ライフサイエンスコーパス: free fraction

1 nt of the arterial input function and plasma free fraction.

2 ir albumin binding sites and increases their free fraction.

3 ontent (1061-2988mgGAE/kg) was determined in free fractions.

4 so found in both membrane-bound and membrane-free fractions.

5 duced 'dinoflagellate', 'bacteria' and 'cell-free' fractions.

6 (11)C-UCB-J exhibited high free fraction (0.46 +/- 0.02) and metabolized at a moder

7 Complete remission (tumor-free fraction, 100%) was found for tumor doses of 12.4 a

8 ume of distribution (0.23 +/- 0.14 L/kg) and free fraction (17.5% +/- 5.0%) were increased in critica

9 ll potency, low clearance in mouse, and high free fraction, 2 demonstrated significant efficacy in mo

10 A target of 50% time of the free fraction above the minimal inhibitory concentration

11 blood was collected to calculate the plasma free fraction and generate the arterial input function.

12 rs, and toxicity risks related to the higher free fraction and lower clearance of bupivacaine in neon

13 ir coimmunoprecipitation in the cytoskeleton-free fraction and neuronal soma.

14 For total flavonoids, an increase in the free fraction and reduction of the bound fraction were o

15 The free fraction and the total sterolic fraction, after sap

16 In the protein-free fraction and water-soluble proteins (WSP), all five

17 ific binding in the brain, (b) higher plasma free fraction, and (c) faster plasma clearance and brain

18 onoid content and antioxidant activities for free fraction, and a-glucosidase and acetylcholinesteras

19 onoid content and antioxidant activities for free fraction, and alpha-glucosidase and acetylcholinest

20 ciently high solubility, high plasma protein free fraction, and favorable pharmacokinetics to suggest

21 rther optimization steps, solubility, plasma free fraction, and other ADME properties of 27 were impr

22 series for (pharmacokinetic) PK properties, free fraction, and solubility resulted in the identifica

23 some previously undetected THM in total and free fractions, and proved to be suitable for high-throu

24 Accordingly, we introduce "dynamic free fraction" as a new binding parameter describing dru

25 and SDS were able to increase the furosemide free fraction available for oral absorption.

26 migrates with polysomes rather than ribosome-free fractions, but this is lost under stress.

27 etically and experimentally that the dynamic free fraction can be determined by coupling the drug bin

28 licity, solubility, metabolic stability, and free fraction could be balanced, maintaining low Pgp eff

29 lasma clearance was 29 +/- 1 L/h, and plasma free fraction (f(1)) was 5% +/- 1%.

30 cantly higher levels of total plasma parent, free fraction (f(1)), and free plasma parent in women th

31 The plasma free fraction (f(1)), total parent, and clearance demons

32 rved extraction ratio when using the dynamic free fraction (f(D)) in place of the unbound fraction (f

33 clearance values calculated with the dynamic free fraction (f(D)), which is markedly better than thos

34 Plasma clearance (in liters per hour) and free fraction (f1) of the parent tracer were measured.

35 cans with arterial input function and plasma free fraction (fP) measurements.

36 PBR28 distribution volume (VT) corrected for free fraction (fP) was measured in patients with TLE and

37 )), pharmacokinetic properties including the free fraction (fraction unbound (fu)) in plasma, and in

38 xtracts and tannins-rich and methylxanthines-free fraction from guarana in the anti-inflammatory and

39 ion of conditions for removal of thyroxine's free fraction from samples without significant interfere

40 ne-containing fraction T and plasma membrane-free fractions H and L.

41 On the basis of the measurable free fraction, high affinity and selectivity, adequate b

42 On the basis of its measurable and stable free fraction, high affinity and selectivity, good blood

43 as attributed to the poor reliability of the free fraction (ICC = 0.35) and free parent (ICC = 0.68).

44 vitro potency and selectivity profile, high free fraction in human plasma, good oral bioavailability

45 In 6 scans, arterial input functions and free fraction in plasma (fp) were measured.

46 of distribution in region of interest, fP is free fraction in plasma).

47 nds with lower cLogP values and an increased free fraction in plasma.

48 alysis (HD) is severely limited by their low free fraction in plasma.

49 cators of binding kinetics, and unmeasurable free fraction in plasma.

50 itrogen on the benzoxazole core ensured high free fraction in the brain without introducing efflux.

51 ed as a clinical candidate based on its high free fraction in the brain, specific binding in the HD m

52 P(ND) equals the product of BP(F) and f(nd) [free fraction in the nondisplaceable compartment]), the

53 igand binding by the increase of radioligand free fractions in plasma.

54 The median DTG free-fraction in SP was 48% of the total drug.

55 tioxidant activity, especially in the 20-min free fraction, in both chemical assays and Caco-2 cell m

56 oskeleton-bound, vs. a soluble, cytoskeleton-free fraction, inducing their coimmunoprecipitation in t

57 The free fraction is 59% +/- 3%.

58 r activity (P. aeruginosa MIC90 = 2 mug/mL), free fraction levels (>20% free), and hydrolytic stabili

59 ns, by reducing the pharmacologically active free fraction, may lead to the diminished CRS efficacy i

60 bolite-corrected arterial input function and free-fraction measurement to estimate 5-HT1A binding pot

61 venient and accurate method of measuring the free fraction of (99m)Tc-MDP by comparing it with the gl

62 al volumes of distribution corrected for the free fraction of 2FA in plasma (V(T)/f(P)) in 10 nonsmok

63 od (69% of parent at 120 min), a high plasma free fraction of 38.5%, and a suitable dosimetry profile

64 od (69% of parent at 120 min), a high plasma free fraction of 38.5%, and a suitable dosimetry profile

65 developed for measuring the noncomplexed or free fraction of a hormone in serum based on the combine

66 he extracorporeal circuit that increases the free fraction of a toxic drug and thereby increases its

67 Aqueous pollen extracts, the protein-free fraction of Amb-APE, and the pollen-contained subst

68 o increased the microsomal stability and the free fraction of compounds as evidenced through a pairwi

69 The free fraction of ferulic, caffeic, p-coumaric, and galli

70 moxifen therapy could improve the metastasis-free fraction of high BRCA1 expression patients.

71 es of events that lead to an increase in the free fraction of his serum bilirubin.

72 The free fraction of MPA and the free MPA AUC were markedly

73 h was evaluated by using it to determine the free fraction of phenytoin in serum or samples containin

74 In the final UFIDA method, the free fraction of phenytoin was extracted in approximatel

75 was also used to measure simultaneously the free fraction of testosterone and its equilibrium consta

76 SA microcolumns were utilized to measure the free fraction of testosterone in hormone/protein mixture

77 for determining the total concentration and free fraction of TH and THM in the human serum.

78 , peripheral blood lymphocytes, and the cell-free fraction of the blood plasma.

79 ssue that increased with the increase of the free fraction of the radioligand in plasma.

80 bumin using both a direct measurement of the free fraction of the small molecule as well as using a c

81 te concentration-dependently neutralized the free fraction of ticagrelor and reversed its antiplatele

82 a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion ac

83 system was tested by using it to measure the free fractions of (R)- or (S)-warfarin in samples with k

84 Additionally, the free fractions of FL (fu) in all the plasma samples were

85 ow that Gbetagamma co-segregates with dynein-free fractions of Tctex-1.

86 Repeat-free fractions of the closely related mammalian genomes

87 Free fractions of the HOCs were determined as C(water(eq

88 binding to plasma proteins that elevated the free fractions of the radioligand in plasma.

89 Brine-releasable (BR-) and free fractions of Volatile Sulfur Compounds were determi

90 was developed for measuring the nonbound (or free) fraction of drugs by using millisecond-scale extra

91 a technique for analyzing myelin and myelin-free fractions separately.

92 ween 3 and 4 were likely to have significant free fraction, so we designed compounds in this range to

93 lasma, purified LDL, or the apolipoprotein B-free fraction through a scaled-down, experimental dextra

94 For the FREE fraction, ultrafiltration and salt-out liquid parti

95 The average plasma free fraction was 0.2%; thus, the tracer's in vivo disso

96 The plasma free fraction was 8.9% +/- 1.6% for (11)C-DASB and was n

97 8% at 30 min after injection, and the plasma free fraction was high (0.29 +/- 0.04).

98 orrelation; however, when compounds with <5% free fraction were excluded, a more predictable correlat

99 i-Gram-negative activity and improved plasma free fraction were identified.

100 orrected arterial input functions and plasma free-fraction were acquired to improve quantification.

101 of this series have improved solubility and free fraction when compared to compounds in the previous

102 cin D, L5 and L11 accumulate in the ribosome-free fraction where they bind to Mdm2.

103 osone were the major products in the protein-free fraction, whereas in the WSP, 3-deoxythreosone was

104 extraction up to 20 min, particularly in the free fraction, while esterified and insoluble-bound frac

105 ) was obtained when pipetting the mixed cell-free fractions with 100 mM of zinc sulfate as a precurso