ライフサイエンスコーパス: functional significance

1 sible mechanisms and provide tools to assess functional significance.

2 ochondrial genomic variations of potentially functional significance.

3 mplex containing beta-catenin and HMGA1 have functional significance.

4 um differentially expressed genes and are of functional significance.

5 ections leading to novel hypotheses on their functional significance.

6 ndicating that ExoU oligomerization may have functional significance.

7 drive, mood, and sexual aversion, providing functional significance.

8 ing firmer inferences to be made about their functional significance.

9 n wing discs reduced wing size demonstrating functional significance.

10 e to demonstrate that this capacity has some functional significance.

11 ic compartment or cellular structure and its functional significance.

12 Regions retaining nucleosomes may be of functional significance.

13 is known about their cortical generators and functional significance.

14 date risk genes and gene variants of unknown functional significance.

15 ctural abnormalities observed at G135 are of functional significance.

16 ns, leading to difficulty interpreting their functional significance.

17 show here that of the two, Lsr2 has greater functional significance.

18 Med-PIC structure reveals two components of functional significance, absent from previous structures

19 s a variety of animal and human studies, its functional significance and behavioral relevance have be

20 However, the functional significance and behavioral relevance of vari

21 Here, we explore the functional significance and evolutionary history of a T/

22 s, but more work is needed to understand the functional significance and fitness consequences for the

23 However, the functional significance and mechanisms of other classes

24 The strength, functional significance and origins of direct parasympat

25 The strength, functional significance and origins of parasympathetic i

26 However, the prevalence, functional significance and targets of lncRNA-mediated s

27 l characterized, the role of adaptation, its functional significance and the ecological conditions wh

28 In the present study, we illustrate the functional significance and therapeutic benefit of miR-2

29 his 19-stranded structure and its associated functional significance are unclear.

30 tional upregulation of GLDC expression is of functional significance, as GLDC depletion by RNA interf

31 We demonstrated that SLPI expression has functional significance, as it promotes CRPC cell surviv

32 epression susceptibility and confirmed their functional significance at the levels of gene transcript

33 We thus aimed to identify GRK5 variants of functional significance by analysing 187 individuals wit

34 tions/case (median 79 mutations of potential functional significance/case).

35 Despite its functional significance, computational methods to accura

36 The precise functional significance for 87% of TNNT2 variants remain

37 These results identify functional significance for neuronal MT stability and su

38 These results provide a possible functional significance for the distinct AOB physiology

39 bout their individual substrates, suggesting functional significance for these genes to the organism.

40 RP1 under steady-state conditions could have functional significance for these proteins.

41 n also strongly binds PtdIns(4,5)P2, but the functional significance has been unclear.

42 ly transcriptional response, and their wider functional significance, has remained unclear.

43 true for soil protists, which despite their functional significance have received comparatively less

44 human exomes and provides evidence for their functional significance, highlighting the importance of

45 ng-lived and heterologous reactivity and its functional significance, if any, need to be taken into a

46 NAs is the initial step in determining their functional significance in ageing and osteoarthritis, an

47 l scope of pioneer factors, indicating their functional significance in biological processes beyond t

48 ocated in excitatory neurons, suggesting its functional significance in epileptogenesis.

49 Cytoplasmic loops are known to have functional significance in membrane proteins such as Yid

50 identify mechanisms involved, and determine functional significance in myocytes of small cerebral ar

51 novel platform with which to interrogate its functional significance in normative and neuropsychiatri

52 m of miR-506 regulation and investigated its functional significance in pancreatic cancer.

53 We aimed to explore its functional significance in prostate tumor initiation and

54 ular damage, extracellular vesicles may have functional significance in renal health and disease by f

55 aphylococcal killing, supporting an IL-1beta functional significance in SaB clearance.

56 human advillin protein, we demonstrate their functional significance in the over 30 proteins that con

57 n hypothalamic WPNs and SPNs and discuss its functional significance in the sleep-wake network.

58 rtant tertiary interactions elucidates their functional significance in transcription regulation.

59 e been discovered, although their extent and functional significance in vascular plants remain uncert

60 Our work opens avenues to exploring the functional significance, informational content, and temp

61 expression changes in vivo and its in vitro-functional significance injured podocytes.

62 While their functional significance is increasingly being recognized

63 ent has been observed in many organisms, its functional significance is not clear.

64 the C terminus of all Coa molecules, but its functional significance is not known.

65 avage under inflammatory conditions, but the functional significance is not known.

66 Their functional significance is often unclear.

67 horylation sites for single kinases, but the functional significance is poorly understood.

68 s is pervasive in most genomes; however, its functional significance is still unclear.

69 cyl-PTMs) have been discovered, of which the functional significance is still under intense study.

70 spacers between 1 and 18 bp; however, their functional significance is unclear at present.

71 fish, yet despite its ubiquitous nature, the functional significance is unclear.

72 s in specific anatomical subfields and their functional significance is unclear.

73 vegetative diploid budding yeast, but their functional significance is unknown.

74 Here, we probed the functional significance of 5 distinct VP2 contact sites

75 398-412) report the functional significance of a "pioneer complex" in mouse

76 taneous wave-free ratio (iFR) are indices of functional significance of a coronary stenosis measured

77 y provides the first in vivo evidence of the functional significance of a minor transcript of BRCA2 t

78 biological evidence indicating the potential functional significance of ABCB1 and ABCB4, underlines t

79 Moreover, the functional significance of acetylation or how specific a

80 The functional significance of ADARs is much more diverse th

81 We investigated the functional significance of age-related differences in me

82 tion, an important step in understanding the functional significance of all TLDc domain-containing pr

83 ur study highlights the need to consider the functional significance of alterations to community attr

84 To investigate the functional significance of altered endothelial cell beha

85 -model system to experimentally validate the functional significance of an especially novel genetic a

86 We analyzed the functional significance of an SRNS-associated gene in vi

87 ed numerous opportunities to interrogate the functional significance of any given genomic site, there

88 llular ATP production, and have demonstrated functional significance of ATPSc methylation.

89 r example, the fact that we address both the functional significance of attractiveness-related biases

90 well understood, however, the mechanisms and functional significance of autonomic circuit modulation

91 However, the functional significance of autophagy in regulating cogni

92 dge gaps and challenges in understanding the functional significance of bacterial communities and bac

93 Collectively, our results demonstrate the functional significance of BMP signaling in regulating M

94 The functional significance of BOP1 in metastatic CaP was as

95 on, we sought to delete the IDR to study the functional significance of calcium-dependent, calmodulin

96 ntly, our findings allow us to interpret the functional significance of cancer associated ZRANB3 muta

97 These data identify the functional significance of CCK(NTS) neurons and reveal a

98 we used CCR9 knockout mice to determine the functional significance of CCR9 in regulating post-MI ca

99 Here, we define the nature and functional significance of chromatic influences on the m

100 The functional significance of chromatin in the cytoplasm is

101 nandez-Alvarez et al. (2016) reveal that the functional significance of clustering is to promote spin

102 ion promises to provide new ways to test the functional significance of coherent neural activity.

103 )Gal linked to hydroxylysine in animals, the functional significance of collagen glycosylation remain

104 For reovirus, the functional significance of conformational rearrangements

105 reserve (FFR) is commonly used to assess the functional significance of coronary artery disease but i

106 low reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is m

107 during coronary angiography to determine the functional significance of coronary stenoses.

108 iagnostic accuracy than DSQCA to predict the functional significance of coronary stenosis.

109 ve site and c-di-GMP binding, as well as the functional significance of crystallographic interprotome

110 The clinical and functional significance of CTCs is still under investiga

111 To explore the functional significance of cytokinin signaling for cambi

112 mprinting and X-chromosome inactivation, the functional significance of cytosine methylation and deme

113 on across species and the exploration of the functional significance of different leaf vein architect

114 any individual organism, the prevalence and functional significance of differentially present genes

115 es consistent causal evidence of the two-way functional significance of direct hippocampal-anterior t

116 However, the functional significance of Dlx5 in patterning the oropha

117 signaling bridge (MSB) score to quantify the functional significance of DmMGenes by assessing functio

118 We then quantified the functional significance of each O2 pathway defect by cal

119 Here, the functional significance of eL4 and the outer region of T

120 Recent efforts to probe the occurrence and functional significance of EMT in clinical samples and a

121 However, the functional significance of extracellular phosphorylation

122 romotes ventricular tachycardia, showing the functional significance of FXR1 upregulation observed in

123 have better cell type coherence, improve the functional significance of gene sets and provide new ins

124 We examined the functional significance of gene variants by using gene e

125 logical tools are required to understand the functional significance of genetic events revealed by wh

126 uture opportunities to better understand the functional significance of genetic variants and to utili

127 lia is well studied, less is known about the functional significance of glial interaction with the so

128 One of the main barriers to explaining the functional significance of glycan-based changes in cance

129 To elucidate the functional significance of glycosylation in ZIKV pathoge

130 hy matched controls to better understand the functional significance of greater extracellular water.

131 sites targeted for H3NT proteolysis and the functional significance of H3NT cleavage remain largely

132 one modifiers as tool compounds to study the functional significance of histone modifications and the

133 we address the current understanding of the functional significance of HO-1 against a variety of vir

134 Here, we reported a novel functional significance of iASPP upregulation in cervica

135 However, the functional significance of INS-membrane interaction is n

136 In the present study, we address the functional significance of interfacial residues between

137 tails of SETDB1's enzymatic activity and the functional significance of its SET-Insertion.

138 These findings shed light on the functional significance of lateral inhibition between MS

139 To characterize the anatomical basis and functional significance of less accessible temporal-lobe

140 expression in cyanobacterium, and reveal the functional significance of light-independent chlorophyll

141 se populations is necessary to establish the functional significance of lobules implicated in cogniti

142 The functional significance of loss of babA expression is un

143 this study is conducive to understanding the functional significance of Lrp6 on the biological proces

144 ANT methylation at Lys-52, and point out the functional significance of Lys-52 methylation in ANT.

145 We sought to examine the transcriptional and functional significance of macrophage repolarization fro

146 S-OPA1 in normal conditions, suggesting the functional significance of maintaining both OPA1 forms,

147 lly well-characterised but the existence and functional significance of many post-translational modif

148 As debates continue over the functional significance of many specific lncRNAs, suppor

149 However, the functional significance of microexons and their contribu

150 terpretation at a time when the ontogeny and functional significance of microglia had not yet been ch

151 ns in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specifi

152 The functional significance of MLSs lies in their members be

153 exception of a few spinal circuits where the functional significance of motor neuron feedback is stil

154 This study demonstrates the functional significance of Mst1r during pancreatic cance

155 re likely to be of value in interpreting the functional significance of mutations in the CTLA-4 pathw

156 Although the functional significance of nearly all of this sequence i

157 Moreover, the in vivo functional significance of NO2-Tyr(166)-apoA-I, a specif

158 The review concludes by considering the functional significance of noisy activity for neural net

159 sed an alternative approach to interpret the functional significance of noncoding somatic mutations i

160 To show the functional significance of nuclear localization, we demo

161 The functional significance of ordered nanodomains (or rafts

162 macromolecules that move in the phloem, the functional significance of phloem transport of these rem

163 Thus, understanding the functional significance of polymorphisms in MOLF STING c

164 Our findings demonstrate the complexity and functional significance of post-translational DNA damage

165 The regulatory dynamics and functional significance of putative aging-related hetero

166 In contrast, the functional significance of PV+ cell NMDA receptors (NMDA

167 To further reveal the functional significance of RBPs during neural developmen

168 nter-subunit interaction domains, reveal the functional significance of regulation of dendritic membr

169 The functional significance of ribosome heterogeneity in dev

170 We demonstrate novel functional significance of serum miR-29a by showing that

171 ficiency in mice leads to tumorigenesis, the functional significance of somatic SIRT2 mutations in hu

172 However, determining the functional significance of specific alterations remains

173 ; however, the expression, localization, and functional significance of specific nucleolar proteins h

174 this review, we focus on the regulation and functional significance of SR-B1 in mediating cholestero

175 To investigate the functional significance of Sts-1 2H phosphoesterase acti

176 role in bird diversification [4-8], whereas functional significance of substantial morphological div

177 of DNA methylation in cord blood, where the functional significance of such changes are unclear, and

178 The functional significance of such orderly patterning is un

179 In order to address the functional significance of the 'off' component of the pr

180 We validated the functional significance of the cardiotrophin-like cytoki

181 Future work on the functional significance of the change in gene expression

182 us due to uncertain order of acquisition and functional significance of the clade's diagnostic traits

183 current understanding of the structural and functional significance of the components of the rabies

184 However, the functional significance of the constricted conformation

185 udied extensively, little is known about the functional significance of the corresponding EF-hand dom

186 y electron microscopic analysis (3), but the functional significance of the different BRCA2 assemblie

187 The direct functional significance of the DNA methylation state of

188 , few studies have directly demonstrated the functional significance of the elytra against diverse en

189 We report here the functional significance of the G1-like M gene in H9N2 vi

190 our data establish a molecular mechanism and functional significance of the HBP in directly linking e

191 In this study, we investigated the functional significance of the HCND.

192 reduced staphylococcal killing, supporting a functional significance of the host IL-1beta response in

193 The functional significance of the Hsc70-TH interaction was

194 SLC16A8 (P = 1.7 x 10-8), further providing functional significance of the identified loci.

195 Finally, we investigated functional significance of the IKZF1 risk locus, and dem

196 required for these activities, we tested the functional significance of the interaction between the C

197 We have tested the functional significance of the ISVAID and of beta-/alpha

198 An analysis of the functional significance of the LTB using proxies indicat

199 However, the functional significance of the maxillary palp remained u

200 In this report, we have identified the functional significance of the membrane-proximal stalk r

201 s study was to characterize the dynamics and functional significance of the miRNA response of the tic

202 of this study was to determine the role and functional significance of the mitochondrial sirtuin 3 (

203 Here we report on the functional significance of the most recurrent PPP2R1A mu

204 The functional significance of the observed patch of carboxy

205 To test the functional significance of the PIMs, we compared foot an

206 The bacterial contribution and functional significance of the proteolytic signature wer

207 However, the functional significance of the pump dimerization remains

208 i protein structure provide insight into the functional significance of the putatively selected amino

209 However, the functional significance of the S6 cytoplasmic region in

210 , and finite element analysis to clarify the functional significance of the sagittal crest in tapirs.

211 Thus, the results illustrate the functional significance of the SPL-IKKepsilon-IFN axis d

212 of key residues in the interface support the functional significance of the structural model and indi

213 Addressing the overall functional significance of the uncinate and cingulum rel

214 ined FGFR and KIT inhibition, validating the functional significance of the underlying epigenetic les

215 and is a first step toward understanding the functional significance of the unusual abundance of opsi

216 However, the detailed functional significance of the vast majority of them rem

217 Users can investigate functional significance of their genetic alterations acr

218 To confirm the functional significance of these ACAAs, we tested and co

219 Yet, the functional significance of these activity-level changes

220 A expression over cancer development but the functional significance of these changes often rests upo

221 The functional significance of these components in ETI was c

222 Interpreting the functional significance of these data sets requires know

223 Finally, we speculate on the functional significance of these diverse polymers.

224 Laser-mediated tissue damage let us test the functional significance of these effects.

225 relatively common in animal genomes, but the functional significance of these endogenous parvoviral e

226 LNCaP and LNCaP-LN3 cells, demonstrating the functional significance of these findings.

227 The functional significance of these frequency bands is supp

228 a foundation for further examination of the functional significance of these genes to improve fruit

229 n shown to bind both AggR and H-NS in vitro, functional significance of these interactions has not be

230 However, characterizing the functional significance of these loci has proven challen

231 ture studies strive to better understand the functional significance of these mutations, including th

232 We experimentally validated the functional significance of these observations by demonst

233 haviours, although the causal mechanisms and functional significance of these oscillations remain unk

234 The functional significance of these projections is not full

235 The functional significance of these sites was demonstrated

236 by DNA polymerase, thereby demonstrating the functional significance of these structures.

237 Here, we sought to test the functional significance of these VP2 contact sites on VP

238 Here, we have investigated the functional significance of this accumulation at a genome

239 lls in a wide variety of structures, but the functional significance of this architectural diversity

240 system of awake rabbits, we investigate the functional significance of this axonal diversity, and th

241 D and sought to understand the mechanism and functional significance of this entry.

242 promoters, and alternative splicing, but the functional significance of this evolutionary conserved d

243 ly at high levels in the lymph node, but the functional significance of this expression is so far unk

244 d with distributed cortical regions, yet the functional significance of this extensive thalamocortica

245 We characterized the functional significance of this FP by using artificial m

246 However, the exact functional significance of this fusion remains unclear.

247 ough odorant receptors in vitro However, the functional significance of this GEF in the olfactory neu

248 iate with chromatin, but the specificity and functional significance of this interaction are not clea

249 on their ability to interact with AP-1, the functional significance of this interaction was unknown.

250 ptor (TCR) clonotypes, though the extent and functional significance of this is not established.

251 in calcium (Ca(2+)), but the mechanisms and functional significance of this localized signaling are

252 The functional significance of this MUC1-C-->BMI1 pathway is

253 9L) missense variant in EHMT1 To examine the functional significance of this novel variant, we perfor

254 However, the functional significance of this pathway in the control o

255 Importantly, revealing the functional significance of this phenomenon, both power a

256 However, the functional significance of this phosphorylation is undef

257 ibly position near nuclear speckles, but the functional significance of this positioning is unknown.

258 To test the functional significance of this predicted structure, we

259 Ts are highly static, yet the mechanisms and functional significance of this property are not well un

260 Furthermore, we demonstrate the functional significance of this rapid transcriptional ch

261 nsible for pigment dephosphorylation and the functional significance of this reaction remain unknown.

262 neutralizing antibody 5J7 and then test the functional significance of this region by transplanting

263 Our goal was to determine the functional significance of this region, which being inte

264 The functional significance of this topological regulation i

265 We discuss the potential functional significance of this unique sub-cellular stru

266 ion on genetic variation, but predicting the functional significance of this variation is a difficult

267 However, the functional significance of this variation remains largel

268 The present results revealed the functional significance of TNFalpha/TNFRI-mtO2(.-)-pCREB

269 a quantitative assessment of the drivers and functional significance of tool shape variation in a non

270 man cell line model systems, we examined the functional significance of two evolutionarily conserved

271 by alternative splicing when evaluating the functional significance of variants such as nonsense and

272 The functional significance of VM in SCLC suggests VM regula

273 igands are expressed in the vasculature, the functional significance of which is poorly understood.

274 furcation formation remains unclear, and the functional significance of WNT10A in regulating root mor

275 t time we unravel the expression pattern and functional significance of Wnt5a in cerebellar developme

276 Functional significances of these projections are discus

277 arate changes on the matrix and explores its functional significance on chemotactic cell migration.

278 erning has both a developmental as well as a functional significance, reflecting the rules governing

279 wever, their physiological basis and precise functional significance remain poorly understood.

280 ytes, however, its underlying mechanisms and functional significance remain unclear.

281 e mechanisms promoting this activity and its functional significance remain unresolved.

282 is increased in the diabetic heart, but its functional significance remains controversial.

283 /CaM signal transduction processes and their functional significance remains enigmatic.

284 and sequential [3], has been identified, its functional significance remains inadequately understood.

285 as a master regulator of cytoprotection, its functional significance remains to be completely defined

286 bout the current interpretation of beta band functional significance.SIGNIFICANCE STATEMENT The findi

287 ning time windows when lateral inhibition is functional.SIGNIFICANCE STATEMENT The olfactory bulb pla

288 solution and uncover structural features of functional significance that extend recent x-ray crystal

289 Despite its functional significance, the molecular mechanism of GnIH

290 g, and singing, are cultural universals with functional significance: these activities increase group

291 Our findings therefore add functional significance to a prominent exception of nucl

292 Adding key functional significance to our biochemical findings, we

293 The work highlights the danger of assigning functional significance to small differences between str

294 Lending functional significance to suppression-related alpha osc

295 within the NS5 dimer interface, providing a functional significance to the crystal structure NS5 dim

296 ted from the guts of numerous mammals, their functional significance to their hosts has never been ex

297 est the prevalence of phylosymbiosis and its functional significance under highly controlled conditio

298 r of response to dasatinib in NSCLC.Methods: Functional significance was evaluated by in vivo models

299 Its functional significance was further demonstrated in vivo

300 In order to characterize the functional significance, we overexpressed miR-335 in hum