled transcripts are available