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1 g regions and a fourth loop within the third framework region.
2 o the different placement of the light chain framework region.
3 main by a disulfide bond engineered into the framework region.
4 H2-terminal V(H) sequences which precede the framework regions.
5 somatic mutations and those occur mainly in framework regions.
6 gions and S as opposed to R mutations in the framework regions.
7 omplementarity-determining regions (CDRs) or framework regions.
8 -determining regions of the gene than in the framework regions.
9 ht chain variable domains, as well as in the framework regions.
10 ns in complementarity-determining regions or framework regions.
11 verwhelming sequence identity with the human framework regions.
12 with VHa2 structures in the first and third framework regions.
13 volved about 1.5- to 2- fold faster than the framework regions.
14 eveal surprising contributions from antibody framework regions.
15 gen epitopes and are scaffolded by canonical framework regions.
16 ty-determining regions onto homologous human framework regions.
17 tency often required additional mutations in framework regions.
18 s can evolve, including the role of antibody framework regions.
24 VH3 gene products revealed possible sites in framework region 1 and/or framework region 3 that could
25 plementarity determining regions than in the framework regions (2.83 vs 1.41, P < .001), (2) higher t
27 s remarkable amino acid substitutions in the framework region-2 to generate an antigen-binding domain
28 arity-determining region 1 (CDR1), CDR2, and framework region 3 (FR3) are predicted to be more mutabl
29 gy, whereas hypervariable region 4 (HV4) and framework region 3 (FR3) contributed a minimal amount of
30 bs) of gp120 by engraftment of the elongated framework region 3 (FR3) from VRC03, which confers the a
31 new paratope, i.e., the extended heavy-chain framework region 3 (FR3) loop of VRC03, which mediates q
34 stinct locations within V(H) (three sites in framework region 3 and one in complementarity determinin
35 rised of Vbeta14+ CD4 T cells, reactive to a framework region 3 determinant on the Vbeta8.2 chain, an
36 ory type 1 CD4 T cells, directed against the framework region 3 determinant within the B5 peptide (aa
37 possible sites in framework region 1 and/or framework region 3 that could be involved in SEA-mediate
41 prisingly, Jkappa2 accounted for >90% of all framework region 4 sequences in the preimmune repertoire
42 ha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR reco
43 that directly bind to the antigen, while the framework region acts as a scaffold for the CDRs and mai
45 Lastly, comparisons of mutations located in framework region and CDR codons coupled with multinomial
46 evealed that the accumulation of SHM in both framework regions and CDRs contributed to the clonal aff
47 nt junctions, the delineation of IG V domain framework regions and complementarity determining region
48 template structures for the light and heavy framework regions and each of the complementarity determ
49 Env, had mutations concentrated in antibody framework regions, and achieved up to 37% neutralization
50 that improved recognition, predominately in framework regions, and combined these to produce a panel
52 ')2 fragments, especially those bearing VHa2 framework region determinants, specifically interact wit
53 complementarity-determining regions than in framework regions due to the distribution and subsequent
54 antibody fragments, consisting of a constant framework region engineered for optimal cluster binding
55 ds frequently fail to correctly identify the framework regions for which backbones can be copied from
57 1 variable fragment (Fv) was established and framework region (FR) residues which supported complemen
58 encoded V region is readily delineated into framework regions (FR) and complementarity-determining r
59 geous) and/or decrement of mutability in the framework regions (FR; where mutations are more likely t
61 sequence tolerance of Ig variable (V) domain framework regions (FRs) to noncanonical disulfide linkag
63 g sites combined with diverse human germline framework regions (FRs), which were selected based on st
65 complementarity-determining region (CDR) and framework region (FRW) structure/function is not clear.
67 matic mutations within antibody variable and framework regions (FWR) can alter thermostability and st
68 The CDR loops are scaffolded by canonical framework regions (FWRs) that are both resistant to and
69 KIR2DL4 (lineage I) defining the central framework region has been a major target for elimination
70 ctive amino acid substitutions (three in the framework region III and two in the complementarity-dete
74 ion was 3- to 10-fold higher in CDRs than in framework regions, most were R mutations and transversio
75 uration, including somatic hypermutation and framework region mutations, contributed to the binding a
76 tion of complementarity-determining regions, framework regions, mutations, antibody specificity, bind
77 od that identifies candidate residues in the framework region of K1 Fv that, when mutated, improved t
78 ed antibody-antigen structure, the conserved framework region of the antibody makes extensive contact
79 ntral cavity of the fragment antigen binding framework region of the chimeric, anti-epidermal growth
80 e neutral residues to acidic residues in the framework region of the Fv portion of an immunotoxin tar
81 ional manner to CDRs and as superantigens to framework regions of anti-SEE IgE in anti-SEE IgE-Fcepsi
82 acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22
84 ntarity-determining regions (CDR) and in the framework regions of nonproductive VHDJH rearrangements.
88 ides corresponding to hypervariable, but not framework, regions of Ig heavy chain specifically stimul
90 etion and T cell receptor and immunoglobulin framework region recombination was determined by clonali
91 regions (CDRs) of high diversity adjacent to framework regions shared across thousands of IgGs, great
93 alpha- and beta-chains and in the beta-chain framework region that is thought to be in proximity to t
94 nctions that utilize double helical stems as framework regions to reliably fold regardless of variati
95 es and as "superantibodies" through CDRs and framework regions to SEEs in SEE-anti-SEE IgE-FcepsilonR
96 man myeloma protein NEW, and the light chain framework regions were consensus sequences similar to th
97 the mouse anti-lysozyme Ab D1.3, heavy chain framework regions were from the human myeloma protein NE
98 entarity-determining region and three in the framework regions) were identified and incorporated into
99 mutations, especially those occurring in the framework regions, were less frequent in productively re
100 n a specific way, increasing the dynamics of framework regions, which can then change their conformat
101 uires the replacement of key residues in the framework regions with corresponding residues from the p
102 avy chain (VH) and variable light chain (VL) framework regions with substantially broader sequence ho