ライフサイエンスコーパス: fucosyl

1 ns are occasionally substituted with alpha-l-fucosyl.

2 ecause of the absence of a conserved alpha-L-fucosyl-(1-->2)-beta-D-galactosyl side chain and excessi

3 (1-->2)-alpha-D-xylosyl-(1--> and/or alpha-L-fucosyl-(1-->2)-beta-D-galactosyluronic acid-(1-->2)-alp

4 hyl-beta-D-galactopyranosyl-(1-->4)-[alpha-L-fucosyl-(1-->6) ]-beta-D-glucopyranoside (2a), has been

5 fucosyl lactose but were not active with 2'- fucosyl-6'-sulfo lactose.

6 s: alpha-d- and alpha-l-arabinosyl-, alpha-l-fucosyl-, alpha-d-ribosyl-, alpha-d-xylosyl-, and even a

7 We identified beta-fucosyl amides as unprecedented high-affinity ligands in

8 raphy of one alpha- and one beta-anomer of N-fucosyl amides in complex with LecB revealed the interac

9 f LecB, we designed and synthesized a set of fucosyl amides, sulfonamides, and thiourea derivatives.

10 UR3 genes of Arabidopsis encode XyG-specific fucosyl and galactosyl transferases, respectively.

11 C. elegans-specific fucosyl and native methylated glycans were found in all

12 ferent heterologously expressed galactosyl-, fucosyl-, and xylosyltransferases can transfer azido-fun

13 (CCIs) via fucosyltransferase (FT)-meditated fucosyl-biotinylation, which has been applied to probe a

14 cells based on their cell-surface enzymatic fucosyl-biotinylation.

15 d, attributed to shape irregularities of the fucosyl branches on an otherwise linear core, being more

16 oglucan, but that the molecular mass and the fucosyl content of the substrates influence enzymatic re

17 l mass balancing of industrially produced 2'-fucosyl-d-lactose.

18 At 6 mo, each 1-mug/mL increase in fucosyl-disialyl-lacto-N-hexaose and lacto-N-neotetraose

19 Fucosyl-disialyllacto-N-hexose (FDSLNH) was the only oli

20 te-beta-l-fucose (GDP-fucose), the universal fucosyl donor, the Le(x) trisaccharide, and their C-5 su

21 charide acceptor moieties, 25 or 26, and the fucosyl donors, 10 and 11, were conducted using similar

22 S group inferred unusual reactivity on these fucosyl donors.

23 ides and intact glycoproteins by using alpha-fucosyl fluoride as a simple donor substrate.

24 which was shown to be able to use modified a-fucosyl fluoride as the donor substrate.

25 Expression of these rice genes, including fucosyl-, galactosyl-, and acetyltransferases, in the co

26 cer-associated antigens globopentaose (Gb5), fucosyl-Gb5 (Globo H), and sialyl-Gb5 (SSEA4) by using o

27 t tumor-associated antigens (fucosyl-GM1 and fucosyl-Gb5), were unambiguously confirmed by 1H-NMR spe

28 cceptorsubstrate specificity toward alpha1,6-fucosyl-GlcNAc-Asn or alpha1,6-fucosyl-GlcNAc-polypeptid

29 ward alpha1,6-fucosyl-GlcNAc-Asn or alpha1,6-fucosyl-GlcNAc-polypeptide in transglycosylation, enabli

30 round of reduced core-1 O-glycans, the novel fucosyl glycans likely replace or mask remaining core-1

31 Challenging 1,2-cis fucosyl glycosylations were achieved satisfactorily by N

32 otected using standard procedures to provide fucosyl GM1 oligosaccharide (1) in 44% yield.

33 s of the novel small cell lung cancer (SCLC) fucosyl GM1-based vaccine construct, featuring insertion

34 de synthesis methodology to the synthesis of fucosyl GM1.

35 n to be important tumor-associated antigens (fucosyl-GM1 and fucosyl-Gb5), were unambiguously confirm

36 nding to multiple GM1 isoforms as well as to fucosyl-GM1, which is a known ligand.

37 om the alphaGal epitope by the presence of a fucosyl group.

38 as located to quantitate possible changes of fucosyl isomeric species associated with the pathologica

39 ctal cancer, being primarily associated with fucosyl isomers.

40 The kinetics for GalNAc transfer to 2'-fucosyl lactose are characteristic of a sequential mecha

41 , 9%, and 188% active, respectively, with 2'-fucosyl lactose but were not active with 2'- fucosyl-6'-

42 e showed exemplarily that as few as 10 pg of fucosyl lactotetra was detectable.

43 EA-3, SSEA-4, and Globo H) and lacto-series (fucosyl-Lc4Cer) to neolacto-series GSLs (SSEA-1 and H ty

44 s and concurrent introduction of two alpha-L-fucosyl moieties at the late stage of the syntheses prov

45 ich collectively remove all known sialyl and fucosyl mucin caps including those on double-sulfated ep

46 Here we characterize the CD15 (3[alpha1-3]-fucosyl-N-acetyl-lactosamine)-positive cells in the mous

47 e-1 glycans are decreased, whereas the novel fucosyl O-glycans are increased in abundance in this reg

48 ogue, and modified structures containing 3-O-fucosyl or 6-O-sulfo substituents in the N-acetylglucosa

49 A series of sialyl fucosyl poly-N-acetylgalactosamine gangliosides without

50 rs which can be used to accurately determine fucosyl positions in glycans.

51 Thus, the presence of a fucosyl residue appears to be obligatory for an oligosac

52 a single methyl group to the 2-position of a fucosyl residue in one of the five O-chain trisaccharide

53 y affected by the presence of an alpha 1,6-L-fucosyl residue located on the distant glucosaminyl resi

54 (mannose3-N-acetylglucosamine2), most with a fucosyl residue on the innermost N-acetylglucosamine.

55 The addition of an alpha 3-fucosyl residue to each of these two competitive inhibit

56 ose of dicotyledonous plants, has a terminal fucosyl residue.

57 pproximately 25% of the 3,4-linked branching fucosyl residues and 10% of the 3-linked fucosyl residue

58 ing fucosyl residues and 10% of the 3-linked fucosyl residues are 2-O-methylated.

59 We show that fucosyl residues do not migrate to hydroxyl groups but t

60 s the regiospecific transfer of terminal 1,2-fucosyl residues to xyloglucan side chains - a key step

61 However, the simple removal of fucosyl residues, which results in reduced C1q binding a

62 ess xylosylated (XXGGn core motif) and lacks fucosyl residues.

63 thaliana) XyG, which contains galactosyl and fucosyl substituents, tomato (Solanum lycopersicum) XyG

64 ights into the molecular mechanisms by which fucosyl sugars contribute to neuronal processes.

65 Galalpha-O-Me] structures containing sialyl, fucosyl, sulfo, methyl, or fluoro substituents by identi

66 that partially purified KpsS functions as a fucosyl sulphotransferase in vitro.

67 A mechanism for fucosyl transfer incorporating these findings is propose

68 eins as potential substrate acceptors in the fucosyl transfer reactions indicated that the two enzyme

69 fucosyl transferase 8 (FUT8) was identified as a potenti

70 and SPINDLY (SPY), which have O-GlcNAc and O-fucosyl transferase activities, respectively, are essent

71 of the resulting compounds by a recombinant fucosyl transferase resulted in only modification of the

72 ith increasing alpha-mannosidase II and core fucosyl-transferase enzyme activities, and with decreasi

73 1 alone or fucT1 and fucT2, which encode the fucosyl transferases necessary for Le(x) and Le(y) expre