ライフサイエンスコーパス: fucose

1 te GDP-Arap, while synthesizing abundant GDP-fucose.

2 examined biofilm formation and chemotaxis to fucose.

3 and the fucP mutant are chemotactic towards fucose.

4 tions and prevented by specific removal of L-fucose.

5 distinction of GlcNAc from GlcNAc with core fucose.

6 the fuc locus and is unable to swim towards fucose.

7 expressed proteins normally modified with O-fucose.

8 6-deoxygulose and likely regeneration of TDP-fucose.

9 red with antibodies with a high amount of Fc fucose.

10 mannose-terminated glycans with and without fucose.

11 ich is involved in the biosynthesis of GDP-l-fucose.

12 n site, enabling Glu-88 to engage Ca(2+) and fucose.

13 roteins were able to salvage l-fucose to GDP-fucose.

14 e (N)-linked paucimannosylation (mannose(1-3)fucose(0-1)N-acetylglucosamine(2)Asn).

15 bidopsis thaliana revealed that 2-fluoro 2-l-fucose (2F-Fuc) reduces root growth at micromolar concen

16 subsequent repeats of this unit composed of fucose, 3OMe6dTal, and MeGlcA would be assembled by a cy

17 the affinities of the protruding domain for fucose (460 muM) and H type 2 trisaccharide (390 muM), a

18 in cancer cells using peracetylated 5-thio-L-fucose (5T-Fuc).

19 plex N-glycans (i.e. contained xylose and/or fucose) (88 %), whereas complex N-glycans comprised a mu

20 L-fucose, a monosaccharide widely distributed in eukaryote

21 WreT would each act once to attach mannose, fucose, a second fucose, and 3-O-methyl-6-deoxytalose (3

22 ovo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequent

23 ovo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequent

24 ed fraction indicate that AAL binds O-linked fucose added to Ser/Thr residues present in or adjacent

25 modification of the glycan core by alpha-1,6-fucose addition to the innermost GlcNAc residue (core fu

26 mice gained no additional protection from l-fucose administration, indicating that the mechanism of

27 Fucose affects the expression of microbial metabolic pat

28 biosynthesis; however, the secretion rate of fucose-alkyne-labeled pectin is greatly decreased in fra

29 Preadaptation of bacterial strains to fucose alleviated growth hindrance by lactose and partia

30 triflation at O2, O3, and O4 of l-rhamnose/l-fucose allowed selective inversions at respective positi

31 The disaccharide motif fucose-alpha(1-2)-galactose (Fucalpha(1-2)Gal) is involv

32 Although fucose-alpha(1-2)-galactose (Fucalpha(1-2)Gal)-containin

33 Similarly, presence or absence of a core fucose alters type I FcgammaR binding of IgG1 by modulat

34 11168 forms less biofilms in the presence of fucose, although its fucose permease mutant (fucP) shows

35 To address this, we screened a panel of fucose analogues and identified 2-fluorofucose and 5-alk

36 uranus fucoidan contained 70.13 +/- 0.22 wt% fucose and 15.16 +/- 1.17 wt% sulphate.

37 say did not reveal any effect until alpha1,3-fucose and beta1,2-xylose in the Asn297-linked glycan we

38 ide gel electrophoresis to measure cell-wall fucose and boron (B)-dependent dimerization of the cell-

39 The comparison of growth on L-fucose and D-glucose allows first insights into the geno

40 ong with metabolism of its monomers glucose, fucose and galactose.

41 In vitro unfolding assays demonstrate that fucose and glucose stabilize folded TSRs in an additive

42 red to catalyse the cleavage of 2'-FL into L-fucose and lactose by constitutively expressing alpha-L-

43 al C-H...O hydrogen bond between H-C(5) of L-fucose and O(5) of D-galactose was identified.

44 domains 11-13) of human Notch1 (hN1) with O-fucose and O-glucose glycans and shown by flow cytometry

45 Taken together, this work suggests that O-fucose and O-glucose glycans cooperatively stabilize ind

46 A new study shows that O-fucose and O-glucose stabilize the repeats but that exte

47 residues on Notch1 are functionalized with O-fucose and O-glucose, which act as surrogate amino acids

48 results uncover a novel and broad role of l-fucose and protein fucosylation in plant immunity.

49 on sources, the pathway for the breakdown of fucose and rhamnose is encapsulated within a bacterial m

50 The breakdown of fucose and rhamnose released from plant cell walls by th

51 of the d-absolute configuration, except for fucose and rhamnose which are l.

52 e, arabinose, and ribose), two deoxyhexoses (fucose and rhamnose), and two hexuronic acids (glucuroni

53 S. typhimurium accesses fucose and sialic acid within the lumen of the gut in a

54 tions between the concentration of HMO-bound fucose and the abundance of fucosidase (a bacterial gene

55 on data revealed PLL to be specific toward l-fucose and the disaccharide glycan 3,6-O-Me2-Glcbeta1-4(

56 t they bind to mannose, GlcNAc, glucose, and fucose and to glycoproteins that bear these sugars in no

57 ies required for salvage and conversion of l-fucose and/or d-Arap into the nucleotide-sugar substrate

58 minic acid (Neu5Ac), galactose, mannose, and fucose) and significantly (p < 0.05) alter infection.

59 act once to attach mannose, fucose, a second fucose, and 3-O-methyl-6-deoxytalose (3OMe6dTal), respec

60 olved in the utilization of glucose, xylose, fucose, and arabinose, which are also substrates for the

61 containing two GlcNAcs, three mannoses, one fucose, and one xylose (N2M3FX) as a substrate.

62 glycogene regulatory networks: high mannose, fucose, and terminal beta-GalNAc, identifying miRNA regu

63 group adjacent to the linking position of L-fucose, and the hydrophobic interaction of L-fucose with

64 lower action where sialic acid neighbors the fucose, and the neuraminidase showed statistically lower

65 ennary structures, only alpha1,6-linked core fucoses, and more LacNAc repeat structures; the MDA-MB-2

66 Core beta-1,2-xylose and alpha-1,3-fucose are antigenic motifs on schistosome N-glycans, as

67 ike particles (VLPs) and identified alpha1,2-fucose as a key attachment factor.

68 We identified l-fucose as a ligand for CTRP6 and that it bound to certai

69 ped by attachment of di- or tri-O-methylated fucose as catalyzed by glycosyltransferase WreB.

70 f apoFgFCO1 and an open complex with product fucose at atomic resolution.

71 lar, collectin-11 has been shown to engage L-fucose at sites of ischemic stress, activating the lecti

72 Fringe-catalyzed addition of GlcNAc to the O-fucose at T466 in EGF12 substantially increases binding

73 fucose from host glycans, resulting in high fucose availability in the gut lumen.

74 fuc + strains, are involved in coordinating fucose availability with biofilm development.

75 rporating a tetrahydroxamic acid and alpha-l-fucose bearing linker to interfere with both iron uptake

76 Here we show that the fucose-binding Aleuria aurantia lectin (AAL) binds to nu

77 A novel fucose-binding lectin (SL2-1) from the bacterium Strepto

78 the family 51 carbohydrate-binding module, a fucose-binding lectin from Ralstonia solanacearum, and h

79 the native source, and characterized as an l-fucose-binding lectin, named P. luminescens lectin (PLL)

80 ifaria genome identified BambL as a putative fucose-binding lectin.

81 teins, but are related to certain eukaryotic fucose-binding lectins.

82 s that have no similarity to known bacterial fucose-binding proteins, but are related to certain euka

83 beta-propeller fold creating seven putative fucose-binding sites per monomer.

84 aled that it associates as a trimer with two fucose-binding sites per monomer.

85 Although the labelling by the fucose-binding Ulex europaeus agglutinin I (UEA-I) was c

86 lex confirmed that at least three sites were fucose-binding.

87 ents that revealed a multi-faceted role of l-fucose biosynthesis in stomatal and apoplastic defenses

88 e sfr8 mutation to MUR1, a gene encoding the fucose biosynthetic enzyme GDP-d-mannose-4,6-dehydratase

89 ed, through alpha-1,3-glycosidic bonds, with fucose branching at C-2, and one sulphate group at C-4 p

90 New work suggests that fucose can have a protective role in both gut-centered a

91 od source for beneficial gut symbionts, host fucose can suppress the virulence of pathogens and patho

92 plex forms (e.g. beta1,2 xylose and alpha1,3 fucose) can render the product immunogenic.

93 eactivity to only a subset of core alpha-1,3-fucose-carrying N-glycans was inversely associated with

94 Within Fut2(-) mice, the B. thetaiotaomicron fucose catabolic pathway was markedly down-regulated, wh

95 Fucose chemotaxis also correlated with possession of the

96 This study suggests that components for fucose chemotaxis are encoded within the fuc locus, but

97 of the GlcNAcPHN unit (311 and 295 Da), and fucose cleavage followed the loss of the chitobiose resi

98 Selective fucose cleavage from the H2-antigen saccharide enables e

99 e crystal structure of the recombinant PLL.l-fucose complex confirmed that at least three sites were

100 Mice were placed on standard chow or fucose-containing diet (equivalent to a control fucosylg

101 L-Fucose-containing glycoconjugates are essential for a my

102 immunohistochemistry confirmed that alpha1,2-fucose-containing H and A antigens of the HBGA family we

103 he polyanionic polysaccharides alginates and fucose-containing sulfated polysaccharides.

104 The maximal fucose content (17% d.b.) was attained at 180 degrees C,

105 ever, Fsar's polydispersity index (1.12) and fucose content (34.50%) were lower than those of Fysk, a

106 Furthermore, these lines display reduced L-fucose content in N-glycan structures accompanied by sev

107 p at the C-6 position of the nonreducing end fucose could elicit a strong IgG immune response.

108 lmonella as well as to the monosaccharides l-fucose, d-mannose, N-acetylglucosamine, N-acetylgalactos

109 roduce the same biochemical phenotype of GDP-fucose deficiency.

110 he inhibitors were used in vitro to generate fucose-deficient antibodies with enhanced antibody-depen

111 bon sources and revealed a new pathway for L-fucose degradation in S. solfataricus.

112 Within the newly discovered pathway for L-fucose degradation the following key reactions were iden

113 The enzymatic product of an adjacent L-fucose dehydrogenase, BmulJ_04919, was shown to be L-fuc

114 The hypothesis is that a high dose of l-fucose delivered to the kidney obstructs the carbohydrat

115 The observation of the m/z 587.3 core fucose diagnostic peak corresponding to [GlcNAc + Fucose

116 er the O-fucose monosaccharide or the GlcNAc-fucose disaccharide at T466 of EGF12 and observed no cha

117 Antibodies with a low amount of fucose displayed higher binding affinity to FcgammaRIIIa

118 Transitions specific to outer arm fucose document a disease-associated increase in outer a

119 At this l-fucose dose, complement activation and acute post-ischem

120 at and that addition of both O-glucose and O-fucose enhances stability in an additive manner.

121 ncrease in the intrarenal concentration of l-fucose following an IP bolus given before the ischemia i

122 ase the local tissue concentration of free l-fucose following systemic administration, in order to bl

123 hese results establish a requirement for GDP-fucose for L. major viability and predict the existence

124 Moreover, the fucose-free antibodies generated in N. benthamiana are c

125 ties, we have now produced glycan-optimized, fucose-free versions of PG9 and RSH in Nicotiana bentham

126 te, 1,2-propanediol, lactate and cleaving of fucose from 2'-FL.

127 transferase (FucT) catalyzes the transfer of fucose from GDP-fucose to asparagine-linked GlcNAc of th

128 yltransferase FUT1 catalyzes the transfer of fucose from GDP-fucose to terminal galactosyl residues o

129 on produces multiple fucosidases that cleave fucose from host glycans, resulting in high fucose avail

130 nts thereof have been used to add and remove fucose from monoclonal antibody N-glycans, with signific

131 arium graminearum (FgFCO1) actively releases fucose from the xyloglucan fragment.

132 25226) and BdXFUC2 (Bd1g28366) can hydrolyze fucose from xyloglucan oligosaccharides but were unable

133 ches the distal d-xylose (Xyl) unit to the l-fucose (Fuc) that is part of the conserved N-glycan core

134 re, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi polysaccharide fraction (de

135 I, which may compensate for the loss of core fucose functions.

136 antennary galactosylated structure with core fucose (Gal(2)GlcNAc(2)Man(3)GlcNAc(2)Fuc), and a group

137 ythroagglutinin (PHA-E) are used to identify fucose, galactose, alpha2-6-linked sialic acid, and bise

138 paration of nine determined monosaccharides (fucose, galactose, arabinose, glucose, rhamnose, xylose,

139 Fucose, galactose, arabinose, glucose, sucrose, rhamnose

140 Previous analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation rea

141 espond to one of four new inducer molecules: fucose, gentiobiose, lactitol and sucralose.

142 subsequently elongated to a glucose beta1-3-fucose (GlcFuc) disaccharide by beta1,3-glucosyltransfer

143 that the lectin AAL had higher binding where fucose groups are displayed on separate branches.

144 erminal galactose, bisecting GlcNAc and core fucose has been realized.

145 ponses to core beta-1,2-xylose and alpha-1,3-fucose have distinctive relationships with Sm infection

146 Host cells modify secreted proteins with O-fucose; here we describe the O-fucosylation pathway in t

147 nt subclasses (IgG1-4) with and without core fucose (i.e., 20% fucose remaining).

148 kely adaptations that allow accommodation of fucose in blood group B active GH110 enzymes or, in the

149 GFT1-silenced plants are almost devoid of L-fucose in cell wall-derived xyloglucan and rhamnogalactu

150 The key role played by fucose in glycoprotein and cellular function has prompte

151 DP-N-acetylglucosamine, GDP-mannose, and GDP-fucose in Plasmodium falciparum intraerythrocytic life s

152 (TSRs) that are modified by C-mannose and O-fucose in Plasmodium spp. and mammals.

153 Although the function of fucose in the parasite is not known, the presence of GDP

154 of three metabolites (copper, trehalose, and fucose) in the environment of a cell population over tim

155 The interface between collectin-11 and L-fucose, in both the recipient and the allograft, is an a

156 e used by fucosyltransferases to incorporate fucose into protein and cellular glycans.

157 eotide sugar transporter for import of GDP-L-fucose into the Golgi and is required for proper plant g

158 de sugar transporter that translocates GDP-L-fucose into the Golgi lumen.

159 Injecting fluorophore-tagged sialic acid and fucose into the yolk of zebrafish embryos at the one-cel

160 Fucose is a common monosaccharide component of cell surf

161 Fucose is a sugar present in glycoconjugates often assoc

162 O-fucose is added to cysteine-rich domains called thrombos

163 Fucose is an L-configuration sugar found abundantly in t

164 Previous studies suggested that O-linked fucose is essential for folding and secretion of POFUT2-

165 re active in vitro, indicating that most GDP-fucose is formed by a de novo pathway that involves the

166 sylated proteins are shed into the lumen and fucose is liberated and metabolized by the gut microbiot

167 e N-glycan structure confirmed that alpha1,3-fucose is missing from the N-glycans of allelic fuct-1 a

168 metabolic labeling experiments showing that fucose is not significantly incorporated by the parasite

169 duce epithelial fucosylation, and epithelial fucose is used as a dietary carbohydrate by many of thes

170 The incorporation of alpha-fucoses is demonstrated for H-type I and II; alpha(1,3)-

171 To test whether GDP-fucose itself was essential for Leishmania viability, we

172 and WbdP) and they transfer glucose (Glc), L-fucose (L-Fuc) and N-acetylperosamine (PerNAc) onto GalN

173 nd not by sequential domains like the fungal fucose lectin from Aleuria aurantia.

174 sfr8 cell walls exhibited low cell-wall fucose levels and reduced RGII bridging.

175 ages, with additional alpha1,2- and alpha1,3 fucose linkages found in MCF-7 cells.

176 ith terminal alpha2,3-sialidic acid and core fucose linkages, with additional alpha1,2- and alpha1,3

177 During growth on L-fucose major changes in the central carbon metabolic net

178 overall yield from commercially available l-fucose, making it the most efficient route reported to d

179 chains consist of typical M. xanthus lipids, fucose, mannose, N-acetylglucosamine and N-acetylgalacto

180 locus revealed that Cj0485 is necessary for fucose metabolism and chemotaxis.

181 g genes for import of fucosylated molecules, fucose metabolism and two alpha-fucosidases.

182 reveals concomitant shifts in cyclic AMP and fucose metabolism consistent with phototaxis and extrace

183 n the parasite genome, but the importance of fucose metabolism for the parasite is unknown.

184 tive on bifidobacterial fucosyllactose and L-fucose metabolism.

185 s with procainamide hydrochloride to inhibit fucose migration during tandem MS analysis.

186 tin and EGF domains of L-selectin bound to a fucose mimetic; that is, a terminal mannose on an N-glyc

187 O-Linked fucose modifications on Notch1 epidermal growth factor-l

188 sual N-glycans with a range of galactose and fucose modifications on the Man2-3GlcNAc2 core region.

189 ponses to core beta-1,2-xylose and alpha-1,3-fucose modified N-glycans were higher in rural versus ur

190 O-fucose-modified TSRs are subsequently elongated to a glu

191 of fucosidase (a bacterial gene that digests fucose moieties) harbored by milk bacteria.

192 cosidase mutants could introduce an alpha1,6-fucose moiety specifically at the Asn-linked GlcNAc moie

193 ains 11-13 of hN1 modified with either the O-fucose monosaccharide or the GlcNAc-fucose disaccharide

194 erved varying degrees of elongation beyond O-fucose monosaccharide, indicating that Fringe preferenti

195 ed statistically lower action where alpha1-2 fucose neighbors the sialic acid or is on the opposing b

196 hated polysaccharide that consists mainly of fucose, normally found in brown seaweeds.

197 Mass spectral analysis showed that O-fucose occurred at high stoichiometry at most consensus

198 he C-4 hydroxyl group of the alpha1-3-linked fucose of sLe(X), which may account for the enhanced hos

199 Removal of the core fucose of this glycan greatly increases the affinity for

200 tained at 160 degrees C, whereas the maximum fucose oligosaccharides was obtained at 180 degrees C.

201 t a disease-associated increase in outer arm fucose on both bi- and triantennary glycans at the N187

202 s studies showed that LFNG modification of O-fucose on EGF8 and -12 of NOTCH2 was responsible for enh

203 Our previous work indicated that fucose on human epithelia is a frequent target for lecti

204 Indeed, removal of fucose on myelin reduced DC-SIGN-dependent homeostatic c

205 COLEC11) recognizes an abnormal pattern of L-fucose on postischemic renal tubule cells and activates

206 f C. elegans N-glycans and that the alpha1,3-fucose on the reducing terminus can be substituted by an

207 ggest that B. bifidum SC555 does not utilize fucose or sialic acid from HMO.

208 analogues in which N-acetyl-d-glucosamine, l-fucose, or d-galactose (D-Gal) are replaced with d-gluco

209 ve carbohydrate cleavage reactivity toward l-fucose over d-glucose.

210 how that GFT preferentially transports GDP-L-fucose over other nucleotide sugars in vitro, while GFT1

211 llowing key reactions were identified: (i) L-fucose oxidation to L-fuconate via a dehydrogenase, (ii)

212 ural symmetry motifs in the Escherichia coli fucose permease (FucP) results in remarkable homology to

213 ilms in the presence of fucose, although its fucose permease mutant (fucP) shows no change.

214 similarity with the glycerol-3-phosphate and fucose permeases from Escherichia coli, respectively.

215 of methods to discriminate unambiguously the fucose position in one-step.

216 Thus, the GDP-fucose precursor is essential in a wide variety of organ

217 e diagnostic peak corresponding to [GlcNAc + Fucose + Procainamide + H](+) in the tandem MS data of f

218 1-4) with and without core fucose (i.e., 20% fucose remaining).

219 or receptor binding is the embrace of an ABO fucose residue by a disulfide-clasped loop, which is ina

220 in proton migration, which in turn leads to fucose residue migration from the glycan core to the ant

221 ltrasferase (FUT)-catalyzed transfer of an L-fucose residue to carbohydrate acceptors.

222 ules with only one N-acetylglucosamine and a fucose residue was fully able to abolish the interaction

223 ical of many other eukaryotes; some of these fucose residues are capped with hexose residues as shown

224 e of labeling allows to distinguish how many fucose residues are on the specific antenna and provides

225 The modification of alpha1,6-linked fucose residues attached to the proximal (reducing-termi

226 Up to three fucose residues can be present on the standard N,N'-diac

227 removal of alpha2,3-sialic acid and alpha1,3-fucose residues from host cell surfaces makes them less

228 /MS), we now reveal that actually up to five fucose residues modify the core region of C. elegans N-g

229 that modulate Notch activity by modifying O-fucose residues on epidermal growth factor-like (EGF) re

230 pha1,3-linked, but also core alpha1,6-linked fucose residues on their N-glycans.

231 onalized glycoclusters with galactose and/or fucose residues targeting both PA-IL and PA-IIL lectins

232 Previously, up to four fucose residues were detected on its N-glycans, despite

233 toid arthritis SF contained both sulfate and fucose residues, and SF lubricin was capable of binding

234 ted glycans, namely O-methylated mannose and fucose residues, as part of bacterial LPS and nematode c

235 olved in the incorporation and cleavage of L-fucose residues, respectively, represent captivating tar

236 ex type containing terminal sialic acids and fucose residues.

237 oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fu

238 f the aldehyde dehydrogenase enzyme from the fucose/rhamnose utilisation BMC with different short-cha

239 Homologues for enzymes involved in a fucose salvage pathway are apparently absent in the P. f

240 ct an Atfkgp mutant that is defective in the fucose salvage pathway indicates that 2F-Fuc must be con

241 ly, these antibodies with a low amount of Fc fucose showed enhanced phagocytosis of platelets using F

242 , similar to the type 2 LacNAc termini, with fucose, sialic acid, or sulfate.

243 In contrast to NOTCH1, a single O-fucose site mutant that substantially blocked the abilit

244 Interestingly, elimination of the O-fucose site on EGF12 allowed LFNG to inhibit JAG1-NOTCH2

245 and that the Fringe enzymes modified more O-fucose sites of NOTCH2 compared with NOTCH1.

246 The majority of the O-fucose sites were modified to high stoichiometries.

247 ified peptides containing all 22 predicted O-fucose sites, all 18 predicted O-glucose sites, and all

248 SL2-1 belongs to a new group of bacterial fucose-specific lectins that have no similarity to known

249 captured core beta-1,2-xylose- and alpha-1,3-fucose-specific responses, and confirmed associations wi

250 ssays reveal that addition of O-glucose or O-fucose stabilizes a single EGF repeat and that addition

251 t8-deficient (Fut8(-/-)) mice that lack core fucose structure die within 3 days after birth, but the

252 ting reports regarding the maximal number of fucose substitutions in C. elegans, which in part may be

253 e parasite is not known, the presence of GDP-fucose suggests that the metabolite may be used for furt

254 njugates, including ones heavily modified by fucose, sulfate, and sialic acid residues.

255 measurements of monosaccharide composition, fucose, sulfate, and uronic acid contents revealed that

256 GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is conserved in the parasite genom

257 ues of GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase enzymes that are active in vitro, indica

258 iparum GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase expressed in transgenic 3D7 parasites sh

259 ck of fucosylation consequent to loss of GDP-fucose synthesis contributes to colon carcinogenesis.

260 nzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were expressed ectopically; fro

261 with Kdo-N3 and an alkynated derivative of L-fucose that incorporates into rhamnogalacturonan I, co-l

262 ed AlfC, with specificity towards alpha(1,6)-fucose, the only linkage found in human N-glycan core fu

263 proximal renal tubule in association with L-fucose, the potential binding ligand for CL-11.

264 at involved in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved

265 ucose derivatives that depleted cells of GDP-fucose, the substrate used by fucosyltransferases to inc

266 stration, indicating that the mechanism of l-fucose therapy was largely CL-11-dependent.

267 ly tert-butyldimethylsilyl (TBDMS) protected fucose thioglycosides as glycosyl donors for oligosaccha

268 T) catalyzes the transfer of fucose from GDP-fucose to asparagine-linked GlcNAc of the N-glycan core

269 osyltransferase-VI and guanosine diphosphate fucose to enhance the interaction of CD34(+) stem and ea

270 d-Arap, both proteins were able to salvage l-fucose to GDP-fucose.

271 We hypothesized that adding fucose to human Tregs, forming the Sialyl Lewis X moiety

272 Here, we show that addition of L-fucose to purified FucP in detergent induces approximate

273 T1 catalyzes the transfer of fucose from GDP-fucose to terminal galactosyl residues on xyloglucan sid

274 gy of Fx-/- mice was reversed by addition of fucose to the diet, which restored fucosylation via a sa

275 xoplasma gondii transfers a different sugar, fucose, to proteins involved in transcription, mRNA proc

276 This pathway as well as L-fucose transport shows interesting overlaps to the D-ara

277 s encoding either POFUT2 or the putative GDP-fucose transporter (NST2) resulted in loss of MIC2 O-fuc

278 Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide s

279 he crystal structure of the Escherichia coli fucose transporter FucP and have identified four transme

280 ucosylation via over-expression of a key GDP-Fucose transporter, Slc35c1, in zebrafish.

281 The third position of the fucose unit is always linked to a rhamnose, which is a s

282 idue of the main chain, (ii) a hyperbranched fucose unit, and (iii) two rhamnose residues with opposi

283 thin the identified glycans, the position of fucose units was located to quantitate possible changes

284 nd one sulphate group at C-4 per every three fucose units, i.e. the structure of fucoidan from Japane

285 of the NCTC11168 locus into 81-176 activated fucose uptake and chemotaxis.

286 now known to encode pathways for glucose and fucose uptake/metabolism.

287 ting from readily available l-rhamnose and l-fucose via highly regioselective, one-pot double serial

288 sII with the C4-epimer of TDP-quinovose (TDP-fucose) was examined.

289 CD epitopes (core beta-1,2-xylose, alpha-1,3-fucose) was positively associated with sensitization to

290 of fragment ions in N-glycans without a core fucose were associated with the loss of the GlcNAcPHN un

291 Responses to core alpha-1,3-fucose were elevated regardless of Sm infection status a

292 ntennary, and triantennary with/without core fucose, were quantified.

293 maR), and whether the absence of the Fc core fucose (which increases binding to FcgammaRIIIa) increas

294 ulphated polysaccharide, made up mainly of l-fucose, which is found in brown seaweeds.

295 o a terminal xylose unit and a hyperbranched fucose, which is in turn substituted with a terminal gal

296 These enzymes depolymerize fucoidan into fucose, which is metabolized in a proteome-costly bacter

297 lammatory responses through recognition of L-fucose, which we confirmed by showing that fucosidase-tr

298 fucose, and the hydrophobic interaction of L-fucose with the beta-face of D-galactose), a nonconventi

299 X stands for different sulfation patterns of fucose (X = 3,4S (46%), 2,4S (39%), and 4S (15%)).

300 e whereas the acidic polysaccharides contain fucose, xylose and 4-O-methylglucuronic acid -residues.