ライフサイエンスコーパス: functional conservation

1 degrade rhesus macaque APOBEC3G, indicating functional conservation.

2 amino acid sequence level, suggesting their functional conservation.

3 tain protein identity, suggesting additional functional conservation.

4 e nonprimate species compared with 67.5% for functional conservation.

5 logues in teleosts and tetrapods, suggesting functional conservation.

6 , little is known about their structural and functional conservation.

7 her in C. crescentus and E. coli, indicating functional conservation.

8 ect to strong purifying selection indicating functional conservation.

9 ary pattern among plants, and suggests their functional conservation.

10 function in C. elegans, demonstrating their functional conservation.

11 totic centromeres, further highlighting this functional conservation.

12 ive regulator of telomere length, indicating functional conservation.

13 in the node and its derivatives, suggesting functional conservation.

14 of these divergent papillomaviruses exhibit functional conservation.

15 in, suggesting that there may be significant functional conservation.

16 otic genomes, present more complex issues in functional conservation.

17 ith clear thresholds for different levels of functional conservation.

18 activating transcription, which indicates a functional conservation.

19 mented the 4091-5-8 pth11 mutant, indicating functional conservation.

20 ats within each species, suggesting a strong functional conservation.

21 ating that the sequence similarities reflect functional conservation.

22 li FtsZ, suggesting a degree of interspecies functional conservation.

23 in the mRNA host gene to eventually address functional conservation.

24 e DmBlm mutant sensitivity to IR, supporting functional conservation.

25 erferon-beta promoter activation, suggesting functional conservation.

26 tive hematopoietic differentiation indicates functional conservation.

27 ns can rescue gonadal dysgenesis, suggesting functional conservation.

28 in mouse and human CD4(+) T cells, revealing functional conservation.

29 uman orthologue TMEM258 in Drosophila proved functional conservation.

30 the structural basis for this difference in functional conservation.

31 the arginines does not translate into strict functional conservation.

32 catula and soybean (Glycine max), indicating functional conservation.

33 ed apoptotic response representing 550 My of functional conservation.

34 rescued their phenotype, which demonstrates functional conservation.

35 ctively-does not necessarily predict lack of functional conservation.

36 use of sequence conservation as a proxy for functional conservation.

37 uired for cell viability, the reason for its functional conservation across all strains of S. pneumon

38 SA share a moderate degree of structural and functional conservation across bacterial species, we sho

39 nctionalization of GAST domains, and explore functional conservation across diverse plant groups.

40 Despite the functional conservation across eukaryotes, the TOR compl

41 tly isolated from human cell lines, implying functional conservation across evolution.

42 dynamics both at protein and DNA levels and functional conservation across kingdoms still needs inve

43 ArgiNLS performance in vivo displays functional conservation across major cortical cell class

44 of PAB is well conserved in eukaryotes, its functional conservation across species has not been exte

45 Caseinolytic Protease B (CLPB) proteins, has functional conservation across species to play roles in

46 CR2 reduces respiration in worms, indicating functional conservation across species.

47 YBP mutant flies by mouse YAF2 demonstrating functional conservation across species.

48 Despite structural and functional conservation across vertebrate species, the g

49 s and paralogues thereafter, indicating that functional conservation after the radiation may also be

50 lation, novel roles in seed germination, and functional conservation among diverse plant groups.

51 These results support structural and functional conservation among Rec12/Spo11/Top6A family m

52 ression in mouse fetal liver HSPCs indicated functional conservation among species.

53 eir homologues in mouse, suggesting a strong functional conservation among the individual isoforms, M

54 The high degree of sequence and functional conservation among the mammalian PLM proteins

55 ether, these results demonstrate significant functional conservation among the prokaryotic SecD and S

56 Thus, there is strong structural and functional conservation among the simian EBNA-LP homolog

57 The degree of functional conservation among the various B-class GATA f

58 Using structural and functional conservation analysis of yeast and Drosophila

59 These examples of functional conservation and convergent evolution emphasi

60 omplementation tests can be used to evaluate functional conservation and divergence of biological pat

61 from related organisms provide insight into functional conservation and diversification.

62 t model for understanding the structural and functional conservation and diversity of this enormous f

63 rocess that produced present-day patterns of functional conservation and diversity.

64 es can yield in-depth understanding of their functional conservation and evolutionary history.

65 of neutralization is paradoxical, given the functional conservation and exposure of receptor-binding

66 The structures shed new light on 14DM functional conservation and open an excellent opportunit

67 We discuss the tension between functional conservation and rapid evolutionary change wi

68 " properties of ESCs from the perspective of functional conservation and variation.

69 ued growth defects in irc6 cells, indicating functional conservation, and modeling predicted a simila

70 On the basis of the known functional conservation between a number of mammalian on

71 In this work we evaluated the level of functional conservation between AMP1 and its human homol

72 These experiments demonstrate regulatory and functional conservation between Ciona and vertebrate Hmx

73 equired for Rec12(Spo11) removal, confirming functional conservation between Ctp1(CtIP) and the more

74 The structural and functional conservation between DET2 and human steroid 5

75 The functional conservation between DOG-1 and FANCJ suggests

76 oylation in P. falciparum, and the degree of functional conservation between enzymes of the human and

77 interspecies transgenesis approach, we find functional conservation between gnathostome Hoxd enhance

78 Here, we investigated the functional conservation between gymnosperms and angiospe

79 We found an intriguing functional conservation between human and mouse immune F

80 te for GON-1 in transgenic worms, suggesting functional conservation between human and nematode homol

81 escues the hok1 mutant phenotype, suggesting functional conservation between humans and fungi.

82 ptors in Arabidopsis, indicating substantial functional conservation between maize and Arabidopsis et

83 The observed functional conservation between mitochondrial import in

84 Next, we measured functional conservation between mouse and human pancreat

85 Lastly, we explored functional conservation between murine and human PSGs by

86 sociated with each paralog, and evidence for functional conservation between paralogs.

87 restore native TgADF activity, demonstrating functional conservation between parasites.

88 A complementation approach revealed functional conservation between plant and human catalyti

89 s confirming a high degree of structural and functional conservation between plant and mammalian SRP

90 Our data illustrate the extreme functional conservation between prokaryotic and eukaryot

91 The structural and functional conservation between Rcn1p and DSCR1 suggests

92 ation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr

93 Our results demonstrate a high degree of functional conservation between the extra-embryonic tiss

94 e human CB1 cannabinoid receptor, indicating functional conservation between the nematode and mammali

95 me and Smith-McCort dysplasia, demonstrating functional conservation between the two species.

96 binds to both yeast and human Ran suggesting functional conservation between the yeast and human MOG1

97 utant deleted for the MMS19 gene, indicating functional conservation between the yeast and mammalian

98 unc-30 mutants, indicating a high degree of functional conservation between these evolutionarily rel

99 EOL-1 in learning regulation, demonstrating functional conservation between these homologs.

100 ssed the yeast pheromone pathway, indicating functional conservation between these human and plant ge

101 the myo7-null mutant, supporting fundamental functional conservation between these two distant myosin

102 HSF isoforms, and demonstrate the remarkable functional conservation between yeast and human HSFs, cr

103 The degree of functional conservation between yeast and human protein

104 Despite their functional conservation, centromeres are among the most

105 interactions are fully conserved, indicating functional conservation despite rapid amino acid-sequenc

106 rafish enhancer, indicating a high degree of functional conservation despite the divergence of cartil

107 We also show functional conservation during human hematopoietic devel

108 This functional conservation emphasizes the fundamental impor

109 These commonalities suggest that there is functional conservation for spalt genes between vertebra

110 . crescentus and that of A. tumefaciens, the functional conservation for this presumptive control pat

111 The functional conservation from human to mouse and widespre

112 mitochondrial polypeptide with sequence and functional conservation from human to yeast.

113 This evolutionary-developmental (evo-devo) functional conservation has been extended to morphogenes

114 Structural and functional conservation have been found between some of

115 enomics of 13 Stammera strains revealed high functional conservation, highlighted by the universal pr

116 distributed in diverse bacteria and exhibit functional conservation, highlighting the versatility of

117 onjecture" (or, more properly, the "ortholog functional conservation hypothesis").

118 These functional conservations imply that human MTO2 may act a

119 are highly conserved across phylogeny, their functional conservation in axon guidance is now being ri

120 odomain, has become a paradigm, illustrating functional conservation in developmental pathways.

121 ast Saccharomyces cerevisiae to assess their functional conservation in farnesylating Ras and a-facto

122 ize and tolerance to H(2)O(2), demonstrating functional conservation in filamentous ascomycete phytop

123 sensitivity in Neuro-2a cells, indicative of functional conservation in mammals.

124 To investigate functional conservation in more detail, we focused on Ci

125 etion, correlation with gene expression, and functional conservation in NCC isolated from chicken emb

126 Importantly, several of these genes show functional conservation in regulating apoptosis in mamma

127 This functional conservation in the absence of precise molecu

128 present a striking example of structural and functional conservation in the almost complete absence o

129 Our findings reveal a surprising degree of functional conservation in the effects of endocannabinoi

130 y, the combined data indicate structural and functional conservation in the Tat systems of these thre

131 However, their physiological roles and functional conservation in vivo are rarely addressed, gi

132 ose that within the N-terminal half of UL37, functional conservation is centered within the R2 surfac

133 This functional conservation is despite the fact that there i

134 Functional conservation is known to constrain protein ev

135 al ACE-like genes, we also suggest that this functional conservation is reflected in an ancestral gen

136 sequence identity threshold above which 100% functional conservation is required, functional inferenc

137 This functional conservation is specific to BLM, as human GAL

138 These results provide evidence for the functional conservation of a DPE-dependent, general tran

139 Moreover, we demonstrate functional conservation of a homolog of Brachyury of the

140 between T. thermophilus and E. coli, and the functional conservation of a number of resurrected ancie

141 This work highlights a functional conservation of a sensory receptor in flies a

142 These findings depicted the functional conservation of allantoin for salinity tolera

143 Functional conservation of AmiA implicates a role in cyt

144 Our results support the functional conservation of an enamel knot-like signallin

145 The identity and functional conservation of cADPR isomer signals is uncle

146 To explore the structural and functional conservation of Cdc5 throughout evolution, we

147 /ELC attracted murine splenocytes suggesting functional conservation of CK beta-11/MIP-3 beta/ELC bet

148 The functional conservation of ClpP in eukaryotes and bacter

149 s that there is a high degree of genetic and functional conservation of coagulation, portending futur

150 To investigate the functional conservation of cohesin in eukaryotes distant

151 pleiotropy is also a good predictor for the functional conservation of CREs, even though this is not

152 To assess the functional conservation of CREs, we generated ATAC-seq a

153 Functional conservation of DME enzyme was confirmed by c

154 We herein study the functional conservation of enzymes and non-enzyme sequen

155 The results document functional conservation of eukaryotic mRNA guanylyltrans

156 Here we have studied the evolutionary and functional conservation of four T3SS proteins from the I

157 Given the functional conservation of Friend of GATA proteins and t

158 igh gamma-secretase expression, suggesting a functional conservation of gamma-secretase.

159 Functional conservation of HB21 during plant evolution w

160 and highlighting the general structural and functional conservation of human Pol II and Pol III pre-

161 ongruent with those in the human, suggesting functional conservation of ICAM-2 across species.

162 emonstrate the high degree of structural and functional conservation of InsP3Rs from nematodes to mam

163 In order to explore the functional conservation of JAGGED, a key gene involved i

164 Our results support the potential functional conservation of key genes in early floral dev

165 Here we demonstrate functional conservation of key UTP-binding and metal-ion

166 of receptor translocation and for structural-functional conservation of ligand binding domains broadl

167 Our findings support a model for functional conservation of lncRNAs independent from sequ

168 tochondrial distribution, suggesting partial functional conservation of Mdm12p activity between buddi

169 Collectively, our results suggest functional conservation of MET1 and CMT families during

170 There is remarkable functional conservation of muSOX host shutoff activities

171 We report the functional conservation of MYC-related TFs between the e

172 To explore the functional conservation of myomixer, we investigated the

173 e nicotine dependence in mammals, suggesting functional conservation of nAChRs in nicotine responses.

174 The high functional conservation of neprilysins and their substra

175 ontent is shared among the grasses; however, functional conservation of orthologous genes has yet to

176 Despite evidence for functional conservation of orthologous genes, their dele

177 genetic and functional analyses revealed the functional conservation of P450s despite belonging to di

178 bserved in silenced plants, highlighting the functional conservation of PIF4 homologs in angiosperms.

179 The functional conservation of proteins that control the G1/

180 To determine the extent of functional conservation of RecQ helicases, hBLM was expr

181 ion Scoring (RRS) model for the detection of functional conservation of regulatory sequences using pr

182 nt-based limitations, we revealed widespread functional conservation of sequence-divergent CREs.

183 0 on both phagocytes and lymphocytes showing functional conservation of several properties of Il10.

184 Although we found extensive functional conservation of short-term learning between l

185 Additionally, functional conservation of SIE in diverse virus groups s

186 The results highlight structural and functional conservation of SRP assembly between archaea

187 These findings indicate functional conservation of Ssdp as a cofactor of Ldb1 du

188 king Slx8-Rfp, underscoring the evolutionary functional conservation of STUbLs.

189 To address this question, we explored the functional conservation of symbiont-induced nuclear calc

190 Supporting functional conservation of T2S and T4P minor components,

191 We further provide evidence for functional conservation of Tao kinase, showing that its

192 It also provides information on functional conservation of target sequences, as well as

193 p1 defect in the Gap1 mutant, indicating the functional conservation of the accessory Sec complex.

194 These results sustain the functional conservation of the alpha-syn expression in c

195 Together, our results establish the functional conservation of the autorepressed conformatio

196 catalytic activity of yeast Ime4, indicating functional conservation of the catalytic domain.

197 The functional conservation of the CrPV-like IRES elements i

198 Functional conservation of the CTE was investigated in t

199 homologues in Escherichia coli demonstrated functional conservation of the encoded proteins.

200 This functional conservation of the epistatic relationship be

201 These studies reveal the functional conservation of the FA pathway and validate t

202 perm gene complementations(6), suggests deep functional conservation of the heterodimeric SMF1 and SC

203 ssion of the alpha-globin gene, suggesting a functional conservation of the homeodomain.

204 e etiology and treatment of bipolar illness, functional conservation of the key enzyme in inositol bi

205 Our findings demonstrate a functional conservation of the lab class homeo proteins

206 These findings strongly suggest functional conservation of the mechanisms used by the ac

207 c defects including stunted growth, implying functional conservation of the miR159-GAMYB pathway amon

208 These observations led us to test the functional conservation of the mouse Pitx2 and worm unc-

209 In this study, we demonstrate additional functional conservation of the NMD pathway through the i

210 ing in light-green tomato fruits, indicating functional conservation of the orthologous genes in cont

211 through regulation of H3K36me3, and indicate functional conservation of the PAF1 complex from yeast t

212 Collectively, our work reveals the functional conservation of the PBL-RBOH module that cont

213 n of wild-type sgll or hPNPO, suggesting the functional conservation of the PNPO enzyme between human

214 Our study also directly demonstrates the functional conservation of the regulatory mechanisms gov

215 ss heat sensitivity of rat TRPV1, supporting functional conservation of the residues.

216 ved, as might be expected from the degree of functional conservation of the ribosome among kingdoms (

217 Here we provide further evidence for the functional conservation of the second step factors betwe

218 and complementation experiments to test the functional conservation of the sporopollenin-associated

219 The functional conservation of the tRNA core is correlated w

220 of ancient duplication, suggesting long-term functional conservation of the underlying genes.

221 residue and activates the enzyme, suggesting functional conservation of the upstream kinases between

222 ble of cleaving insulin, suggesting that the functional conservation of these enzymes may not be bidi

223 chanotransduction in invertebrates; however, functional conservation of these ion channels in mammali

224 e results demonstrate a remarkable degree of functional conservation of these myogenic factors despit

225 Drosophila gos28 mutants, demonstrating the functional conservation of these proteins.

226 re1 and adaptation to hypoxia, demonstrating functional conservation of this cleavage recognition mot

227 expressed from the ARR1 promoter, indicating functional conservation of this divergent family member.

228 enic zebrafish enhancer assay we demonstrate functional conservation of this element over 500 million

229 Furthermore, we demonstrate the functional conservation of this factor, as depletion of

230 the developing retina and limbs, suggesting functional conservation of this gene.

231 owth in lats mutant flies, demonstrating the functional conservation of this gene.

232 (+) from tryptophan via QA, highlighting the functional conservation of this important biosynthetic a

233 regions of these two proteins, demonstrating functional conservation of this important stress protein

234 Functional conservation of this protein is supported by

235 Functional conservation of this protein is supported by

236 her, these results demonstrate the exquisite functional conservation of this protein throughout evolu

237 Together, our work identifies the functional conservation of two transcription factors in

238 The results imply a highly functional conservation of type III secretion between P.

239 escued by human ubiquilin 1 or 2, suggesting functional conservation of ubiquilin proteins.

240 on development, and provide evidence for the functional conservation of Vg1 activity in mice.

241 immunity, and they highlight structural and functional conservation of X-type lectins among chordate

242 ed the same functions as OsXAXT1, indicating functional conservation of XAXTs in grass species.

243 he data presented here provide support for a functional conservation of XyG structure in higher plant

244 rescues the Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2.

245 Taken together, these results demonstrate a functional conservation of Zic3 in L-R patterning and un

246 The phylogenetic and functional conservations of SmedOB1 provide one mechanis

247 riable and is correlated with the effects of functional conservation on gene sequences.

248 ish T2Rs indicating an astonishing degree of functional conservation over nearly 500 mya of separate

249 This functional conservation over ~160 million years of evolu

250 e expression) and suggest a higher degree of functional conservation than implied by previous studies

251 ulti-domain proteins have significantly less functional conservation than single-domain ones, except

252 nt identity is more effective at quantifying functional conservation than the more modern scores (e.g

253 ing due to the high degree of structural and functional conservation that exists not only between K2P

254 are striking in light of the structural and functional conservation that typifies other imprinted do

255 Despite this functional conservation, the actin cytoskeleton has unde

256 pite an overall high level of structural and functional conservation, the enzymatic activities and co

257 To gain insight into its functional conservation, the organization of the functio

258 ell documented aspects of Hox structural and functional conservation, there are mechanistic differenc

259 rol biosynthetic intermediate, demonstrating functional conservation to human C14SR.

260 ven by the high degree of genetic as well as functional conservation to humans.

261 timizes both the protein and the interaction functional conservations, using a novel alignment search

262 Functional conservation was confirmed in C. briggsae, wh

263 Functional conservation was demonstrated by the ability

264 se overwhelming compositional shifts, higher functional conservation was indicated as measured by fun

265 In light of this functional conservation, we examined the potential role

266 Consistent with functional conservation, we found that roX RNAs of dista

267 h atonal and its mouse homolog Math1 exhibit functional conservation, we inserted (beta)-galactosidas

268 hans show similar evolutionary signatures of functional conservation, we propose that orphan loss is

269 sequence conservation is presumed to reflect functional conservation, which indeed has been demonstra

270 ore of conserved residues that could reflect functional conservation, while allowing for immune evasi

271 these systems have revealed a high degree of functional conservation, while also uncovering features

272 n mammals and Drosophila shows molecular and functional conservation with C. elegans sleep.

273 scent myotubes, thus establishing a possible functional conservation with Drosophila Sns.

274 y retaining expression, sequence and partial functional conservation with its ancestral copy, NANOGP1

275 s in both mammalian cryptochromes highlights functional conservation with plant and insect cryptochro

276 binds stretches of poly(dG)/poly(dC) showing functional conservation with plant AP2/ERF proteins.

277 flecting evolutionary pressures that balance functional conservation with signaling adaptability.

278 dings provide a foundation for comparing the functional conservation with the evolutionary conservati

279 atis that displays remarkable structural and functional conservation with the human enzyme CD38.

280 e that hUBC9 retains striking structural and functional conservation with yUBC9 and suggest a possibl

281 o the central region of the gene, suggesting functional conservation within the amino and carboxy ter

282 Lastly, we provide evidence of functional conservation within the PLAA family by showin

283 ar how these viruses achieve such a level of functional conservation without clear conserved genetic