ライフサイエンスコーパス: functional genomics

1 obial fitness screens are a key technique in functional genomics.

2 nucleases is transforming genome editing and functional genomics.

3 ting channel catfish genetic enhancement and functional genomics.

4 technology have emerged as a major tool for functional genomics.

5 ing the utility of this collection for plant functional genomics.

6 is a crucial foundation for comparative and functional genomics.

7 RNAi screens are widely used in functional genomics.

8 wheat, thus opening up their pan-genomes to functional genomics.

9 gineering platforms and their application to functional genomics.

10 t CRISPR screens have shown great promise in functional genomics.

11 method for programmable and high-throughput functional genomics.

12 rtunities, including studies in the field of functional genomics.

13 ues which can utilize as a potential tool in functional genomics.

14 rapid development of liver cancer models and functional genomics.

15 s feasible and has exciting implications for functional genomics.

16 solution transcriptional analysis coupled to functional genomics.

17 making it a potential model plant for orchid functional genomics.

18 nsformative approaches in human genetics and functional genomics.

19 consequently used in function prediction and functional genomics.

20 as evolved into the study of high-throughput functional genomics.

21 reverse- and forward-genetics tool in plant functional genomics.

22 formation among variables such as those from functional genomics.

23 portance of these non-reference sequences in functional genomics.

24 ed to create genetic variation resources for functional genomics.

25 ockout screens are revolutionizing mammalian functional genomics.

26 iology and Gene Expression Omnibus (GEO) for functional genomics.

27 individuals of European origin from the 200 Functional Genomics (200FG) cohort in the Human Function

28 In summary, our functional genomics analysis highlighted novel genes and

29 what is, to our knowledge, the first global functional genomics analysis of L. casei symbiosis.

30 heterogeneity induced by condition change in functional genomics analysis.

31 r control and PAH lung pericytes followed by functional genomics analysis.

32 sequence information has hitherto precluded functional genomics analysis.

33 plants with practical applications in plant functional genomics and agriculture.

34 both normal and pathological aspects of the functional genomics and anatomy of the CNS.

35 Here we use whole-genome sequencing, functional genomics and biochemical assays to reveal the

36 Further, with functional genomics and biochemical dissection we demons

37 ant role in the fields of synthetic biology, functional genomics and bioengineering.

38 structural variation system for dosage-based functional genomics and breeding of poplar.

39 ocomplex approach has the potential for both functional genomics and cancer therapy.

40 that integrates new patient-derived models, functional genomics and chemical screens to facilitate t

41 tion (SSM) is an important tool for mosquito functional genomics and comparative gene expression stud

42 y available tool to aid our understanding of functional genomics and comparative genomics.

43 to edit the plant genome are much needed for functional genomics and crop improvement.

44 will provide novel means for studying human functional genomics and development.

45 d pluripotency, providing a novel system for functional genomics and developmental research in humans

46 ome sequence provides a fundamental tool for functional genomics and DNA-informed breeding.

47 ich will aid in the advancement of tools for functional genomics and elucidation of the biosynthesis

48 understanding of the vast troves of existing functional genomics and epigenomics data for K562.

49 iant information and structural context with functional genomics and epigenomics data.

50 Functional genomics and exome sequencing further support

51 reat potential as designer viruses to pursue functional genomics and for the rational design of novel

52 sons and retroviruses are versatile tools in functional genomics and gene therapy.

53 rologous genomic or metagenomic libraries in functional genomics and genome engineering is the low ex

54 Applying functional genomics and genome-engineering, we demonstra

55 Thus, iRIGS can leverage accumulating functional genomics and GWAS data to advance our underst

56 rence (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic po

57 A combination of proteomics, functional genomics and in vivo studies presented here i

58 user-provided private and publicly available functional genomics and interaction datasets, 3) queryin

59 able elements, which is an important tool in functional genomics and is well established in several c

60 ral and/or spatial control are invaluable to functional genomics and medical research.

61 to employDNNs to solve important problems in functional genomics and moleculargenetics.

62 wSeq may serve as a rapid screening tool for functional genomics and offer the opportunity to explore

63 approaches to uncovering gene function using functional genomics and other approaches.

64 and others, also providing a cornerstone for functional genomics and peanut improvement.

65 rocess that has multiple applications within functional genomics and personalized medicine.

66 practical resource available for the broader functional genomics and population genetics communities,

67 ted RNAi approach is a tool for studying bee functional genomics and potentially for safeguarding bee

68 Using functional genomics and proteomic approaches, we found t

69 y providing an invaluable tool to accelerate functional genomics and proteomic research in monocot an

70 nerated using bacTRAP, with postmortem human functional genomics and quantitative genetics data.

71 nitzschia multistriata Here, we describe how functional genomics and reverse genetics have contribute

72 r the last few years, numerous approaches in functional genomics and systems biology have led to a gr

73 ating and advancing our understanding of the functional genomics and systems biology of any process f

74 A-seq data, provides a valuable resource for functional genomics and tools for breeding elite Hevea c

75 technologies are widely used in the field of functional genomics and used in an increasing number of

76 gence of virus-delivered genetic queries for functional genomics and virology (vectors 3.0).

77 -throughput sequencing, structural genomics, functional genomics, and chemical genomics into unified

78 g biological knowledge from model organisms, functional genomics, and integrative approaches can empo

79 ation sequencing with selection, transplant, functional genomics, and mapping studies.

80 n of phenotypes has become a crucial tool of functional genomics, and several large international pro

81 a CRISPR/Cas9-based in vivo platform for BCL functional genomics, and validate discovered genes, such

82 ries of variable size and coverage depth for functional genomics application.

83 Furthermore, using a complementary functional genomics approach and mouse xenograft models,

84 is challenge, we developed a high-throughput functional genomics approach combining inducible CRISPR-

85 Here, a functional genomics approach identified the full complem

86 By using a functional genomics approach leveraged from the model ye

87 In the present study, an integrative functional genomics approach shows that genetic datasets

88 ress this, we implemented a multidimensional functional genomics approach that incorporates 7 differe

89 We take a functional genomics approach to congenital heart disease

90 te and applied an integrated data-mining and functional genomics approach to identify a rheostat of D

91 We took a comprehensive, functional genomics approach to identify sources of GC r

92 Herein, we used a biochemical and functional genomics approach to identify the sand fly sa

93 e subsequently prioritized with a convergent functional genomics approach using previous evidence in

94 To address this, using a functional genomics approach, we have identified a small

95 By applying a functional genomics approach, we identified several nove

96 Using a functional genomics approach, we integrated transcriptom

97 ion through an integrated bioinformatics and functional genomics approach.

98 Functional genomics approaches can overcome limitations-

99 This Review describes how new CRISPR-based functional genomics approaches can uncover disease mecha

100 High-throughput functional genomics approaches have provided insight int

101 In conclusion, functional genomics approaches reveal the architecture o

102 Here we discuss the use of functional genomics approaches that integrate transcript

103 Functional genomics approaches that leverage the RNAi pa

104 ecessitates developing novel high-throughput functional genomics approaches to elucidate the molecula

105 ssue of Cell use genome-wide association and functional genomics approaches to provide deep insights

106 Using in vitro, in vivo and functional genomics approaches, we examined infections b

107 Using functional genomics approaches, we identified a polymorp

108 Recently, by applying integrative functional genomics approaches, we identified and interr

109 loid-centric cell biological, proteomic, and functional genomics approaches.

110 of individual algae, with phylogenomics and functional genomics as tools for contextualizing and tra

111 as the potential to become a useful tool for functional genomics, as well as for combating protein-ex

112 Functional genomics assays based on high-throughput sequ

113 Cells can be probed using various functional genomics assays, but it is difficult to disen

114 d the BMP pathway and serve as an example of functional genomics-based hypothesis generation.

115 cture/network information such as those from functional genomics, besides using sparsity penalty so t

116 is a valuable reverse genetics tool used in functional genomics, but recently, it has also shown pro

117 ucture prediction plays an important role in Functional Genomics by providing structural models of ge

118 Functional genomics can be used to screen for plant adap

119 We demonstrate that functional genomics can complement traditional sequence

120 Second, we used a comprehensive Convergent Functional Genomics (CFG) approach to identify and prior

121 We then used a Convergent Functional Genomics (CFG) approach to prioritize the can

122 Third, we used a convergent functional genomics (CFG) approach to prioritize these g

123 We then used a convergent functional genomics (CFG) approach with existing prior e

124 Evolutionary conservation, functional genomics, chromatin state, sequence motifs an

125 ing RNA has potential applications for plant functional genomics, crop improvement and crop protectio

126 Existing tools utilize functional genomics data and evolutionary information to

127 The analysis of functional genomics data and genome-scale mutant librari

128 integrated our data with publicly available functional genomics data and identified a growth regulat

129 d provides an efficient intermediary between functional genomics data and reverse-genetics resources

130 on in a population of European ancestry, (3) functional genomics data comprised of protein-protein in

131 and complete interpretation of the extensive functional genomics data from HepG2 requires an understa

132 ability of cancer whole genome sequences and functional genomics data from the Encyclopedia of DNA El

133 Functional genomics data has the potential to increase G

134 The ArrayExpress Archive of Functional Genomics Data is an international functional

135 The ArrayExpress Archive of Functional Genomics Data is one of three international f

136 tuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasit

137 We leverage functional genomics data sets for three organisms--H. sa

138 cess several public interaction networks and functional genomics data sets through the portal as well

139 82 individuals by uniformly processing 1,263 functional genomics data sets, developing approaches to

140 Integrating high-throughput functional genomics data with this information can help

141 The integration of genome-wide functional genomics data, followed by the construction o

142 erstanding of both GWAS and eQTL results and functional genomics data.

143 th random graphs and graphs constructed from functional genomics data.

144 an essential quality measure when analyzing functional genomics data.

145 els and the integration of these models with functional genomics data.

146 Functional Genomics Data is an international functional genomics database at the European Bioinformat

147 e motifs, evolutionary patterns, and diverse functional genomics datasets from a variety of cell type

148 The generation of functional genomics datasets is surging, because they pr

149 ry statistics with large-scale collection of functional genomics datasets spanning enhancer activity,

150 ENCODE comprises thousands of functional genomics datasets, and the encyclopedia cover

151 Functional genomics describes a field of biology that us

152 n loosely termed evolutionary and ecological functional genomics (EEFG), and have been providing key

153 Functional genomics efforts face tradeoffs between numbe

154 ular mutations, as well as for the design of functional genomics experiments and for decision support

155 Functional genomics experiments generate genomewide sign

156 The intent behind functional genomics experiments is not necessarily to st

157 Bioinformatic analysis and functional genomics experiments suggested a correlation

158 Microarray technology, as well as other functional genomics experiments, allow simultaneous meas

159 of Data is an open web resource for analysed functional genomics experiments.

160 markers also have value beyond B. napus for functional genomics, facilitated by the close genetic re

161 Functional genomics (FG) screens, using RNAi or CRISPR t

162 ct isoform function have been limited in the functional genomics field.

163 The work provides a functional genomics foundation for understanding neural

164 A combination of functional genomics, gene expression, in vivo and in vit

165 Using a combination of functional genomics, genetic and biochemical approaches,

166 1 CRISPRi system will have broad utility for functional genomics, genetic interaction mapping and dru

167 Although functional genomics has accelerated therapeutic target d

168 The advent of functional genomics has enabled the genome-wide characte

169 ntional pathology with genomic profiling and functional genomics have begun to enhance our understand

170 Rapid advances in chemical biology and functional genomics have facilitated exploration of targ

171 CRISPR/Cas9-based functional genomics have transformed our ability to eluc

172 Here, we employed functional genomics (i.e. RNAseq) to determine different

173 is a curated online resource for comparative functional genomics in crops and model plant species, cu

174 ramene is an online resource for comparative functional genomics in crops and model plant species.

175 it is expected to revolutionize the field of functional genomics in Dictyostelium by greatly expandin

176 -generated RNAi is an effective strategy for functional genomics in rust fungi.

177 l application of programmed gene editing for functional genomics in schistosomes.

178 and allows an assessment of the progress in functional genomics in the past 12 years.

179 o fully exploit the potential of single-cell functional genomics in the study of development and dise

180 These results show the utility of functional genomics in understanding mechanisms of resis

181 RISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates.

182 high throughput leaf metabolomics along with functional genomics in wild tomato unreveal potential ro

183 eighting each GWAS by using information from functional genomics increased the number of loci with hi

184 increase statistical power is to incorporate functional genomics information, especially gene express

185 interference (RNAi) in molecular biology and functional genomics is a well-established technology, in

186 One of the goals of functional genomics is to understand the regulatory impl

187 n the model yeast, Saccharomyces cerevisiae, functional genomics is used to explore the role of metal

188 ning strategy, combined with comparative and functional genomics, led to the identification of the Co

189 ese two species and their comparisons at the functional genomics level to support tailor-designed bre

190 nsposons, or other transgenes underlies many functional genomics measurements.

191 molecular Fluorescence Complementation-based functional genomics method to perform a high throughput

192 In this study, we developed an integrative functional genomics methodology to identify cancer susce

193 We used a functional genomics methodology to interrogate human chr

194 y employed in the fields of evolutionary and functional genomics of both well established and newly s

195 ch will open doors to the study of bacterial functional genomics of different species in numerous set

196 am, microRNA-mediated EBV viral oncogenesis, functional genomics of EBV and its biology, and differen

197 ach will find wider application as a tool in functional genomics of filamentous fungi.

198 ghput infectious cell culture model enabling functional genomics of hepatitis delta virus entry and i

199 Many techniques for studying functional genomics of important target sites of anthelm

200 ll as their development and applications for functional genomics of plant coding and non-coding genes

201 provide a platform for the evolutionary and functional genomics of satDNAs in pericentric heterochro

202 tablished as a model for the comparative and functional genomics of temperate cereals and grasses.

203 ant applications of the viral vector include functional genomics of the grapevine and disease control

204 ls that can be used for investigation of the functional genomics of these loci, and progress has been

205 clerosis and CAD will be learned through the functional genomics of these loci, and the hope is that

206 f fungi situates them as a relatively simple functional genomics platform for identification of mutat

207 This new functional genomics platform has broad potential applica

208 a genome-scale CRISPR interference (CRISPRi) functional genomics platform to systematically identify

209 We provide an overview of contemporary functional genomics platforms, highlighting areas of dis

210 As part of the Human Functional Genomics Project (HFGP), we investigate how d

211 ctional Genomics (200FG) cohort in the Human Functional Genomics Project, obtained over three differe

212 Studies from the Human Functional Genomics Project, presented in Cell and other

213 In three studies within the Human Functional Genomics Project, we assessed the effect of e

214 As part of the Human Functional Genomics Project, which aims to understand th

215 cohorts of Western Europeans from the Human Functional Genomics Project.

216 Over the past decade, large-scale functional genomics projects have driven transformative

217 mutLBSgeneDB provides a useful resource for functional genomics, protein structure, drug and disease

218 ression networks have been a useful tool for functional genomics, providing important clues about the

219 Genomics Data is one of three international functional genomics public data repositories, alongside

220 A large part of functional genomics' public catalogs is based on ChIP-se

221 p a data-sanitization procedure allowing raw functional genomics reads to be shared while minimizing

222 Targeted functional genomics represents a powerful approach for s

223 iew summarizes current GWAS efforts in maize functional genomics research and discusses future prospe

224 The recent surge in genome sequence data and functional genomics research has ushered in the discover

225 lish a standardized RT-qPCR protocol for the functional genomics research in a ladybeetle C. maculate

226 l C3 grass used as a monocot model system in functional genomics research.

227 s that NF genes may play in evolutionary and functional genomics research.

228 Gene Ontology (GO) is a central resource for functional-genomics research.

229 The recent availability of large-scale functional genomics resources provides an opportunity to

230 g unprecedented opportunities to develop the functional genomics resources required to investigate co

231 vard Medical School and associated DRSC/TRiP Functional Genomics Resources website serve as a reagent

232 A functional genomics screen led to the discovery of Epk1,

233 In a functional genomics screen of mouse embryonic stem cells

234 ng a shRNA library targeting 15,000 genes, a functional genomics screen was performed to identify gen

235 ppression pathway was identified by way of a functional genomics screening in human hepatoma cells.

236 researchers at all stages of high-throughput functional genomics screening, from assay design and rea

237 We demonstrated that AsCpf1 can be used for functional genomics screenings and that an AsCpf1-based

238 eutics, we combined antibody engineering and functional genomics screens to identify putative mechani

239 t HNSCC cell lines to RNA interference-based functional genomics screens to identify, in an unbiased

240 scale image-based analyses for mycobacterial functional genomics, simultaneously establishing the uti

241 Here we apply integrative functional genomics strategies to elucidate global HCV-m

242 combinatorial genomics-assisted breeding and functional genomics strategy, this study identified natu

243 cs in populations as a part of an integrated functional genomics strategy.

244 r effector technology is a powerful tool for functional genomics studies and biotechnological applica

245 ts for cancer treatment in clinical studies, functional genomics studies and computational studies an

246 sed to probe combinatorial gene functions in functional genomics studies and have the potential to ad

247 ng sequences and genes, which are needed for functional genomics studies and trait improvement in cro

248 encing of many crops has been achieved, crop functional genomics studies have stepped into the big-da

249 transformation method should help facilitate functional genomics studies in ferns.

250 applications of this viral vector system for functional genomics studies in maize and other monocots.

251 Such image-driven functional genomics studies may be expected to appear at

252 eated a variety of clone and mutant sets for functional genomics studies of Escherichia coli K-12.

253 ction of miRNA in P. aphrodite, and will aid functional genomics studies of orchids.

254 agenesis in B. distachyon, which will aid in functional genomics studies of other C3 grasses.

255 d to be mapped to variants and genes through functional genomics studies that combine annotation of v

256 Comparative functional genomics studies the evolution of biological

257 es focus on rare event categorical data, and functional genomics studies typically study the presence

258 In functional genomics studies, tests on mean heterogeneity

259 cRNAs) have been recently discovered through functional genomics studies.

260 ajor bottlenecks hindering crop breeding and functional genomics studies.

261 me engineering has opened up new avenues for functional genomics studies.

262 y assignment is crucial for evolutionary and functional genomics studies.

263 drug discovery and in protein structural and functional genomics studies.

264 undetermined, in part, because of a lack of functional genomics studies.

265 the relevance of human vascular explants for functional genomics studies.

266 resequencing had been performed, followed by functional genomics studies.

267 Our functional genomics study highlights the utility of NSCs

268 -wide association is a powerful approach for functional genomics study of specialized metabolism.

269 A functional genomics study revealed that the activity of

270 Numerous functional genomics techniques (e.g. machine learning) t

271 milar to human GWASs, it is important to use functional genomics techniques to gain a mechanistic und

272 As and the integration of RNA-seq with other functional genomics techniques.

273 ent state of knowledge concerning the use of functional genomics technologies to understand mechanism

274 advances in genomic resources and tools for functional genomics that are shifting the paradigm of wh

275 evelopments in transcriptomics (RNA-seq) and functional genomics that we expect to help us develop an

276 In addition to the potential application in functional genomics, this study provides the foundation

277 adly applicable platform for high-throughput functional genomics to accelerate biological studies and

278 We used functional genomics to classify a panel of diverse lipos

279 oot phenotyping, whole-plant physiology, and functional genomics to discover novel root traits and th

280 We combined functional genomics to identify a missing pathway enzyme

281 sms are poorly understood.Objectives: To use functional genomics to identify cellular mechanisms asso

282 We demonstrated the use of functional genomics to identify SNPs of potential functi

283 In this study, we used functional genomics to investigate noncytolytic mechanis

284 This study represents the first use of functional genomics to investigate the copper tolerance

285 be fundamental in applications ranging from functional genomics to precision medicine and is a conje

286 pigenetics research aligns with the field of functional genomics to provide insights into environment

287 To aid in the translation of functional genomics to therapeutics, we developed DrugTh

288 th Illumina sequencing as a maize (Zea mays) functional genomics tool.

289 Integrative analysis using functional genomics tools that included GeneWeaver, Stri

290 To facilitate fast-growing needs in functional genomics, two reverse genetics approaches hav

291 on gene discovery, fine mapping of loci, and functional genomics using state-of-the-art technologies.

292 enetic mapping, linkage group selection, and functional genomics was used to identify Pfs47 as a P. f

293 To accelerate legume functional genomics, we developed a Lotus japonicus Gene

294 Using molecular genetics and functional genomics, we find that these auxiliary regula

295 Using functional genomics, we identify new genes involved in f

296 Using a combination of transcriptomics and functional genomics, we unexpectedly identified a nodal

297 Continued advances in bioimaging and functional genomics will be important for quantitative a

298 s focused on the field of autoimmune disease functional genomics with a particular focus on the most

299 of studies at the proximate level, including functional genomics, with behavioral and ecological stud

300 roscopy-based screens are powerful tools for functional genomics, yielding intracellular information