ライフサイエンスコーパス: functional domain

1 rium and that the loop 3 helix is a critical functional domain.

2 g coatomer subunit alpha) affecting the same functional domain.

3 eatly even if substitutions were in the same functional domain.

4 derlying "structure" modulating this central functional domain.

5 deficiency and identified a new antithrombin functional domain.

6 ted power of sequence-based features in that functional domain.

7 of the astrocytes can extend across neuronal functional domains.

8 henotypic innovation than changes in protein functional domains.

9 onventional building conditions for all nine functional domains.

10 cating NPHP5 at Leu87 and removing all known functional domains.

11 uct bound structures encompassing all of the functional domains.

12 biquitin substrate were located to different functional domains.

13 nts, but they contain no known structural or functional domains.

14 are commonly viewed as membrane anchors for functional domains.

15 s that are mediated by each of the protein's functional domains.

16 entifying 4 acetylated lysines in 3 distinct functional domains.

17 or different constituents, forming specific, functional domains.

18 dendritic cell (DC) migration to define its functional domains.

19 ents of RNA polymerase, contacting different functional domains.

20 sual ability overall (r = -0.42) and for all functional domains.

21 erent clonal origins that are organized into functional domains.

22 predominantly reside in CTCF/cohesin-limited functional domains.

23 significant independent effect on the other functional domains.

24 an residues distributed evenly over all four functional domains.

25 nal (3D) network with diverse structural and functional domains.

26 any different proteins where they bridge two functional domains.

27 ption and organizing eukaryotic genomes into functional domains.

28 for human social groups across a variety of functional domains.

29 T-boxes have two functional domains.

30 pathfinding through a non-overlapping set of functional domains.

31 the extent of concurrent impairment in these functional domains.

32 s possess large N termini containing various functional domains.

33 ole of the structural rich club to interlink functional domains.

34 rovide evidence that CT694 contains multiple functional domains.

35 trabody efficacy via fusions to heterologous functional domains.

36 s of MAPT promoter deletions revealed unique functional domains.

37 ing proteins with substitutions in different functional domains.

38 on of the human MAPT promoter by mapping its functional domains.

39 ers the properties of an RNA guide, creating functional domains.

40 lly into at least three large structural and functional domains.

41 ons in the context of protein structures and functional domains.

42 ative splicing within specific subregions of functional domains.

43 NA, producing isoforms that delete or retain functional domains.

44 ctural states and is organized into multiple functional domains.

45 htforward mechanism for strategically fusing functional domains.

46 more diverse than a minimal set of conserved functional domains.

47 tion across residues to predict conserved gK functional domains.

48 d ribosomal proteins that are organized into functional domains.

49 echanisms that allow differentiation between functional domains.

50 hod named "Tiling CRISPR" to identify lncRNA functional domains.

51 leted forms of dystrophin, missing important functional domains.

52 tRNA genes, and the occurrence of conserved functional domains.

53 s have orthologs in many species and contain functional domains.

54 SA complexes impairs accessibility to all FH functional domains.

55 xtreme mutations giving rise to partial, but functional, domains.

56 4 months between the two treatment groups in functional domains 1 and 2 of the Motor Function Measure

57 Despite residing in the functional domain, 16 of 17 mutants retained Ure2 activi

58 The structure of the Slo1 channel has two functional domains, a core consisting of four voltage se

59 which catalyze pilus assembly, contain five functional domains: a 24-stranded transmembrane beta-bar

60 These enzymes contain two functional domains: a catalytic domain and a C-terminal

61 argeting functionalities of chimera with two functional domains: a dsRNA binding domain (dsRBD) for s

62 al mRNAs, they are generally composed of two functional domains: a receptor (aptamer) domain that bin

63 The PapC usher contains five functional domains: a transmembrane beta-barrel, a beta-

64 d even lower activity, indicating that these functional domains accounted for most of the pro-chemota

65 hubs based on their participation in several functional domains across different networks and ability

66 emonstrates significant deficits in multiple functional domains across pediatric burn survivors compa

67 Furthermore, mutations in these functional domains acted as dominant negatives that affe

68 tion factor, ERalpha has two transactivating functional domains (AF), AF-1 and AF-2.

69 on regulator, containing two transactivation functional domains, AF-1 and AF-2.

70 rypanosoma and Leishmania JBP1 has two known functional domains: an N-terminal T hydroxylase (TH) hom

71 ns with amino acid substitutions in the same functional domain and between alleles encoding proteins

72 he identification of four genes that share a functional domain and modulate heterocyst commitment: he

73 s challenging due to the lack of a conserved functional domain and the low sequence similarity among

74 Functional domains and amino acid motifs in the viral pr

75 Further, we discuss the functional domains and biological processes that may be

76 ns clustered in recurrent hotspots affecting functional domains and caused defective RHOA signaling,

77 h the complementary sequences in the arms of functional domains and connector.

78 major sigma factor, sigma(70), have similar functional domains and contact similar regions of RNAP,

79 associated with, and interplay between, its functional domains and defining the requirement for its

80 Toxicity in yeast has been used to identify functional domains and elucidate the biochemical functio

81 Establishing causative links between protein functional domains and global gene regulation is critica

82 ignificant improvements in the EORTC QLQ-C30 functional domains and Global Health Status/QoL versus p

83 ful in both reconstructing the already known functional domains and in identifying the structural cou

84 is a plasma protein consisting of 6 distinct functional domains and is an important regulator of key

85 sion of truncated mRNAs and proteins lacking functional domains and is cell lethal.

86 1 is a large protein that lacks well defined functional domains and is predicted to be largely intrin

87 bellum's contributions to a diverse array of functional domains and neuropsychiatric disorders.

88 nalysis of mutants, in vivo, that identifies functional domains and phosphorylation sites critical fo

89 nt and synergistic relationship of all three functional domains and provide an explanation for the de

90 SroHCN contains highly conserved functional domains and sequence motifs that are correlat

91 ncluding missense mutations within important functional domains and start-loss and splicing mutations

92 Although commonalities can be found in the functional domains and strategies used to carry out and

93 utations in 200 genes, highlighting specific functional domains and synaptic candidate genes importan

94 expressed different forms of EZH2 to analyze functional domains and used small interfering RNAs to re

95 structed based on common replication protein functional domains and, even within one replication doma

96 ates of heritability cluster strongly within functional domains, and across all traits the reported h

97 t clustered at specific positions within the functional domains, and one small in-frame deletion was

98 of the enzyme, the relative positions of its functional domains, and the mode of its interaction with

99 Little is known about the functional domain architecture of long noncoding RNAs (l

100 zed allelic murine mutants in which distinct functional domains are deleted.

101 ediction of conserved domains indicated that functional domains are preserved.

102 ll visual ability and in visual ability in 4 functional domains as measured by the Activity Inventory

103 Predictors of visual ability and functional domains as measured by the AI.

104 s to enable selective extraction of specific functional domain-based networks, whether it be by botto

105 oplasmic reticulum (ER) membranes (MAMs) are functional domains between both organelles involved in C

106 predicted protein of 24 kD with no annotated functional domains but containing domains that are highl

107 a caveolin-1 protein that contains all known functional domains but has a change in only the final 20

108 o caveolin-1 protein that contains all known functional domains but has a change only in the final 20

109 Finally, the functional domain by which the toxin inhibits ASIC1a cha

110 erentiated into 2 distinct morphological and functional domains called grana and stroma lamellae.

111 For deciphering them, functional domains can be overexpressed.

112 addition, we provide an understanding of how functional domains can evolve over time, resulting in su

113 These functional domains depend on the combined activities of

114 uroclinical Assessment that incorporates key functional domains derived from the neurocircuitry of ad

115 mbinant EBOV carrying mutations disabling GP functional domains did not restore DC maturation.

116 he patient together with physician from four functional domains (dressing, hygiene, limb position, an

117 prostate cancer commonly had declines in all functional domains during 15 years of follow-up.

118 d with multiple copies of multiple different functional domains, e.g., epitopes for vaccines.

119 nmental variance (c(2)) values for all MaTCH functional domains except 'all traits' were erroneously

120 Its C-terminal functional domain exhibits autophosphorylation activity

121 repeat (LRR) 5 region comprises an important functional domain for mammalian ANP32 proteins.

122 The 3 functional domains for cases, their unaffected siblings,

123 example of Arabidopsis PATL2, we dissect the functional domains for in vitro binding to phosphoinosit

124 ely studied; however, its full complement of functional domains has yet to be characterized.

125 elements upon which the more variable viral functional domains have evolved.

126 CTLs targeting Nef epitopes outside critical functional domains have little effect on the pathogenic

127 Through small modifications in two key functional domains, HCNL1 evolutionarily adapted to a lo

128 are organized into topologically constrained functional domains; however, the molecular mechanisms re

129 Both of RV-cyclin's functional domains, i.e., the cyclin box and the activat

130 the similarity of tyrosine- and lysine-rich functional domains identifies this protein as a new memb

131 In view of the observation that apoE and its functional domains impact extracellular matrix (ECM) rem

132 n the cytoplasmic domain of RyR1 in multiple functional domains implicated in RyR1 activity-regulatin

133 Within the protein, multiple functional domains important for uncoating, host cell me

134 We characterized the functional domain in AKR1B10 and found that helix 10 (am

135 y, the ectodomain, a region that carries the functional domain in GPI-APs, in Pd-resident proteins fu

136 Yet undiscovered functional domains in addition to the homeodomain and th

137 Overall, our method allows mapping of lncRNA functional domains in an unbiased and potentially high-t

138 We characterized non-conserved functional domains in ATL paralogues and show that the A

139 and FANCI contribute to the organization of functional domains in chromatin, ensuring the coordinati

140 Finally, we have elucidated the functional domains in EGL-27/MTA that mediate its reprog

141 itro transcription assays, we identified two functional domains in Gdown1.

142 ether, these results suggest how the size of functional domains in homeothermic cells may be regulate

143 rotein expression, the role of the protein's functional domains in host immunity is unknown.

144 ultidomain architecture and the shuffling of functional domains in many protein families.

145 ll type-specific deletions of Nkx2.2 and its functional domains in order to characterize its role in

146 , transcriptional activation, as well as the functional domains in p44 related to its growth inhibiti

147 the number of phenotypes in CaTCH and MaTCH functional domains in the y axes of panels a and b; the

148 modular design with distinct structural and functional domains; in particular, a highly conserved po

149 ion of RyR1, which are clustered in multiple functional domains including those implicated in the act

150 CpsA has multiple functional domains, including a DNA-binding/transcriptio

151 KDM2B contains multiple functional domains, including a JmjC domain that catalyz

152 CPG proteins altogether contained 19 unique functional domains, including Kunitz and endostatin doma

153 e factors that contain a very similar set of functional domains, including N-terminal pleckstrin homo

154 can occur in the same molecular pathways and functional domains, including synaptic transmission, the

155 thogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rabs and

156 uced in Bacillus subtilis and encompassing a functional domain, induces antibodies that recognize the

157 tion approach may also enable exploration of functional domain interactions in other protein systems.

158 tudies provide new information regarding the functional domains involved in transcriptional regulatio

159 nstrate that while the loop 3 helix is a key functional domain, its function does not exclusively rel

160 ge regression to relate deficits in multiple functional domains (left and right visual, left and righ

161 ression in the muscle, we confirmed that the functional domain lies within the VP3 portion of the cap

162 arcomeric integration, but retains all other functional domains (M-band exon 1/2 [M1/2]-KO).

163 Functional domain mapping based on super-resolution imag

164 Functional domain mapping of CheZ(HP) determined the pol

165 ses, is a polyprotein comprising three major functional domains: matrix (MA), capsid (CA), and nucleo

166 Our results provide evidence that high-level functional domains may be mapped according to early rudi

167 ustrate that disruption of particular CEP290 functional domains may lead to particular disease phenot

168 We further found that the 8q24 functional domains more likely interacted with genomic r

169 resolved annotation of coding and non-coding functional domains, motifs, and sites, in combination wi

170 ntials of mean force, and time dependence of functional domain motions in proteins.

171 The functional domain of Ag43a displays a twisted L-shaped b

172 We sought to analyze whether each functional domain of AIRE is critical for the activation

173 ole of BAI1 in apoptotic cell clearance, the functional domain of BAI1 was used as a competitive inhi

174 These data provide evidence for a functional domain of high CA activity around mitochondri

175 f and that is mediated by a newly identified functional domain of NP, the central domain.IMPORTANCE I

176 A functional domain of piwil2, PIWI domain, was targeted b

177 One very important functional domain of proteins is the protein-protein int

178 hat the conserved HMG box domain is the only functional domain of Sry, and highlight an evolutionary

179 f IL-33 (amino acids 66-111) as an important functional domain of the protein and suggests that inter

180 ole in visual perception and recognition-the functional domain of the ventral pathway.

181 et(249), Met(331), and Met(496) in important functional domains of ADAMTS13 were oxidized to methioni

182 e as a test bed for dissecting the different functional domains of BEACH (for beige and human Chediak

183 logical membranes segregate into specialized functional domains of distinct composition, which can pe

184 However, S-OPA1 contains all functional domains of dynamin proteins, suggesting that

185 With further dissection of the functional domains of EXO1, we report that the PIN domai

186 ilisin cleavage sites reside within critical functional domains of FH, including the complement regul

187 Functional domains of GRK2/3 were stably expressed, or s

188 uristic stages map onto the dysregulation of functional domains of incentive salience/habits, negativ

189 ling to identify EE mutation hotspots in key functional domains of K(v)7.2 including voltage sensing

190 ing myeloid differentiation, but how the two functional domains of LBR support this role is currently

191 Various mutants of functional domains of MCPIP1 showed disruption of the RN

192 The functional domains of MEGF10 and drpr bear striking simi

193 Two functional domains of mortalin, the N-terminal ATPase do

194 Here, we characterized the functional domains of mouse Liat1 and found that its N-t

195 To define the functional domains of myomaker required to direct fusion

196 We dissected the functional domains of p44 for protein interaction with t

197 biochemical and structural insights into the functional domains of PARP-2, which has restricted our u

198 In addition, mutational analyses identified functional domains of r129 resulting in recombinant prot

199 subjected to variation and demonstrate that functional domains of ribosomes are targets of 2'-O-Me p

200 terminal truncation, could be gated by fused functional domains of STIM1.

201 Using point mutations, we identify the key functional domains of Talin that mediate its response to

202 ese data identify the critical intracellular functional domains of Thbs4, which was formerly thought

203 e sequence corresponding at the RNA level to functional domains of the 5' UTR, could also potentially

204 rticipate in synaptic plasticity in specific functional domains of the adult central nervous system,

205 tive PirAB(vp) heterodimer might emulate the functional domains of the Cry protein, and in particular

206 s are absent from gnomAD, and are located in functional domains of the encoded protein.

207 within a 20-kb window that spans several key functional domains of the gene.

208 les are localized in distinct structural and functional domains of the Golgi.

209 ntegration of information between segregated functional domains of the human cortex.

210 In this study, we have analyzed the functional domains of the KSHV NEC proteins and their in

211 Recent genetic analysis identified the functional domains of the lambda spanins, which are simi

212 al consequence of these perturbations to key functional domains of the motor.

213 Different functional domains of the PC2 Cterm have been studied us

214 computational modules that reflect the known functional domains of the pharynx.

215 ny of these sites are localized in different functional domains of the protein, including the catalyt

216 Here, we have identified 4 functional domains of the protein.

217 cid variations were found at positions where functional domains of the proteins were identified.

218 This synergy is dependent on conserved functional domains of the proteins, as well as on a nove

219 tural motifs recognized by L7Ae, in distinct functional domains of the RPR and suggest testable mecha

220 hology is described in relation to the known functional domains of the VNS neuropil and based on the

221 gammaherpesvirus conserved residues revealed functional domains of these two proteins, which in many

222 Two isoforms of the C. sapidus TPS encode functional domains of TPS and trehalose-6-phosphorylase

223 Herein, we have identified the essential functional domains of TR from the basal eukaryotic speci

224 we report that the separated and coexpressed functional domains of UL16 are mutually responsive to ea

225 functional analysis of chimeras in which the functional domains of VILIP-2 are substituted in CaM.

226 Here we define functional domains of ZLD required for both DNA binding

227 es form mutation hotspots that disrupt their functional domains or active sites, leading to gain- or

228 membrane domains but with no other predicted functional domains or homology outside of nematodes.

229 alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellu

230 Ig domains interact with each other forming functional domain pairs, where the interaction with sign

231 tified a gene (Hs-Tyr) encoding a tyrosinase functional domain (PF00264).

232 intain secondary and tertiary structural and functional domains present in certain DNA sequences.

233 anticipated from the molar concentration of functional domains present in the constructs.

234 n increased concomitantly with the number of functional domains present.

235 erall visual ability and visual ability in 4 functional domains (reading, mobility, visual motor func

236 erall visual ability and visual ability in 4 functional domains (reading, mobility, visual motor func

237 4 months) in overall visual ability and in 4 functional domains (reading, visual information, visual

238 4 months) in overall visual ability and in 4 functional domains (reading, visual information, visual

239 the plant databases and 45 contigs based on functional domains referencing to the Pfam database.

240 ue opportunity to detect the movement of the functional domains relative to the substrate-binding cat

241 Impacted amino acids occupied a number of functional domains relevant to SOS1 activity, including

242 -binding domain on the beta-chain, and other functional domains remain elusive.

243 ties required for tissue growth, as well the functional domains required for cell binding.

244 h residues 28 to 39 constituting the minimal functional domain responsible for chNHE1 binding of ALV-

245 They contain three functional domains responsible for receptor-binding, mem

246 HIV fusion inhibitors, containing different functional domains resulted in synergistic anti-HIV-1 ef

247 SPs possess functional domains (SAND, PHD, bromodomain) that dock to

248 shared among multiple cancer types, we found functional domains selectively engaged in different canc

249 runcation or point mutations in well-defined functional domains sensitize cancers to PORCN inhibitors

250 ith nine transmembrane regions and conserved functional domains similar to other flavonoid and isofla

251 on alternative splicing event due to loss of functional domains/sites or shifting of the open reading

252 y tethering two chromosome loci together via functional domain-swapped dimers formed through their DN

253 the association process impedes to link the functional domain swapping to human-associated diseases.

254 n the viral life cycle and, depending on the functional domain targeted, either attenuated or amplifi

255 veal a previously uncharacterized C-terminal functional domain that uncouples ATP hydrolysis from str

256 A) envelope glycoproteins are organized into functional domains that allow changes in receptor choice

257 of vaccinia virus is organized into distinct functional domains that are critical for the efficiency

258 coronavirus genome, and it contains multiple functional domains that are required for coronavirus rep

259 ous polymorphism in the regions encoding the functional domains that are required for lysing parasite

260 contain modular architectures with distinct functional domains that combine to send signals in respo

261 The present studies identify distinct functional domains that confer differential sensitivitie

262 karyotic genome into distinct structural and functional domains that contribute to gene regulation an

263 Thus, Q-rich repeats are dynamic functional domains that modulate a regulator's innate fu

264 the UAF complex, describe new structural and functional domains that play roles in UAF complex integr

265 The two functional domains (the Rieske and the catalytic mononuc

266 PARP-1 consists of three functional domains: the N-terminal DNA-binding domain (D

267 scription factor that is composed of several functional domains: the N-terminal transactivation domai

268 r truncating or affect conserved residues in functional domains, thus supporting a putative role for

269 In alpha, we narrowed down the functional domain to a 48-nt-long, highly conserved segm

270 hose sequences to feline CRM1, we mapped the functional domain to HEAT (Huntingtin, elongation factor

271 esses the non-genomic pathway via its unique functional domain to inactivate c-Src.

272 BC transporters, allowing all four consensus functional domains to be linked.

273 ed in utero electroporation of shRNAs or LIC functional domains to determine the relative contributio

274 vities, we analyzed the contributions of its functional domains to its localization and function.

275 proteins can be modified to carry additional functional domains to regulate expression of genomic loc

276 2AR in ASM and the ability to exploit GRK2/3 functional domains to render ASM hyporesponsive to contr

277 ions in the gene encoding the 330-kDa triple functional domain (TRIO) protein associated with neurode

278 otein folds and a lack of well-characterized functional domains typically result in a low discovery r

279 noscale expand the existing phenomenology of functional domain walls.

280 of and the coupling between these different functional domains, we analyzed the thermal unfolding of

281 Based on crystal structures of three functional domains, we generated a computational structu

282 t variants are likely to cluster together on functional domains, we propose a protein structure guide

283 Here, to dissect APP functional domains, we used APP mutant mice lacking the

284 s for tissue-specific isoform expression and functional domain were integrated.

285 y important differences in visual ability in functional domains were reading (44% [95% CI, 42%-48%]),

286 < .001) on overall visual ability and on all functional domains, whereas cognition had an effect on o

287 posed of modules that house repeated sets of functional domains, which select, activate and couple am

288 the CpRbp1 gene allowed for analysis of its functional domains, which was previously hampered due to

289 ws us to identify and characterize potential functional domains with feature patterns similar to cano

290 We find that 186 CII possesses two functional domains, with an independent activation epito

291 These data reveal a novel functional domain within SteC, raising the possibility t

292 nformation of CR1 and points to LHR-D as the functional domain within the CR1 protein that mediates t

293 le fMRI networks and, by indicating multiple functional domains within a single voxel, present a new

294 Here, we searched for the functional domains within Ac45 by analyzing a set of del

295 cue assay in Drosophila S2 cells to identify functional domains within integrator subunit 12 (IntS12)

296 body and used it as a molecular probe to map functional domains within nicastrin ectodomain.

297 , in a completely un-biased manner, distinct functional domains within prefrontal and (pre)motor cort

298 ity to modulate circuit activity in discrete functional domains within the basal ganglia circuitry wi

299 To investigate functional domains within the gH/gL structure, we constr

300 of XIST allowed us to understand the unique functional domains within the human XIST RNA.