ライフサイエンスコーパス: fulfill @2 role

1 to RhoA-dependent actin-based structures to fulfill its roles.

2 region, the atypical myosin light chains may fulfill that role.

3 lothionein or cellular zinc transporters may fulfill that role.

4 set but distinct from natural T(R) cells may fulfill this role.

5 entate gyrus subregion has been suggested to fulfill this role.

6 activating kinases, Sak1, Tos3, or Elm1, can fulfill this role.

7 ndicates that Arg93 in NucA is positioned to fulfill this role.

8 second zebrafish mitf gene, mitfb, which may fulfill this role.

9 on miR-7 accumulation, suggest that targets fulfill this role.

10 regulated, and cell type-specific enhancers fulfill this role.

11 ave been proposed as promising biomarkers to fulfill this role.

12 ent and about how clinicians could help them fulfill this role.

13 cognized as an important sequence class that fulfill many roles.

14 space of plastids and we propose that Tic22 fulfills this role.

15 ARC6-like protein unique to vascular plants, fulfills this role.

16 ucing agent is required for the reaction and fulfills two roles.

17 naling pathway is an attractive candidate to fulfill such a role.

18 fy apex2 and ercc4 (xpf) as putative players fulfilling this role.

19 e stria terminalis (aBST) as a candidate for fulfilling this role.

20 w that inducible cAMP early repressor (ICER) fulfills such a role.

21 FNR proteins that presumably have evolved to fulfill distinct roles.

22 how these highly similar pathways evolved to fulfill different roles.

23 s engaged in retrograde signaling, it cannot fulfill the latter role.

24 se their typical endo-binding mode would not fulfill a targeting role.

25 gulation with the deNADding activity of Xrn1 fulfilling a central role.

26 Another endopeptidase, PBP 7, fulfills a secondary role.

27 merization event, which switches the strands fulfilling these two roles.

28 is not essential for catalysis, and possibly fulfills a structural role.

29 formation is metal-dependent, with the metal fulfilling a structural role.

30 disposal of cell-cycle regulators that have fulfilled their mitotic roles.

31 redundant PSs already present in the genome fulfilling their packaging role.

32 rties of the tandem HMG boxes, presumably to fulfill different cellular roles.

33 re structurally diverse which allows them to fulfill multiple functional roles.

34 oids may exploit multiple assembly routes to fulfill their physiological roles.

35 e residues are not involved in catalysis but fulfill important structural roles.

36 To fulfill its biological role, a cell globally responds wi

37 /UL131A (Pentamer) complex has been found to fulfill this role, accounting for HCMV entry into almost

38 We suggest that synapsin fulfills this role also in vertebrates, including humans

39 imply that vertebrate odorant receptors may fulfill a dual role, also serving as address molecules t

40 Divalent ions fulfill essential cellular roles and are required for vi

41 To fulfill its diverse roles and maintain hemostasis, this

42 ursing is dependent on available evidence to fulfill that role and on the sociopolitical and organiza

43 Branched-chain amino acid (BCAA) metabolism fulfills numerous physiological roles and can be harness

44 is a fundamental duty of physicians both to fulfill a role as trusted adviser and to promote the eth

45 To fulfill its role as the major energy-storing tissue, adi

46 e COP9 signalosome have been hypothesized to fulfill the roles as an ubiquitin ligase (E3) and an ess

47 ly inhibit the ability of dendritic cells to fulfill their role as antigen-presenting cells.

48 The electrochemically active particles fulfill their role as energy exchange reservoirs through

49 es of oral health and disease if they are to fulfill their role as professionals dedicated to the hea

50 ur results indicate that UBA(Cez) can indeed fulfill this role as regulatory domain by binding variou

51 ultiple downstream repair processes, thereby fulfilling its role as a caretaker tumor suppressor.

52 (NO) is an important signaling molecule that fulfills diverse functional roles as a neurotransmitter

53 The CytR repressor fulfills dual roles as both a repressor of transcription

54 which confirms that the restored tryptophan fulfills its ancestral role as a core side chain, fillin

55 To understand how micro 1 fulfills its role as the reovirus penetration protein, w

56 a dynamic change in phosphorylation state to fulfill its multiple roles at different stages of viral

57 which is a multifunctional metabolic enzyme fulfilling several metabolic roles (beta-oxidation of fa

58 Hence, we show that cellulose fulfills an adhesion role between the extracellular muci

59 between Cu(I) and Cu(II) oxidation states to fulfill its physiological roles, but alterations in cell

60 Noteworthy, sugars not only fulfill metabolic roles, but also act as signaling molec

61 support a model in which theta oscillations fulfill this role, but results in humans have not been a

62 enterochromaffin (EC) cells are proposed to fulfill this role by acting as chemosensors, but underst

63 cell immunity in viral infection and that it fulfills this role by acting as a complement inhibitor t

64 ERRalpha fulfills this role by acting directly at genes important

65 previous information by demonstrating SRC-2 fulfills this role by serving as a critical coactivator

66 iver regeneration after CCl(4) injury, which fulfills multiple roles; C3a generated early after toxin

67 The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus

68 Fulfilling these roles could place conflicting constrain

69 leukin-1 receptor-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like recep

70 e, we focus on two intriguing candidates for fulfilling this role, Drosophila Dscams and vertebrate c

71 and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division.

72 AAV Rep's structural flexibility required to fulfill its multifunctional role during the AAV life cyc

73 Surface proteins of Staphylococcus aureus fulfill many important roles during the pathogenesis of

74 Dynamin may also fulfill other roles during earlier stages of vesicle for

75 Thus, Crb fulfills a protective role during light exposure by limi

76 In polydiacetylenes, the substituents fulfill another important role: During topochemical poly

77 presents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles, first in the kidney t

78 function, individual isoforms of PIP5KIgamma fulfill unique roles for the integrin-dependent integrit

79 vation through an ionic mechanism, that A440 fulfills a structural role forming part of the G-protein

80 We conclude that Ile216 and Thr220 fulfill a structural role, forming the foundation of the

81 leotidyltransferases, with the vast majority fulfilling multifunctional roles from DNA replication to

82 However, DAGLs that might fulfill this role have not been previously identified in

83 How katanin fulfills its controlling role, however, remains poorly u

84 oute AGT to the mitochondria where it cannot fulfill its metabolic role (i.e. glyoxylate detoxificati

85 Such services fulfill a crucial role in ensuring transparency and repr

86 ch has been redesigned from the ground up to fulfill a greater role in the HDX-MS analysis pipeline.

87 e properties of PEP-19 suggest that it could fulfill a role in neuroprotection.

88 Therefore, Anp32b appears to fulfill a role in regulating adequate adaptive immune re

89 ammation--NOD proteins have been proposed to fulfill a role in the intracellular sensing of bacteria.

90 These proteins fulfill a similar role in biological condensates, where

91 rotein subunit, which allows each subunit to fulfill a unique role in the energy transfer network.

92 eous plethora of receptors, each tailored to fulfill a vital role in fast synaptic signaling and plas

93 Ultrasonic vocalizations (USVs) fulfill an important role in communication and navigatio

94 g body of evidence shows that gut microbiota fulfill an important role in health and disease by modul

95 These genes thus appear to fulfill an unexpected role in fostering cell cooperation

96 aped by natural selection as they evolved to fulfill changing functional roles in their native enviro

97 tissues in multicellular organisms, yet they fulfill critical roles in development and normal physiol

98 These surface lipoproteins (SLPs) fulfill critical roles in immune evasion and nutrient ac

99 Innate lymphoid cells (ILCs) fulfill critical roles in maintenance of tissue-specific

100 ne channel-like (TMC) proteins TMC1 and TMC2 fulfill critical roles in MET, and substantial evidence

101 They fulfill critical roles in tissue homeostasis and develop

102 onal properties suggested that the GDU genes fulfill different roles in roots, vasculature, and repro

103 ractions, tailoring their gating behavior to fulfill distinct roles in neuronal signaling.

104 AMPARs of different subunit compositions fulfill distinct roles in synaptic long-term potentiatio

105 and ionotropic glutamate receptors (iGluRs) fulfill divergent roles in vertebrate nervous systems.

106 Mitochondria fulfill essential roles in ATP production, metabolic reg

107 rties, and might therefore act in concert to fulfill essential roles in vivo.

108 ed with disease, over those whose aggregates fulfill functional roles in biology, to those that aggre

109 Strong RNA binding allows Mss116 to fulfill its biological role in the stabilization of grou

110 We propose that PARylation enables HIRA to fulfill its essential role in the adaptive response to A

111 To fulfill its role in hemostasis, the platelet is equipped

112 that interact with a variety of proteins to fulfill key roles in signal transduction pathways trigge

113 SRF and its pathway fulfill multiple complex roles in the regulation of the

114 e T cell mediated suggests that some B cells fulfill other roles in autoimmunity.

115 Although distinct DNA repair machinery fulfill overlapping roles in the repair of DNA lesions,

116 nating oligodendrocytes, NG2 glia might also fulfill physiological roles in CNS homeostasis, although

117 al maintenance of chromosomes (SMC) proteins fulfill pivotal roles in chromosome dynamics.

118 LPs fulfill signaling roles in organisms as diverse as yeast

119 t that other signaling pathways can probably fulfill similar roles in vivo.

120 ndent, suggesting that cyclopentenones could fulfill some JA roles in vivo.

121 In the leaf cells, nutrient ions fulfill specific roles in biochemical reactions, especia

122 contains five imperfect repeating units that fulfill specific roles in directing amyloid formation.

123 , indicate that individual PIP5KI isoenzymes fulfill specific roles in embryonic development.

124 It is currently not known whether mRNAs fulfill structural roles in the cytoplasm.

125 enzyme OGT are highly elevated in cancer and fulfill the crucial role in regulating many hallmarks of

126 is a key step toward understanding how they fulfill their distinct roles in cortical network operati

127 this control system that may enable ABCs to fulfill their distinctive role in immune responses.

128 endowing them with the plasticity needed to fulfill their key roles in cell functioning.

129 tosis and thus is crucial for neutrophils to fulfill their roles in innate immunity.

130 es of different myosin isoforms are tuned to fulfill these roles in an array of cellular processes, a

131 ted mechanisms have been identified that can fulfill this role in a variety of mammalian cell types,

132 ns, but also show that a tyrosine is able to fulfill this very role in Chlamydomonas reinhardtii cryp

133 Thus, sterols fulfill two roles in mammalian cells: (i) a bulk membran

134 teins containing the STAR RNA-binding domain fulfill vital roles in RNA biogenesis, yet a detailed un

135 ued presence of XORC or XCdc6 once they have fulfilled their essential role in licensing.

136 CCR6-CCL20 to recirculate through the skin, fulfilling a novel role in skin immunity and inflammatio

137 body responses to EGFR hold the potential of fulfilling a pathogenic role in autoimmune disease.

138 ne system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or path

139 omeostatic processes in eukaryotic organisms fulfilling essential roles in development and adaptation

140 In fulfilling its biosynthetic roles in nuclear replication

141 to be the major cellular protease capable of fulfilling such a role in maturation.

142 o be quickly reactivated may be essential to fulfilling the physiological role in cyanobacteria, orga

143 ent anatomical sites in vivo is critical for fulfilling their roles in the induction of Ag-specific i

144 Abeta fulfills a central role in AD pathogenesis, and reductio

145 t TFIIH enters the preinitiation complex and fulfills a critical role in initiation by catalyzing ATP

146 that the von Willebrand (vWA) domain of Ku80 fulfills a critical role in this process by recruiting A

147 MEF2C fulfills a critical role in VSMC differentiation and reg

148 In the retina, dopamine fulfills a crucial role in neural adaptation to photopic

149 otransmitter systems in the brain and mainly fulfills a homeostatic role in terms of neurotransmissio

150 A subpopulation of platelets fulfills a procoagulant role in hemostasis and thrombosi

151 t long-term depression (t-LTD) that probably fulfills a role in synaptic refinement.

152 synaptic form plasticity (LTD) that probably fulfills a role in synaptic refinement.

153 These results indicate that flightin fulfills an essential role in defining the structural an

154 The ubiquitin-proteasome system fulfills an essential role in regulating protein homeost

155 It was concluded that STE50 fulfills an essential role in the activation of the high

156 une responses, and recent studies suggest it fulfills critical roles in CNS function and maintenance.

157 conserved component of innate immunity that fulfills diverse roles in defense and homeostasis.

158 STAT5 fulfills essential roles in hematopoietic stem cell (HSC

159 It fulfills important roles in whole-body lipid handling, s

160 protein, INAF-B, is encoded by the locus and fulfills its critical role in retinal physiology.

161 How RIF1 (RAP1 interacting factor 1) fulfills its diverse roles in DNA double-strand break re

162 light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand

163 NS3, encoded by Seg-10 of the BTV genome, fulfills key roles in BTV infection.

164 cosal surfaces, and secretory component (SC) fulfills multiple roles in this defense.

165 exactly as predicted for a transferase that fulfills the proposed role in the fatty acid synthase re

166 ve ortholog, MITOCHONDRIAL EDITING FACTOR29, fulfills the same role in Arabidopsis thaliana.

167 er hand, mutation of the Arg-82 homolog that fulfills this role in bacteriorhodopsin caused minimal s

168 r optimal integrin activation, and kindlin-3 fulfills this role in hematopoietic cells.

169 This probe fulfills two critical roles in the screen: by locking th

170 ipate in decision-making, and (6) willing to fulfill several supportive roles including patient advoc

171 ng, vesiculation and internalization process fulfilling numerous roles including compensation of memb

172 In Escherichia coli, components of the PTS fulfill many regulatory roles, including regulation of n

173 synthases have undergone a specialization to fulfill sporulation-specific roles, including synthesizi

174 How it might fulfill these roles is unclear.

175 One likely candidate to fulfill this role is the anterior cingulate cortex (ACC)

176 We find that PAR signaling fulfills two roles: localizing NMY-2 to the anterior cor

177 that the anterior and posterior hippocampus fulfill distinct cognitive roles may seem unsurprising.

178 time window to act and that Rad54 and Rdh54 fulfill a role of prorecombinogenic licensing factors.

179 he ability of the Office of AIDS Research to fulfill its role of steward of the NIH HIV/AIDS research

180 ss-sectional studies, the field is poised to fulfill its ultimate role of linking defects in molecula

181 We propose that MF can fulfill most roles of JH, but its epoxidation to JH was

182 wild-type Cdc34 in vitro or in vivo and can fulfill the physiological role of Cdc34 with only modera

183 does imply that both lysine and tyrosine can fulfill the role of an active site proton donor, albeit

184 with linear geometries, while the K(+) ions fulfill the role of linking a-cyclodextrin tori together

185 with linear geometries, while the K(+) ions fulfill the role of linking alpha-cyclodextrin tori toge

186 another cellular amidotransferase is able to fulfill the role of PabA in this organism.

187 functionally equivalent, as only Phox2b can fulfill the role of Phox2a in the structures that depend

188 ntinuous soft structures that simultaneously fulfill the role of robotic link and actuator, where pri

189 d residue (a glutamic acid residue, E) could fulfill the role of the D3 residue, we generated the mut

190 the cell cycle and, therefore, competent to fulfill the role of the transiently proliferating compar

191 vels of thymidine phosphorylation suffice to fulfill the role of the viral enzyme in ganglia and that

192 , and visceral myocytes, which are needed to fulfill the unique roles of the lymphatic system.

193 As well as fulfilling the basic role of protein folding, they may a

194 ose that INS2 allosterically activates PP2C, fulfilling the role of a putative mediator mimetic of in

195 Thus, pyrene also fulfills the plugging role of the Leu191 side chain.

196 Arg96 fulfills the role of an electrophile by lowering the res

197 tial for yeast growth and, by itself, cannot fulfill the essential role played by Cet1p in vivo.

198 fector potentialities supports that each one fulfills nonredundant roles related to their Ag specific

199 The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.

200 In eukaryotes, these channels fulfill numerous biological roles requiring gated anion

201 probably because other Suc transporters can fulfill its role(s).

202 Mid-sized mammals (i.e., mesomammals) fulfill important ecological roles, serving as essential

203 ere, we show that photoswitchable imines can fulfill both roles simultaneously, autonomously driving

204 te that flux is maintained in these cells to fulfill other functional roles such as error correction

205 eraldehyde-3-phosphate dehydrogenase (GAPDH) fulfills various physiological roles that are unrelated

206 However, for aggregates that have evolved to fulfill a structural role, the rate of self-replication

207 We conclude that Tyr161 fulfills a critical role through its chemical nature and

208 m and lymphocyte development in the rat, OAZ fulfills this role through clusters of fingers that are

209 Iron-sulfur clusters fulfill numerous roles throughout biology.

210 1 and U6atac snRNPs in the AT-AC spliceosome fulfill analogous roles to U1 and U6, respectively, in t

211 versity collections of all types are able to fulfill their role to foster more diverse, equitable, re

212 Shallow-water ichthyosaur falls thus fulfilled similar ecological roles to shallow whale fall

213 plasmic B component of enzyme II(Chb), which fulfills an analogous role to IIB(Mtl) in the N,N'-diace

214 ow here that the cancer/testis antigen PASD1 fulfills this role to suppress circadian rhythms.

215 cond signal through CD28 has been thought to fulfill two roles, to stimulate T cell proliferation and

216 e switching from Arg290/Glu167 to Arg290/ATP fulfills a dual role: to destabilize the closed state of

217 Once recruited, FANCD2 fulfills a dual role towards replication fork recovery:

218 IpRGCs fulfill their roles using mechanisms that include an unu

219 ges exist when microbiologists are trying to fulfill a professional role very similar to that of thei

220 To fulfill its role, we show that an effective molecular an

221 infection, suggesting that other kinases can fulfill its role when it is absent.

222 The identification of DCs fulfilling this role will enable future studies to bette

223 ion and describes how they are regulated and fulfill their roles without causing parasite self-harm.

224 However, to fulfill this role without preventing flagellar bend form